JP4265150B2 - Volatile drug sustained release device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
TECHNICAL FIELD The present invention relates to a volatile drug sustained release device that releases a volatile drug by temperature or humidity change, and gradually releases the volatile drug along with temperature fluctuation or humidity fluctuation and releases more drug than necessary. It can be widely applied to the field that wants to prevent. For example, the present invention can be widely applied to fields such as air conditioners that want to prevent the growth of mold and fungi by releasing a necessary amount of antifungal and antibacterial agents.
[0002]
[Prior art]
Various techniques have been proposed for the sustained release of a filled volatile drug over a long period of time. In general, it is a method in which a porous material is impregnated and gradually volatilized by capillary action. The porous material was an inorganic compound such as zeolite or silica gel, or a foam or fiber bundle of polypropylene, polyester or cellulose. In addition, methods for inclusion in a small pore of an organic substance called cyclodextrin for sustained release have also been proposed in JP-A-5-176733 and JP-A-6-40890. Also, methods for microencapsulation to realize sustained release are disclosed in JP-A-6-9377, JP-A-6-65064, JP-A-7-89848, JP-A-9-911, JP-A-9-12447, It is proposed in Japanese Laid-Open Patent Publication No. 9-57091.
[0003]
In addition, we have proposed a volatilizing drug sustained release member in which a drug filled inside a container is slowly released by a permeation control film or a humidity sensitive film.
[0004]
[Problems to be solved by the invention]
However, in the conventional configuration described above, due to the influence of the external environment, when the temperature of the volatile drug sustained release member rises excessively, the amount of the volatile drug released cannot be suppressed only by the permeation amount control film. As a result, unnecessary drug release or excessive release of drug results in discomfort to the user.
[0005]
The present invention, in response to such a conventional problem, prevents the unnecessary release of the drug by forcibly suppressing the release of the drug at a predetermined temperature or higher, and allows the user to use the volatile drug slowly. A release device is provided.
[0006]
[Means for Solving the Problems]
  In response to the above problem, a container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug are provided in the container, and movable on the outer surface of the permeation amount control film. A movable shutter mechanism comprising at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion, A pair of shape memory wire springs or a pair of shape memory leaf springs and a pair of wire springs or a pair of leaf springs in a parallel relationshipA volatile drug sustained release device,
  In the movable shutter mechanism, a pair of fixed support shafts and a pair of movable support shafts are disposed in parallel with the transmission amount control film surface, and the movable shutter portion is fixedly supported by the movable support shafts, and the movable support is provided. The shaft is positioned inside the fixed support shaft with respect to the permeation amount control membrane surface, and the shape memory wire spring or the shape memory leaf spring is below the fixed support shaft with respect to the permeation amount control membrane surface, The wire spring or the leaf spring is disposed above the fixed support shaft and below the movable support shaft. The wire spring or the leaf spring is disposed above the movable support shaft. It is a mechanism in which the movable shutter portion moves from top to bottom by the action of a leaf spring and the shape memory wire spring or the shape memory leaf spring, so that the movable shutter portion moves from the open state to the closed state.It is a volatile drug sustained-release device composed of
[0007]
With the above configuration, the spring force of the wire spring or the leaf spring is superior to the spring force of the shape memory wire spring or the shape memory leaf spring below a predetermined temperature, and the shape memory wire spring force or the spring of the shape memory leaf spring above the predetermined temperature. A movable shutter mechanism comprising a shape memory wire spring or a shape memory leaf spring, a wire spring or a leaf spring, and a movable shutter portion by configuring the force to be greater than the spring force of the wire spring or leaf spring; It becomes possible to do. As a result, it is possible to effectively utilize the required amount of the drug that is gradually released from the container filled with the volatile drug having antifungal property, fragrance and the like, and contribute to the extension of the life of the drug. Moreover, there is no discomfort to the user due to unnecessary drug release.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
  According to the first aspect of the present invention, there is provided a container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug in the container, and the outer surface of the permeation amount control film The movable shutter mechanism is configured by at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion. The pair of shape memory wire springs or the pair of shape memory leaf springs and the pair of wire springs or the pair of leaf springs are in a parallel relationship.A volatile drug sustained release device,
In the movable shutter mechanism, a pair of fixed support shafts and a pair of movable support shafts are disposed in parallel with the transmission amount control film surface, and the movable shutter portion is fixedly supported by the movable support shafts, and the movable support is provided. The shaft is positioned inside the fixed support shaft with respect to the permeation amount control membrane surface, and the shape memory wire spring or the shape memory leaf spring is below the fixed support shaft with respect to the permeation amount control membrane surface, The wire spring or the leaf spring is disposed above the fixed support shaft and below the movable support shaft. The wire spring or the leaf spring is disposed above the movable support shaft. It is a mechanism that is moved from the open state to the closed state when the movable shutter portion operates from top to bottom by the action of the leaf spring and the shape memory wire spring or the shape memory leaf spring.This is a volatile drug sustained-release device.
