JP3921202B2 - 抗刺激性酒さ治療 - Google Patents
抗刺激性酒さ治療 Download PDFInfo
- Publication number
- JP3921202B2 JP3921202B2 JP2003533847A JP2003533847A JP3921202B2 JP 3921202 B2 JP3921202 B2 JP 3921202B2 JP 2003533847 A JP2003533847 A JP 2003533847A JP 2003533847 A JP2003533847 A JP 2003533847A JP 3921202 B2 JP3921202 B2 JP 3921202B2
- Authority
- JP
- Japan
- Prior art keywords
- rosacea
- composition
- skin
- extract
- phytosphingosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Description
本発明は、酒さを治療する局所適用化粧品用組成物および医薬組成物に関する。特に本発明は、酒さを治療するために用いられる際に皮膚に対して実質的に無刺激性である成分の混合物を含有する化粧品用組成物および医薬組成物に関する。
酒さは、顔面紅潮の発症、紅斑、毛細血管拡張症、ならびに繰り返し現れる顔面の炎症性丘疹および膿疱(これらは通常は、頬から鼻にかけて対称性分布で並ぶ)の症状によって特徴付けられる一般的な皮膚の病的状態である。肌の白い人々の方が、酒さを経験し悩まされることが多い。一般に、酒さの患者は、脂性で薄く、かつ微生物相のカウント数が高い肌を有すると考えられている。酒さの影響の大部分は皮膚に関連するが、酒さは、身体的には社会的に体裁が悪く見えたり、明らかに外見を損なうように見えたりするため、それによって心の傷を生じることもありうる。従って、酒さの治療法の進歩は、この病的状態に苦しむ人々の生活に非常に大きな影響を及ぼしうる。
本発明は、フィトスフィンゴシン、少なくとも緑茶を含有する抗酸化成分、少なくともヒノキチオールおよびサリチレートを含有する抗菌成分、ならびに少なくとも多糖およびヤギ目サンゴ虫(gorgonian)抽出物を含有する抗刺激成分を含む、酒さの病的状態に対してレチノイドを用いて処置した皮膚に局所適用するための化粧品用組成物および医薬組成物に関する。本発明の組成物は、酒さの症状、特に毛細血管拡張症に関連する症状(顔面紅潮など)を治療することができ、しかも実質的に無刺激性である。フィトスフィンゴシン、少なくとも緑茶を含有する抗酸化成分、少なくともヒノキチオールおよびサリチレートを含有する抗菌成分、ならびに少なくとも多糖およびヤギ目サンゴ虫(gorgonian)抽出物成分を含有する抗刺激成分の組み合わせにより、酒さの治療が向上し、さらに酒さ治療のためのレチノイドの使用によって皮膚に感じる刺激の可能性を最小限にする。
本発明の酒さ治療は、酒さ状態に対してレチノイドを用いて処置した皮膚において有効である。以前に記述されたように、レチノイドは酒さ性座瘡の治療に有用であることが証明された。しかしながら、酒さに悩まされている顔面皮膚の過敏状態のせいで、酒さの治療のためにレチノールを用いる際に刺激を経験することがある。刺激せずに酒さを治療できる不飽和レチノール脂肪酸エステルが米国特許第5,885,595号に記載されている。しかしながら、本発明の製剤は、様々な種類のレチノイドを用いた酒さ治療に通常伴う刺激をうまく低減することができる。従って酒さ患者は、様々なレチノール治療計画から選択することができる。酒さを治療するのに用いるレチノイドは、レチノール(ビタミンA)であってもよいし、その誘導体(例えばレチニル・パルミテート、レチナール、レチニル・アセテート、レチノイン酸など)であってもよい。レチノイドは、酒さの症状を有効に治療するのに十分な量で、本発明の他の成分と組み合わせて使用される。レチノイドは、本発明の組成物に含有させてもよいし、別個の治療の一部としてもよい。しかしながら、レチノイドの適用は、別個の酒さ局所治療計画の一部であるのが好ましい。レチノイドの具体的な量は、酒さ治療用の組成物の総重量に対する濃度で、例えば約0.001〜5.00%、より好ましくは約0.01〜2.00%でありうる。
実施例II
実施例Iにて同様に提供された本発明の組成物を、酒さの徴候、特に毛細血管拡張症に伴う発赤を低減する効果について確認する試験に供する。この試験には、18歳〜50歳までの女性の参加者18人が参加する。参加者は肌タイプI〜IIであり、顔面紅潮または赤面する肌を有するものとみなされている。従って、参加者は低〜中程度の酒さを示し、特に酒さに伴う顔面紅潮/赤面による発赤を示す。参加者は酒さに伴う極端な座瘡の徴候は示さず、低〜中程度の酒さ以外の皮膚学上または眼科上の問題を含む急性疾患または慢性疾患の徴候もしくは証拠もなく、健常であると考えられる。参加者は現在日焼け、発疹、擦過傷、または火傷跡がないが、それは、これらの皮膚状態が試験結果の評価に差し障るためである。さらにこの試験では、妊娠しているかまたは授乳中の女性は参加者から除外する。
Claims (10)
- 以下の組み合わせ:
フィトスフィンゴシン、
抗酸化成分、
少なくともヒノキチオールおよびサリチレートを含む抗菌成分、ならびに
少なくともポルフィリジウム(Porphyridium)種の紅藻の抽出物である多糖およびヤギ目サンゴ虫(gorgonian)抽出物を含む抗刺激成分、
を含む、酒さの病的状態に対してレチノイドを用いて処置した皮膚のための局所化粧品用または医薬組成物。 - さらに以下を含む、請求項1に記載の組成物:
0.01〜10.0%のフィトスフィンゴシン、
0.1〜0.5%の、少なくとも緑茶を含む抗酸化成分、
0.05〜0.2%のヒノキチオール、
0.1〜5.0%のサリチレート、
0.05〜0.2%のヤギ目サンゴ虫抽出物、ならびに
