CA2434643C - Peptides for activation and inhibition of.delta.pkc - Google Patents
Peptides for activation and inhibition of.delta.pkc Download PDFInfo
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- CA2434643C CA2434643C CA2434643A CA2434643A CA2434643C CA 2434643 C CA2434643 C CA 2434643C CA 2434643 A CA2434643 A CA 2434643A CA 2434643 A CA2434643 A CA 2434643A CA 2434643 C CA2434643 C CA 2434643C
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- 229940124597 therapeutic agent Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26206001P | 2001-01-18 | 2001-01-18 | |
| US60/262,060 | 2001-01-18 | ||
| PCT/US2001/047556 WO2002057413A2 (en) | 2001-01-18 | 2001-11-09 | Peptides for activation and inhibition of delta pkc |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2434643A1 CA2434643A1 (en) | 2002-07-25 |
| CA2434643C true CA2434643C (en) | 2013-10-29 |
Family
ID=22995990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2434643A Expired - Fee Related CA2434643C (en) | 2001-01-18 | 2001-11-09 | Peptides for activation and inhibition of.delta.pkc |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US6855693B2 (enExample) |
| EP (2) | EP2338899A1 (enExample) |
| JP (2) | JP4115838B2 (enExample) |
| AU (1) | AU2002226061B2 (enExample) |
| CA (1) | CA2434643C (enExample) |
| WO (1) | WO2002057413A2 (enExample) |
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| US20020168354A1 (en) * | 2000-11-10 | 2002-11-14 | Daria Mochly-Rosen | psiepsilonRack peptide composition and method for protection against tissue damage due to ischemia |
| AU2002226061B2 (en) * | 2001-01-18 | 2007-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for activation and inhibition of delta PKC |
| US7645739B2 (en) * | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
| WO2004045535A2 (en) * | 2002-11-14 | 2004-06-03 | Arbor Vita Corporation | Molecular interactions in neurons |
| US7507711B2 (en) * | 2002-04-22 | 2009-03-24 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase C |
| US20110002978A1 (en) * | 2003-06-17 | 2011-01-06 | Harrison Roger G | Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof |
| US7700553B2 (en) * | 2003-09-24 | 2010-04-20 | Institut Pasteur | Selective inhibition of NF-κB activation by peptides designed to disrupt nemo oligomerization |
| WO2005057213A1 (en) * | 2003-12-09 | 2005-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2 |
| WO2005065666A1 (en) * | 2003-12-22 | 2005-07-21 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Us of a pkc-delta inhibitor for the inhibition of metastatic melanoma |
| US20050267030A1 (en) * | 2004-04-30 | 2005-12-01 | Tsao Philip S | Use of deltaPKC peptides for modulation of reactive oxygen species |
| JP2008508363A (ja) * | 2004-08-02 | 2008-03-21 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | δプロテインキナーゼＣの調節のためのペプチド配列 |
| US7265092B2 (en) * | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| US20060148700A1 (en) * | 2004-11-10 | 2006-07-06 | Daria Mochly-Rosen | Methods and compositions for reducing injury to a transplanted organ |
| AU2005325128A1 (en) | 2005-01-04 | 2006-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of increasing cerebral blood flow |
| US20060160062A1 (en) * | 2005-01-14 | 2006-07-20 | Young Lindon H | Perfusion and/or preservation solution for organs |
| US20090186814A1 (en) * | 2005-01-26 | 2009-07-23 | Fumiaki Ikeno | Methods and Compositions for Reducing Ischemia-Derived Microvascular Damage |
| US9523688B2 (en) * | 2005-03-07 | 2016-12-20 | Laurence Faure | Diagnosis method and treatment for cancer using liv21 proteins and E2F1/E2F4 biomarkers |
| WO2007027974A1 (en) * | 2005-09-02 | 2007-03-08 | The Board Of Trustees Of The Leland Stanford Junior University | Method for reducing risk of and extent of injury due to stroke in hypertensive subjects |
| EP2194124A1 (en) * | 2005-09-19 | 2010-06-09 | Kai Pharmaceuticals, Inc. | Protein kinase c peptide modulators of angiogenesis |
| US20070148628A1 (en) * | 2005-12-09 | 2007-06-28 | Philadelphia College Of Osteopathic Medicine | Organ preservation and/or perfusion |
