JP4117253B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that performs qualitative and quantitative analysis of a specific component in a biological sample, and more particularly to an automatic analyzer that measures absorbance at a plurality of wavelengths.

  In a clinical test that analyzes components contained in a patient's blood, urine, and other biological samples, the sample is reacted with the reagent, and the change in the color of the reaction solution is measured as a change in absorbance (measurement of the change in light intensity at a specific wavelength). A method of measuring and qualitatively and quantitatively analyzing the target component is common. Since the wavelength of light at which the greatest change in absorbance appears depends on the type of reagent used, measurements are usually made at multiple wavelengths (e.g., 8 wavelengths, 12 wavelengths, 16 wavelengths, etc.), and changes in absorbance at wavelengths set by analysis parameters Based on this, the concentration of the target component is calculated.

  As shown in Patent Document 1, the conventional automatic analyzer displays only the reaction process (absorbance change) at the wavelength set by the analysis parameter, that is, one wavelength used for calculation of the measurement result, on the screen. Is common. In addition, the function of comparing and displaying the reaction processes of different specimens for the same item was also provided in a conventional automatic analyzer, but no means for efficiently reviewing the reaction process by comparison has been provided.

Japanese Patent Publication No. 6-27743

  Even with conventional devices, the measurement results at multiple wavelengths (8 wavelengths, 12 wavelengths, 16 wavelengths, etc.) are temporarily stored in the analyzer, but the reaction process at wavelengths other than the calculation of the measurement results specified by the analysis parameters There is no function for comparison display and means for easily performing comparison work for a plurality of reaction processes, and the review work for the reaction process is complicated. On the other hand, in recent years, the relationship between a change in absorbance at a wavelength other than the wavelength for which a measurement result is calculated and a disease has been studied.

  An object of the present invention is to provide an automatic analyzer having means for efficiently performing a review operation of absorbance changes at a plurality of wavelengths.

  In order to achieve the above object, the present invention provides a screen for inputting a plurality of designated conditions, means for storing a reaction process at a wavelength that can be used by the apparatus, and the reaction process based on the plurality of designated conditions. It is comprised by the means to extract only a desired reaction process from the reaction process memorize | stored in the memory | storage means, and the means to display the extracted reaction process.

  ADVANTAGE OF THE INVENTION According to this invention, the review process of a reaction process can be performed efficiently in the automatic analyzer for clinical laboratories.

  Embodiments of the present invention will be described below with reference to the drawings.

  FIG. 1 is a schematic view showing an automatic analyzer to which the present invention is applied.

In FIG. 1, 1 is a specimen container, 2 is a sample disk, 3 is a computer, 4 is an interface, 5 is a specimen dispensing mechanism, 6 is a reaction container, 7 is a specimen pump, 8 is a reagent dispensing probe, and 9 is a reaction. Tank, 11 is a reagent pump, 12 is a reagent container, 13 is a stirring mechanism, 15 is a multi-wavelength photometer, 16 is an A / D converter, 17 is a printer, 18 is a display unit, 19 is a cleaning mechanism,
21 is a keyboard as an input means, 23 is a reagent barcode reading device, 25 is a hard disk, and 26 is a reagent disk. The hard disk 25 stores analysis parameters, measurement results, reaction processes, and the like. Analysis parameters include wavelength and concentration calculation methods for calculating measurement results.

  The operation of the automatic analyzer is performed in the order of data processing such as sampling, reagent dispensing, stirring, photometry, washing of the reaction vessel, and concentration conversion as described below.

  A plurality of specimen containers 1 each containing a sample are installed on a sample disk 2. The sample container 1 is controlled by the computer 3 via the interface 4. Further, the sample container 1 moves under the sample dispensing mechanism 5 according to the order of samples to be analyzed, and a sample in a predetermined sample container 1 is moved by a sample pump 7 connected to the sample dispensing mechanism 5. A predetermined amount is dispensed into the reaction vessel 6. The reaction container 6 into which the sample has been dispensed moves in the reaction tank 9 to the first reagent addition position. A predetermined amount of the reagent sucked from the reagent container 12 by the reagent pump 11 connected to the reagent dispensing probe 8 is added to the moved reaction container 6. The reaction vessel 6 after the addition of the first reagent moves to the position of the stirring mechanism 13 and the first stirring is performed. Such reagent addition-stirring is performed for the first to fourth reagents. The reaction vessel 6 in which the contents are stirred passes through a light beam emitted from a light source, and the absorbance at this time is detected by a multi-wavelength photometer 15. The detected absorbance signal enters the computer 3 via the interface 4 via the A / D converter 16. The absorbance signal at the wavelength specified by the analysis parameter is converted into the concentration of the specimen. The density-converted data is printed out from the printer 17 via the interface 4 and stored in the hard disk 25. Absorbance signals having wavelengths not specified by the analysis parameters are also stored in the hard disk 25 after passing through the A / D converter 16 and the interface 4. After completion of photometry, the reaction vessel 6 moves to the position of the cleaning mechanism 19, discharges the internal liquid, and is then washed with water and used for the next analysis.

  The computer 3 extracts the reaction process from a number of reaction processes stored in the hard disk 25 based on the designated condition input by the input means such as the keyboard 21 and displays it on the display unit 18.

  In this way, it is possible to efficiently perform a review process of a reaction process by an operator by making it possible to specify conditions that make it easy to compare reaction processes.

