JP4191259B2 - ＧｎＲＨ拮抗物質 - Google Patents

ＧｎＲＨ拮抗物質 Download PDF

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Publication number
JP4191259B2
JP4191259B2 JP54422598A JP54422598A JP4191259B2 JP 4191259 B2 JP4191259 B2 JP 4191259B2 JP 54422598 A JP54422598 A JP 54422598A JP 54422598 A JP54422598 A JP 54422598A JP 4191259 B2 JP4191259 B2 JP 4191259B2
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JP
Japan
Prior art keywords
xaa
4aph
peptide
gln
ala
Prior art date
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Expired - Lifetime
Application number
JP54422598A
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English (en)
Japanese (ja)
Other versions
JP2001523232A (ja
JP2001523232A5 (cg-RX-API-DMAC7.html
Inventor
ジアン，ガンチェン．
センプル，グレーメ．
Original Assignee
フェリング ベスローテン フェンノートシャップ
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Application filed by フェリング ベスローテン フェンノートシャップ filed Critical フェリング ベスローテン フェンノートシャップ
Publication of JP2001523232A publication Critical patent/JP2001523232A/ja
Publication of JP2001523232A5 publication Critical patent/JP2001523232A5/ja
Application granted granted Critical
Publication of JP4191259B2 publication Critical patent/JP4191259B2/ja
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP54422598A 1997-04-11 1998-04-13 ＧｎＲＨ拮抗物質 Expired - Lifetime JP4191259B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/837,041 US5821230A (en) 1997-04-11 1997-04-11 GnRH antagonist decapeptides
US08/837,041 1997-04-11
PCT/US1998/007519 WO1998046635A1 (en) 1997-04-11 1998-04-13 GnRH ANTAGONISTS

Publications (3)

Publication Number Publication Date
JP2001523232A JP2001523232A (ja) 2001-11-20
JP2001523232A5 JP2001523232A5 (cg-RX-API-DMAC7.html) 2005-12-02
JP4191259B2 true JP4191259B2 (ja) 2008-12-03

Family

ID=25273348

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54422598A Expired - Lifetime JP4191259B2 (ja) 1997-04-11 1998-04-13 ＧｎＲＨ拮抗物質

Country Status (10)

Country Link
US (1) US5821230A (cg-RX-API-DMAC7.html)
EP (1) EP0973801B1 (cg-RX-API-DMAC7.html)
JP (1) JP4191259B2 (cg-RX-API-DMAC7.html)
AT (1) ATE229976T1 (cg-RX-API-DMAC7.html)
AU (1) AU7117498A (cg-RX-API-DMAC7.html)
DE (1) DE69810283T2 (cg-RX-API-DMAC7.html)
DK (1) DK0973801T3 (cg-RX-API-DMAC7.html)
ES (1) ES2187958T3 (cg-RX-API-DMAC7.html)
PT (1) PT973801E (cg-RX-API-DMAC7.html)
WO (1) WO1998046635A1 (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6828415B2 (en) * 1993-02-19 2004-12-07 Zentaris Gmbh Oligopeptide lyophilisate, their preparation and use
DE19712718C2 (de) * 1997-03-26 1999-09-23 Asta Medica Ag Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung
AU1590699A (en) * 1997-11-20 1999-06-15 Ortho-Mcneil Pharmaceutical, Inc. Liquid phase process for the preparation of gnrh peptides
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
JP4524823B2 (ja) * 1999-04-14 2010-08-18 住友化学株式会社 タンパク質のアミノ末端のアミノ酸配列決定方法
US7109171B2 (en) * 2000-02-28 2006-09-19 Praecis Pharmaceuticals Inc. Methods for treating FSH related conditions with GnRH antagonists
GB0117057D0 (en) * 2001-07-12 2001-09-05 Ferring Bv Pharmaceutical composition
BRPI0710503A2 (pt) * 2006-04-07 2011-08-16 Merrion Res Iii Ltd uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
JOP20090061B1 (ar) 2008-02-11 2021-08-17 Ferring Int Center Sa طريقة معالجة سرطان البروستاتا بمضادات الهرمونات التناسلية GnRH
TW200950799A (en) * 2008-05-07 2009-12-16 Merrion Res Iii Ltd Compositions of GnRH related compounds and processes of preparation
EP3225250B1 (en) 2008-05-21 2019-08-21 Ferring B.V. Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
TWI480286B (zh) * 2009-02-25 2015-04-11 Merrion Res Iii Ltd 雙膦酸鹽類組合物及藥物遞送
EP2424503B1 (en) 2009-05-01 2017-07-05 Ferring BV Composition for the treatment of prostate cancer
TW201043221A (en) * 2009-05-06 2010-12-16 Ferring Int Ct Sa Kit and method for preparation of a Degarelix solution
US20110039787A1 (en) * 2009-07-06 2011-02-17 Ferring International Center S.A. Compositions, kits and methods for treating benign prostate hyperplasia
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
DK2632934T3 (en) 2010-10-27 2017-01-23 Ferring Bv Process for the preparation of Degarelix and its intermediates
CN103476419A (zh) 2011-01-07 2013-12-25 梅里翁第三研究有限公司 口服投药的含铁药物组合物
JO3755B1 (ar) 2011-01-26 2021-01-31 Ferring Bv تركيبات تستوستيرون
PL4512389T1 (pl) 2012-06-01 2025-09-01 Ferring B.V. Produkt leczniczy degareliksu
US10265384B2 (en) 2015-01-29 2019-04-23 Novo Nordisk A/S Tablets comprising GLP-1 agonist and enteric coating

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073624A (en) * 1985-04-09 1991-12-17 Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4866160A (en) * 1985-04-09 1989-09-12 The Administrators Of The Tulane Educational Fund Therapeutic decapeptides
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US4935491A (en) * 1987-08-24 1990-06-19 Board Of Regents, The University Of Texas System Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5171835A (en) * 1988-10-21 1992-12-15 The Administrators Of The Tulane Educational Fund LHRH antagonists
US5169932A (en) * 1989-10-30 1992-12-08 The Salk Institute For Biological Studies Gnrh analogs
US5296468A (en) * 1989-10-30 1994-03-22 The Salk Institute For Biological Studies GnRH analogs
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
IL101074A (en) * 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
DE593491T1 (de) * 1991-04-25 1994-11-17 Romano S.-Cergue Deghenghi LHRH-Antagonisten.
US5508383A (en) * 1994-03-09 1996-04-16 Tap Holdings Inc. Cyclic peptide LHRH antagonists
US5506207A (en) * 1994-03-18 1996-04-09 The Salk Institute For Biological Studies GNRH antagonists XIII
US5681928A (en) * 1994-12-16 1997-10-28 The Salk Institute For Biological Studies Betides and methods for screening peptides using same
WO1997022622A1 (en) * 1995-12-15 1997-06-26 The Salk Institute For Biological Studies Betide-substituted gnrh antagonists

Also Published As

Publication number Publication date
DK0973801T3 (da) 2003-04-07
EP0973801A1 (en) 2000-01-26
ES2187958T3 (es) 2003-06-16
DE69810283D1 (de) 2003-01-30
JP2001523232A (ja) 2001-11-20
ATE229976T1 (de) 2003-01-15
PT973801E (pt) 2003-04-30
DE69810283T2 (de) 2003-07-24
EP0973801B1 (en) 2002-12-18
AU7117498A (en) 1998-11-11
US5821230A (en) 1998-10-13
WO1998046635A1 (en) 1998-10-22

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