JP4190037B2 - Rubber plug silicon processing method and apparatus - Google Patents

Rubber plug silicon processing method and apparatus Download PDF

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JP4190037B2
JP4190037B2 JP54688398A JP54688398A JP4190037B2 JP 4190037 B2 JP4190037 B2 JP 4190037B2 JP 54688398 A JP54688398 A JP 54688398A JP 54688398 A JP54688398 A JP 54688398A JP 4190037 B2 JP4190037 B2 JP 4190037B2
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emulsion
rubber plug
pump
water
container
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JP2001522339A (en
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エリクソン，イアン−オロフ
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ゲティンゲ ステラリゼエイション アクチエボラーク
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C3/00—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material
    • B05C3/02—Apparatus in which the work is brought into contact with a bulk quantity of liquid or other fluent material the work being immersed in the liquid or other fluent material

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  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Closures For Containers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Sealing Material Composition (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

本発明は、殺菌製品、例えば、調合された薬剤が入っているパッケージをシールするためのゴム栓を処理する方法に関する。
薬剤が入っている試験管形態のパッケージをシールする場合、パッケージに入っている殺菌された薬剤がまさしくそのパッケージシール工程中に汚染されないようにすることが重要である。この点については、そのような試験管の口を塞ぐためにゴム栓が用いられている。ゴム栓は、まず洗浄処理とすすぎ処理を受けた後、続いて殺菌処理と乾燥処理を受ける。殺菌工程の前に、ゴム栓は、シリコンで処理される。これは、殺菌工程後貯蔵された際にゴム栓が互いに付着しないように保証するとともに、ゴム栓をひとつずつ試験管に取り付けやすくしかつ試験管を効率良くシールするのに十分な柔軟性をゴム栓に付与するためである。
従来知られている方法によれば、洗浄したゴム栓を、シェーカ（shaker）として知られている振動台の上に置く。そして、霧状のシリコンをゴム栓に吹きかけた後、そのゴム栓を容器又は袋の中に集め、それごとオートクレーブ内で殺菌する。
他の従来技術の方法によれば、薄いシリコン油を水と混ぜ合わせ、混合を促進するために乳化剤を加える。そして、乳濁液が形成されると、これをゴム栓が入っている容器にポンプで注入する。ゴム栓は、容器内でシリコン処理され、殺菌され、乾燥される。
後者の方法は、比較的実施しやすいため、最初に述べた方法と比較して有利である。しかしながら、環境の面からは、この後者の方法は、乳濁液を形成するために化学物質を加える必要がある点で、不利である。
本発明の目的は、化学物質を一切加える必要なしにシリコンと水とから乳濁液を形成する方法を提供することである。この乳濁液を用いてゴム栓を効率良くシリコン処理することができる。この目的は、乳濁液を形成するのに十分強力な攪拌を加えながらシリコン油と水のみを混合し、得られた乳濁液をゴム栓が貯蔵されシリコン処理が行われる容器に導くという本発明方法の手段によって達成される。
また、本発明は、本方法を実行する装置に関する。本装置の特徴は、請求の範囲第４項に記載されている。
以下、本発明に係る装置の略図である添付図面を参照して、本発明をより詳細に説明する。
シリコン油３が入っている容器２から通じる導管１に計量ポンプ（dosage pump）４が取り付けられている。計量ポンプ４の下流には、導管１にシャットオフ弁が取り付けられている。導管１から給水管６が分かれており、この給水管６には同じようにシャットオフ弁７が取り付けられている。給水管６によって供給される水は、ポンプ４から吐出され導管１を通って輸送される計量された量のシリコン油３と混合される。導管１から給水管６が分かれている分岐点８の下流には、分散ポンプ（dispersing pump）９が設けられており、この分散ポンプ９からシリコン処理を施すゴム栓を貯蔵する容器１１に通じる導管１０には、別のシャットオフ弁１２及び絞り弁１３が取り付けられている。
本発明に係る方法は、以下のようにして実行される。水とシリコン油とを所望の割合で分散ポンプ９に圧送、注入する。ここで行われる分散は、シリコン油の粘度が高いか低いかとは無関係に、乳濁液を形成するのに十分強力である。その後、乳濁液を容器１１に圧送、注入し、ここで乳濁液とゴム栓との混合物１４が形成される。その後、ゴム栓のシリコン処理を行い、この結果、ゴム栓は薄いシリコンコーティングを受ける。
本発明に係る方法の他の展開によれば、乳濁液とゴム栓との混合物１４に空気を吹き付ける。この結果、乳濁液（シリコン）はゴム栓の表面に完全に付着するので残りの液体はほとんど水のみからなる。この水は排出する。すでに知られている方法では、蒸気を容器に供給してゴム栓を殺菌した後、乾燥させる。このとき、容器は、ゴム栓を使用時までしまっておくゴム栓貯蔵手段の用をしている。
絞り弁１３は、容器１１への流れを絞り作用によって可変できるようにするために設けられている。このようにして、最適な分散結果を得るために分散ポンプ９内で乳濁液混合時間を調整することができる。The present invention relates to a method of treating a rubber plug to seal a sterilized product, eg, a package containing a formulated drug.
When sealing a test tube package containing the drug, it is important that the sterilized drug contained in the package is not contaminated during the package sealing process. In this regard, rubber stoppers are used to close the mouth of such test tubes. The rubber plug is first subjected to a cleaning process and a rinsing process, and then to a sterilization process and a drying process. Prior to the sterilization process, the rubber plug is treated with silicon. This ensures that the rubber plugs do not stick to each other when stored after the sterilization process, and that the rubber plugs are easy to attach to the test tubes one by one and have enough flexibility to efficiently seal the test tubes. It is for giving to a stopper.
