JP2003299721A - Volatilizable chemical sustainedly releasing apparatus and air supply circuit for automobile having the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a volatilizable chemical sustained releasing apparatus which prevents an unnecessary chemical from being discharged by forcibly suppressing the release of the chemical at a predetermined temperature or higher and which can be safely used by a user. <P>SOLUTION: The volatilizable chemical sustainedly releasing apparatus comprises: an inside body container 3 which fills a volatilizable chemical therein and which has an opening becoming a part of a space 7 and arranged in the container, a movable shutter mechanism arranged on the outer surface of the opening and having at least a shape memory coiled spring 13, a coiled spring 12 and a movable shutter 14. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a volatile drug sustained-release device for gradually releasing a volatile drug by temperature or humidity changes. The volatile drug is gradually released with temperature or humidity changes. In addition, it can be widely applied to fields where it is desired to prevent drug release more than necessary. For example, it can be widely applied to fields such as air conditioners, refrigerators, and food storages where it is desired to release a necessary amount of antifungal and antibacterial agents to prevent the growth of mold and fungi.

[0002]

2. Description of the Related Art A variety of techniques have been proposed for the sustained release of a filled volatile drug over a long period of time. In general, there is a method of impregnating a volatile drug into a porous material and gradually evaporating it by a capillary phenomenon. The porous material was an inorganic compound such as zeolite or silica gel, or a polypropylene, polyester, cellulose foam or fiber bundle. Further, there is also a method in which a volatile drug is included in a small hole of an organic substance called cyclodextrin and is gradually released.
No. 176733 and Japanese Patent Laid-Open No. 6-40890. Further, a method for realizing sustained release by encapsulating microcapsules is also disclosed in JP-A-6-9377 and JP-A-6-650.
64, JP-A-7-89848, JP-A-9-911.
No. 9-12447 and No. 9-57091.

Further, the inventor of the present application has proposed a volatile drug sustained-release member for gradually releasing a drug filled in a container with a permeation amount control film or a humidity sensitive film.

However, in the above-mentioned conventional structure, when the volatile drug sustained-release member is excessively heated due to the influence of the external environment, the permeation amount control film alone cannot suppress the volatile drug release amount. It was As a result, the drug is unnecessarily released, and an excessive amount of the drug is released, which causes discomfort to the user.

[0005]

SUMMARY OF THE INVENTION In view of the problems of the prior art as described above, the problem to be solved by the present invention is to forcibly suppress the release of the drug at a temperature higher than a predetermined temperature, thereby unnecessary drug is released. It is intended to provide a volatile drug sustained release device that prevents release and can be used by users with peace of mind.

[0006]

[Means for Solving the Problems] In order to solve the above-mentioned problems, according to the present invention, an opening is provided in a container in which a volatile drug is filled, and a movable shutter mechanism is provided in the opening to provide the movable structure. Elasticity of the elastic body having a shape memory effect in which the elasticity of the volatile drug changes according to a change in a specific temperature by opening and closing the opening of the formula shutter mechanism, and elasticity of the elastic body having the shape memory effect at the specific temperature. It is a volatile drug sustained-release device that opens and closes the movable shutter mechanism by the difference from the elasticity of an elastic body that does not have a shape memory effect in which elasticity changes significantly less than changes.

With the above structure, the spring force of the elastic body having no shape memory effect is higher than the spring force of the elastic body having the shape memory effect at a predetermined temperature or lower, and the elastic body having the shape memory effect at a predetermined temperature or higher. It is possible to provide a movable shutter mechanism by arranging the spring force of 1 to exceed the spring force of an elastic body having no shape memory effect. As a result, it is possible to effectively release the required amount of the drug from a container filled with a volatile drug having antifungal properties, aromatic properties, etc. inside, which can contribute to prolonging the life of the drug. In addition, the user does not feel uncomfortable due to unnecessary drug release.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The object of the present invention can be achieved by adopting the constitution described in each claim as an embodiment. Therefore, in the following, the constitution and effect of the constitution are described together with the constitution of each claim. At the same time, a detailed description will be added to specific terms that require an explanation among the configurations described in the claims, and the embodiments of the present invention will be described.

In the invention according to claim 1 of the present invention, a container containing a volatile drug is provided with an opening through which the volatile drug can be discharged to the outside of the container, and the movable shutter is provided in the opening. A volatile drug sustained-release device capable of releasing a volatile drug by opening and closing the opening of the movable shutter mechanism by providing a mechanism, and a shape memory effect in which elasticity changes with a specific temperature change. Due to the difference between the elasticity of the elastic body having the shape memory effect and the elasticity of the elastic body having no shape memory effect, which is significantly smaller than the elasticity change of the elastic body having the shape memory effect at the specific temperature. The movable shutter mechanism is configured to open and close.

Therefore, the spring force of a normal elastic body having no shape memory effect exceeds a spring force of an elastic body having a shape memory effect at a predetermined temperature or lower, and the spring force of an elastic body having a shape memory effect at a predetermined temperature or higher. By configuring so that the force exceeds the spring force of a normal elastic body, it is possible to realize a movable shutter mechanism in which an elastic body having a shape memory effect and a normal elastic body are combined. With the above structure, effective use can be achieved by gradually releasing the required amount of the drug from the container containing the volatile drug having antifungal property, aromaticity, etc. in the required temperature range of the drug, which contributes to the longevity of the drug. Moreover, the user does not feel uncomfortable due to unnecessary drug release. In this claim, an elastic body having a shape memory effect is
For example, it means that the elastic body made of a high temperature molded alloy returns to its original shape by heating even if it deforms at room temperature, and this effect is due to the transformation of martensite.

According to a second aspect of the present invention, the elastic body having a shape memory effect in which elasticity changes according to a change in a specific temperature is a coil spring made of a shape memory alloy. Therefore, it is possible to easily realize an elastic body having a shape memory effect in which elasticity is changed by a specific temperature change by a coil spring made of a shape memory alloy.

According to the third aspect of the present invention, the volatile drug has a mechanism for gradually releasing the drug to the outside of the container through a permeation control membrane that controls the permeation amount of the drug. Therefore, by selecting an appropriate permeation control membrane according to the application, it is possible to continue the stable and sustained release of the drug at a low concentration.

According to a fourth aspect of the present invention, when the temperature is lower than a predetermined temperature, the movable shutter portion of the movable shutter mechanism is opened to gradually release the volatile drug outside the container, and when the temperature is lower than the predetermined temperature, the movable shutter portion is closed. As a state, the release of the volatile drug from the outside of the container is suppressed.

According to a fifth aspect of the invention, in the movable shutter mechanism, an elastic body having a shape memory effect is arranged above the movable shutter section, and an elastic body having no shape memory effect is arranged below the movable shutter section. The movable shutter is moved from above to below due to the difference in elasticity between the elastic body having the shape memory effect and the elastic body not having the shape memory effect at a predetermined temperature or higher. The mechanism is changed from the open state to the closed state.

Therefore, depending on the temperature range, the normal elastic spring force having no shape memory effect prevails at low temperatures, and the elastic body spring force having a shape memory effect prevails at high temperatures. Can be moved from top to bottom in the open to closed state. As a result, it is possible to realize a volatile drug sustained-release device in which the drug is sufficiently controlled to be released in a high temperature range by the spring force of an elastic body having a shape memory effect.

According to a sixth aspect of the invention, in the movable shutter mechanism, an elastic body having a shape memory effect is provided on the left side or the right side of the movable shutter portion, and an elastic body having no shape memory effect is provided on the opposite side. At a temperature equal to or higher than a predetermined temperature, the movable shutter portion moves leftward or rightward due to a difference in elasticity between the elastic body having the shape memory effect and the elastic body not having the shape memory effect, so that the movable shutter mechanism is formed. The state is changed from the open state to the closed state.

Therefore, since the movable shutter mechanism can be changed from the open state to the closed state by optimizing the moving distance by the structure of the movable shutter portion, it is possible to sufficiently suppress the release of the drug at a high temperature.