  FIG. 2 is an example of a screen for designating reaction process extraction conditions in an automatic analyzer to which the present invention is applied. Item name 31, measurement time range 32, measurement result range 33, wavelength 34, photometric point and absorbance range 35 at the photometric point. For the item name 31, an item name of the reaction process to be extracted, for example, “glucose” is selected. The measurement time range 32 designates a measurement time range of the measurement result, for example, “August 21, 2003, 7:00:00 to August 23, 2003, 17:00”. The measurement result range 33 is designated as “70 to 73 mg / dl” when the measurement range of the measurement result, for example, glucose is taken as an example. For the wavelength 34, the wavelength of the reaction process to be extracted is selected. The wavelength selected here is not necessarily the wavelength used for calculation of the measurement result. In the photometry point / absorbance range 35, the photometry point and the absorbance range at the photometry point at the wavelength designated by the wavelength 34 are designated. As described above, a plurality of conditions for extracting reaction processes can be designated. When the conditions for extracting the input reaction process are stored in the memory, the setting condition registration button 38 is selected. When the name of the condition to be stored here is edited to a name that can be easily recognized by the operator, it is entered in the setting condition registration name area 39.

  FIG. 3 is an example of a comparison display screen of reaction processes extracted according to the specified conditions set in FIG. In this example, an item for calculating a measurement result using the difference between the absorbance at T1 and the absorbance at T2 is taken up. When the reaction process (A), the reaction process (B), and the reaction process (C) are compared, the difference in absorbance at T1 and T2 is almost the same, so the measurement result also has the same value. However, in the reaction process (c), some abnormality occurs during the reaction, for example, the phenomenon that the reaction solution is diluted due to the scattered washing water entering the reaction vessel during the reaction, resulting in a decrease in absorbance. Can be easily determined.

  By pressing the comparison display condition setting button 36 provided on the same screen on which the reaction process is displayed, it is possible to easily execute the screen for designating the reaction process extraction condition shown in FIG.

  Furthermore, by providing an automatic comparison button 37 for the apparatus to automatically extract and display from a plurality of reaction processes storing reaction processes suitable for conditions set in advance by the operator, Time and effort can be reduced.

  FIG. 4 is an example of a screen having a function of adjusting the absorbance of a plurality of displayed reaction processes. When the measurement result range 33 and the measurement point / absorbance range 35 are not properly set under the specified conditions in FIG. 2 above, or because the absorbance at T1 differs for each sample depending on the properties of the sample, a plurality of reaction processes are performed. Is displayed at the same time, the absorbance scale of the displayed reaction process increases, and as a result, it is difficult to distinguish between the reaction process (d), reaction process (e), and reaction process (f). Become. In that case, it is necessary to set the reference absorbance at the reference photometry point and redisplay the reaction process so that the comparison is easy. As described above, when the display of the reaction process is performed again, the adjusted reaction process is displayed again by the operator specifying the display reaction process adjustment 41.

  FIG. 5 is a process flow diagram for redisplaying the reaction process executed when the “display reaction process adjustment 41” described in FIG. 4 is designated.

  FIG. 6 is a diagram showing the reaction process shown in FIG. 4 after the redisplay process described in FIG. 5 is executed. The function of adjusting the display reaction process makes it easy to compare the reaction processes of a plurality of specimens.

BRIEF DESCRIPTION OF THE DRAWINGS Schematic which shows the automatic analyzer of one Example of this invention. Setting screen for reaction process extraction conditions. Display screen of reaction process. Display screen of reaction process with display reaction process adjustment function. The processing flowchart for redisplay of the reaction process. Display screen of reaction process.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Sample container, 2 ... Sample disk, 3 ... Computer, 4 ... Interface, 5 ... Sample dispensing mechanism, 6 ... Reaction container, 7 ... Sample pump, 8 ... Reagent dispensing probe, 9 ... Reaction tank, 11 ... Reagent pump, 12 ... Reagent container, 13 ... Stirring mechanism, 15 ... Multi-wavelength photometer, 16 ... A / D conversion converter, 17 ... Printer, 18 ... Display unit, 19 ... Cleaning mechanism, 23 ... Reagent barcode reader , 25 ... hard disk, 26 ... reagent disk, 31 ... item name input area, 32 ... measurement time range input area, 33 ... measurement result range input area, 34 ... wavelength selection area, 35 ... photometry point / absorbance range input area, 36 ... comparison display condition setting button, 37 ... automatic comparison button, 38 ... setting condition registration button, 39 ... setting condition registration name area.

Claims (4)

A reaction vessel for mixing the sample and the reagent;
A photometer capable of measuring the change in absorbance of the liquid in the reaction vessel at a plurality of wavelengths;
Storage means for storing absorbance change information at a plurality of wavelengths measured by the photometer;
A search condition specifying means capable of specifying at least a measurement item and a range of measurement values of the measurement result of the measurement item ;
Extraction means for extracting absorbance change information that matches the search condition designated by the search condition designating means from the storage means;
Output means for simultaneously outputting the absorbance change information extracted by the extraction means;
An automatic analyzer characterized by comprising: Automatic analyzer, characterized in that the search condition according to claim 1, wherein comprises a measuring wave length.   2. The automatic analyzer according to claim 1, wherein the search condition according to claim 1 further includes a photometric point and an absorbance range at the photometric point.   2. The automatic analyzer according to claim 1, further comprising an adjusting means for adjusting an absorbance display scale or an absorbance display time scale of the output absorbance change information of the plurality of reaction processes.

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