JP3817001B2 - Volatile drug container - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a volatile drug container, and more particularly to a container for slow release of a volatile drug.
[0002]
[Prior art and problems]
Conventionally, a volatile drug containing a medicinal component is gradually released and the volatile drug is wrapped in various sustained-release sheets in a bag shape so that the medicinal effect can be maintained for a long time.
By the way, in the pre-use stage, it is inconvenient if the volatile chemicals are volatilized, and therefore, as shown in FIG. 3, the outer side is further wrapped with a certain gas-impermeable sheet to form a container.
[0003]
However, when trying to break the gas-impermeable sheet in use, there is a volatile chemical gas that reaches a saturated concentration in the space between the inner bag of the sustained-release sheet and the outer bag of the gas-impermeable sheet, Since this is released to the outside at once, there is almost no sustained release effect at the initial stage of use, and in particular, in the case of a drug with an irritating odor such as allyl isothiocyanate (hereinafter referred to as AIT), it causes extremely great discomfort to humans. It was a thing. Moreover, it is necessary to provide a break means in the bag body made of a gas-impermeable sheet, and handling is troublesome.
[0004]
Furthermore, it is conceivable that the sustained release sheet and the gas impermeable sheet are directly laminated, and a certain breaking means is provided on the gas impermeable sheet, but this is difficult to process and damages the sustained release sheet at break. There is also a risk.
[0005]
In view of this, the present invention is intended to obtain a volatile drug container that exhibits a sustained release effect from the initial stage of use, maintains the function of the volatile drug for a long period of time, and is easy to handle.
[0006]
[Means for Solving the Problems]
In order to solve the above-described problems, the volatile drug container of the present invention stores a volatile drug in a bag made of a gas-impermeable sheet, and forms an opening in the bag. A drug release film having an oxygen permeability of 5,000 to 1,000,000 cm ³ / m ² · hr is formed, and a lid member that is made of a gas-impermeable base material and seals the opening is formed outside the drug release film. A release sheet is provided, and a sustained release sheet having an oxygen permeability of 10 to 100,000 cm ³ / m ² · hr and smaller than the oxygen permeability of the drug release film is provided inside the drug release film.
[0007]
In this case, the oxygen permeability which prescribes | regulates gas permeability to ASTM (AMERICAN SOCIETY FOR TESTING AND MATERIALS) was digitized.
[0008]
Even if the lid member is peeled off from the bag body, since at least the drug release film exists in the opening, it is possible to prevent the volatilizing drug gas present in the bag body from being released at a stroke, from the initial stage. The sustained release effect depending on the sustained release sheet can be exhibited.
[0009]
In particular, in the case of a drug having an irritating odor such as AIT, there is no discomfort in the vicinity. Moreover, since the purpose can be achieved simply by peeling off the lid member, there is no possibility of damaging the drug release film and the sustained release sheet, and the handling is easy.
[0010]
In addition, when the state of this invention product is shown with a conceptual diagram, it will become like FIG. 1 and 2, reference numeral 1 denotes a gas impermeable sheet, 2 denotes a drug release film, 3 denotes a lid member, 4 denotes a sustained release sheet, and 5 denotes a volatile drug.
[0011]
DETAILED DESCRIPTION OF THE INVENTION
Specific examples of the volatile drug in the present invention include the following.
Fragrance: Antibacterial and antifungal agents such as linalool, menthol, citral, anisole, thymol, eugenol, anethole, methylquinoline, lemon oil, sandalwood oil, mint oil, musk, etc. Others such as pyrethroids: When these volatile chemicals such as pheromone, repellents, and agricultural chemicals are in liquid form, it is preferable to impregnate a porous carrier or knead them with wax to form a pallet.
[0012]
As the porous carrier, cellulose particles formed by the method shown in Japanese Patent Application Laid-Open No. 3-231942 having a certain size and being easy to handle and having a solid partition wall are preferable. Furthermore, it is more preferable in terms of sustained release when a hydrophobic substance such as wax is melted and embedded in the pores of the cellulose particles in a state in which a volatile agent is kneaded.
[0013]
Next, examples of the gas impermeable sheet that forms the bag and the lid member that seals the opening include aluminum sheets such as aluminum foil and aluminum vapor deposition films, and ceramic vapor deposition films. In particular, the aluminum sheet is effective when the light-shielding and volatile chemicals are modified by light.
[0014]
For adhesion between the bag body and the lid member for allowing the lid member to be peeled off, acrylic or synthetic rubber pressure-sensitive adhesives as well as various hot-melt adhesives are used as the pressure-sensitive adhesive.
[0015]
Next, as the drug release membrane, polyolefins such as polyethylene and polypropylene are preferable, and when the permeability is to be increased, those having a perforated treatment are suitable. Of these, polyethylene which is itself thermoplastic and is easy to process is preferred. When polyethylene is used, if it is laminated on the entire gas-impermeable sheet forming the bag, the bag can be easily formed as shown in FIG.
[0016]
Examples of the sustained release sheet include viscose processed paper, nylon film, and polyethylene terephthalate (hereinafter referred to as PET) film. Of these, viscose processed paper is a method as shown in Japanese Patent Publication No. 4-3742. It is preferable because the air permeability can be easily changed by appropriately changing the cellulose concentration of the viscose to be produced and applied. Furthermore, it is more effective to laminate a viscose-processed paper and PET to form a sustained release sheet, such as AIT, which has high volatility.
[0017]