According to a seventh aspect of the invention, the elastic body having the shape memory effect and the elastic body having no shape memory effect are connected to the support shaft of the movable shutter section through separate support sections. is there. Therefore, the movable shutter mechanism can be changed from the open state to the closed state by optimizing the moving distance according to the configuration of the movable shutter portion, and the release of the drug can be sufficiently controlled at a high temperature.

According to an eighth aspect of the present invention, a fixed shutter portion is provided between the opening of the container containing the volatile chemical and the movable shutter portion of the movable shutter mechanism, and the fixed shutter portion and the fixed shutter portion are provided. The shutter section is provided with a plurality of opening windows, respectively, and the movable shutter mechanism is opened and closed by moving the plurality of opening windows of the movable shutter section in a vertical direction or a horizontal direction. Therefore, it is possible to sufficiently increase the opening portion required for the sustained release of the volatile drug while reducing the moving distance of the movable shutter portion due to the spring action of the elastic body having the shape mechanism effect.

According to a ninth aspect of the invention, a container containing a volatile chemical is an inner body container, an outer body container is provided outside the inner body container, and a movable shutter portion of a movable shutter mechanism is the outer container. It is configured to move in the left-right direction while being guided by the inner wall surface in the operation direction.

According to a tenth aspect of the present invention, support portions are provided at both left and right ends of the movable shutter portion, and the moving distance when the movable shutter portion moves to the left and right is determined by the side wall of the support portion and the inner main body container. It is configured to be regulated by the interval between and. Therefore, by devising the clearance between the inner wall surface of the outer main body container and the movable shutter portion and the clearance between the support portion of the movable shutter portion and the inner main body container, the movable shutter mechanism is configured to move while being guided. be able to.

According to an eleventh aspect of the present invention, the movable shutter portion of the movable shutter mechanism is composed of a metal plate or a laminated plate containing a metal plate. The fixed shutter portion is composed of a metal plate or a laminated plate containing a metal plate. Therefore, sufficient strength and gas barrier property as the shutter member can be obtained, and the release of the drug can be sufficiently controlled in the closed state at high temperature.

According to a thirteenth aspect of the present invention, the interval width of the opening windows provided in the movable shutter portion of the movable shutter mechanism is made larger than the width of the opening windows provided in the fixed shutter portion. Therefore, when the movable shutter portion overlaps with the fixed shutter portion, an overlapping portion can be provided, and as a result, the drug can be sufficiently controlled to be released in the closed state at high temperature.

According to the fourteenth aspect of the present invention, a gas seal member is provided between the movable shutter portion of the movable shutter mechanism and the fixed shutter portion. Therefore,
Even if the overlapping area between the movable shutter portion and the fixed shutter portion is small, the gas barrier property can be improved and the sliding characteristic of the movable shutter portion in the left-right direction can be improved.

In the invention according to claim 15, the gas seal member is a resin material selected from the group consisting of polyethylene, polypropylene, nylon and polyethylene terephthalate. Therefore, it is possible to reduce the coefficient of friction when the movable shutter portion moves in the left-right direction while having sufficient chemical resistance against chemicals.

In the sixteenth aspect of the present invention, the gas seal member is polyethylene or polypropylene having closed cells. Therefore, when the movable shutter portion moves, sufficient flexibility can be imparted to the gas seal member, and the gas barrier property can be improved.

According to the seventeenth aspect of the present invention, the permeation amount of the volatile chemical is controlled by the humidity sensitive membrane. Therefore, it is possible to sufficiently exhibit antifungal properties under high humidity conditions, and it is possible to control the unnecessary release amount of the volatile chemicals under low humidity conditions and impart humidity responsiveness.

[0028] In the invention according to claim 18, the volatile agent is allyl isothiocyanate, tay tree oil or eucalyptus oil. Therefore, an antibacterial and antifungal effect friendly to the environment due to the low concentration can be exhibited.

In the invention according to claim 19, the humidity-sensitive film has a laminated structure containing viscose-processed paper. Therefore, it is possible to provide a moisture-sensitive film that is sensitive to humidity, and it is possible to effectively and slowly release a drug having antifungal properties due to the swelling of the film at high humidity, and when the humidity is low, the film becomes compact and the drug release is sufficiently suppressed. it can.

According to the twentieth aspect of the invention, the spring characteristic of the elastic body having the shape memory effect is controlled by the repeated transformation of the mother phase and the R phase. Therefore, it is possible to obtain a very small one having a temperature hysteresis of about 1 to 2 ° C., and it is possible to suppress the release of the volatile drug from a lower temperature, so that it is possible to effectively use the drug and prolong its life.

According to a twenty-first aspect of the present invention, the volatile drug sustained-release device of the present invention can be provided in an air blowing circuit of an automobile, and the action and effect of the volatile drug sustained-release device of the present invention is exhibited. It is possible to realize an excellent car.

[0032]

Embodiments of the present invention will be described below with reference to the drawings.

(Example 1) FIG. 1 is a top view of a volatile drug sustained-release device showing the present embodiment, and FIGS. 2 and 3 are lines AA 'of the volatile drug sustained-release device in FIG. FIG. 2 shows a sustained release state of the drug, and FIG. 3 shows a drug release suppression state in a side sectional configuration diagram. In the figure, 1 is a polyurethane continuous porous body swollen by absorbing allyl isothiocyanate as a drug, specifically, a polyurethane continuous porous body of 50 × 30 × 6 mm, having a bulk density of 0.3 g / ml, Approximately 70 x 42 x 8.4 m after absorbing 30 g of allyl isothiocyanate with an average pore diameter of 30 µm and a porosity of 70%.
Swelled to m. Reference numeral 2 denotes a permeation control film, which is a pillow package of a laminated film that is an exterior of the polyurethane continuous porous body 1. The polyethylene side is heat-sealed with respect to a laminated film of polyethylene terephthalate having a thickness of 12 μm and polyethylene having a thickness of 70 μm. It is a pillow package with a width of 5 mm.

Reference numeral 3 denotes an inner main body container made of translucent polypropylene having a thickness of 1 mm for filling the polyurethane continuous porous body 1 packed with the permeation control film 2, which was processed by injection molding. The inner size of the inner body container 3 is 71 × 43 × 15 mm. Reference numeral 4 denotes an inner lid for the inner main body container 3, which is also made of a semitransparent polypropylene having a thickness of 2 mm, has a large window in the center of the inner lid 4, and ribs 5 are formed in a cross shape on the large window. Formed,
A humidity-sensitive membrane 6 of 65 × 37 mm is arranged in the central portion on the surface side of the inner lid 4, and the rib 5 fixes the continuous polyurethane porous body 1 to the bottom surface of the inner main body container 3 and reinforces the humidity-sensitive membrane 6. Plays the role of.

The humidity sensitive film 6 is made by laminating viscose-processed paper on polyethylene / stretched polypropylene / polyethylene. Specifically, a viscose film formed on a polyethylene having a thickness of 40 μm / drawn polypropylene having a thickness of 60 μm / polyethylene having a thickness of 40 μm through a rayon / pulp nonwoven fabric at a coating amount of 12 g / m ² is used. The outer peripheral portion of the humidity sensitive film 6 is welded to the inner lid 4 by heat sealing the polyethylene side.
The heat seal width is 5 mm. The inner body container 3 and the inner lid 4 are joined by ultrasonic joining.

Reference numeral 7 denotes a space portion formed by the permeation control film 2, the inner main body container 3 and the inner lid 4, and the space volume thereof is about 21.
ml. Reference numeral 8 denotes a fixed shutter portion made of an aluminum plate having a thickness of 3 mm. Opening windows 8a are arranged at equal intervals and adhered to the upper surface of the humidity sensitive film 6. Further, around the opening window 8a on the fixed shutter portion 8, as a gas seal member 9, a polypropylene packing width of 1 mm having a closed cell and a thickness of 0.3 mm is provided. Reference numeral 10 denotes an outer main body container in which the inner main body container 3 is housed, which is made of translucent polypropylene having a thickness of 1 mm and processed by injection molding.

