JP4091566B2 - Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant - Google Patents

Description

The present invention relates to an antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant. An object of the present invention is to provide an antiseptic fungicide that can enhance the antibacterial activity inherent to 1,2-alkanediol by containing a 1,2-alkanediol having 5 to 10 carbon atoms and a glycerol fatty acid monoester. Another object of the present invention is to provide cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant.

Parabens, benzoic acids, salicylic acids, and the like are used as antiseptic fungicides in cosmetics (including quasi drugs), pharmaceuticals, and foods. However, the antiseptic disinfectant described above has a drawback that the concentration range of use is limited because it is highly skin irritating and low in safety. For example, the use restriction concentration of paraben and benzoate is 1%, and the use restriction concentration of benzoic acid and salicylic acid is 0.2%.
Moreover, since the above-mentioned antiseptic disinfectant is easily influenced by pH, the antiseptic disinfecting effect is poor in stability, and the antibacterial and antibacterial activity is remarkably reduced by the combined use with other components such as surfactants. There was also a problem that there was a case.

  In recent years, there has been a tendency to increase the number of people who cause allergic reactions to the above-mentioned antiseptic disinfectants. There is an increasing demand for cosmetics, pharmaceuticals and foods with reduced amounts.

  As a technique for reducing or eliminating the antiseptic disinfectant, an antiseptic disinfectant composed of 1,2-alkanediol (see Patent Document 1) and a detergency or non-detergent cosmetic moisturizing bacteriostatic agent composed of 1,2-octanediol (See Patent Document 2) and the like. However, when 1,2-alkanediol such as 1,2-octanediol is used alone as an antiseptic disinfectant, a high blending amount may be required to obtain sufficient effectiveness. Since 2-alkanediol has a peculiar raw material odor, a technique capable of exhibiting a sufficient antiseptic sterilization effect even with a low content is desired.

  In addition, as a technique related to an antiseptic fungicide using 1,2-alkanediol, an external composition (see Patent Document 3) formulated by combining 1,2-pentanediol and 2-phenoxyethanol, and 1,2-alkanediol An antiseptic disinfectant comprising paraben (see Patent Document 4) is disclosed. However, these are intended to improve the effect of the preservative by using a preservative and a 1,2-alkanediol such as 1,2-pentanediol in an attempt to completely eliminate the preservative itself. It was not intended to enhance the antibacterial activity of 1,2-alkanediol.

Japanese Patent Laid-Open No. 11-322591 JP 2001-48720 A JP-A-10-53510 JP 11-310506 A

In view of this situation, as a result of intensive studies by the present inventors, by using both 1,2-alkanediol and glycerin fatty acid monoester as an antiseptic fungicide, antibacterial activity inherently possessed by 1,2-alkanediol As a result, the present invention has been completed.

That is, the invention according to claim 1 relates to an antiseptic disinfectant characterized by containing a 1,2-alkanediol having 5 to 10 carbon atoms and a glycerin fatty acid monoester .
The invention according to claim 2 relates to the antiseptic fungicide according to claim 1, wherein the 1,2-alkanediol is 1,2-hexanediol and / or 1,2-octanediol.
The invention according to claim 3 relates to the antiseptic fungicide according to claim 1, wherein the 1,2-alkanediol is 1,2-octanediol.

The invention according to claim 4 relates to the antiseptic disinfectant according to any one of claims 1 to 3, wherein the glycerin fatty acid monoester is a compound represented by the following formula 1 (chemical formula 1).

（式中、Ｒ_１〜Ｒ_４のうちの１つは式２（化２）に示されるアシル基であり、残りは水素原子である。ａは０又は１であり、ｂは０〜９の整数であり、０≦ａ＋ｂ≦９である。）

(In the formula, _one of R _{1 to} R ₄ is an acyl group represented by Formula 2 (Chemical Formula 2), and the rest is a hydrogen atom. A is 0 or 1, and b is 0-9. (It is an integer and 0 ≦ a + b ≦ 9.)

（式中、Ｒ_５は炭素数７〜２１の飽和又は不飽和の脂肪族炭化水素基である。）

(In the formula, R ₅ is a saturated or unsaturated aliphatic hydrocarbon group having 7 to 21 carbon atoms.)