According to the methods known in the art, the cleaned rubber stopper is placed on a shaking table known as a shaker. And after spraying a mist-like silicon on a rubber stopper, the rubber stopper is collected in a container or a bag, and it sterilizes in an autoclave.
According to other prior art methods, a thin silicone oil is mixed with water and an emulsifier is added to facilitate mixing. When an emulsion is formed, it is pumped into a container containing a rubber stopper. The rubber stopper is siliconized, sterilized and dried in the container.
The latter method is advantageous compared to the first method because it is relatively easy to implement. However, from an environmental standpoint, this latter method is disadvantageous in that chemicals need to be added to form an emulsion.
It is an object of the present invention to provide a method for forming an emulsion from silicon and water without the need to add any chemicals. The rubber stopper can be efficiently siliconized using this emulsion. The purpose of this is to mix only silicone oil and water with strong enough stirring to form an emulsion and to guide the resulting emulsion to a container where a rubber stopper is stored and siliconized. This is achieved by means of the inventive method.
The invention also relates to an apparatus for performing the method. The features of this device are described in claim 4.
The present invention will now be described in more detail with reference to the accompanying drawings, which are schematic illustrations of devices according to the present invention.
A metering pump 4 is attached to a conduit 1 leading from a container 2 containing silicon oil 3. A shutoff valve is attached to the conduit 1 downstream of the metering pump 4. A water supply pipe 6 is separated from the conduit 1, and a shutoff valve 7 is similarly attached to the water supply pipe 6. The water supplied by the water supply pipe 6 is mixed with a metered amount of silicon oil 3 discharged from the pump 4 and transported through the conduit 1. A dispersion pump 9 is provided downstream of the branch point 8 where the water supply pipe 6 is separated from the conduit 1. 10, another shut-off valve 12 and a throttle valve 13 are attached.
The method according to the present invention is performed as follows. Water and silicon oil are pumped and injected into the dispersion pump 9 at a desired ratio. The dispersion performed here is strong enough to form an emulsion, regardless of whether the viscosity of the silicone oil is high or low. Thereafter, the emulsion is pumped and injected into the container 11, where a mixture 14 of emulsion and rubber stopper is formed. Thereafter, the siliconization of the rubber plug is performed, and as a result, the rubber plug receives a thin silicon coating.
According to another development of the method according to the invention, air is blown onto the mixture 14 of emulsion and rubber plug. As a result, the emulsion (silicone) adheres completely to the surface of the rubber plug, so that the remaining liquid consists almost entirely of water. This water is discharged. In the known method, steam is supplied to the container to sterilize the rubber stopper and then dried. At this time, the container is used as a rubber plug storage means for storing the rubber plug until use.
The throttle valve 13 is provided so that the flow to the container 11 can be varied by a throttle action. In this way, the emulsion mixing time can be adjusted within the dispersion pump 9 to obtain the optimum dispersion result.