The inner dimensions of the outer body container 10 are 76 × 48 ×
It is 25 mm. Reference numeral 11 denotes an outer lid for the outer main body container 10, which is also made of translucent polypropylene having a thickness of 2 mm, and an opening 11 a of 67 × 39 mm is arranged in the central portion of the outer lid 11. A coil spring 12 as an elastic body having no shape memory effect between the outer lid 11 and the inner lid 4.
And a shape memory coil spring 13 as an elastic body having a shape memory effect, and a thickness of 1 m to be the movable shutter portion 14.
m, a 75 × 45 aluminum plate, and opening windows 14a are arranged in the movable shutter portion 14 at equal intervals.

Coil spring 12 and shape memory coil spring 13
Have a sandwich structure in which the shape memory coil spring 13 is located above the movable shutter portion 14 and the coil spring 12 is located below the movable shutter portion 14. The transformation end temperature during heating of the shape memory coil spring 13 is 45 ° C., and the transformation end temperature during cooling is 30 ° C.

The sustained release mechanism of the volatile drug sustained release device will be described. First, at 30 ° C. or lower, the spring force of the coil spring 12 exceeds the spring force of the shape memory coil spring 13, so that the aluminum plate serving as the movable shutter portion 14 moves upward from the aluminum plate serving as the fixed shutter portion 8 as shown in FIG. Inner main body container 3 located at a distance of about 2 mm from
Does not interfere with the release of allyl isothiocyanate from. The allyl isothiocyanate vapor volatilized from the polyurethane continuous porous body 1 can reach the saturated vapor pressure concentration in the space 7.

For example, since the vapor pressure of allyl isothiocyanate at 25 ° C. is about 5 mmHg, the space 7
The maximum saturated vapor concentration is about 6600 ppm.
When the humidity is low, the humidity-sensitive film 6 suppresses the release of allyl isothiocyanate to some extent, so that the space 7 is maintained in a state close to the saturated vapor pressure concentration. However, when the humidity sensitive film 6 is sufficiently moistened, allyl isothiocyanate vapor permeates the humidity sensitive film 6.
The humidity-sensitive film 6 swells in the film structure due to a change in humidity and has a loose structure, and the allyl isothiocyanate molecule easily permeates and is easily released to the outside. After that, the opening window 8a of the fixed shutter portion 8 and the opening window 1 of the movable shutter portion 14
After passing through 4a, it is discharged from the opening 11a of the outer lid 11 to the outside.

However, the transformation of the shape memory coil spring 13 from the martensite phase to the mother phase starts at around 40 ° C. and the transformation ends at 45 ° C., and the spring force of the shape memory coil spring 13 exceeds the spring force of the coil spring 12. Like As a result, the aluminum plate serving as the movable shutter portion 14 is pressed downward by the spring force of the shape memory coil spring 13 as shown in FIG. 3, and the movable shutter portion 14 and the fixed shutter portion 8 are in close contact with each other via the gas seal member 9. It becomes a state. The opening window 8a and the opening window 14a have a structure in which they do not vertically overlap with each other.
The release of allyl isothiocyanate from inside the is completely suppressed.

Further, the external environment temperature is gradually lowered to 35
The transformation of the shape memory coil spring 13 from the matrix phase to the martensite phase starts around 30 ° C., and the transformation ends at 30 ° C., and the spring force of the coil spring 12 again exceeds the spring force of the shape memory coil spring 13. Therefore, the movable shutter portion 14 moves upward, and the allyl isothiocyanate is gradually released from the inner body container 3.

As described above, the movable shutter portion 14 operates in the vertical direction while having the temperature hysteresis. At this time, the outer dimension of the movable shutter portion 14 is about 0.5 mm with respect to the inner wall dimension of the outer main body container 10. By adopting such a structure, it is possible to guide the movable shutter portion 14 in the vertical moving direction without displacement. Figure 4
The temperature-strain curve by the constant load test of the shape memory coil spring used in this example is shown in FIG. Since the shape memory coil spring generally has a temperature hysteresis with respect to temperature rise and fall, it has been necessary to design the shape memory coil spring so that the intended drug sustained-release function is not deteriorated.

With such a constitution, 30 mg / mg of the drug from the humidity sensitive film is obtained under the conditions of 25 ° C. and 95% relative humidity.
It has a sustained release property that can be continuously released at the daily level and can respond to humidity, completely suppresses the release of allyl isothiocyanate above 45 ° C, and can release allyl isothiocyanate again below 30 ° C. It was possible to provide a volatile drug sustained release device having the above.

The volatile drug sustained-release device obtained in this example was used as a fungicide-proof device for car air conditioners for automobiles, and FIG.
Figure 2 shows a schematic diagram of the air-conditioning circuit for car air conditioners. The outside air or the inside air of the automobile is blown to the evaporator 16 by the blower fan 15. A dust collecting filter 17 and a volatile drug sustained-release device 18 are arranged on the upstream side of the evaporator 16 so that they can be replaced periodically. A heater core 19 and an air mix door 20 are arranged downstream of the evaporator 16. After changing the mixing ratio of the cool air of the evaporator 16 and the warm air of the heater core 19 by the air mix door 20, the center register, the side register, the rear heater duct, Cold or warm air is blown from the front defroster, side defroster, and so on. During cooling, the evaporator 16 stops the operation while holding the condensed water. The dew condensation water re-evaporates to increase the humidity inside the blower circuit, so that the atmosphere becomes prone to mold. At this time, the fungicidal performance could be exhibited by gradually releasing the low-concentration allylisothiocyanate from the humidity sensitive film 6 by the volatile drug sustained release device 18. Specifically, by retaining about 0.3 to 1 ppm of allyl isothiocyanate, Cladosporium, Al
Common molds such as ternaria, Aspergillus, Penicillium, and Rhizopus were able to show sufficient antifungal effect.

In the case of a car left in the hot sun in summer, the room temperature rises to about 60 ° C. Even in such a case, it is necessary to control the release of the drug so that the user does not feel discomfort. Molds generally do not grow above 40 ° C., so the release of the drug in the temperature range above this is useless. However, the shape memory coil spring of this embodiment has a temperature of about 15 ° C.
Therefore, the transformation end temperature accompanying the temperature rise was set to 45 ° C, and the transformation termination temperature accompanying the temperature drop was set to 30 ° C. When a user drives an automobile to perform cooling operation, it is assumed that the temperature will always be 30 ° C or lower. Therefore, a transformation end temperature of 30 ° C accompanying a temperature drop is designed for a volatile drug sustained release device for automobile air conditioners. It was used as a standard. As a result, a sufficient fungicidal effect was confirmed in the field test even when nutrients were regularly given from the suction route.

(Embodiment 2) FIG. 6 is a top view of a volatile drug sustained-release device showing the present embodiment, and FIGS. 7 and 8 are BB 'lines of the volatile drug sustained-release device in FIG. FIG. 7 is a side cross-sectional configuration diagram of FIG. 7, FIG. 7 shows a sustained release state of the drug, and FIG.

Reference numeral 21 is a tablet obtained by solidifying allyl isothiocyanate, which is a volatile drug, with cellulose ethyl ether. Specifically, cellulose ethyl ether powder (Nisshin Kasei; Etocel STD-10) is placed in a mold container.
0, weight average molecular weight 180,000) 15 g, ethanol 30 g was added, and after standing for 2 hours, allyl isothiocyanate 30 g was further added and vacuum-dried at room temperature to evaporate ethanol to give allyl iso- The thiocyanate was tabletted with cellulose ethyl ether. Reference numeral 22 denotes a permeation control film of allyl isothiocyanate, which is a pillow package of a laminated film of polyethylene terephthalate having a thickness of 12 μm and polyethylene having a thickness of 70 μm.

Reference numeral 23 denotes an inner main body container made of a semitransparent polypropylene having a thickness of 2 mm for filling the tablet 21 packed with the permeation control film 22.
The inner dimensions of 3 are 71 × 43 × 15 mm. Reference numeral 24 denotes an inner lid for the inner body container 23, which is also made of translucent polypropylene having a thickness of 2 mm, has a large window in the center of the inner lid 24, and ribs 25 are formed in a cross shape on the large window. , 65 × 3 in the central portion on the front surface side of the inner lid 24
A 7 mm humidity sensitive membrane 26 was placed and the same as in Example 1 was used.