[0011]
  Claim2In the described invention, the movable shutter mechanism isTransparentIn parallel with the quantity control film surfaceA pair ofWith fixed support shaftA pair ofA movable support shaft is disposed, a movable shutter portion is fixedly supported on the movable support shaft, and the movable support shaft isFor the permeation amount control membrane surfaceLocated inside the fixed support shaft, the shape memory wire spring or the shape memory leaf spring isFor the permeation amount control membrane surfaceLocated below the fixed support shaft and above the movable support shaft, the wire spring or leaf spring is above the fixed support shaft and below the movable support shaft.set onIn a mechanism above the predetermined temperature, the movable shutter portion is moved from top to bottom by the action of the wire spring or leaf spring and the shape memory wire spring or shape memory leaf spring, so that the movable shutter portion moves from top to bottom. It is a volatile drug sustained release device.
[0012]
  Claim2The invention described isA container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug are provided in the container, and a movable shutter mechanism is disposed on the outer surface of the permeation amount control film. The movable shutter mechanism includes at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion, and the pair of shape memory wire springs. Or a pair of shape memory leaf springs and a pair of wire springs or a pair of leaf springs in a volatile drug sustained release device in a parallel relationship,
  AboveThe movable shutter mechanismAboveA pair of fixed support shafts and a pair of movable support shafts are disposed in parallel with the permeation amount control film surface, and the movable support shaftsAboveA movable shutter portion is fixedly supported, and the movable support shaft is located inside the fixed support shaft with respect to the transmission amount control film surface,AboveShape memory wire springAboveAbove the fixed support shaft,AboveIt is arranged to be below the movable support shaft,AboveWire spring orAboveThe leaf spring is against the permeation amount control membrane surface.AboveBelow the fixed support shaft,AboveIt is arranged so as to be above the movable support shaft, and the wire spring or above at a predetermined temperature or higherAboveA leaf spring and the shape memory wire spring orAboveIt is a volatile drug sustained release device which is a mechanism that is moved from the open state to the closed state when the movable shutter portion operates from the bottom to the top by the action of the shape memory leaf spring.
[0013]
  Claim3The invention described isA container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug are provided in the container, and a movable shutter mechanism is disposed on the outer surface of the permeation amount control film. The movable shutter mechanism includes at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion, and the pair of shape memory wire springs. Or a pair of shape memory leaf springs and a pair of wire springs or a pair of leaf springs in a volatile drug sustained release device in a parallel relationship,
  AboveThe movable shutter mechanismAboveA pair of fixed support shafts and a pair of movable support shafts are disposed perpendicularly to the permeation amount control membrane surface, and the movable support shafts are connected via a connecting shaft.AboveFixedly supported by a movable shutter portion, and the movable support shaft is located inside the fixed support shaft with respect to the transmission amount control film surface,AboveShape memory wire spring orAboveShape memory leaf springAboveThe right side of the fixed support shaft,AboveIt is arranged to be on the left side of the movable support shaft,AboveWire spring orAboveLeaf springAboveThe left side of the fixed support shaft,AboveArranged to be on the right side of the movable support shaft, orAboveShape memory wire spring orAboveShape memory leaf springAboveThe left side of the fixed support shaft,AboveIt is arranged to be on the right side of the movable support shaft,AboveWire spring orAboveLeaf springAboveThe right side of the fixed support shaft,AboveIt is arranged so as to be on the left side of the movable support shaft, and at a predetermined temperature or higher, the wire spring orAboveA leaf spring and the shape memory wire spring orAboveIt is a volatile drug sustained release device that is a mechanism that changes from an open state to a closed state by operating the movable shutter portion from right to left or from left to right by the action of a shape memory leaf spring.
[0014]
  Claim4In the described invention, a fixed shutter part is disposed between the movable shutter part and the opening part or between the movable shutter part and the transmission amount control film, and both the fixed shutter part and the movable shutter part include a plurality of The volatile drug sustained release device is provided with an open window and is opened and closed by moving the open window portion of the movable shutter portion in the vertical direction or the horizontal direction.