0.5〜2.0%のポルフィリジウム(Porphyridium)種の紅藻の抽出物である多糖。 - サリチレートがサリチル酸およびサリチル酸エステルからなる群より選択される、請求項2に記載の組成物。
- サリチレートが組成物全体の重量に対して0.2〜1.0%の量で存在することを特徴とする、請求項1に記載の組成物。
- サリチレート;フィトスフィンゴシン;ならびに、緑茶、ヒノキチオール、ヤギ目サンゴ虫(gorgonian)抽出物およびポルフィリジウム(Porphyridium)種の紅藻の抽出物である多糖の混合物を含有する抗刺激成分を含む組成物であって、酒さの病的状態に対してレチノイドを用いて処置した皮膚への刺激を、その皮膚に該組成物を局所適用することにより低減するために使用される、前記組成物。
- フィトスフィンゴシン;サリチレート;ならびに少なくとも緑茶を含有する抗酸化成分と、少なくともヒノキチオールを含有する抗菌成分と、ヤギ目サンゴ虫(gorgonian)抽出物およびポルフィリジウム(Porphyridium)種の紅藻の抽出物である多糖の混合物を含有する抗刺激成分との混合物を含む組成物であって、酒さの病的状態に対してレチノイドを用いて局所的に処置した皮膚における発赤を、その皮膚に該組成物を局所適用することにより低減するために使用される、前記組成物。
- 前記皮膚に局所適用することにより毛細血管拡張症を治療するために使用される、請求項1に記載の組成物。
- 前記皮膚に局所適用することにより酒さを治療するために使用される、請求項1に記載の組成物。
- 以下のa)〜d)の組み合わせを含む、レチノイドを用いて処置した皮膚における酒さの毛細血管拡張症状を治療するための局所化粧品用または医薬組成物。
a) 0.01〜10.0%のフィトスフィンゴシン、
b) 有効量の、0.1〜0.5%の緑茶を少なくとも含有する抗酸化成分の組み合わせ、
c) 0.05〜0.2%のヒノキチオールおよび0.1〜5.0%のサリチレートを少なくとも含有する抗菌成分、ならびに
d) 0.05〜0.2%のヤギ目サンゴ虫(gorgonian)抽出物および0.5〜2.0%のポルフィリジウム(Porphyridium)種の紅藻の抽出物である多糖の組み合わせを含有する、抗刺激成分 - 以下のa)〜d)を含有する、レチノイドを用いて処置した皮膚に局所適用するための酒さ治療システム。
a) 0.1〜5.0%のサリチル酸および0.05〜0.2%のヒノキチオールを含有する抗菌成分、
b) 0.01〜10.0%のフィトスフィンゴシン、
c) 有効量の、0.1〜0.5%の緑茶を少なくとも含有する抗酸化成分、ならびに
d) 0.05〜0.2%のヤギ目サンゴ虫(gorgonian)抽出物および0.5〜2.0%のポルフィリジウム(Porphyridium)種の紅藻の抽出物である多糖の組み合わせを含有する、抗刺激成分
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US10080734B2 (en) | 2012-07-26 | 2018-09-25 | The William M. Yarbrough Foundation | Method for treating autism and other neurodevelopmental disorders |
US10434082B2 (en) | 2012-07-26 | 2019-10-08 | The William M. Yarbrough Foundation | Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms |
US9839621B2 (en) | 2012-07-26 | 2017-12-12 | The William M. Yarbrough Foundation | Method for treating bladder cancer |
US10441561B2 (en) | 2012-07-26 | 2019-10-15 | The William M. Yanbrough Foundation | Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer |
US9949943B2 (en) * | 2012-07-26 | 2018-04-24 | The William M. Yarbrough Foundation | Method for treating neurodegenerative diseases |
US9861645B2 (en) | 2012-12-28 | 2018-01-09 | Rak Holdings Llc | Anti-itch scalp treatment compositions and combinations |
BR112015028457A8 (pt) | 2013-05-15 | 2017-10-03 | Solazyme Inc | Composições cosméticas compreendendo óleo de microalgas |
DE202015009366U1 (de) | 2014-07-11 | 2017-04-10 | Mary Kay Inc. | Porenminimierer |
GB2528482A (en) * | 2014-07-23 | 2016-01-27 | Skintech Life Science Ltd | Pharmaceutical agent |
US10576048B2 (en) * | 2018-03-09 | 2020-03-03 | Ocusoft, Inc. | Topical skin care compositions |
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KR900007498B1 (ko) | 1987-06-18 | 1990-10-11 | 구레하 가가꾸 고교 가부시끼가이샤 | 다당류 및 그것을 활성성분으로 함유하는 항바이러스 약제 |