27 is a permeation control film 22 and an inner body container 23.
It is a space portion formed by the inner lid 24 and the inner lid 24. A laminated plate was used as the fixed shutter portion 28 on the humidity sensitive film 26. Specifically, polypropylene with a thickness of 100 μm / aluminum with a thickness of 20 μm / 300 μm with a thickness
The fixed shutter part 28 is made of nylon and has an opening window 2
8a are arranged at equal intervals and are bonded to the upper surface of the humidity sensitive film 26. Further, the opening window 2 on the fixed shutter portion 28
A polyethylene packing having a closed cell as a gas seal member 29 around 8a has a width of 1 mm and a thickness of 0.3 mm.
Is provided.

Reference numeral 30 denotes an outer main body container for accommodating the inner main body container 23, which is made of translucent polypropylene having a thickness of 2 mm and processed by injection molding. Outer body container 30
The inner dimension of the is 103 × 48 × 26 mm. Reference numeral 31 denotes an outer lid for the outer main body container 30, which is also made of translucent polypropylene having a thickness of 2 mm, and an opening 31a of 67 × 39 mm is arranged in the central portion of the outer lid 31. A coil spring 32, a shape memory coil spring 33, and a movable shutter portion 34 are provided between the outer lid 31 and the bottom surface of the outer main body container 30.
An aluminum plate having a thickness of 1 mm and a size of 102 × 47 is provided, and opening windows 34a are provided in the movable shutter portion 34 at equal intervals.

Coil spring 32 and shape memory coil spring 33
Are arranged in four places on both sides of the movable shutter portion 34, and the shape memory coil spring 33 is located above and the coil spring 32 is located below the movable shutter portion 34 to form a sandwich structure. The transformation end temperature during heating of the shape memory coil spring 33 is 45 ° C., and the transformation end temperature during cooling is 30 ° C.

The sustained release mechanism of the volatile drug sustained release device will be described. First, at 30 ° C. or lower, the spring force of the coil spring 32 exceeds the spring force of the shape memory coil spring 33, so that the aluminum plate serving as the movable shutter portion 34 moves upward from the aluminum plate serving as the fixed shutter portion 28 as shown in FIG. Located about 2 mm away from the inner main body container 23 and does not interfere with the release of allyl isothiocyanate from the inner body container 23.
The allyl isothiocyanate vapor volatilized from the tablet 21 was able to be gradually released in a fixed amount while the permeation amount was regulated by the permeation control film 22 and the humidity sensitive film 26.

However, the transformation of the shape memory coil spring 32 starts from around 40 ° C. and the transformation ends at 45 ° C., and the spring force of the shape memory coil spring 33 becomes greater than the spring force of the coil spring 32. As a result, the movable shutter unit 34
As shown in FIG. 8, the aluminum plate is pressed downward by the spring force of the shape memory coil spring 33 so that the movable shutter portion 34 and the fixed shutter portion 28 are in close contact with each other via the gas seal member 29. Since the opening window 34a and the opening window 28a do not vertically overlap each other, the release of allyl isothiocyanate from the inside of the inner main body container 23 is completely suppressed.

Further, the external environment temperature is gradually lowered to 35
The transformation of the shape memory coil spring 33 starts at around 30 ° C., and the transformation ends at 30 ° C., and the spring force of the coil spring 32 exceeds the spring force of the shape memory coil spring 33. Therefore, the movable shutter portion 34 moves upward. As a result, allyl isothiocyanate is gradually released from the inner body container 23.
As described above, the movable shutter portion 34 operates in the vertical direction while having the temperature hysteresis, and at this time, the outer dimension of the movable shutter portion 34 has a clearance of about 0.5 mm with respect to the inner dimension of the outer main body container 30. With the structure, it is possible to guide the movable shutter portion 34 in the upward and downward directions without displacement.

With this structure, 30 m of the drug can be fed from the humidity sensitive film 26 under the conditions of 25 ° C. and 95% relative humidity.
It has a sustained release property that can be continuously released at the level of g / day and can respond to humidity, and completely suppresses the release of allyl isothiocyanate at 45 ° C or higher, and the temperature at which allyl isothiocyanate can be released again at 30 ° C or lower. A volatile drug sustained release device having responsiveness could be provided.

(Embodiment 3) FIG. 9 is a top external view of a volatile drug sustained-release device showing the present embodiment, and FIG. 10 is a side sectional view taken along line CC ′ of the volatile drug sustained-release device in FIG. It is a block diagram and both show the sustained release state of the drug. FIG. 11 is a top external view of the volatile drug sustained-release device of the present embodiment in a state in which the drug release is suppressed, and FIG. 12 is a side sectional view taken along line CC ′ of the volatile drug sustained-release device in FIG. 11. FIG. 3 is a configuration diagram, both showing a drug release suppression state. Reference numeral 35 denotes a polyurethane continuous porous body swollen by absorbing allyl isothiocyanate as a drug, and the same one as in Example 1 was used.

Reference numeral 36 denotes a permeation control film, which is a pillow packaging body of a laminated film which covers the polyurethane continuous porous body 35, and the same permeation control film of Example 1 was used. 37 is a semi-transparent thickness of 2 for filling the polyurethane continuous porous body 35 with the permeation control film 36 wrapped therein.
It is an inner main body container made of polypropylene of mm and processed by injection molding. The inner size of the inner body container 37 is 71
It is × 43 × 15 mm. Reference numeral 38 denotes an inner lid for the inner main body container 37, which is also made of translucent polypropylene having a thickness of 2 mm, has a large window in the center of the inner lid 38, and ribs 39 are formed in a cross shape on the large window. The humidity-sensitive film 40 of 65 × 37 mm was placed in the central portion on the surface side of the inner lid 38, and the same one as in Example 1 was used. Rib 39 allows polyurethane continuous porous body 35
Is fixed to the bottom surface of the inner body container 37 and also serves to reinforce the humidity sensitive film 40.

The humidity sensitive film 40 is made of polyethylene having a thickness of 40 μm / nylon 6 having a thickness of 15 μm / 40 μm
It is a laminated film of polyethylene of m. The outer peripheral portion of the humidity sensitive film 40 is welded and joined to the inner lid 38 by heat sealing the polyethylene side. Heat seal width is 5m
m. The inner body container 37 and the inner lid 38 are joined by ultrasonic joining. 41 is a space formed by the permeation control film 36, which is a pillow package, the inner body container 37, and the inner lid 38. 42 is a fixed shutter portion, which has a thickness of 3
It is made of a stainless steel plate of 0 μm, and opening windows 42a are arranged at equal intervals and adhered to the upper surface of the humidity sensitive film 40. A gas seal member 43 having a packing width of 1 mm and a thickness of 0.5 mm made of ultra-high molecular weight polyethylene is arranged around the opening window 42a on the fixed shutter portion 42. Reference numeral 44 denotes an outer main body container in which the inner main body container 37 is housed, which is made of translucent polypropylene and has a thickness of 2 mm and is processed by injection molding. The inner dimensions of the outer body container 44 are 95 × 48 × 23 mm. The inner main body container 37 is adhesively fixed at the bottom surface portion of the outer main body container 44. 45
Is an outer lid for the outer body container 44, which is also made of translucent polypropylene and has a thickness of 2 mm, and an opening 45 a of 67 × 39 mm is arranged in the central portion of the outer lid 45. A movable shutter portion 46 is a laminate plate. Specifically, it is a laminate of polypropylene having a thickness of 100 μm / aluminum having a thickness of 20 μm / polypropylene having a thickness of 800 μm. Further, support portions 47 and 48 capable of guiding the movable shutter portion 46 in the left-right direction are welded to both ends of the movable shutter portion 46. Specifically, a polypropylene plate of 45 × 10 × 2 mm is arranged so as to be oriented vertically with respect to the movable shutter portion 46. Shape memory coil springs 49 are arranged in two places between the support portion 47 and the inner side wall of the outer body container 44, and coil springs 50 are arranged in two places between the support portion 48 and the inner side wall of the outer body container 44. Has been done. The transformation end temperature during heating of the shape memory coil spring 49 is 45 ° C., and the transformation end temperature during cooling is 30 ° C.