| DK2056851T3 (da) * | 2005-12-09 | 2013-10-14 | Philadelphia College Of Osteopathic Medicine | Organkonservering og/eller -perfusion |
| EP2069388A2 (en) | 2006-10-02 | 2009-06-17 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides derived from the c2 domain of epsilon pkc, and use thereof |
| KR101552843B1 (ko) * | 2006-11-16 | 2015-09-14 | 카이 파마슈티컬즈 | 부갑상선 기능항진증 및 고칼슘혈증 장애의 치료를 위한 폴리양이온성 칼슘 조절제 펩타이드 |
| WO2008080153A2 (en) * | 2006-12-22 | 2008-07-03 | The Children's Hospital Of Philadelphia | A novel protein kinase c therapy for the treatment of acute lung injury |
| US20080293640A1 (en) * | 2007-01-10 | 2008-11-27 | Arizona Board of Regents, A body Corporate, of the State of Arizona, acting for and on behalf of | Polypeptide inhibitors of HSP27 kinase and uses therefor |
| ES2476842T3 (es) | 2007-01-10 | 2014-07-15 | Purdue Research Foundation | Inhibidores polipept�dicos de HSP27 quinasa y usos de los mismos |
| CN103524623A (zh) * | 2007-01-19 | 2014-01-22 | 凯制药公司 | 肽组合物的修饰以提高稳定性和递送效率 |
| US20090062208A1 (en) * | 2007-02-06 | 2009-03-05 | Mochly-Rosen Daria D | Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor |
| KR100906153B1 (ko) | 2007-07-04 | 2009-07-03 | 재단법인 한국원자력의학원 | 프로테인 카이네즈 씨 활성 저해용 단백질 및 이를포함하는 약제학적 조성물 |
| DK2185698T3 (en) | 2007-08-07 | 2015-07-27 | Purdue Research Foundation | Kinase Inhibitors and Uses thereof |
| CA2698013A1 (en) * | 2007-08-27 | 2009-03-05 | Kai Pharmaceuticals, Inc. | Protein kinase c-d inhibitors that protect against cellular injury and inflammation and promote astrocyte proliferation |
| CA2705862C (en) * | 2007-11-16 | 2018-03-27 | San Diego State University Research Foundation | Compositions and method for manipulating pim-1 activity in circulatory system cells |
| US20090318351A1 (en) * | 2008-03-12 | 2009-12-24 | Kevin Grimes | Method of treating acute st-elevation myocardial infarction with a delta pkc antagonist |
| WO2010019965A1 (en) * | 2008-08-15 | 2010-02-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for modulating epsilon protein kinase c-mediated cytoprotection |
| US9327008B2 (en) | 2008-12-10 | 2016-05-03 | Purdue Research Foundation | Cell-permeant peptide-based inhibitor of kinases |
| WO2011017132A2 (en) * | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| PT2459208T (pt) | 2009-07-29 | 2017-01-03 | Kai Pharmaceuticals Inc | Agentes terapêuticos para redução dos niveis de hormona paratiroideia |
| WO2011041385A2 (en) | 2009-09-29 | 2011-04-07 | Joslin Diabetes Center, Inc. | Use of protein kinase c delta (pkcd) inhibitors to treat diabetes, obesity, and hepatic steatosis |
| SMT201700081T1 (it) | 2011-06-08 | 2017-03-08 | Kai Pharmaceuticals Inc | Agenti terapeutici per la regolazione del fosforo sierico |
| US9217137B2 (en) | 2011-08-12 | 2015-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for specific regulation of pyruvate dehydrogenase kinase |
| WO2013134636A1 (en) | 2012-03-09 | 2013-09-12 | Purdue Research Foundation | Compositions and methods for delivery of kinase inhibiting peptides |
| KR101611494B1 (ko) | 2012-12-20 | 2016-04-12 | 한양대학교 산학협력단 | ＰＫＣ－δ 검출용 폴리펩티드 및 이의 용도 |
| US9987241B2 (en) | 2014-09-25 | 2018-06-05 | The Board Of Regents Of The University Of Oklahoma | Enzyme conjugate and prodrug cancer therapy |
| US20170044212A1 (en) * | 2015-08-14 | 2017-02-16 | Jingyi Wang | Compound for treating sequelae of ischemic cerebral stroke |
| US11446365B2 (en) | 2017-08-09 | 2022-09-20 | The Board Of Regents Of The University Of Oklahoma | Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same |
| TW202146071A (zh) * | 2020-03-31 | 2021-12-16 | 日商東麗股份有限公司 | 影像解析裝置、影像解析裝置的控制方法、影像解析系統、及影像解析系統的控制方法 |
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| JPS60500673A (ja) * | 1983-03-08 | 1985-05-09 | コモンウエルス セラム ラボラトリ−ズ コミツシヨン | 抗原活性を有するアミノ酸配列 |
| US5804604A (en) * | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| US5783405A (en) | 1994-02-01 | 1998-07-21 | Terrapin Technologies, Inc. | Rapid screening method for effectors of signal transduction |
