JP3948674B1 - Blood pressure measurement system and method - Google Patents

Abstract

Blood pressure is accurately measured regardless of the state of the subject's autonomic nerve.
A blood pressure measurement system 10 first measures LF / HF and blood pressure, respectively. Next, the storage device 18 stores the measured LF / HF and blood pressure in association with each other. Then, the CPU 17 determines whether or not the number of measurements of LF / HF and blood pressure in a state where the values of LF / HF are different from each other has reached a predetermined number, and if so, the relationship of blood pressure to LF / HF is determined. Approximate to a linear function by, for example, the least square method. Further, the UI device 19 displays the result approximated by the CPU 17. And the memory | storage device 18 memorize | stores the result which CPU17 approximated, and complete | finishes a process.
[Selection] Figure 9

Description

  The present invention relates to a blood pressure measurement system and method for measuring blood pressure.

  It is known that blood pressure varies as the sympathetic nerves contract blood vessels while parasympathetic nerves dilate blood vessels. For example, in Non-Patent Document 1, it is reported that the effect of deep breathing is compared between the diabetic group and the non-diabetic group, and the blood pressure is lower when the deep breathing is performed in both groups than when the deep breathing is not performed. Thus, blood pressure varies depending on various factors.

Yasuo Mori, 6 others, “Relationship between antihypertensive rate and deep breathing and blood pressure / pulse in diabetic patients”, Japanese Hypertension Society, 27th Annual Meeting of the Japanese Hypertension Society, October 7 to 9 , P. 126

  However, there is a problem that even if deep breathing is performed, the measurement subject is not always in a sufficiently resting state.

  It is an object of the present invention to provide a blood pressure measurement system and method that can accurately measure blood pressure regardless of the state of the subject's autonomic nerve.

The first feature of the present invention is that a deep breath display means for displaying how to take a deep breath, a blood pressure measuring means for measuring blood pressure, an electrocardiographic monitoring means for monitoring electrocardiogram, and an autonomous function from the electrocardiographic monitoring means. Autonomic nerve function measuring means for measuring nerve function, storage means for storing the measurement result by the autonomic nerve function measuring means and the measurement result of the blood pressure measuring means, and the autonomic nerve based on each of the measurement results stored by the storage means calculating means for calculating a blood pressure relationship to function, possess and output means for outputting the result of this calculation means has calculated, the autonomic nervous function measuring means and said blood pressure measuring means, after completion of presentation of the deep breath display means Each is in a blood pressure measurement system that starts the measurement.

  Preferably, the calculation means approximates the relationship of blood pressure to the autonomic nerve function with a linear function.

The second feature of the present invention is that the control means of the blood pressure measurement system controls the deep breath display means, the autonomic nerve function measurement means, the blood pressure measurement means, the storage means, the calculation means, and the output means. The deep breath display means displays how to take a deep breath, and after the display of the deep breath display means is finished, measurement is performed by the autonomic nerve function measuring means and the blood pressure measuring means , and the measured autonomic nerve function and blood pressure measurement results are stored respectively. The means for storing the blood pressure is based on each of the stored measurement results, the calculation means calculates the relationship of the blood pressure to the autonomic nerve function, and the control means performs the control for outputting the calculated result by the output means. .

  According to the present invention, blood pressure can be accurately measured regardless of the state of the subject's autonomic nerve.

  Hereinafter, embodiments according to the present invention will be described with reference to the drawings.

  In FIG. 1, an outline of a blood pressure measurement system 10 is shown. The blood pressure measurement system 10 includes a sphygmomanometer 12 as means for measuring blood pressure, and an electrocardiogram monitor 14 as means for monitoring electrocardiogram. The sphygmomanometer 12 has a manchette wound around the upper arm of a living body, and pressurizes and depressurizes the manchette to measure the maximum blood pressure, the minimum blood pressure, or the average blood pressure.

  The electrocardiogram monitor 14 wears a minus electrode at the throat of the measurement subject, for example, a plus electrode on the left flank, and a body ground on the right flank, and obtains the action of the heart as an electrical signal and records it as an electrocardiogram.

  The blood pressure monitor 12 and the electrocardiogram monitor 14 are connected to a personal computer 16, for example. The personal computer 16 includes a user interface device (UI device) 19 having a CPU 17, a storage device 18, and a display device. The personal computer 16 processes the electrocardiogram obtained from the electrocardiogram monitor 14 and controls the sphygmomanometer 12.

FIG. 2 shows a processing flow by the blood pressure measurement system 10.
First, in step S10, the personal computer 16 displays a deep breathing method on the UI device 19. A specific display mode in step S10 will be described later. When the deep breath display in step S10 is completed, in the next step S20, the CPU 17 calculates a sympathetic nerve activity index (LF / HF) which is one of the autonomic nerve functions based on the electrocardiogram obtained from the electrocardiogram monitor 14. To do. A specific method for obtaining LF / HF will be described later. In the next step S30, the sphygmomanometer 12 measures blood pressure. Further, in step S40, the storage device 18 stores LF / HF and blood pressure in association with each other as a measurement result, and in the next step S50, the sphygmomanometer 12 or the UI device 19 displays the measured data and performs processing. finish.