The sustained release mechanism of the volatile drug sustained release device will be described. First, at 30 ° C. or lower, the spring force of the coil spring 50 exceeds the spring force of the shape memory coil spring 49.
As shown by 0, the movable shutter portion 46 connected to the support portion 47 is moved by the spring force of the coil spring 50 to the outer main body container 4.
4 is pushed from the inner side wall of the inner surface of the inner main body container 3
The position of the movable shutter portion 46 is regulated by hitting the outer side wall of 7. At this time, the opening window 42a provided in the fixed shutter portion 42 and the opening window 46a provided in the movable shutter portion 46 are located at vertically overlapping positions. As a result, the release of allyl isothiocyanate from the inner body container 37 is not hindered. The allyl isothiocyanate vapor volatilized from the polyurethane continuous porous body 35 was able to be gradually released in a constant amount while the permeation amount was regulated by the permeation control film 36 and the humidity sensitive film 40.

However, the transformation of the shape memory coil spring 49 begins at around 40 ° C. and the transformation ends at 45 ° C., and the spring force of the shape memory coil spring 49 becomes greater than the spring force of the coil spring 50. As a result, the movable shutter unit 4
As shown in FIGS. 11 and 12, the laminated plate of No. 6 has the outer main body container 4 by the spring force of the shape memory coil spring 49.
The support portion 47 is pushed and moved by the inner side wall of No. 4 and the support portion 47 collides with the outer side wall of the inner main body container 37, whereby the moving position of the movable shutter portion 46 is regulated. At this time, the opening window 42a provided in the fixed shutter portion 42 and the opening window 46a provided in the movable shutter portion 46 do not vertically overlap each other, so that the allyl isothiocyanate is removed from the inside of the inner main body container 37. Release is completely suppressed. Therefore, the fixed shutter unit 42
The width of the space between the opening windows 46a provided in the movable shutter portion 46 is larger than the width of the opening window 42a provided in the fixed shutter portion 42 according to the moving distance of the movable shutter portion 46. The provided opening window 42a is completely sealed.

Further, the external environment temperature is gradually lowered to 35
The transformation of the shape memory coil spring 49 begins at around 30 ° C. and the transformation ends at 30 ° C., and the spring force of the coil spring 50 exceeds the spring force of the shape memory coil spring 49, so that the movable shutter portion 46 moves from right to left. Allyl isothiocyanate is gradually released from the inner body container 37 by moving. As described above, the movable shutter portion 46 has a temperature hysteresis and slides in the left-right direction. At this time, the outer dimensions of the support portions 47 and 48 are set to 0 relative to the inner wall dimension of the outer main body container 44 and the lower surface of the outer lid 45. With the structure having a clearance of about 0.5 mm, the direction in which the movable shutter portion 46 slides left and right can be accurately guided.

With such a constitution, the drug has a sustained release characteristic that the drug is continuously released from the permeation control membrane at a level of 20 mg / day at 25 ° C., and the release of allyl isothiocyanate is completely suppressed at 45 ° C. or higher. And 30 ℃
In the following, a volatile drug sustained-release device having temperature responsiveness capable of releasing allyl isothiocyanate can be provided again.

(Embodiment 4) FIG. 13 is a top view of a volatile drug sustained-release device showing the present embodiment, and FIG. 14 is a side sectional view taken along line D-D 'of the volatile drug sustained-release device in FIG. It is a block diagram and both show the sustained release state of the drug. See also FIG.
5 is a top external view of the volatile drug sustained-release device of the present embodiment when the drug release is suppressed, and FIG. 16 is a side cross-sectional configuration diagram of line DD ′ of the volatile drug sustained-release device in FIG. 15. And both represent the drug release suppression state.

Numeral 51 is a continuous polyurethane porous material which is swollen by absorbing allyl isothiocyanate, which is the same as that used in Example 1. Reference numeral 52 is a permeation control film, which is a pillow packaging body of a laminated film as an exterior of the polyurethane continuous porous body 51, and the same one as in Example 1 was used. 53 is the polyurethane continuous porous body 5
An inner main body container made of translucent polypropylene having a thickness of 2 mm for filling a state in which 1 was wrapped with a permeation control film 52 was processed by injection molding. The inner dimensions of the inner body container 53 are 71 × 43 × 15 mm. Reference numeral 54 is an inner lid for the inner body container 53, which also has a thickness of 2 m.
It is made of semi-transparent polypropylene of m, and has a large window in the center of the inner lid 54, and ribs 55 are formed in a cross shape on the large window.
A humidity sensitive film 56 of 37 mm is arranged, and the continuous polyurethane porous body 51 is attached to the inner main body container 5 by the rib 55.
The position of the film is fixed to the bottom surface of No. 3 and the moisture-sensitive film 56 is reinforced. As the humidity sensitive film 56, the same one as in Example 1 was used. The outer peripheral portion of the humidity sensitive film 56 is welded to the inner lid 54 by heat sealing the polyethylene side. The heat seal width is 5 mm. The inner body container 53 and the inner lid 54 are joined by ultrasonic joining. 57 is a space formed by the permeation control film 52, the inner main body container 53, and the inner lid 54. Reference numeral 58 denotes a fixed shutter portion, which is made of a stainless steel plate having a thickness of 30 μm, has opening windows 58a arranged at equal intervals, and is adhered to the upper surface of the humidity sensitive film 56. A gas seal member 59 having a packing width of 1 mm and a thickness of 0.5 mm made of nylon 66 is provided around the opening window 58a on the fixed shutter portion 58. Reference numeral 60 denotes an outer main body container in which the inner main body container 53 is housed, which is made of translucent polypropylene having a thickness of 2 mm and processed by injection molding. Inner body container 5
The inner dimension of 3 is 101 × 48 × 23 mm. The inner body container 53 is adhesively fixed at the bottom surface of the outer body container 60. 61 is an outer lid for the outer main body container 60, which is also made of translucent polypropylene having a thickness of 2 mm,
A 67 × 39 mm opening 61a is formed in the approximate center of the outer lid 61.
Are arranged. A movable shutter portion 62 is made of a laminated plate. Specifically, the thickness is 100 μm polypropylene / the thickness is 20 μm aluminum / the thickness is 80
It is 0 μm polypropylene. Further, support portions 63 and 64 that can guide the movement of the movable shutter portion 62 in the left-right direction are welded to both ends of the movable shutter portion 62. Specifically, a polypropylene plate of 45 × 10 × 2 mm is arranged so as to have a vertical relationship with the movable shutter portion 62. Reference numeral 65 denotes a partition plate, which is arranged in contact with the wall surface of the inner main body container 53 and has a structural arrangement such that it almost reaches the outer lid 61. Two communication holes are provided in the partition plate 65, and a support rod 66 that connects the movable shutter portion 62 and the support portion 64 is provided inside the communication hole.
The force received by the movable shutter portion 62 is transmitted via the support rod 66.
Transmitted to. A shape memory coil spring 67 and a coil spring 68 are provided between the partition plate 65 and the inner side wall of the outer body container 60.
Are arranged in two places, and the support portion 64 has a structure sandwiched between the shape memory coil spring 67 and the coil spring 68. The shape memory coil spring 67 is disposed between the partition plate 65 and the support portion 64, and the coil spring 68 is connected to the support portion 64. It is arranged between the inner wall of the outer main body container 60. Shape memory coil spring 67
The support rod 66 passes through the inside of the. Mother phase and R phase as shape memory coil spring 67 (Rhombohedral, rhombohedral)
I used the one that causes transformation in and. Therefore, the transformation end temperature during heating is 40 ° C, and the transformation end temperature during cooling is 3
6 ° C.