Moreover, when an inner bag as shown in FIG. 1 is formed with these sustained release sheets, it becomes strong against impact from the outside, and a drug is formed at the boundary between the space formed between the bag body and the inner bag and the outside. Due to the presence of the release membrane, there is a certain difference in the concentration of each drug. For this reason, it is effective when it is desired to volatilize more slowly.
[0018]
Furthermore, when using viscose-processed paper as a sustained release sheet, there is a drawback that the sustained release effect is reduced when the humidity is high, and the above configuration is extremely effective in the sense of blocking external moisture.
[0019]
When the lid member is peeled off in use, the volatile drug is sequentially released through the sustained release sheet and the drug release film.
[0020]
【Example】
Next, the present invention will be described in more detail with reference to examples.
[0021]
[Example 1]
AIT is impregnated into porous cellulose beads (Rengo Co., Ltd .: Viscopearl), and 1.2 g of this AIT-impregnated cellulose beads is formed from a laminated sheet of viscose-treated paper (Rengo Co., Ltd .: Saffron) and a PET film. Store in an inner bag (50 mm x 60 mm). On the other hand, a sheet (90 mm × 100 mm) obtained by extruding and laminating polyethylene on an aluminum foil having a rectangular hole (20 mm × 40 mm) in part is sandwiched from above and below with polyethylene as the inner side so as to surround the inner bag, and its peripheral edge Was heat-sealed to form a bag.
An aluminum foil (30 mm x 50 mm) is covered as a lid member so as to seal the hole, and a hot melt adhesive is used for bonding to the bag body so that the lid member can be peeled off. It was.
FIG. 1 shows a schematic cross-sectional view when the lid member is peeled off.
[0022]
[Example 2]
A sheet (30 mm × 50 mm) obtained by laminating the viscose processed paper, the PET film and polyethylene used in Example 1 on an aluminum foil (65 mm × 95 mm) provided with a rectangular hole (20 mm × 40 mm) in part is provided with the above holes. Sealed with polyethylene to cover.
The laminated aluminum foil is sandwiched from above and below with the viscose-treated paper side inward so as to surround 1.2 g of the AIT-impregnated cellulose beads used in Example 1, and the periphery is heat-sealed with polyethylene in four directions. Formed.
The said hole was sealed with the cover member which can be peeled similarly to Example 1, and it was set as the AIT accommodating body.
FIG. 2 shows a schematic cross-sectional view when the lid member is peeled off.
[0023]
[Comparative Example 1]
In the same manner as in Example 1, 1.2 g of the AIT-impregnated cellulose beads used in Example 1 were stored in an inner bag (50 mm × 60 mm) formed of a laminated sheet of viscose processed paper and PET film. The inner bag was sandwiched from above and below so as to surround the inner bag with an aluminum foil (90 mm × 100 mm) provided with a notch, and its peripheral edge was heat-sealed with polyethylene in four directions to obtain an AIT container.
FIG. 3 shows a schematic cross-sectional view when the aluminum foil bag body is broken starting from the notch.
[0024]
[Experimental example]
The AIT release amount of each AIT container of Examples 1 and 2 and Comparative Example 1 was measured as follows.
Each AIT container is left in a constant temperature and humidity room at room temperature 20 ° C. and humidity 65 ° C. RH until the weight becomes constant. Each of the conditioned AIT storage bodies is opened on a precision electronic balance by peeling the lid member in the case of Examples 1 and 2 or by breaking the aluminum foil in the case of Comparative Example 1, and after the opening, the weight change due to the elapsed time Was measured. From the measured weight, the weight loss with respect to the elapsed (AIT release) time was determined, and this was defined as the amount of AIT released into the air. The result is shown in FIG.
[0025]
As shown in this result, it can be seen that in Comparative Example 1, AIT is released more rapidly than immediately after opening. On the other hand, in Examples 1 and 2, it can be seen that the release is linearly performed from the beginning when the lid member is peeled off. Moreover, it turns out that the direction of Example 2 is more sustained release.
[0026]
【The invention's effect】
As described above, the present invention exerts a sustained release effect depending on the sustained release sheet of the volatile drug from the initial stage of use, and in a drug with an irritating odor, it may cause discomfort around. Absent.
[Brief description of the drawings]
FIG. 1 is a schematic sectional view showing an embodiment of a volatile drug container according to the present invention. FIG. 2 is a schematic sectional view showing another embodiment of a volatile drug container according to the present invention. Schematic cross-sectional view of a volatile drug container [Fig. 4] Graph showing the effect of the present invention [Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Gas-impermeable sheet 2 Drug release film 3 Lid member 4 Controlled release sheet 5 Volatile drug 6 Opening part

Claims (4)

A volatile drug is stored in a bag made of a gas-impermeable sheet, an opening is formed in the bag, and an oxygen permeability of 5,000 to 1,000,000 cm ³ / m ² · hr is formed in the opening. The drug release film is formed, and a gas impermeable base material is formed on the outside of the drug release film. A lid member for sealing the opening is detachably provided, and the oxygen permeability is 10 to 100 on the inside of the drug release film. A volatile drug container comprising a sustained-release sheet having a thickness of 1,000,000 cm ³ / m ² · hr and smaller than the oxygen permeability of the drug release membrane. The volatile drug container according to claim 1, wherein the volatile drug is surrounded by an inner bag formed of the sustained release sheet. The volatile drug container according to claim 1 or 2, wherein the gas impermeable sheet and the lid member are made of an aluminum sheet, the drug release film is made of a polyethylene film, and the sustained release sheet is made of viscose processed paper. The volatile drug container according to any one of claims 1 to 3, wherein the volatile drug is contained in cellulose particles.

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