3 to 5 show details of the deep breathing method performed in step S10 described above.
First, in step S11, a display for sucking is performed. As shown in FIG. 4, the display in the case of inhalation displays an animation part 26 that gradually expands so that the lung portion of the living body 24 inhales air, an arrow part 28 that is set in the direction of inhaling air, and the inhalation timing. And a suction timing display unit 30 that includes The suction timing display unit 30 has, for example, two lighting units 30a and 30b arranged vertically. The upper lighting unit 30a lights blue for a predetermined time (for example, 1 second), and then the lower lighting unit 30b continues for a predetermined time. Lights blue (for example, 1 second). The person to be measured only needs to inhale air in accordance with the display timing of the lighting sections 30a and 30b.

  When the display in the case of sucking in step S11 is completed, in the next step S12, the display for discharging is performed. As shown in FIG. 5, the display in the case of exhaling displays an animation part 32 that gradually reduces so that the lung portion of the living body 24 exhales air, an arrow part 34 that is set in the direction of exhaling air, and the exhalation timing. The discharge timing display part 36 to be included is included. The discharge timing display unit 36 includes, for example, four lighting units 36a, 36b, 36c, and 36d arranged vertically, following the two lighting units 30a and 30b of the suction timing display unit 30 described above, and the upper lighting unit 36a. Is lit in green for a predetermined time (for example, 1 second), and then the lower lighting unit 36b is lit in green for a predetermined time (for example, 1 second), and the lower lighting units 36c and 36d are further turned on for a predetermined time (for example, 1 second). Lights green. The person to be measured may exhale air in accordance with the display timing of the lighting parts 36a, 36b, 36c, 36d.

In the next step S13, it is determined whether or not the deep breath has reached a predetermined number of times (for example, 5 times). If the predetermined number of times has not been reached, the process returns to step S11, and the processes of steps S11 and S12, that is, deep breathing is displayed again. If it is determined in step S13 that the display of deep breathing has been completed a predetermined number of times, the process proceeds to step S14, the display of deep breathing is turned OFF, the process is terminated, and the biological information measurement step is entered as described above.
The number of deep breaths is displayed on the number display unit 38 as shown in FIGS.
As described above, in this embodiment, 6 seconds are allocated to one deep breath, and the deep breath is performed in a total of 30 seconds by 5 deep breaths.

  In this way, the method of deep breathing is displayed to cause the subject to take a deep breath so that the subject is in a resting state, and erroneous blood pressure measurement, such as white coat hypertension, is not performed. However, even if the subject is prompted to take a deep breath, the subject may not actually be at rest. Therefore, in step S20, LF / HF at the time of blood pressure measurement is calculated (measured). ing.

6 to 8, the details of the LF / HF calculation method are shown in step S20 described above.
First, in step S <b> 21, the CPU 17 calculates heart rate variability from the electrocardiogram input from the electrocardiogram monitor 14. Heart rate variability is measured as the RR interval of a continuous normal sinus rhythm. In order to perform the spectrum analysis, as shown in FIGS. 7A and 7B, the R-R interval was measured by taking an interval between the R wave and the next R wave, and then measured as shown in FIGS. 7C and D. The R-R interval data is plotted at the time position of the backward R-wave, and after interpolating, the data is resampled at equal intervals (dotted line in FIG. 7C). In the next step S22, spectrum analysis (frequency conversion) is performed on the data obtained in step S21. An example of the spectrum analysis performed in step S22 is shown in FIG. In the next step S23, a low frequency component LF is obtained. Here, the low frequency component LF is an integral value of the power spectrum component of 0.04 to 0.15 Hz. In the next step S24, a high frequency component HF is obtained. Here, the high frequency component HF is an integral value of power spectrum components of 0.15 to 0.40. In step S25, the ratio obtained in step S23 and the ratio obtained in step S24 are calculated and set to LF / HF.

Next, a process performed by the blood pressure measurement system 10 when the subject is not sufficiently rested even though the subject is prompted to take a deep breath will be described.
FIG. 9 shows a processing flow performed by the blood pressure measurement system 10 when the subject is not sufficiently rested even though the subject is prompted to take a deep breath.
The blood pressure measurement system 10 first measures LF / HF and blood pressure in step S100. The measurement method in step S100 is, for example, the same method as shown in FIG. When the measurement in step S100 is completed, in the next step S110, the storage device 18 stores the LF / HF measured in the step S100 in association with the blood pressure. In the next step S120, the CPU 17 determines whether or not the number of measurements of LF / HF and blood pressure in a state where the values of LF / HF are different from each other has reached a predetermined number, and if so, the processing of S130 is performed. If not reached, the process proceeds to S100. In step S130, the CPU 17 approximates the relationship of blood pressure to LF / HF to a linear function by, for example, the least square method. Furthermore, it progresses to step S140 and the UI apparatus 19 displays the result which CPU17 approximated. In step S150, the storage device 18 further stores the result approximated by the CPU 17, and the process ends.