The sustained release mechanism of the volatile drug sustained release device will be described. First, since the spring force of the coil spring 68 exceeds the spring force of the shape memory coil spring 67 at 36 ° C. or lower, the laminated plate which becomes the movable shutter portion 62 includes the support portion 64 and the support rod 66 as shown in FIGS. 14 and 15. The position of the movable shutter portion 62 is regulated by pushing the movable shutter portion 62 connected through the inner side wall of the outer body container 60 by the spring force of the coil spring 68 and hitting the support portion 63 against the inner side wall of the outer body container 60. ing. At this time, the opening window 58a provided in the fixed shutter portion 58 and the opening window 62a provided in the movable shutter portion 62 are located at vertically overlapping positions. As a result, the release of allyl isothiocyanate from the inner body container 53 is not hindered. The allyl isothiocyanate vapor volatilized from the polyurethane continuous porous body 51 was able to be gradually released in a constant amount while the permeation amount was regulated by the permeation control film 52 and the humidity sensitive film 56.

However, the transformation of the shape memory coil spring 67 from the R phase to the mother phase begins at around 37 ° C., and the transformation ends at 40 ° C. so that the spring force of the shape memory coil spring 67 exceeds the spring force of the coil spring 68. become. As a result, the laminated plate which becomes the movable shutter portion 62 is shown in FIGS.
As shown in FIG. 5, the movable shutter portion 62 connected to the support rod 66 also slides when the supporting portion 64 is pushed and moved from the partition plate 65 side by the spring force of the shape memory coil spring 67, and the supporting portion 63 is moved to the inner main body. The moving position of the movable shutter portion 62 is regulated by hitting the outer side wall of the container 53. At this time, the opening window 58a provided in the fixed shutter portion 58 and the opening window 62a provided in the movable shutter portion 62 do not vertically overlap each other, so that the allyl isothiocyanate from the inside of the inner main body container 53 is removed. Release is completely suppressed. Therefore, the width of the gap between the opening windows 62a provided in the movable shutter portion 62 is larger than the width of the opening window 58a provided in the fixed shutter portion 58. The opening window 58a provided in the shutter portion 58 is completely sealed.

Further, the external environment temperature is gradually lowered to 39
The transformation of the shape memory coil spring 67 from the parent phase to the R phase begins at around ℃, and the transformation ends at 36 ℃, and the spring force of the coil spring 68 becomes greater than the spring force of the shape memory coil spring 67. 62 moves from right to left to gradually release allyl isothiocyanate from the inner body container 53. In this way, the movable shutter unit 6
2 has a very small temperature hysteresis and slides to the left and right, but at this time, the supporting portions 63 and 64
The outer dimensions of the inner wall dimension of the outer body container 60 and the outer lid 61
It was possible to guide the direction in which the movable shutter portion 62 slides left and right by taking a clearance of about 0.5 mm from the lower surface of the. FIG. 17 shows a temperature-strain curve obtained by a constant load test of the shape memory coil spring used in this example. The shape memory coil spring was able to extremely reduce the temperature hysteresis with respect to temperature rise and fall by repeating transformation in the mother phase and the R phase. As a result, it has become possible to provide a volatile drug sustained release device capable of stopping sustained release of a drug at a temperature above a predetermined temperature and continuing sustained release of the drug below a predetermined temperature.

The volatile drug sustained-release device obtained in this example was used as a mildew-proofing device for a car air conditioner for automobiles similar to that in Example 1. When the cooling operation is stopped, the dew condensation water of the evaporator is re-evaporated to increase the humidity inside the blower circuit, resulting in an atmosphere in which mold is likely to occur. However, at this time, the fungicidal performance could be exhibited by gradually releasing the low-concentration allylisothiocyanate from the humidity-sensitive film by the volatile drug sustained-release device. Also in summer, the release of the drug could be suppressed by the movable shutter part and the fixed shutter part at 40 ° C. or higher, and the sustained release state could be restored again at 36 ° C. or lower. Since the temperature hysteresis was also small, the drug could be effectively released as intended.

(Embodiment 5) FIG. 18 is a top external view of a volatile drug sustained-release device showing the present embodiment, and FIG. 19 is a side sectional view taken along the line EE ′ in FIG. FIG. 19
Both represent the sustained release state of the drug. FIG. 20 is a top external view of the volatile drug sustained-release device according to this example.
FIG. 21 is a side sectional configuration view taken along line EE ′ in FIG. 20, and both FIGS. 20 and 21 show a drug release suppression state. Since the structure of the fifth embodiment is almost the same as that of the fourth embodiment, only different parts will be described. In Example 5,
The coil spring 69 is arranged between the partition plate 70 and the supporting portion 71, and the shape memory coil spring 72 is arranged between the supporting portion 71 and the inner wall of the outer main body container 73. When the ambient temperature rises, the spring force of the shape memory coil spring 72 exceeds the spring force of the coil spring 69, whereby the movable shutter portion 74 moves from the right to the left in the figure, and the temperature drop causes the movable shutter portion 74 to move to the left in the figure. Is a movable shutter mechanism that moves to the right from. Therefore, when the movable shutter portion 74 is located on the right side, that is, when the movable shutter portion 74 is positioned as shown in FIG. 18 and FIG. By devising the constitution with 75a, the action and effect of the volatile drug sustained-release device will be the same as in Example 4.

In the embodiment, an example in which an aluminum plate, a stainless plate, or a laminated plate having an inner layer of aluminum is used as the material of the fixed shutter part or the movable shutter part is shown, but the present invention is not limited to this. The material is not particularly limited as long as it is a material having excellent gas barrier properties. It is also possible to select a material other than aluminum as the metal for the inner layer of the laminate plate.

In the embodiment, the case where the gas seal member is applied between the movable shutter portion and the fixed shutter portion has been described. However, the overlapping area between the movable shutter portion and the fixed shutter portion is small, and the gas barrier property is improved. The gas seal member is effective when desired. However, if the movable shutter portion and the fixed shutter portion have a sufficient overlapping area and the release of the drug can be suppressed by this, the gas seal member is not necessary. For example, when the movable shutter unit moves in the vertical direction, it is possible to do so by taking a sufficient overlapping area. Further, polypropylene having closed cells as a gas seal member,
Polyethylene, ultra high molecular weight polyethylene, nylon 66
Although an example using is shown, the present invention is not limited to this. For example, when the movable shutter portion operates in the vertical direction, it is possible to enhance the gas barrier property by using a gas seal member having elasticity. For that purpose, it is necessary to have 30 vol% or more closed cells inside the gas seal member. I liked what I had. Further, when the movable shutter portion slides in the left-right direction, importance is attached to sliding characteristics, and a resin material having a small surface roughness and good slipperiness is preferable. For example, polypropylene and polyethylene terephthalate could also be used.

In the examples, polypropylene resin was used as the container for filling the drug, but the present invention is not limited to this. In addition to this, a material that does not cause a problem may be selected in view of chemical resistance with the medicine to be filled.

Further, in the examples, the examples were shown in which the drug was used by being absorbed in the liquid absorber, or was mixed with the solid polymer material to be used as the tablet state, but the form usable in the present invention is not limited to this. . Any structure may be used as long as the medicine is filled inside the container. However, considering the physical distribution of the volatile drug sustained release device, it is necessary to consider that the liquid drug does not flow out.

In the embodiment, the case where the permeation control film or the humidity sensitive film is provided in the opening of the container filled with the drug has been described, but the present invention also includes the case where only the opening is provided in the container. The fixed shutter part and the movable shutter part are provided in the opening to form a movable shutter mechanism, and the medicine is tableted inside the container to prevent the medicine from flowing out in the physical distribution.

Although allyl isothiocyanate was exclusively used in the examples, the present invention is not limited to this. Essential oils such as lavender oil and rosemary oil can also be used as aromatic agents.
Further, tea tree oil, eucalyptus oil and the like can be used to obtain antibacterial and antifungal effects with a low volatilization amount.

