JP3881011B2 - 受容体ポテンシエーターの使用 - Google Patents

受容体ポテンシエーターの使用 Download PDF

Info

Publication number
JP3881011B2
JP3881011B2 JP51476796A JP51476796A JP3881011B2 JP 3881011 B2 JP3881011 B2 JP 3881011B2 JP 51476796 A JP51476796 A JP 51476796A JP 51476796 A JP51476796 A JP 51476796A JP 3881011 B2 JP3881011 B2 JP 3881011B2
Authority
JP
Japan
Prior art keywords
receptor
ner
dopamine
tofa
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP51476796A
Other languages
English (en)
Japanese (ja)
Other versions
JPH10509139A (ja
Inventor
フリードマン,イータン
ハロウエイ,エム・キヤサリン
ロダン,ギデオン・エイ
シユミツト,アズリエル
ボーゲル,ロバート・エル
Original Assignee
メルク エンド カンパニー インコーポレーテッド
メデイカル・カレツジ・オブ・ペンシルバニア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メルク エンド カンパニー インコーポレーテッド, メデイカル・カレツジ・オブ・ペンシルバニア filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH10509139A publication Critical patent/JPH10509139A/ja
Application granted granted Critical
Publication of JP3881011B2 publication Critical patent/JP3881011B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Furan Compounds (AREA)
JP51476796A 1994-10-27 1995-10-24 受容体ポテンシエーターの使用 Expired - Fee Related JP3881011B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/330,518 US5607967A (en) 1994-10-27 1994-10-27 Treatment of alzheimer's disease with 5-(tetradecyloxy)-2-furan carboxylic acid
US330,518 1994-10-27
PCT/US1995/013931 WO1996013257A1 (en) 1994-10-27 1995-10-24 Use of receptor potentiators

Publications (2)

Publication Number Publication Date
JPH10509139A JPH10509139A (ja) 1998-09-08
JP3881011B2 true JP3881011B2 (ja) 2007-02-14

Family

ID=23290124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51476796A Expired - Fee Related JP3881011B2 (ja) 1994-10-27 1995-10-24 受容体ポテンシエーターの使用

Country Status (9)

Country Link
US (1) US5607967A (enExample)
EP (1) EP0786995B1 (enExample)
JP (1) JP3881011B2 (enExample)
AT (1) ATE241354T1 (enExample)
AU (1) AU705987B2 (enExample)
CA (1) CA2200886A1 (enExample)
DE (1) DE69530933T2 (enExample)
ES (1) ES2198447T3 (enExample)
WO (1) WO1996013257A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0726073A3 (en) * 1995-02-10 1998-07-08 Eduardo Samuel Bleiweiss Pharmaceutical compositions containing at least one of haloperidol, imipramine or trifluoroperazine
JP2001514663A (ja) * 1997-03-12 2001-09-11 エスモンド,ロバート ダブリュー. アルツハイマー病を処置または予防するための方法
US6262049B1 (en) 1997-10-28 2001-07-17 Schering Corporation Method of reducing nicotine and tobacco craving in mammals
IL135659A0 (en) * 1997-10-28 2001-05-20 Schering Corp Method of reducing craving in mammals
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
US6890716B1 (en) * 1998-05-07 2005-05-10 Howard Hughes Medical Institute Recombinant cell line and screening method for identifying agents which regulate apoptosis and tumor suppression
US6191154B1 (en) * 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
US20030086923A1 (en) * 1999-12-13 2003-05-08 Sparrow Carl P. Method for the prevention and/or treatment of atherosclerosis
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
ES2752800T3 (es) 2000-05-01 2020-04-06 Cerecin Inc Uso de triglicéridos de cadena media para el tratamiento y la prevención de la enfermedad del Parkinson resultante de un metabolismo neuronal reducido
US8124589B2 (en) 2000-05-01 2012-02-28 Accera, Inc. Use of ketogenic compounds for treatment of age-associated memory impairment
GB0017951D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of movement disorders
AU2001289834A1 (en) * 2000-08-24 2002-03-04 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders
US6924311B2 (en) * 2001-10-17 2005-08-02 X-Ceptor Therapeutics, Inc. Methods for affecting various diseases utilizing LXR compounds
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) * 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
US20030185884A1 (en) * 2002-04-01 2003-10-02 Singh Nikhilesh Nihala Therapeutic agent delivery compositions for buccal cavity absorption of pilocarpine
WO2004058717A1 (en) * 2002-12-20 2004-07-15 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2005101007A1 (en) * 2004-04-15 2005-10-27 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with liver x receptor beta (lxrb)
US20110003767A1 (en) * 2007-05-14 2011-01-06 Neuera Pharmaceuticals, Inc. Inhibitors of Acetyl-CoA Carboxylase for Treatment of Neuronal Hypometabolism
EP2179284B1 (en) 2007-07-31 2016-09-28 Accera, Inc. Use of genomic testing and ketogenic compounds for treatment of reduced cognitive function
CA2740029C (en) * 2008-05-16 2016-12-20 Axis, Inc. Pharmaceutical composition for treatment of fibromyalgia
US9125881B2 (en) * 2008-07-03 2015-09-08 Accera, Inc. Monoglyceride of acetoacetate and derivatives for the treatment of neurological disorders
EP4616915A3 (en) * 2012-07-12 2025-12-17 Emalex Biosciences, Inc. Ecopipam for treatment of tourettes syndrome
CN110833621A (zh) * 2019-12-06 2020-02-25 中国医科大学 多巴胺受体1拮抗剂在制备治疗对氯胺酮致小鼠类精神分裂症药物上的应用
WO2025194153A1 (en) 2024-03-15 2025-09-18 Emalex Biosciences, Inc. Pharmaceutical dosage forms and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601247A1 (fr) * 1986-07-09 1988-01-15 Merk Sharp Dohme Chibret Labor Combinaison d'agents beta-bloquants et de pilocarpine.
US4981784A (en) * 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5153205A (en) * 1990-10-01 1992-10-06 Merck & Co., Inc. Method to reduce introacular pressure without causing miosis
ES2183815T3 (es) * 1992-07-24 2003-04-01 Univ Johns Hopkins Quimioterapia para el cancer.