US5306486A (en) | 1993-03-01 | 1994-04-26 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic sunscreen composition containing green tea and a sunscreen |
FR2732221B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
US5624911A (en) | 1995-06-07 | 1997-04-29 | The Regents Of The University Of California | Ether derivatives of pseudopterosin |
IL114267A0 (en) | 1995-06-22 | 1995-10-31 | Univ Ben Gurion | Antiviral agents |
DE69606514T2 (de) | 1995-09-01 | 2000-09-14 | Dsm Nv | Derivate von sphingoid basen auf basis von retinoylamid |
US5885595A (en) | 1996-05-13 | 1999-03-23 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic composition with a retinol fatty acid ester |
US5811114A (en) | 1996-06-12 | 1998-09-22 | E-L Management Corp. | Stabilized hinokitiol and compositions containing same |
US5728732A (en) | 1996-11-27 | 1998-03-17 | Elizabeth Arden Company, Division Of Conopco, Inc. | Skin treatment with salicylic acid esters and retinoids |
BR9811789A (pt) * | 1997-09-12 | 2000-09-05 | Procter & Gamble | Artigo de limpeza e condicionamento para tratamento pessoal de utilização única, descartável e processos para manufaturar esse artigo e para limpar e condicionar a pele ou cabelo com esse artigo |
EP0975325B1 (en) | 1997-12-05 | 2003-09-17 | Cosmoferm B.V. | Compositions comprising a combination of a free sphingoid base and a ceramide and use thereof |
US5972993A (en) | 1998-03-20 | 1999-10-26 | Avon Products, Inc. | Composition and method for treating rosacea and sensitive skin with free radical scavengers |
EP1093525A1 (en) | 1998-07-03 | 2001-04-25 | Cosmoferm B.V. | Improved microbial strains producing sphingoid bases |
US5952372A (en) | 1998-09-17 | 1999-09-14 | Mcdaniel; William Robert | Method for treating rosacea using oral or topical ivermectin |
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2001
- 2001-10-05 US US09/971,561 patent/US6680062B2/en not_active Expired - Lifetime
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2002
- 2002-09-18 DE DE60229971T patent/DE60229971D1/de not_active Expired - Lifetime
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EP1441685A2 (en) | 2004-08-04 |
EP1441685B1 (en) | 2008-11-19 |
CA2461941A1 (en) | 2003-04-17 |
ES2316647T3 (es) | 2009-04-16 |
US20030068343A1 (en) | 2003-04-10 |
JP2006306899A (ja) | 2006-11-09 |
CA2461941C (en) | 2011-07-26 |
WO2003030813A2 (en) | 2003-04-17 |
DE60229971D1 (de) | 2009-01-02 |
EP1441685A4 (en) | 2007-10-31 |
AU2002334601B2 (en) | 2007-01-25 |
WO2003030813A3 (en) | 2004-03-11 |
US6680062B2 (en) | 2004-01-20 |
ATE414527T1 (de) | 2008-12-15 |
JP2005508936A (ja) | 2005-04-07 |
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