[0077]

As is apparent from the above description, claim 1
According to the inventions described in and 2, the effective use can be achieved by gradually releasing the required amount of the drug from the container filled with the volatile drug having the antifungal property, the aromatic property, etc., and the long life of the drug. It does not cause discomfort to the user due to unnecessary drug release.

According to the third aspect of the present invention, by disposing the permeation control film for controlling the permeation amount of the drug, the optimum permeation control film can be selected according to the application, thereby stabilizing the drug at a low concentration. Since it can be sustainedly released, functions such as antifungal and aromatic properties can be continued for a long period of time.

According to the fourth aspect of the invention, the movable shutter portion is opened to release the volatile chemical at a predetermined temperature or lower, and the movable shutter portion is closed to maintain the volatile property at a predetermined temperature or higher. By suppressing the release of the drug, effective use can be achieved by gradually releasing the required amount of the drug from the container filled with the volatile drug, prolonging the life of the drug, and unnecessary release of the drug to the user. There is no discomfort.

According to the fifth aspect of the present invention, the movable shutter mechanism has an elastic body having a shape memory effect on the upper surface of the movable shutter portion and an elastic body having no shape memory effect on the lower portion of the movable shutter mechanism. Depending on the region, the spring force of the elastic body that does not have a shape effect will prevail at low temperatures, and the spring force of the elastic body that has a shape memory effect will prevail at high temperatures, and the movable shutter part will move from top to bottom above a certain temperature. Further, it is possible to provide a volatile drug sustained-release device which can be brought from the open state to the closed state, and as a result, the drug is sufficiently released in the high temperature region by the sufficient spring force of the elastic body having the shape memory effect.

According to the invention of claim 6, as the movable shutter mechanism, an elastic body having a shape memory effect is arranged on the left side of the movable shutter portion, and an elastic body having no shape effect is arranged on the right side of the movable shutter portion, or the movable shutter mechanism is movable. An elastic body having a shape memory effect is arranged on the right side of the shutter portion, and an elastic body having no shape memory effect is arranged on the left side thereof, and springs of the elastic body arranged on the left and right sides of the movable shutter portion having the shape memory effect are arranged. The force is overcome, or the spring force of the elastic body that does not have a shape memory effect is overcome, so that the spring force is transmitted to the movable shutter unit, and the movable shutter unit moves from left to right or from right to left. It can be operated and can be moved from the open state to the closed state by optimizing the moving distance by the configuration of the movable shutter part, and as a result, the drug is sufficiently suppressed from being released at high temperature. It is possible to provide a volatile drug controlled release device.

According to the seventh aspect of the invention, the elastic body having the shape memory effect and the elastic body having no shape memory effect are connected to the support shaft of the movable shutter section via separate support sections. The movable shutter part can be moved in the left-right direction by the operation, and it can be moved from the open state to the closed state by optimizing the moving distance due to the configuration of the movable shutter part, and as a result, the drug is sufficiently suppressed from being released at high temperatures. A volatile drug sustained release device can be provided.

According to the eighth aspect of the present invention, the fixed shutter portion is provided between the movable shutter portion and the opening portion of the container, and the fixed shutter portion and the movable shutter portion both have a plurality of opening windows. By moving the plurality of opening windows of the movable shutter portion in the vertical direction or the horizontal direction, the portion for gradually releasing the drug can be opened and closed. At this time, the moving distance of the movable shutter portion due to the spring action of the elastic body having the shape memory effect can be reduced, while the opening portion required for the sustained release of the volatile drug can be made sufficiently large.

According to the ninth aspect of the present invention, the outer main body container is disposed outside the inner main body container filled with the volatile chemicals, and when the movable shutter portion is operated, By devising the clearance with the movable shutter part, it can be configured to move while guiding the operation direction, that is, the arrangement configuration and the clearance of the inner main body container and the outer main body container without using a new member. By using it, it is possible to accurately guide the direction in which the movable shutter portion moves.

According to the tenth aspect of the present invention, the supporting portions are provided at both left and right ends of the movable shutter portion, and the moving distance when the movable shutter portion moves left and right is regulated. That is, if the support portion is configured to act as a stopper function by colliding with the outside of the inner container, accurate positioning can be performed while maintaining the relationship between the opening window of the movable shutter portion and the opening window of the fixed shutter portion. You can

According to the eleventh and twelfth aspects of the present invention, the movable shutter portion and the fixed shutter portion are made of a metal plate or a laminated plate containing a metal plate as an inner layer, so that sufficient strength and gas barrier property as a shutter member can be obtained. Thus, it is possible to provide a volatile drug sustained-release device that sufficiently suppresses drug release in a closed state at high temperature.

According to the thirteenth aspect of the present invention, since the opening window provided in the movable shutter portion is smaller than the opening window provided in the fixed shutter portion, it is over when the movable shutter portion overlaps with the fixed shutter portion. It is possible to provide a wrap portion, and as a result, it is possible to provide a volatile drug sustained-release device that sufficiently suppresses drug release in a closed state at high temperatures.

According to the fourteenth aspect of the present invention, by disposing the gas seal member between the movable shutter portion and the fixed shutter portion, even if the overlapping area between the movable shutter portion and the fixed shutter portion is small. The gas barrier property can be improved, and the sliding characteristics when the movable shutter part slides in the left-right direction can be improved.

According to the fifteenth aspect of the present invention, by using any one of polyethylene, polypropylene, nylon, and polyethylene terephthalate as the gas seal member, the movable shutter portion can be moved to the left and right while having sufficient chemical resistance against chemicals. It was also possible to reduce the coefficient of friction when moving in the direction.

According to the sixteenth aspect of the present invention, by using polyethylene or polypropylene having closed cells as the gas seal member, sufficient flexibility as the gas seal member can be obtained when the movable shutter portion operates in the vertical direction. Can be added, and the gas barrier property can be improved.

According to the seventeenth aspect of the present invention, by using the humidity sensitive film, the fungicidal property can be sufficiently exerted under the high humidity condition, and the volatile chemical is unnecessary under the low humidity condition. It was possible to provide humidity responsiveness that sufficiently regulates the release amount.

According to the eighteenth aspect of the present invention, allyl isothiocyanate, tea tree oil, or eucalyptus oil is used as a drug to provide an environment-friendly antibacterial and antifungal effect utilizing a natural component and having a low concentration. it can.

According to the nineteenth aspect of the present invention, by using a laminated structure containing viscose-processed paper as the humidity-sensitive film, it is possible to provide a humidity-sensitive film sensitive to humidity, and the film can be provided at high humidity. Due to the swelling, the drug having antifungal properties can be effectively and slowly released, and the film can be densified at low humidity to sufficiently suppress the drug release.

According to the twentieth aspect of the present invention, the elastic body having the shape memory effect is selected from the material whose spring characteristics can be controlled by the repeated transformation of the matrix phase and the R phase, and the temperature hysteresis is It was possible to obtain a very small product of about 1 to 2 ° C. As a result, it becomes possible to provide a sustained-release device capable of suppressing the release of the volatile drug from a lower temperature, which makes it possible to effectively use the drug and prolong its life.

According to the twenty-first aspect of the invention, the volatile drug sustained-release device of the present invention can be provided in an air blowing circuit of an automobile, and the excellent action of the volatile drug sustained-release device of the present invention is achieved. It is possible to realize a car that demonstrates the above.

[Brief description of drawings]

FIG. 1 is a top view of a volatile drug sustained-release device of Example 1.

FIG. 2 is a side cross-sectional configuration diagram showing an open state in the volatile drug sustained-release device of Example 1.

FIG. 3 is a side sectional configuration view showing a closed state in the volatile drug sustained-release device of Example 1.

FIG. 4 is a temperature-strain curve diagram of a shape memory coil spring of Example 1 by a constant load test.

FIG. 5 is a schematic configuration diagram in which the volatile drug sustained-release device of Example 1 is used in a ventilation circuit of a car air conditioner.

FIG. 6 is a top view of a volatile drug sustained-release device of Example 2.

FIG. 7 is a side cross-sectional configuration diagram showing an open state in the volatile drug sustained release device of Example 2.

FIG. 8 is a side cross-sectional configuration diagram showing a closed state in the volatile drug sustained release device of Example 2.