The invention according to claim 5 relates to the antiseptic disinfectant according to any one of claims 1 to 3, wherein the glycerin fatty acid monoester is a compound represented by the following formula 3 (chemical formula 3).

（式中、Ｒ_６〜Ｒ_９のうちの１つはオクタノイル基又はラウロイル基であり、残りは水素原子である。ｃは０又は１であり、ｄは０〜９の整数であり、０≦ｃ＋ｄ≦９である。）

(In the formula, one of R _{6 to} R ₉ is an octanoyl group or a lauroyl group, and the rest is a hydrogen atom. C is 0 or 1, d is an integer of 0 to 9, and 0 ≦ c + d ≦ 9.)

The invention according to claim 6 relates to the antiseptic disinfectant according to any one of claims 1 to 3, wherein the glycerin fatty acid monoester is a compound represented by the following formula 4 (chemical formula 4).

（式中、Ｒ_１０〜Ｒ_１３のうちの１つはオクタノイル基であり、残りは水素原子である。ｅは０又は１であり、ｆは０〜９の整数であり、１≦ｅ＋ｆ≦９である。）

(In the formula, one of R _{10 to} R ₁₃ is an octanoyl group, and the rest is a hydrogen atom. E is 0 or 1, f is an integer of 0 to 9, and 1 ≦ e + f ≦ 9. .)

The invention according to claim 7 is characterized in that the glycerin fatty acid monoester is at least one selected from the group consisting of glyceryl monolaurate, decaglyceryl monolaurate, diglyceryl monocaprylate and decaglyceryl monocaprylate. The antiseptic disinfectant according to any one of claims 1 to 3.
The invention according to claim 8 relates to a cosmetic, pharmaceutical product or food comprising the antiseptic disinfectant according to any one of claims 1 to 7 (however, 1,2-pentanediol or 1, (Except for an external preparation composition containing 2-hexanediol, glycerin fatty acid monoester, and an emulsified composition containing 1,2-alkanediol and glyceryl monostearate).

Since the antiseptic fungicide according to the present invention contains 1,2-alkanediol and glycerin fatty acid monoester , the antibacterial activity inherent in 1,2-alkanediol is enhanced. Therefore, it is not necessary to add a conventional antiseptic disinfectant, and high safety can be obtained.

When 1,2-hexanediol or 1,2-octanediol is used as the 1,2-alkanediol, an antiseptic disinfectant with higher antibacterial activity can be obtained.
Moreover, when one or more of glyceryl monolaurate, glyceryl monolaurate, decaglyceryl monolaurate, diglyceryl monocaprylate and decaglyceryl monocaprylate are used as the glycerin fatty acid monoester , a preservative and fungicide with higher antimicrobial activity can be obtained. .

  Cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant according to the present invention do not need to contain conventional antiseptic disinfectants such as salicylic acid, benzoic acid and parabens, and the antiseptic disinfectant according to the present invention has excellent antibacterial activity. Therefore, the preservative disinfectant itself can be made into a low blending amount and is extremely safe.

Hereinafter, the antiseptic disinfectant according to the present invention will be described in detail. The antiseptic fungicide according to the present invention contains 1,2-alkanediol and glycerin fatty acid monoester as active ingredients.

  The first component of the antiseptic disinfectant according to the present invention is a 1,2-alkanediol having 5 to 10 carbon atoms represented by the following formula 5 (chemical formula 5), specifically, 1,2-pentanediol. 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol.

（式中、ｎは２〜７の整数を示す。）

(In the formula, n represents an integer of 2 to 7.)

In the present invention, one of the above-mentioned 1,5-alkanediols having 5 to 10 carbon atoms can be used alone, or two or more kinds can be mixed and used.
1,2-alkanediol itself has excellent antibacterial activity, and has the effect of increasing the antibacterial activity of the antiseptic disinfectant according to the present invention. In particular, in the present invention, since it exhibits an excellent antibacterial action against general bacteria, yeast and the like, among 1,2-alkanediols having 5 to 10 carbon atoms, 1,2-hexanediol, 1,2-octanediol It is preferable to use 1,2-octanediol.