FIG. 10 is a display example (graph) in which the UI device 19 displays the result approximated by the CPU 17 in step S140 shown in FIG.
As shown in FIG. 10, the approximate result by the CPU 17 displayed by the UI device 19 is approximated from, for example, four measurement results of LF / HF and blood pressure, and y = 2.2585x + 143. 48 is a linear function. That is, the UI device 19 indicates that the blood pressure at rest (cooled) of the subject is 143.48 mmHg (intercept), and the slope of the blood pressure with respect to the LF / HF of the subject is 2.2585. It shows that.

Therefore, the blood pressure measurement system 10 can display the inclination of blood pressure relative to LF / HF for each person to be measured, and accurately measure the blood pressure regardless of the state of the person's autonomic nerve. Can do.
In addition, the blood pressure with respect to LF / HF is not limited to a maximum blood pressure etc., For example, an average blood pressure or a minimum blood pressure may be sufficient.
Further, in S150 shown in FIG. 9, since the storage device 18 stores the result approximated by the CPU 17, it is possible to create a database corresponding to the inclination of blood pressure with respect to LF / HF for each person to be measured.

In the above embodiment, the sympathetic nerve activity index LF / HF is used as the autonomic nerve function measuring means for measuring the autonomic nerve function. However, the present invention is not limited to this. For example, the parasympathetic nerve activity index HF is used. It may be used. In the embodiment described above, it is determined whether or not to perform blood pressure measurement according to the measurement result of the autonomic nerve function. However, the present invention is not limited to this. However, it may be determined whether or not to adopt the blood pressure value measured according to the measurement result of the autonomic nerve function.
Moreover, you may make it use what reads a blood flow with an optical sensor as a means to monitor electrocardiogram.

  As described above, the present invention can be used for a blood pressure measurement system that needs to accurately measure blood pressure.

1 is a schematic diagram showing a blood pressure measurement system according to an embodiment of the present invention. It is a flowchart which shows the processing flow in the case of measuring LF / HF and a blood pressure in the blood-pressure measurement system which concerns on embodiment of this invention. It is a flowchart which shows the control flow regarding deep breath display in the blood pressure measurement system which concerns on embodiment of this invention. It is a screen figure in the display which displayed the case where it inhales at the time of deep breathing in the blood pressure measurement system concerning the embodiment of the present invention. In the blood pressure measurement system concerning the embodiment of the present invention, it is a screen figure in the display which displayed the case where it exhales at the time of deep breath. It is a flowchart which shows the flow which calculates LF / HF in the blood-pressure measurement system which concerns on embodiment of this invention. It is a figure which shows the heart rate variability measuring method in the blood-pressure measuring system which concerns on embodiment of this invention. It is a figure which shows an example which carried out the spectrum analysis in the blood pressure measurement system which concerns on embodiment of this invention. It is a flowchart which shows the processing flow which a blood-pressure measurement system performs when a to-be-measured person is not in a sufficiently quiet state even if a to-be-measured person is encouraged to take a deep breath. 9 is a display example (graph) in which the UI device 19 displays a result approximated by the CPU 17 in step S140 illustrated in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Blood pressure measurement system 12 Blood pressure monitor 14 ECG monitor 16 Personal computer 17 CPU
18 Storage device 19 UI device

Claims (3)

A deep breath display means for displaying the way of deep breathing, a blood pressure measuring means for measuring blood pressure, an electrocardiographic monitoring means for monitoring an electrocardiogram, an autonomic nerve function measuring means for measuring an autonomic nerve function from the electrocardiographic monitoring means, Storage means for storing the measurement result by the autonomic nerve function measurement means and the measurement result of the blood pressure measurement means, and calculation means for calculating the relationship of blood pressure to the autonomic nerve function based on each measurement result stored by the storage means; possess and output means for outputting the result of this calculation means has calculated, the autonomic nervous function measuring means and said blood pressure measuring means, the blood pressure measuring system to start the measurement, respectively after completion of presentation of the deep breath display means.   The blood pressure measurement system according to claim 1, wherein the calculation means approximates a relationship of blood pressure with respect to autonomic nerve function to a linear function. The control means of the blood pressure measurement system is a method of operating the blood pressure measurement system in which the deep breath display means controls the autonomic nervous function measurement means, the blood pressure measurement means, the storage means, the calculation means and the output means, and the deep breath display means And after the display of the deep breath display means, measurement is performed by the autonomic nerve function measuring means and the blood pressure measuring means , and the measured autonomic nerve function and blood pressure measurement results are stored in the storage means, and based on each stored measurement result A method for operating the blood pressure measurement system in which the control means performs control in which the calculation means calculates the relationship of the blood pressure to the autonomic nerve function and the output means outputs the calculated result.

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