JP4115838B2 - δＰＫＣの活性化および阻害のためのペプチド - Google Patents

δＰＫＣの活性化および阻害のためのペプチド Download PDF

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Publication number
JP4115838B2
JP4115838B2 JP2002558467A JP2002558467A JP4115838B2 JP 4115838 B2 JP4115838 B2 JP 4115838B2 JP 2002558467 A JP2002558467 A JP 2002558467A JP 2002558467 A JP2002558467 A JP 2002558467A JP 4115838 B2 JP4115838 B2 JP 4115838B2
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seq
peptide
amino acid
δpkc
ischemia
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JP2004521108A (ja
JP2004521108A5 (enExample
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ダリア モックリー−ローゼン，
レオン チェン，
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Leland Stanford Junior University
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Leland Stanford Junior University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002558467A 2001-01-18 2001-11-09 δＰＫＣの活性化および阻害のためのペプチド Expired - Fee Related JP4115838B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26206001P 2001-01-18 2001-01-18
PCT/US2001/047556 WO2002057413A2 (en) 2001-01-18 2001-11-09 Peptides for activation and inhibition of delta pkc

Related Child Applications (1)

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JP2008048806A Division JP4592772B2 (ja) 2001-01-18 2008-02-28 δＰＫＣの活性化および阻害のためのペプチド

Publications (3)

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JP2004521108A JP2004521108A (ja) 2004-07-15
JP2004521108A5 JP2004521108A5 (enExample) 2006-01-05
JP4115838B2 true JP4115838B2 (ja) 2008-07-09

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JP2002558467A Expired - Fee Related JP4115838B2 (ja) 2001-01-18 2001-11-09 δＰＫＣの活性化および阻害のためのペプチド
JP2008048806A Expired - Fee Related JP4592772B2 (ja) 2001-01-18 2008-02-28 δＰＫＣの活性化および阻害のためのペプチド

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Country Link
US (5) US6855693B2 (enExample)
EP (2) EP1351980B1 (enExample)
JP (2) JP4115838B2 (enExample)
AU (1) AU2002226061B2 (enExample)
CA (1) CA2434643C (enExample)
WO (1) WO2002057413A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008231103A (ja) * 2001-01-18 2008-10-02 Univ Leland Stanford Jr δＰＫＣの活性化および阻害のためのペプチド

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WO2003089456A2 (en) * 2002-04-22 2003-10-30 The Board Of Trustees Of The Leland Stanford Junior University Peptide inhibitors of protein kinase c
US20110002978A1 (en) 2003-06-17 2011-01-06 Harrison Roger G Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof
BRPI0414714A (pt) * 2003-09-24 2006-11-21 Pasteur Institut polinucleotìdeo purificado, vetor, célula hospedeira, construto de fusão de polipeptìdeo, métodos de inibir a rota de sinalização de nf-capab, de interromper a oligomerização de nemo, e, de identificar polipeptìdeos que modulam a oligomerização de nemo, e, uso de uma quantidade eficaz de uma composição
US7560241B2 (en) * 2003-12-09 2009-07-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2
WO2005065666A1 (en) * 2003-12-22 2005-07-21 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Us of a pkc-delta inhibitor for the inhibition of metastatic melanoma
US20050267030A1 (en) * 2004-04-30 2005-12-01 Tsao Philip S Use of deltaPKC peptides for modulation of reactive oxygen species
US20090155236A1 (en) * 2004-08-02 2009-06-18 National Institues Of Health (Nih), U.S. Dept Of Health And Human Service U.S. Government Peptide sequence for modulation of delta protein kinase c
US7265092B2 (en) 2004-09-30 2007-09-04 Kai Pharmaceuticals, Inc. Pharmaceutical formulation
US20060148700A1 (en) * 2004-11-10 2006-07-06 Daria Mochly-Rosen Methods and compositions for reducing injury to a transplanted organ
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US20060160062A1 (en) * 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
US20090186814A1 (en) * 2005-01-26 2009-07-23 Fumiaki Ikeno Methods and Compositions for Reducing Ischemia-Derived Microvascular Damage
WO2006095086A2 (fr) * 2005-03-07 2006-09-14 Laurence Faure Traçabilite des anomalies du cycle cellulaire ciblant l'oncologie et la neurodegenerescence.
WO2007027974A1 (en) * 2005-09-02 2007-03-08 The Board Of Trustees Of The Leland Stanford Junior University Method for reducing risk of and extent of injury due to stroke in hypertensive subjects
CN101305092A (zh) * 2005-09-19 2008-11-12 凯制药公司 血管发生的蛋白激酶c肽调节剂
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US20070148628A1 (en) * 2005-12-09 2007-06-28 Philadelphia College Of Osteopathic Medicine Organ preservation and/or perfusion
EP2069388A2 (en) * 2006-10-02 2009-06-17 The Board Of Trustees Of The Leland Stanford Junior University Peptides derived from the c2 domain of epsilon pkc, and use thereof
JP5645408B2 (ja) * 2006-11-16 2014-12-24 カイ ファーマシューティカルズ インコーポレーティッド 副甲状腺機能亢進症および高カルシウム血症性障害の治療のためのポリカチオン性カルシウムモジュレーターペプチド
WO2008080153A2 (en) * 2006-12-22 2008-07-03 The Children's Hospital Of Philadelphia A novel protein kinase c therapy for the treatment of acute lung injury
CA2689296C (en) * 2007-01-10 2015-11-17 Purdue Research Foundation Polypeptide inhibitors of hsp27 kinase and uses therefor
US20080293640A1 (en) * 2007-01-10 2008-11-27 Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of Polypeptide inhibitors of HSP27 kinase and uses therefor
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WO2008097563A1 (en) * 2007-02-06 2008-08-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-pkc inhibitor
KR100906153B1 (ko) 2007-07-04 2009-07-03 재단법인 한국원자력의학원 프로테인 카이네즈 씨 활성 저해용 단백질 및 이를포함하는 약제학적 조성물
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Publication number Priority date Publication date Assignee Title
JP2008231103A (ja) * 2001-01-18 2008-10-02 Univ Leland Stanford Jr δＰＫＣの活性化および阻害のためのペプチド

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Publication number Publication date
JP2004521108A (ja) 2004-07-15
US6855693B2 (en) 2005-02-15
US20090075901A1 (en) 2009-03-19
CA2434643C (en) 2013-10-29
EP1351980A4 (en) 2005-02-02
US20040204364A1 (en) 2004-10-14
US7915219B2 (en) 2011-03-29
EP1351980B1 (en) 2014-12-31
US8822636B2 (en) 2014-09-02
JP2008231103A (ja) 2008-10-02
AU2002226061B2 (en) 2007-08-02
US7851586B2 (en) 2010-12-14
JP4592772B2 (ja) 2010-12-08
CA2434643A1 (en) 2002-07-25
US7745388B2 (en) 2010-06-29
US20020150984A1 (en) 2002-10-17
WO2002057413A2 (en) 2002-07-25
US20090192089A1 (en) 2009-07-30
WO2002057413A3 (en) 2003-04-03
EP1351980A2 (en) 2003-10-15
EP2338899A1 (en) 2011-06-29
US20110143991A1 (en) 2011-06-16

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