The second component of the antiseptic disinfectant according to the present invention is a glycerin fatty acid monoester . Specifically, a glycerin fatty acid monoester represented by the following formula 6 (chemical formula 6) can be exemplified.

式中、Ｒ_１〜Ｒ_４のうちの１つは式７（化７）に示されるアシル基であり、残りは水素原子である。ａは０又は１であり、ｂは０〜９の整数であり、０≦ａ＋ｂ≦９である。
尚、ａ及びｂは単に構成単位の個数を示すだけであって、配列の順序までも示すものではない。

In the formula, _one of R _{1 to} R ₄ is an acyl group represented by Formula 7 (Chemical Formula 7), and the rest is a hydrogen atom. a is 0 or 1, b is an integer of 0 to 9, and 0 ≦ a + b ≦ 9.
It should be noted that a and b merely indicate the number of structural units, and do not indicate the order of arrangement.

式中、Ｒ_５は炭素数７〜２１の飽和又は不飽和の脂肪族炭化水素基である。

In the formula, R ₅ is a saturated or unsaturated aliphatic hydrocarbon group having 7 to 21 carbon atoms.

Specific monoglyceryl fatty acid monoesters include glyceryl monocaprylate, glyceryl monocaprate, glyceryl monolaurate, glyceryl monomyristate, glyceryl monopalmitate, glyceryl monostearate, glyceryl monoisostearate, glyceryl monobehenate, mono Examples thereof include glyceryl oleate and glyceryl monoerucate.
Specific examples of the polyglyceryl fatty acid monoester include diglyceryl monocaprylate, decaglyceryl monocaprylate, hexaglyceryl monocaprate, tetraglyceryl monolaurate, hexaglyceryl monolaurate, decaglyceryl monolaurate, poly (monolaurate poly ( 4-10) Glyceryl, decaglyceryl monomyristate, decaglyceryl monostearate, poly (2-10) glyceryl monostearate, diglyceryl monooleate, hexaglyceryl monooleate, decaglyceryl monobehenate, decaglyceryl monoerucate Examples thereof include polyglycerol derivatives having a polymerization degree of 2 to 10 of the above-described monoglycerol fatty acid monoester.
One of these can be used alone, or two or more can be mixed and used.

In the present invention, it is preferable to use a monolauryl glycerin derivative represented by the following formula 8 or a monocaprylate glycerin derivative as the glycerin fatty acid monoester .

式中、Ｒ_６〜Ｒ_９のうちの１つはオクタノイル基又はラウロイル基であり、残りは水素原子である。ｃは０又は１であり、ｄは０〜９の整数であり、０≦ｃ＋ｄ≦９である。
尚、ｃ及びｄは単に構成単位の個数を示すだけであって、配列の順序までも示すものではない。

In the formula, one of R _{6 to} R ₉ is an octanoyl group or a lauroyl group, and the remainder is a hydrogen atom. c is 0 or 1, d is an integer of 0 to 9, and 0 ≦ c + d ≦ 9.
Note that c and d merely indicate the number of structural units, and do not indicate the order of arrangement.

As the glycerol fatty acid monoester used in the present invention, glyceryl monolaurate can be preferably used as the monoglycerol fatty acid monoester, and polyglycerol monocaprylate of formula 9 (Chemical Formula 9) can be preferably used as the polyglycerol fatty acid monoester.

式中、Ｒ_１０〜Ｒ_１３のうちの１つはオクタノイル基であり、残りは水素原子である。ｅは０又は１であり、ｆは０〜９の整数であり、１≦ｅ＋ｆ≦９である。
尚、ｅ及びｆは単に構成単位の個数を示すだけであって、配列の順序までも示すものではない。

In the formula, one of R _{10 to} R ₁₃ is an octanoyl group, and the remainder is a hydrogen atom. e is 0 or 1, f is an integer of 0 to 9, and 1 ≦ e + f ≦ 9.
Note that e and f merely indicate the number of structural units, and do not indicate the order of arrangement.

In particular, in the present invention, among the glyceryl fatty acid monoesters described above, one or more of glyceryl monolaurate, decaglyceryl monolaurate, diglyceryl monocaprylate, decaglyceryl monocaprylate have a higher antibacterial action. In view of the above, diglyceryl monocaprylate and decaglyceryl monocaprylate are particularly preferably used.