| US5776716A (en) * | 1994-02-01 | 1998-07-07 | Terrapin Technologies, Inc. | Methods for identifying agents which block the interaction of fyn with PKC-theta, and uses thereof |
| US5519003A (en) | 1994-02-01 | 1996-05-21 | Board Of Trustees Of The Leland Stanford Junior University | WD-40-derived peptides and uses thereof |
| US5935803A (en) * | 1994-02-01 | 1999-08-10 | Terrapin Technologies, Inc. | Methods to identify immunomodulators using cognate interaction of PKC-theta |
| US6165977A (en) | 1996-10-18 | 2000-12-26 | Board Of Trustees Of The Leland Stanford Junior University | Isozyme-specific activators of protein kinase C methods and compositions |
| US6228843B1 (en) * | 1999-04-23 | 2001-05-08 | University Technology Corporation | Method of using PKC inhibiting compounds to treat vascular disease |
| US6664040B2 (en) | 2000-05-23 | 2003-12-16 | The Regents Of The University Of California | Compositions and methods for delivery of a molecule into a cell |
| AU2002226061B2 (en) * | 2001-01-18 | 2007-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for activation and inhibition of delta PKC |
| US7224668B1 (en) * | 2002-11-27 | 2007-05-29 | Cisco Technology, Inc. | Control plane security and traffic flow management |
| US7265092B2 (en) | 2004-09-30 | 2007-09-04 | Kai Pharmaceuticals, Inc. | Pharmaceutical formulation |
| US20060148700A1 (en) * | 2004-11-10 | 2006-07-06 | Daria Mochly-Rosen | Methods and compositions for reducing injury to a transplanted organ |
| AU2005325128A1 (en) * | 2005-01-04 | 2006-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of increasing cerebral blood flow |
| US20090186814A1 (en) * | 2005-01-26 | 2009-07-23 | Fumiaki Ikeno | Methods and Compositions for Reducing Ischemia-Derived Microvascular Damage |
| US20090062208A1 (en) * | 2007-02-06 | 2009-03-05 | Mochly-Rosen Daria D | Methods for maintaining blood-brain barrier integrity in hypertensive subjects using a delta-PKC inhibitor |
| CA2698013A1 (en) | 2007-08-27 | 2009-03-05 | Kai Pharmaceuticals, Inc. | Protein kinase c-d inhibitors that protect against cellular injury and inflammation and promote astrocyte proliferation |
-
2001
- 2001-11-09 AU AU2002226061A patent/AU2002226061B2/en not_active Ceased
- 2001-11-09 EP EP10190462A patent/EP2338899A1/en not_active Withdrawn
- 2001-11-09 US US10/007,761 patent/US6855693B2/en not_active Expired - Lifetime
- 2001-11-09 WO PCT/US2001/047556 patent/WO2002057413A2/en not_active Ceased
- 2001-11-09 CA CA2434643A patent/CA2434643C/en not_active Expired - Fee Related
- 2001-11-09 EP EP01995483.3A patent/EP1351980B1/en not_active Expired - Lifetime
- 2001-11-09 JP JP2002558467A patent/JP4115838B2/ja not_active Expired - Fee Related
-
2004
- 2004-05-12 US US10/843,731 patent/US7745388B2/en not_active Expired - Fee Related
-
2007
- 2007-04-30 US US11/799,290 patent/US7851586B2/en not_active Expired - Fee Related
- 2007-08-14 US US11/838,732 patent/US7915219B2/en not_active Expired - Fee Related
-
2008
- 2008-02-28 JP JP2008048806A patent/JP4592772B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-30 US US12/956,900 patent/US8822636B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6855693B2 (en) | 2005-02-15 |
| WO2002057413A2 (en) | 2002-07-25 |
| JP2004521108A (ja) | 2004-07-15 |
| EP1351980B1 (en) | 2014-12-31 |
| JP2008231103A (ja) | 2008-10-02 |
| US7851586B2 (en) | 2010-12-14 |
| JP4115838B2 (ja) | 2008-07-09 |
| US20090192089A1 (en) | 2009-07-30 |
| US7915219B2 (en) | 2011-03-29 |
| EP1351980A4 (en) | 2005-02-02 |
| US20020150984A1 (en) | 2002-10-17 |
| JP4592772B2 (ja) | 2010-12-08 |
| US7745388B2 (en) | 2010-06-29 |
| AU2002226061B2 (en) | 2007-08-02 |
| EP1351980A2 (en) | 2003-10-15 |
| US20040204364A1 (en) | 2004-10-14 |
| US20110143991A1 (en) | 2011-06-16 |
| WO2002057413A3 (en) | 2003-04-03 |
| US8822636B2 (en) | 2014-09-02 |
| US20090075901A1 (en) | 2009-03-19 |
| EP2338899A1 (en) | 2011-06-29 |
| CA2434643A1 (en) | 2002-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20181109 |