Claims (4)

殺菌製品が入っているパッケージをシールするためのゴム栓を処理する方法であって、洗浄しすすいだ後に前記ゴム栓をシリコン油と水との乳濁液でシリコン処理した後、殺菌し乾燥させるものにおいて、乳濁液を形成するためにシリコン油と水とを分散ポンプ（９）内で攪拌しながら混合し、得られた乳濁液を、前記分散ポンプ（９）内での混合時間を調節するために設けられた絞り弁（１３）を通じて、前記ゴム栓が貯蔵されシリコン処理が行われる容器（１１）に供給することを特徴とする方法。A method of treating a rubber plug for sealing a package containing a sterilized product , which is cleaned and rinsed, and then siliconized with an emulsion of silicone oil and water, and then sterilized and dried. In order to form an emulsion, silicon oil and water are mixed with stirring in the dispersion pump (9), and the resulting emulsion is mixed with the mixing time in the dispersion pump (9). A method characterized in that the rubber plug is supplied to a container (11) where the rubber stopper is stored and siliconized through a throttle valve (13) provided for adjustment. 前記殺菌製品は、調合された薬剤であることを特徴とする請求の範囲第１項に記載の方法。The method of claim 1 wherein the sterilized product is a formulated drug. ゴム栓のシリコン処理を促進させるために乳濁液とゴム栓との混合物（１４）に空気を吹き付けることを特徴とする請求の範囲第１項に記載の方法。2. A method according to claim 1, characterized in that air is blown onto the mixture of emulsion and rubber plug (14) in order to accelerate the silicone treatment of the rubber plug. 殺菌製品が入っているパッケージをシールするためのゴム栓を処理する請求の範囲第１項に係る方法を実行する装置であって、当該装置は、計量した量のシリコン油を給水管（６）へ圧送するための第１のポンプ（４）と、分散作用のもとに、前記計量した量のシリコン油と前記給水管（６）を流通する水とを混合して乳濁液を形成し、得られた乳濁液を、シリコン処理のために前記ゴム栓が貯蔵されている容器（１１）へ圧送するための前記分散ポンプからなる第２のポンプ（９）とを有しており、前記第２のポンプ（９）内での混合時間を調節するため、前記第２のポンプ（９）から前記容器（１１）への流路内に絞り弁（１３）が設けられていることを特徴とする装置。A device for carrying out the method according to claim 1 for treating a rubber plug for sealing a package containing a sterilized product , the device comprising a metered amount of silicone oil in a water supply pipe (6) A first pump (4) for pumping to the water, and under a dispersing action, the measured amount of silicon oil and water flowing through the water supply pipe (6) are mixed to form an emulsion. A second pump (9) comprising the dispersion pump for pumping the obtained emulsion into a container (11) in which the rubber stopper is stored for silicon treatment; In order to adjust the mixing time in the second pump (9), a throttle valve (13) is provided in the flow path from the second pump (9) to the container (11). Features device.
JP54688398A 1997-04-29 1998-04-23 Rubber plug silicon processing method and apparatus Expired - Lifetime JP4190037B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9701602A SE512231C2 (en) 1997-04-29 1997-04-29 Method and apparatus for silicone rubber stoppers
SE9701602-6 1997-04-29
PCT/SE1998/000738 WO1998049069A1 (en) 1997-04-29 1998-04-23 A method and a device for siliconising rubber stoppers

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JP2001522339A JP2001522339A (en) 2001-11-13
JP4190037B2 true JP4190037B2 (en) 2008-12-03

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JP54688398A Expired - Lifetime JP4190037B2 (en) 1997-04-29 1998-04-23 Rubber plug silicon processing method and apparatus

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EP (1) EP1037815B2 (en)
JP (1) JP4190037B2 (en)
AU (1) AU7354198A (en)
DE (1) DE69809083T3 (en)
SE (1) SE512231C2 (en)
WO (1) WO1998049069A1 (en)

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CN114133608B (en) * 2021-11-26 2023-02-03 湖北华强科技股份有限公司 Silicification method for improving silicification uniformity of butyl rubber plug

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* Cited by examiner, † Cited by third party
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JPS5926129A (en) * 1982-08-05 1984-02-10 Konishiroku Photo Ind Co Ltd Apparatus for preparing dispersion liquid droplets
FR2637606B1 (en) * 1988-10-11 1990-12-14 Rhone Poulenc Chimie AQUEOUS SILICONE DISPERSION BASED ON ALCENYLOXYSILANE CROSSLINKING TO AN ELASTOMER BY REMOVAL OF WATER
FR2647798B1 (en) * 1989-05-31 1991-09-13 Rhone Poulenc Chimie AQUEOUS DISPERSION BASED ON FUNCTIONALIZED SILICON OILS WHICH CAN CROSSLINK TO AN ELASTOMER BY REMOVING WATER
DE8915896U1 (en) * 1989-09-20 1992-04-02 Smeja Gmbh & Co Kg, 4172 Straelen Cleaning and sterilizing machine for small objects, such as closure elements of pharmaceutical containers
GB9519972D0 (en) * 1995-09-28 1995-11-29 Ag Patents Ltd Improved container stoppers

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SE9701602D0 (en) 1997-04-29
WO1998049069A1 (en) 1998-11-05
DE69809083D1 (en) 2002-12-05
DE69809083T3 (en) 2006-03-16
EP1037815B1 (en) 2002-10-30
DE69809083T2 (en) 2003-07-24
JP2001522339A (en) 2001-11-13
EP1037815A1 (en) 2000-09-27
EP1037815B2 (en) 2005-06-29
SE512231C2 (en) 2000-02-14
SE9701602L (en) 1998-10-30
AU7354198A (en) 1998-11-24

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