In the antiseptic disinfectant according to the present invention, the content of the 1,5-alkanediol having 5 to 10 carbon atoms as the first component and the glycerin fatty acid monoester as the second component is not particularly limited. It mix | blends so that it may become 1: 100-100: 1, Preferably it is 1: 10-10: 1. When formulating the 1,2-alkanediol than 100 times by weight of the amount of glycerin fatty acid monoester and the glycerin fatty acid monoester to blend more than 100 times by weight of the amount of 1,2-alkanediol, together This is not preferable because an antibacterial activity enhancing effect cannot be expected.

Since the antiseptic disinfectant according to the present invention contains 1,2-alkanediol as the first component and glycerin fatty acid monoester as the second component, as shown in the test described later, Due to the synergistic effect of this component and the second component, an excellent antiseptic sterilization effect is exhibited against bacteria such as general bacteria and yeast. Therefore, it is not necessary to blend or blend a preservative antibacterial agent such as paraben, benzoic acid or salicylic acid, which has been used before, and extremely high safety can be obtained.

The antiseptic disinfectant according to the present invention described above can be used by blending it in cosmetics, pharmaceuticals, foods and the like.
Specifically, cosmetics for skin such as face wash, lotion, milky lotion, cream, foundation, mascara, nail enamel, lipstick, shampoo, hair treatment, hair nourishing and hair restorer, hair cream, hair lotion, hair foam, Hair cosmetics such as permanent wave agents, medicinal cosmetics (quasi-drugs) with specific uses such as stains and freckles, acne medicines, gargles, lozenges, chewing gum, candy, It can use suitably for foodstuffs, such as a drink.

In the case of preparing cosmetics, pharmaceuticals or foods using the antiseptic disinfectant according to the present invention, components usually used in cosmetics, pharmaceuticals or foods can be arbitrarily arbitrarily blended within the range where the effects of the present invention are not impaired. . For example, in the case of cosmetics and pharmaceuticals (including quasi drugs), fats and oils, waxes, higher fatty acids, lower alcohols, higher alcohols, sterols, fatty acid esters, humectants, surfactants, polymer compounds, inorganic pigments, dyes , Fragrances, antioxidants, ultraviolet absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering agents, purified water, and the like.
In the case of foods, animal and vegetable oils, polysaccharides, sweeteners, colorants, gum bases and the like can be exemplified.

When preparing cosmetics, pharmaceuticals or foods, the amount of the antiseptic disinfectant according to the present invention is not particularly limited, but is 0.01 to 20% by weight, preferably 0.05 to 5% by weight in the composition.
Even if it exceeds 20% by weight, no further effect can be expected. Moreover, when it is less than 0.01% by weight, the antibacterial effect is inferior, which is not preferable.

[Example 1]
(Test bacteria)
As test bacteria, Staphylococcus aureus IFO13276 (Staphylococcus aureus) was used as a Gram-positive bacterium, and Candida albicans IFO1594 (oral candidiasis bacterium) was used as a yeast.

(Preparation of bacterial solution for inoculation)
As a bacterial solution for inoculation, in the case of Staphylococcus aureus, after culturing at 35 ° C. on an agar medium, it was further transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution to about 10 ⁸ cells / mL with a bouillon medium was used as a bacterial solution for inoculation.
Further, in the case of oral candidiasis, the same culture at 30 ° C. and diluted to about 10 ⁷ cells / mL were used as the inoculum.

(Preparation of dilution series of test substance)
5, 4-, 3, 2.5, 2.25, 2, 1.75, 1.5, 1.25, 1 w / v% 1,2-octane using 20 w / w% ethyl cellosolve as a diluent solvent A diol solution was prepared.
In addition, for an equal weight mixture of diglyceryl monocaprylate and 1,2-octanediol and diglyceryl monocaprylate, a dilution series was prepared by doubling a 5 w / v% solution.