Also Published As

Publication number Publication date
DE69530933D1 (de) 2003-07-03
JPH10509139A (ja) 1998-09-08
EP0786995A4 (enExample) 1997-08-20
ATE241354T1 (de) 2003-06-15
WO1996013257A1 (en) 1996-05-09
ES2198447T3 (es) 2004-02-01
EP0786995A1 (en) 1997-08-06
DE69530933T2 (de) 2004-02-12
US5607967A (en) 1997-03-04
AU3970095A (en) 1996-05-23
EP0786995B1 (en) 2003-05-28
CA2200886A1 (en) 1996-05-09
AU705987B2 (en) 1999-06-03

Similar Documents

Publication Publication Date Title
US5607967A (en) Treatment of alzheimer's disease with 5-(tetradecyloxy)-2-furan carboxylic acid
Miller et al. Primate trace amine receptor 1 modulation by the dopamine transporter
Sibley et al. Molecular biology of dopamine receptors
Tamminga Partial dopamine agonists in the treatment of psychosis
Yao et al. Characterization of a Cannabinoid CB2 Receptor-Selective Agonist, A-836339 [2, 2, 3, 3-Tetramethyl-cyclopropanecarboxylic Acid [3-(2-Methoxy-ethyl)-4, 5-dimethyl-3 H-thiazol-(2 Z)-ylidene]-amide], Using in Vitro Pharmacological Assays, in Vivo Pain Models, and Pharmacological Magnetic Resonance Imaging
Maggio et al. Dopamine D2–D3 receptor heteromers: pharmacological properties and therapeutic significance
Yea et al. Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells
EP1984395A2 (en) Modulation of bone formation
CA3005375C (en) Pharmaceutical compositions for treating pain
US5679518A (en) Method for finding transcription activators of the NER steroid hormone receptor
Simmler et al. The SERT Met172 mouse: An engineered model to elucidate the contributions of serotonin signaling to cocaine action
JP2002526098A (ja) 新規なぺプチド類
EP3881840A1 (en) Sortilin antagonists for use inthe treatment of diabetic retinopathy
Huynh et al. Brain-derived neurotrophic factor gene organization and transcription in the zebrafish embryo
WO2006059081A2 (en) Methods of treatment using melanopsin
Leo et al. Trace amine-associated receptor 1 modulation of dopamine system
AU767031B2 (en) Mammalian (elk) potassium channel genes
US7442767B2 (en) α1D calcium channel expressed in atrium
Büschbell Characterization of Protein-Protein Interactions Involving G-Protein-Coupled Receptor 143 By Computational And Pharmacological Methods
US20040072187A1 (en) Novel mammalian receptor genes and uses
JP2002526097A (ja) 新規なぺプチド類
Plach Serotonin 5-HT2A-Dopamine D2 Receptor Heterodimers: Characterization and Functional Evaluation
Hudson Interactions between the cannabinoid and the [beta]-adrenergic systems: receptor heterodimerization, signalling interactions and the regulation of intraocular pressure.
WO2004009630A1 (en) Regulation of human serotonin receptor
JPH10330286A (ja) 異常遺伝子産物作動物質の用途およびスクリーニング方法

Legal Events

Date Code Title Description
A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060221

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060404

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20060529

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060821

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20061024

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20061109

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees