JP4283666B2 - 水溶性ポリマー金属イオンアフィニティ組成物、およびその使用方法 - Google Patents
水溶性ポリマー金属イオンアフィニティ組成物、およびその使用方法 Download PDFInfo
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- JP4283666B2 JP4283666B2 JP2003507111A JP2003507111A JP4283666B2 JP 4283666 B2 JP4283666 B2 JP 4283666B2 JP 2003507111 A JP2003507111 A JP 2003507111A JP 2003507111 A JP2003507111 A JP 2003507111A JP 4283666 B2 JP4283666 B2 JP 4283666B2
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- metal ion
- water
- soluble
- ion affinity
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- 108010046334 Urease Proteins 0.000 description 1
- GKXVJHDEWHKBFH-UHFFFAOYSA-N [2-(aminomethyl)phenyl]methanamine Chemical compound NCC1=CC=CC=C1CN GKXVJHDEWHKBFH-UHFFFAOYSA-N 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
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- 150000001299 aldehydes Chemical class 0.000 description 1
- 108010004469 allophycocyanin Proteins 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
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- VYLDEYYOISNGST-UHFFFAOYSA-N bissulfosuccinimidyl suberate Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)C(S(O)(=O)=O)CC1=O VYLDEYYOISNGST-UHFFFAOYSA-N 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
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- 238000006352 cycloaddition reaction Methods 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
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- 238000000502 dialysis Methods 0.000 description 1
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- ZLFRJHOBQVVTOJ-UHFFFAOYSA-N dimethyl hexanediimidate Chemical compound COC(=N)CCCCC(=N)OC ZLFRJHOBQVVTOJ-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
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- 150000002170 ethers Chemical class 0.000 description 1
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- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
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- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- HYQBVSXBLGKEDT-UHFFFAOYSA-N hexane-1,4-diamine Chemical compound CCC(N)CCCN HYQBVSXBLGKEDT-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
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- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
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- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
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- 238000007899 nucleic acid hybridization Methods 0.000 description 1
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- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- UCUUFSAXZMGPGH-UHFFFAOYSA-N penta-1,4-dien-3-one Chemical compound C=CC(=O)C=C UCUUFSAXZMGPGH-UHFFFAOYSA-N 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- 230000000865 phosphorylative effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
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- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- ABZLKHKQJHEPAX-UHFFFAOYSA-N tetramethylrhodamine Chemical compound C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C([O-])=O ABZLKHKQJHEPAX-UHFFFAOYSA-N 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Manufacture And Refinement Of Metals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30033601P | 2001-06-21 | 2001-06-21 | |
| PCT/US2002/019879 WO2003000708A1 (en) | 2001-06-21 | 2002-06-20 | Water-soluble polymeric metal ion affinity compositions and methods for using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005517152A JP2005517152A (ja) | 2005-06-09 |
| JP2005517152A5 JP2005517152A5 (https=) | 2008-07-24 |
| JP4283666B2 true JP4283666B2 (ja) | 2009-06-24 |
Family
ID=23158678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003507111A Expired - Lifetime JP4283666B2 (ja) | 2001-06-21 | 2002-06-20 | 水溶性ポリマー金属イオンアフィニティ組成物、およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6703498B2 (https=) |
| EP (1) | EP1397372B1 (https=) |
| JP (1) | JP4283666B2 (https=) |
| AT (1) | ATE394412T1 (https=) |
| AU (1) | AU2002315414B2 (https=) |
| CA (1) | CA2447594A1 (https=) |
| DE (1) | DE60226437D1 (https=) |
| WO (1) | WO2003000708A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070921B2 (en) * | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| US7745142B2 (en) * | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
| US20050227294A1 (en) * | 1997-09-15 | 2005-10-13 | Molecular Devices Corporation | Molecular modification assays involving lipids |
| US7632651B2 (en) * | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US7297553B2 (en) * | 2002-05-28 | 2007-11-20 | Nanosphere, Inc. | Method for attachment of silylated molecules to glass surfaces |