(Measurement of minimum inhibitory concentration (MIC))
For each 1 mL of dilution series containing the test substance, 9 mL of each agar medium was placed in a petri dish, and for each, the inoculum bacterial solution was streaked to a length of about 1 cm. Culturing was performed at 35 ° C. for Staphylococcus aureus and the presence or absence of the growth of the bacteria after 2 days was determined. Moreover, about oral candidiasis bacteria, it culture | cultivated at 25 degreeC and the presence or absence of the growth of a microbe after 3 days was determined. At this time, the minimum concentration at which no growth was observed was determined as MIC. The results are shown in Table 1.

  In addition, antibacterial power can be evaluated by MIC. There is no effect on microorganisms when the concentration of the test substance is low, but growth suppression occurs when the concentration is increased. This degree of growth proceeds depending on the concentration, and finally the growth stops. The concentration at this time is expressed as MIC. Therefore, when the concentration is higher than MIC, the microorganisms are killed.

(Dual minimum inhibitory concentration)
Each MIC of the obtained 1,2-octanediol, diglyceryl monocaprylate, and an equal weight mixture of 1,2-octanediol and diglyceryl monocaprylate was converted into 1,2-octanediol and diglyceryl monocaprylate. Was plotted with respect to the blending amount, and a binary minimum inhibitory concentration diagram was obtained.
In addition, the effect at the time of mix | blending two types of substances which have antimicrobial property can be determined with a binary minimum growth inhibitory density | concentration. Specifically, when two types of substances having antibacterial properties are blended, the action caused by the substances is roughly classified into a synergistic action, an additive action, and an antagonistic action. The synergistic action is an action in which two drugs act synergistically to further enhance the inherent antibacterial power. The additive action is an action in which the antibacterial powers of the respective drugs are combined. Antagonism is an action when one drug counteracts the antibacterial activity of another drug. Then, the method based on the binary minimum growth inhibition concentration diagram is a method of determining from the graph by measuring the MIC for each of the A substance and B substance while changing their ratios, as shown in FIG. According to this, when MIC (point A) in only substance A and MIC (point B) only in substance B are connected, the MIC when both substances are used is on the inner side of this line (point C) is a synergistic effect in which the antibacterial activity is enhanced by the combined use, if it is on the line (point D), if it is an additive action, if it is outside the line (point E), either or both It can be determined that the antagonistic action counteracts the antibacterial activity and decreases the antibacterial activity.
FIG. 2 shows a binary minimum inhibitory concentration diagram for diglyceryl monocaprylate.

[Example 2]
Using decaglyceryl monocaprylate in the same manner as in Example 1, the MIC in Table 2 and the binary minimum inhibitory concentration diagram in FIG. 3 were determined.

[Example 3]
Using glyceryl monolaurate, the same operation as in Example 1 was performed, and the MIC in Table 3 and the binary minimum growth inhibitory concentration diagram in FIG. 4 were obtained.

[Example 4]
Using decaglyceryl monolaurate, the same operation as in Example 1 was performed, and the MIC in Table 4 and the binary minimum growth inhibitory concentration diagram in FIG. 5 were obtained.

(Evaluation of antibacterial effect)
The antibacterial effects of Examples 1 to 4 were determined according to the following evaluation criteria. The results are shown in Table 5.
<Evaluation criteria>
○: Synergistic action is recognized in antibacterial effect.
Δ: Additive action is observed in antibacterial effect.
X: Antagonism is recognized in antibacterial effect.

From the results of FIGS. 2 to 5 and Table 5, the combination of 1,2-octanediol and a glycerin fatty acid monoester such as diglyceryl monocaprylate , decaglyceryl monocaprylate, glyceryl monolaurate, decaglyceryl monolaurate, etc. It can be seen that the antibacterial activity inherent in 1,2-octanediol is synergistically enhanced.

