JP4051331B2 - 有害物質の排泄促進剤 - Google Patents
有害物質の排泄促進剤 Download PDFInfo
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- JP4051331B2 JP4051331B2 JP2003349416A JP2003349416A JP4051331B2 JP 4051331 B2 JP4051331 B2 JP 4051331B2 JP 2003349416 A JP2003349416 A JP 2003349416A JP 2003349416 A JP2003349416 A JP 2003349416A JP 4051331 B2 JP4051331 B2 JP 4051331B2
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- dioxins
- excretion
- dioxin
- isothiocyanate
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- 230000029142 excretion Effects 0.000 title claims description 36
- 239000000383 hazardous chemical Substances 0.000 title 1
- 150000002013 dioxins Chemical class 0.000 claims description 37
- 244000195452 Wasabia japonica Species 0.000 claims description 20
- 235000000760 Wasabia japonica Nutrition 0.000 claims description 20
- 150000002540 isothiocyanates Chemical class 0.000 claims description 20
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- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims description 2
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 19
- 239000000463 material Substances 0.000 description 14
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- WCYYQNSQJHPVMG-UHFFFAOYSA-N 1,2,3,4,7,8-Hexachlorodibenzodioxin Chemical compound O1C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C2OC2=C1C=C(Cl)C(Cl)=C2 WCYYQNSQJHPVMG-UHFFFAOYSA-N 0.000 description 1
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- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
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- SUVMJBTUFCVSAD-JTQLQIEISA-N 4-Methylsulfinylbutyl isothiocyanate Natural products C[S@](=O)CCCCN=C=S SUVMJBTUFCVSAD-JTQLQIEISA-N 0.000 description 1
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seasonings (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
メタノール80mlに15%メチルメルカプタンナトリウム溶液26gを加え、これに氷冷下、6−ブロモヘキサンニトリル10gをゆっくり滴下した。滴下後、氷冷下で2分攪拌し、さらに室温で3時間攪拌した。次いで、エバポレーターでメタノールを完全に留去し、得られた残渣に水40mlを加え、ジエチルエーテル40mlで3回抽出し、エーテル層を得た。これを5%塩酸、水、および飽和食塩水で順番に洗浄し、6−メチルチオヘキサンニトリル7.5gを得た。
飼料組成
基本食 WP食 6MSITC食 CP食
カゼイン 25 25 25 25
コーンオイル 5.0 5.0 5.0 5.0
ミネラル類 1) 3.5 3.5 3.5 3.5
ビタミン類 2) 3.5 3.5 3.5 3.5
塩化コリン 0.2 0.2 0.2 0.2
わさびパウダー − 1.0 − −
6MSITC − − 30mg − セルロースパウダー − − − 5.0
シュークロース to100 to100 to100 to 100
1)AIN−76 2)AIN−77 共にオリエンタル酵母社製。
各群において体重増加には有意差は見られなかった(図1)。糞中のTCDDの排泄量は、WP群で有意に増加し、6MSITC群では増加傾向が見られた(図2)。セルロース群よりもWP群では排泄量の増加が見られたことから、わさびパウダーでは、食物繊維等の吸着作用によるTCDDの排泄作用だけでなく、体内代謝を促進している可能性がある。このことは、6MSITC群でも排泄量の増加傾向が見られたことから、単に食物繊維等による物理的吸着作用によるものではないことを示している。
グラニユー糖 85部
濃縮果汁 5部
クエン酸 6部
香料 2部
わさびパウダー 2部
お茶の葉 90部
本わさび茎(5mm幅に刻んだもの) 7部
わさびパウダー 3部
本わさび茎は凍結させた状態で粉砕して用いた。
本わさび根茎 80部
本わさび茎 10部
食用油 4部
わさびパウダー 3部
食物繊維 2.9部
着色料 0.1部
Claims (7)
- アブラナ科植物に含まれるω−メチルスルフイニルアルキルイソチオシアネート(アルキル基の炭素数4〜8)からなるイソチオシアネート類を有効成分として含有し、生体内のダイオキシン類の排泄を促進してダイオキシン類の生体内蓄積量を減少させてなり前記ダイオキシン類がポリ塩化ジベンゾダイオキシン、ポリ塩化ジベンゾフランおよびコプラナ−PCBの群から選択される一種またはそれ以上であることを特徴とするダイオキシン類の排泄促進剤。
- 請求項1において、アブラナ科植物が本わさびである請求項1に記載のダイオキシン類の排泄促進剤。
- 請求項1において、アブラナ科植物が西洋わさび、キャベツ、クレソン、芽キャベツ、カリフラワー、大根、からみ大根、ナタネ、ブロッコリーの群から選択される1種または複数種である請求項1に記載のダイオキシン類の排泄促進剤。
- 請求項1において、ω−メチルスルフイニルアルキルイソチオシアネートが6−メチルスルフイニルヘキシルイソチオシアネートである請求項1に記載のダイオキシン類の排泄促進剤。
- 請求項1において、ω−メチルスルフイニルアルキルイソチオシアネートがアブラナ科植物の粉砕またはすりおろし処理、溶媒による抽出処理、または乾燥処理を単独で、または組み合わせ処理することにより得られる請求項1に記載のダイオキシン類の排泄促進剤。
- 化学合成法によって合成されるω−メチルスルフイニルアルキルイソチオシアネート(アルキル基の炭素数4〜8)からなるイソチオシアネート類を有効成分として含有し、生体内のダイオキシン類の排泄を促進してダイオキシン類の生体内蓄積量を減少させてなり前記ダイオキシン類がポリ塩化ジベンゾダイオキシン、ポリ塩化ジベンゾフランおよびコプラナ−PCBの群から選択される一種またはそれ以上であることを特徴とするダイオキシン類の排泄促進剤。
- 請求項6において、ω−メチルスルフイニルアルキルイソチオシアネートが6−メチルスルフイニルヘキシルイソチオシアネートである請求項6に記載のダイオキシン類の排泄促進剤。
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