| WO2003006676A2 (en) * | 2001-07-13 | 2003-01-23 | Nanosphere, Inc. | Method for immobilizing molecules onto surfaces |
| EP1534755B1 (en) | 2002-05-10 | 2011-10-12 | Bio-Layer Pty Limited | Generation of surface coating diversity |
| CA2519086A1 (en) * | 2003-03-14 | 2004-09-23 | Kitakyushu Foundation For The Advancement Of Industry Science And Techno Logy | Biological molecule-immobilized chip and its use |
| US20060189797A1 (en) * | 2003-06-27 | 2006-08-24 | Pal Songe | Magnetic polymer particles |
| US7956165B2 (en) | 2003-07-24 | 2011-06-07 | Affisink Biotechnology Ltd. | Compositions and methods for purifying and crystallizing molecules of interest |
| EP1700244A4 (en) | 2003-12-12 | 2009-07-08 | Bio Layer Pty Ltd | PROCESS FOR THE PREPARATION OF SURFACES |
| JP4897676B2 (ja) | 2004-07-02 | 2012-03-14 | バイオ‐レイヤー ピーティーワイ リミティッド | 金属錯体の使用方法 |
| US7294614B2 (en) * | 2004-10-12 | 2007-11-13 | Clontech Laboratories, Inc. | Phosphoprotein affinity resins and methods for making and using the same |
| US20070161785A1 (en) * | 2005-12-05 | 2007-07-12 | Clontech Laboratories, Inc. | High density metal ion affinity compositions and methods for making and using the same |
| EP2015071A1 (en) | 2007-07-13 | 2009-01-14 | FUJIFILM Corporation | Carrier, process for producing same, bioreactor, and chip for surface plasmon resonance analysis |
| US7946155B2 (en) * | 2007-09-19 | 2011-05-24 | Albion Laboratories, Inc. | Method for quantitatively determining unbound metal in formulations containing chelates |
| WO2010036520A1 (en) * | 2008-09-26 | 2010-04-01 | Wisconsin Alumni Research Foundation | Mesoporous metal oxide materials for phosphoproteomics |
| US10130711B2 (en) | 2013-06-19 | 2018-11-20 | The Regents Of The University Of California | Chemical structures for localized delivery of therapeutic agents |
| WO2015126522A1 (en) * | 2014-02-21 | 2015-08-27 | Clontech Laboratories, Inc. | Assay devices comprising a poly(acid) membrane, and methods using the same |
| WO2015126523A1 (en) * | 2014-02-21 | 2015-08-27 | Clontech Laboratories, Inc. | Spin columns comprising poly(acid) membrane separation matrices, and methods of making and using the same |
| ES2880468T3 (es) | 2014-03-14 | 2021-11-24 | Univ California | Conjugados de TCO y métodos para el suministro de agentes terapéuticos |
| JP6823067B2 (ja) | 2015-09-10 | 2021-01-27 | タンボ・インコーポレイテッド | 生体直交型組成物 |
| ES2983582T3 (es) | 2017-04-07 | 2024-10-23 | Tambo Inc | Composiciones bioortogonales |
| EP4295917A3 (en) | 2020-08-07 | 2024-02-28 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4569794A (en) | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
| US5047513A (en) | 1986-07-10 | 1991-09-10 | Hoffmann-La Roche Inc. | Metal chelate resins |
| CA1340522C (en) | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
| US5594115A (en) | 1990-04-09 | 1997-01-14 | Pharmacia & Upjohn Company | Process of purifying recombinant proteins and compounds useful in such process |
| TW442492B (en) * | 1995-07-26 | 2001-06-23 | Novartis Ag | Process for the enrichment of interferon |
| JP2000510332A (ja) * | 1996-04-19 | 2000-08-15 | ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン | インチミンを単独で、または１以上の他の抗原との融合タンパク質として発現する宿主生物の投与による、免疫応答を刺激する方法 |
| US5962641A (en) | 1996-08-16 | 1999-10-05 | Clontech Laboratories, Inc. | Method for purification of recombinant proteins |
| WO1998036054A1 (en) * | 1997-02-13 | 1998-08-20 | Amrad Operations Pty. Ltd. | Novel molecules |
| US6365147B1 (en) * | 1999-10-13 | 2002-04-02 | New Jersey Institute Of Technology | Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography |
| US20020019496A1 (en) | 2000-08-04 | 2002-02-14 | Gerald Pevow | Ligands for metal affinity chromatography |
-
2002
- 2002-06-20 JP JP2003507111A patent/JP4283666B2/ja not_active Expired - Lifetime
- 2002-06-20 US US10/176,955 patent/US6703498B2/en not_active Expired - Lifetime
- 2002-06-20 WO PCT/US2002/019879 patent/WO2003000708A1/en not_active Ceased
- 2002-06-20 CA CA002447594A patent/CA2447594A1/en not_active Abandoned
- 2002-06-20 AT AT02742266T patent/ATE394412T1/de not_active IP Right Cessation
- 2002-06-20 AU AU2002315414A patent/AU2002315414B2/en not_active Ceased
- 2002-06-20 DE DE60226437T patent/DE60226437D1/de not_active Expired - Fee Related
- 2002-06-20 EP EP02742266A patent/EP1397372B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60226437D1 (de) | 2008-06-19 |
| EP1397372A1 (en) | 2004-03-17 |
| US6703498B2 (en) | 2004-03-09 |
| JP2005517152A (ja) | 2005-06-09 |
| US20030023037A1 (en) | 2003-01-30 |
| ATE394412T1 (de) | 2008-05-15 |
| AU2002315414B2 (en) | 2008-02-07 |
| EP1397372B1 (en) | 2008-05-07 |
| WO2003000708A1 (en) | 2003-01-03 |
| CA2447594A1 (en) | 2003-01-03 |
| EP1397372A4 (en) | 2007-03-07 |
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