Hereinafter, formulation examples of cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant according to the present invention will be shown.
<Formulation Example 1: Moisturizing cream>
Decaglyceryl monolaurate 1.0
Monostearic acid POE (15) glyceryl 1.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Cetanol 2.0
Behenyl alcohol 2.0
Paraffin 3.0
Squalane 12.0
Jojoba oil 4.0
Methylpolysiloxane 0.2
1,3-butylene glycol 3.0
L-Arginine 0.1
Xanthan gum 0.001
1,2-octanediol 0.25
Diglyceryl monocaprylate 0.10
Purified water
Total 100.0% by weight

<Formulation Example 2: Hydrophilic ointment>
Ascorbic acid 0.5
Polyoxyethylene cetyl ether 2.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Glycerol monostearate 10.0
Liquid paraffin 10.0
Vaseline 4.0
Cetanol 5.0
Propylene glycol 5.0
1,2-hexanediol 0.5
Decaglyceryl monocaprylate 0.2
Purified water
Total 100.0% by weight

<Prescription Example 3: Beverage>
Glucose liquid sugar 33.0
Grapefruit juice 64.0
1,2-pentanediol 0.5
Glyceryl monolaurate 0.01
Fragrance 0.5
Acidulant appropriate amount
Total 100.0% by weight

The antiseptic disinfectant according to the invention synergistically enhances the antiseptic disinfecting activity inherent to 1,2-alkanediol by using a 1,5-alkanediol having 5 to 10 carbon atoms and a glycerin fatty acid monoester in combination. Therefore, it is useful as an antiseptic disinfectant for cosmetics, pharmaceuticals or foods.
Since cosmetics, pharmaceuticals or foods according to the present invention contain 1,2-alkanediol having 5 to 10 carbon atoms and glycerin fatty acid monoester as an antiseptic disinfectant, the compounding amount of the conventional antiseptic disinfectant Is useful as cosmetics, pharmaceuticals or foods having high safety.

It is a figure which shows an example of the method of judging the effect produced by the case where two types of substances which have antimicrobial property are mix | blended from binary minimum growth inhibitory density | concentration. 2 is a binary minimum growth inhibitory concentration diagram of Example 1. FIG. 3 is a binary minimum growth inhibition concentration diagram of Example 2. FIG. 4 is a binary minimum growth inhibition concentration diagram of Example 3. FIG. 6 is a binary minimum growth inhibition concentration diagram of Example 4. FIG.

Claims (8)

An antiseptic fungicide containing a 1,2-alkanediol having 5 to 10 carbon atoms and a glycerin fatty acid monoester .   The antiseptic disinfectant according to claim 1, wherein the 1,2-alkanediol is 1,2-hexanediol and / or 1,2-octanediol.   The antiseptic disinfectant according to claim 1, wherein the 1,2-alkanediol is 1,2-octanediol. The antiseptic disinfectant according to any one of claims 1 to 3, wherein the glycerin fatty acid monoester is a compound represented by the following formula 1 (Chemical formula 1).

(In the formula, one of R1 to R4 is an acyl group represented by Formula 2 (Chemical Formula 2), and the rest is a hydrogen atom. A is 0 or 1, and b is an integer of 0 to 9. Yes, 0 ≦ a + b ≦ 9.)

(In the formula, R5 is a saturated or unsaturated aliphatic hydrocarbon group having 7 to 21 carbon atoms.) The antiseptic disinfectant according to any one of claims 1 to 3, wherein the glycerin fatty acid monoester is a compound represented by the following formula 3 (Chemical formula 3).

(In the formula, one of R 6 to R 9 is an octanoyl group or a lauroyl group, and the rest is a hydrogen atom. C is 0 or 1, d is an integer of 0 to 9, and 0 ≦ c + d ≦ 9) The antiseptic disinfectant according to any one of claims 1 to 3, wherein the glycerin fatty acid monoester is a compound represented by the following formula 4 (Chemical formula 4).

(In the formula, one of R10 to R13 is an octanoyl group and the rest is a hydrogen atom. E is 0 or 1, f is an integer of 0 to 9, and 1 ≦ e + f ≦ 9. .) The glycerin fatty acid monoester is at least one selected from the group consisting of glyceryl monolaurate, decaglyceryl monolaurate, diglyceryl monocaprylate and decaglyceryl monocaprylate. The antiseptic disinfectant in any one. Cosmetics, pharmaceuticals or foods, wherein the antiseptic and fungicide according to any one of claims 1 to 7 is blended (however, 1,2-pentanediol or 1,2-hexanediol and glycerin fatty acid mono) Except for an external preparation composition containing an ester, and an emulsified composition containing 1,2-alkanediol and glyceryl monostearate).

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