FIG. 9 is an external view of the upper surface of the volatile drug sustained-release device of Example 3 in an open state.

FIG. 10 is a side sectional configuration view showing an open state in the volatile drug sustained release device of Example 3.

FIG. 11 is an external view of an upper surface in a closed state in the volatile drug sustained release device of Example 3.

FIG. 12 is a side cross-sectional configuration diagram showing a closed state in the volatile drug sustained release device of Example 3.

FIG. 13 is a top view of the volatile drug sustained-release device of Example 4 in an open state.

FIG. 14 is a side cross-sectional configuration diagram showing an open state in the volatile drug sustained release device of Example 4.

FIG. 15 is a top view of the volatile drug sustained-release device of Example 4 in a closed state.

FIG. 16 is a side cross-sectional configuration diagram showing a closed state in the volatile drug sustained release device of Example 4.

FIG. 17 is a temperature-strain curve diagram of a shape memory coil spring of Example 4 by a constant load test.

FIG. 18 is a top view of the volatile drug sustained-release device of Example 5 in an open state.

FIG. 19 is a side cross-sectional configuration diagram showing an open state in the volatile drug sustained release device of Example 5.

FIG. 20 is a top view of the volatile drug sustained-release device of Example 5 in a closed state.

FIG. 21 is a side sectional configuration view showing a closed state in the volatile drug sustained release device of Example 5.

[Explanation of symbols]

1,35,51 Polyurethane continuous porous body 2, 22, 36, 52 Permeation control membrane 3, 23, 37, 53 Inner main body container 6, 26, 40, 56 Humidity sensitive membrane 8, 28, 42, 58, 75 Fixed shutter part 28a, 42a, 58a Opening window 9, 29, 43, 59 Gas seal member 10, 30, 44, 60, 73 Outer body container 12, 32, 50, 68, 69 Coil spring 13, 33, 49, 67, 72 Shape memory coil springs 14, 34, 46, 62, 74 Movable shutter section 34a, 46a, 62a, 74a, 75a Open window 15 Blower Fan 16 Evaporator 17 Dust collection filter 18 Volatile drug sustained release device 19 heater core 20 air mix door 21 tablets 47, 48, 63, 64, 71 Supports 66 Support rod

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Shiho Furuya             1006 Kadoma, Kadoma-shi, Osaka Matsushita Electric             Sangyo Co., Ltd. F-term (reference) 4C002 AA01 AA06 BB04 DD03 EE01                       FF06 HH05 KK01                 4H011 AA03 BA01 BB11 BB22 BC19                       DA07 DB04 DC05 DD07 DH02

Claims (21)

[Claims] 1. A movable shutter in which a container containing a volatile drug is provided with an opening through which the volatile drug can be discharged to the outside of the container, and a movable shutter mechanism is disposed in the opening. A volatile drug sustained-release device capable of releasing a volatile drug by opening and closing the opening of a mechanism, the elasticity of which is changed by a specific temperature change, and the elasticity of an elastic body having a shape memory effect and the specific temperature. A mechanism for opening and closing the movable shutter mechanism by a difference from the elasticity of the elastic body having no shape memory effect, in which the change in elasticity is significantly smaller than the elasticity change of the elastic body having the shape memory effect. A volatile drug sustained-release device characterized in that 2. The volatile drug sustained-release device according to claim 1, wherein the elastic body having a shape memory effect of which elasticity is changed by a specific temperature change is a coil spring made of a shape memory alloy. 3. The volatile drug according to claim 1 or 2, wherein the volatile drug has a mechanism of gradually releasing the drug to the outside of the container through a permeation control membrane that controls the permeation amount of the drug. Sustained release device. 4. A container for a volatile drug when the temperature is below a predetermined temperature, and the volatile drug is gradually released outside the container by opening the movable shutter part of the movable shutter mechanism, and when the temperature is above a predetermined temperature, the volatile drug is closed. The volatile drug release device according to any one of claims 1 to 3, characterized in that the release to the outside is suppressed. 5. The movable shutter mechanism has an elastic body having a shape memory effect at the upper part of the movable shutter, and an elastic body having no shape memory effect at the lower part of the movable shutter part, and has a predetermined temperature or more. Then, the movable shutter mechanism is moved from the upper side to the lower side due to a difference in elasticity between the elastic body having the shape memory effect and the elastic body having no shape memory effect, thereby moving the movable shutter mechanism from the open state to the closed state. The volatile drug sustained-release device according to any one of claims 1 to 4, wherein 6. The movable shutter mechanism is provided with an elastic body having a shape memory effect on the left side or the right side of the movable shutter section, and an elastic body having no shape memory effect on the opposite side.
At a temperature equal to or higher than a predetermined temperature, the movable shutter mechanism moves leftward or rightward due to a difference in elasticity between the elastic body having the shape memory effect and the elastic body having no shape memory effect, thereby opening the movable shutter mechanism. The volatile drug sustained-release device according to any one of claims 1 to 4, characterized in that the state is changed to a closed state. 7. The elastic body having a shape memory effect and the elastic body having no shape memory effect are connected to a support shaft of a movable shutter portion via separate support portions, respectively. Volatile drug sustained release device. 8. A fixed shutter portion is provided between an opening of a container containing a volatile drug and a movable shutter portion of a movable shutter mechanism, and the movable shutter portion and the fixed shutter portion each have a plurality of fixed shutter portions. 8. A mechanism for opening and closing a movable shutter mechanism by providing an opening window and moving the plurality of opening windows of the movable shutter part in a vertical direction or a horizontal direction. The volatile drug sustained release device described. 9. A container containing a volatile drug is used as an inner main body container, and an outer main body container is provided outside the inner main body container, and a movable shutter portion of a movable shutter mechanism is configured to move in an inner wall surface of the outer container. The volatile drug sustained-release device according to any one of claims 6 to 8, which is configured to move in the left-right direction while being guided. 10. A mechanism in which support portions are provided at both left and right ends of the movable shutter portion, and a moving distance when the movable shutter portion moves left and right is regulated by a distance between the support portion and a side wall of the inner main body container. Claim 1 characterized in that
The volatile drug sustained-release device according to any one of 2, 3, 4, 6, 7, 8, and 9. 11. The movable shutter portion of the movable shutter mechanism is composed of a metal plate or a laminated plate containing a metal plate, as claimed in claim 1, 4, 5, 6, 7, 8.
9. The volatile drug sustained release device according to any one of 9 and 10. 12. The volatile drug sustained-release device according to claim 8, wherein the fixed shutter portion of the movable shutter mechanism is made of a metal plate or a laminated plate containing a metal plate. 13. The movable shutter part of the movable shutter mechanism is provided with opening windows at equal intervals, and the width of the opening windows is larger than that of the opening windows provided in the fixed shutter part. Alternatively, the volatile drug sustained-release device according to item 12. 14. The volatile drug according to claim 8, wherein a gas seal member is disposed between the movable shutter portion and the fixed shutter portion of the movable shutter mechanism. Sustained release device. 15. The volatile drug sustained-release device according to claim 14, wherein the gas seal member is a resin material selected from the group consisting of polyethylene, polypropylene, nylon, and polyethylene terephthalate. 16. The volatile drug sustained-release device according to claim 14 or 15, wherein the gas seal member is polyethylene or polypropylene having closed cells. 17. The volatile drug sustained-release device according to claim 1, wherein the permeation amount of the volatile drug is controlled by a temperature-sensitive membrane. 18. The volatile drug sustained-release device according to claim 1, wherein the volatile drug is allyl isothiocyanate, tea tree oil, or eucalyptus oil. 19. The temperature-sensitive film has a laminated structure including viscose-processed paper.
7. The volatile drug sustained release device according to 7. 20. The volatile drug sustained release according to any one of claims 1 to 19, wherein the spring characteristic of the elastic body having a shape memory effect is controlled by the repeated transformation of the mother phase and the R phase. apparatus. 21. A blower circuit for an automobile, comprising the volatile drug sustained-release device according to claim 1.