JP4210734B2 - Hla結合ペプチド及びその使用 - Google Patents
Hla結合ペプチド及びその使用 Download PDFInfo
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- JP4210734B2 JP4210734B2 JP53369097A JP53369097A JP4210734B2 JP 4210734 B2 JP4210734 B2 JP 4210734B2 JP 53369097 A JP53369097 A JP 53369097A JP 53369097 A JP53369097 A JP 53369097A JP 4210734 B2 JP4210734 B2 JP 4210734B2
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US1383396P | 1996-03-21 | 1996-03-21 | |
| US60/013,833 | 1996-03-21 | ||
| US08/821,739 US20020168374A1 (en) | 1992-08-07 | 1997-03-20 | Hla binding peptides and their uses |
| US08/821,739 | 1997-03-20 | ||
| PCT/US1997/004451 WO1997034617A1 (en) | 1996-03-21 | 1997-03-21 | Hla binding peptides and their uses |
Publications (3)
| Publication Number | Publication Date |
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| JP2002515868A JP2002515868A (ja) | 2002-05-28 |
| JP2002515868A5 JP2002515868A5 (enExample) | 2004-12-02 |
| JP4210734B2 true JP4210734B2 (ja) | 2009-01-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP53369097A Expired - Lifetime JP4210734B2 (ja) | 1996-03-21 | 1997-03-21 | Hla結合ペプチド及びその使用 |
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| Country | Link |
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| US (1) | US20020168374A1 (enExample) |
| EP (1) | EP0888120B1 (enExample) |
| JP (1) | JP4210734B2 (enExample) |
| CN (1) | CN1218404A (enExample) |
| AU (1) | AU725550B2 (enExample) |
| BR (1) | BR9708217A (enExample) |
| CA (1) | CA2248659A1 (enExample) |
| WO (1) | WO1997034617A1 (enExample) |
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| US20110097352A9 (en) * | 1992-01-29 | 2011-04-28 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
| US7611713B2 (en) * | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
| US9266930B1 (en) | 1993-03-05 | 2016-02-23 | Epimmune Inc. | Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions |
| US6265215B1 (en) * | 1996-09-13 | 2001-07-24 | Ludwig Institute For Cancer Research | Isolated peptides which complex with HLA-Cw16 and uses thereof |
| CN1268738C (zh) * | 1997-07-15 | 2006-08-09 | 宝生物工程株式会社 | 细胞毒性t淋巴细胞 |
| US6183746B1 (en) | 1997-10-09 | 2001-02-06 | Zycos Inc. | Immunogenic peptides from the HPV E7 protein |
| EP1064022A4 (en) * | 1998-03-13 | 2004-09-29 | Epimmune Inc | HLA BINDING PEPTIDES AND THEIR APPLICATIONS |
| US6534482B1 (en) * | 1998-05-13 | 2003-03-18 | Epimmune, Inc. | Expression vectors for stimulating an immune response and methods of using the same |
| WO2000002907A1 (fr) * | 1998-07-10 | 2000-01-20 | Kyogo Itoh | Peptide antigene tumoral produit dans le sart-1 |
| US20070020327A1 (en) * | 1998-11-10 | 2007-01-25 | John Fikes | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
| US6395714B1 (en) * | 1999-02-24 | 2002-05-28 | Aventis Pasteur Limited | Expressing gp140 fragment of primary HIV-1 isolate |
| GB9905911D0 (en) * | 1999-03-15 | 1999-05-05 | Photocure As | Method |
| CA2377525A1 (en) * | 1999-07-19 | 2001-03-29 | Epimmune, Inc. | Inducing cellular immune responses to hepatitis c virus using peptide and nucleic acid compositions |
| EP1225907A4 (en) * | 1999-10-05 | 2005-06-22 | Epimmune Inc | INDUCING CELLULAR IMMUNE RESPONSES TO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS |
| EP1230268B1 (en) * | 1999-11-18 | 2009-10-14 | Pharmexa Inc. | Heteroclitic analogs of class i epitopes |
| EP1237564A4 (en) * | 1999-12-10 | 2005-05-04 | Epimmune Inc | TRIGGERING OF CELLULAR IMMUNE RESPONSES AGAINST P53 USING NUCLEIC ACID AND PEPTIDE COMPOSITIONS |
| US7026443B1 (en) * | 1999-12-10 | 2006-04-11 | Epimmune Inc. | Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions |
| US20040146519A1 (en) * | 1999-12-10 | 2004-07-29 | John Fikes | Inducing cellular immune responses to carcinoembryonic antigen using peptide and nucleic acid compositions |
| US20070098776A1 (en) * | 1999-12-13 | 2007-05-03 | Fikes John D | HLA class I A2 tumor associated antigen peptides and vaccine compositions |
| US20040037843A1 (en) * | 1999-12-21 | 2004-02-26 | John Fikes | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
| US20040248113A1 (en) * | 1999-12-28 | 2004-12-09 | Alessandro Sette | Method and system for optimizing multi-epitope nucleic acid constructs and peptides encoded thereby |
| US7462354B2 (en) * | 1999-12-28 | 2008-12-09 | Pharmexa Inc. | Method and system for optimizing minigenes and peptides encoded thereby |
| US6399067B1 (en) * | 2000-04-28 | 2002-06-04 | Thymon L.L.C. | Methods and compositions for impairing multiplication of HIV-1 |
| EP1313505A4 (en) * | 2000-09-01 | 2005-10-12 | Epimmune Inc | HLA BINDING PEPTIDES AND THEIR USES (18.03.02) |
| US20040121946A9 (en) * | 2000-12-11 | 2004-06-24 | John Fikes | Inducing cellular immune responses to her2/neu using peptide and nucleic acid compositions |
| AU2002305138A1 (en) | 2001-04-09 | 2002-10-21 | Mayo Foundation For Medical Education And Research | Methods and materials for cancer treatment |
| WO2005012502A2 (en) * | 2003-03-28 | 2005-02-10 | Idm Pharma, Inc. | Methods of identifying optimal variants of peptide epitopes |
| WO2005089164A2 (en) * | 2003-12-31 | 2005-09-29 | Pharmexa Inc. | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
| JP2008509654A (ja) * | 2004-06-01 | 2008-04-03 | イノジェネティックス・ナムローゼ・フェンノートシャップ | C型肝炎ウイルスに対するctlおよび/またはhtl応答を誘導するためのペプチド |
| WO2006080142A1 (ja) * | 2005-01-25 | 2006-08-03 | Nec Corporation | Hla結合性ペプチド、それをコードするdna断片および組み換えベクター |
| CA2597373A1 (en) | 2005-02-15 | 2006-08-24 | Thymon, L.L.C. | Methods and compositions for impairing multiplication of hiv-1 |
| PL2562182T3 (pl) * | 2007-07-27 | 2016-03-31 | Immatics Biotechnologies Gmbh | Nowe immunogenne epitopy do immunoterapii |
| WO2010086294A2 (en) | 2009-01-28 | 2010-08-05 | Epimmune Inc. | Pan-dr binding polypeptides and uses thereof |
| JP2010001303A (ja) * | 2009-08-17 | 2010-01-07 | Pharmexa Inc | Hla結合ペプチド及びその使用 |
| EP2745845A1 (en) | 2012-12-19 | 2014-06-25 | Centre Hospitalier Universitaire de Bordeaux | A method for preventing or treating an HIV infection |
| WO2024077601A1 (en) * | 2022-10-14 | 2024-04-18 | Guangdong Tcrcure Biopharma Technology Co., Ltd. | Peptide vaccines against glioma and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE280180T1 (de) * | 1992-08-31 | 2004-11-15 | Ludwig Inst Cancer Res | Vom mage-3-gen abgeleitetes und von hla-a1 präsentiertes, isoliertes nonapeptid und dessen anwendungen |
| US5519117A (en) * | 1992-12-22 | 1996-05-21 | Ludwig Institute For Cancer Research | Isolated, tyrosinase derived peptides and uses thereof |
| EP0703783B1 (en) * | 1993-03-05 | 2010-05-05 | Epimmune Inc. | Methods of making immunogenic hla-a2.1 binding peptides |
| KR100235849B1 (ko) * | 1993-10-19 | 1999-12-15 | 에가시라 구니오 | HIV에 대한 면역응답을 유도할 수 있는 펩티드 및 그 펩티드를 함유하는 항 AIDS 예방, 치료제(Peptides Capable of Inducing Immune Response to HIV and Anti-AIDS Agent for Preventing and Curing AIDS) |
| US5788963A (en) * | 1995-07-31 | 1998-08-04 | Pacific Northwest Cancer Foundation | Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy |
-
1997
- 1997-03-20 US US08/821,739 patent/US20020168374A1/en not_active Abandoned
- 1997-03-21 CN CN97194554A patent/CN1218404A/zh active Pending
- 1997-03-21 AU AU23365/97A patent/AU725550B2/en not_active Ceased
- 1997-03-21 WO PCT/US1997/004451 patent/WO1997034617A1/en not_active Ceased
- 1997-03-21 EP EP97916104A patent/EP0888120B1/en not_active Expired - Lifetime
- 1997-03-21 BR BR9708217A patent/BR9708217A/pt unknown
- 1997-03-21 JP JP53369097A patent/JP4210734B2/ja not_active Expired - Lifetime
- 1997-03-21 CA CA002248659A patent/CA2248659A1/en not_active Abandoned
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|---|---|
| EP0888120A1 (en) | 1999-01-07 |
| EP0888120A4 (en) | 2000-01-05 |
| CN1218404A (zh) | 1999-06-02 |
| AU2336597A (en) | 1997-10-10 |
| US20020168374A1 (en) | 2002-11-14 |
| JP2002515868A (ja) | 2002-05-28 |
| WO1997034617A1 (en) | 1997-09-25 |
| BR9708217A (pt) | 1999-07-27 |
| AU725550B2 (en) | 2000-10-12 |
| CA2248659A1 (en) | 1997-09-25 |
| EP0888120B1 (en) | 2008-11-19 |
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