[0015]
  Claim5The described invention is a volatilizing drug sustained release device in which a movable support shaft is provided with a recess in a portion in contact with a wire spring or a leaf spring and a shape memory wire spring or a shape memory leaf spring.
[0016]
  Claim6In the described invention, a support portion is disposed at the end of the movable shutter portion, and the movement distance when the movable shutter portion is operated by the action of the shape memory wire spring or the shape memory leaf spring and the wire spring or the leaf spring is regulated. It is a volatilizing drug sustained release device that is configured to perform.
[0017]
  Claim7The described invention is a volatile drug sustained release device in which opening windows are provided at equal intervals in the movable shutter portion, and the interval width of the opening windows is larger than that of the opening window provided in the fixed shutter portion.
[0021]
  Claim8The described invention is a volatile drug sustained release device in which the permeation amount control membrane is a humidity sensitive membrane.
[0022]
  Claim9The described invention is a volatile drug sustained-release device in which the drug is allyl isothiocyanate, tea tree oil, or eucalyptus oil.
[0023]
  Claim10The described invention is a volatilizing drug sustained-release device having a laminated structure in which the humidity-sensitive film includes viscose-processed paper.
[0024]
  Claim11The described invention is a volatile drug sustained-release device in which the spring characteristics of the shape memory wire spring or the leaf spring are controlled by repeated transformation between the mother phase and the R phase.
[0025]
【Example】
Embodiments of the present invention will be described below with reference to the drawings.
[0026]
Example 1
FIG. 1 is an external view of the upper surface of the volatile drug sustained-release device showing the present embodiment. 2 is a side cross-sectional configuration diagram with respect to the volatile drug sustained-release device AA ′ line, and FIG. 3 is a side cross-sectional configuration diagram with respect to the volatile drug sustained-release device BB ′ line. Represents a state. FIG. 4 is a side cross-sectional configuration diagram with respect to the volatile drug sustained release device A-A ′ line, and FIG. 5 is a side cross-sectional configuration diagram with respect to the volatile drug sustained release device BB ′ line. Represents a state. Reference numeral 1 denotes a polyurethane continuous porous body that has swelled by absorbing allyl isothiocyanate serving as a drug. Specifically, a polyurethane continuous porous body of 50 × 30 × 6 mm, a bulk density of 0.35 g / ml, an average pore diameter of 30 μm, and a porosity of 70% absorb 30 g of allyl isothiocyanate to about 70 × 42 × 8.4 mm. Swollen. 2 is a pillow package body of a laminate film that becomes an exterior of the polyurethane continuous porous body 1, and is a pillow package of polyethylene terephthalate 12 μm and polyethylene 70 μm on the polyethylene side with a heat seal width of 5 mm. It becomes the primary control film. 3 is an inner main body container made of translucent polypropylene and a thickness of 2 mm for filling it, and was processed by injection molding. The inner dimensions of the container are 71 × 43 × 15 mm. 4 is an inner lid for the inner body container 3, which is also made of translucent polypropylene and 2 mm in thickness, and has a large window at the center of the inner lid 4, and ribs 5 are formed in cross over the large window, A 65 × 37 mm humidity sensitive film 6 is disposed at the center of the front side of the inner lid 4, and the polyurethane continuous porous body 1 is fixed to the bottom surface of the inner body container 3 by the ribs 5 and is reinforced to the humidity sensitive film 6. It plays the role of The humidity sensitive film 6 is obtained by laminating viscose processed paper on polyethylene / stretched polypropylene / polyethylene. Specifically, a viscose film is 10 g / m on a polyethylene 40 μm / stretched polypropylene 60 μm / polyethylene 40 μm via a rayon / pulp nonwoven fabric.²The outer peripheral portion of the humidity sensitive film 6 is welded and joined to the inner lid 4 by heat sealing. The heat seal width is 5 mm. The main body container 3 and the inner lid 4 are joined by ultrasonic joining. Reference numeral 7 denotes a space formed by the pillow packaging body 2, the inner main body container 3, and the inner lid 4, and the space volume is about 21 ml. Reference numeral 8 denotes a polyethylene terephthalate plate having a thickness of 3 mm, which serves as a fixed shutter portion. Opening windows 8a are arranged at equal intervals, and are bonded and fixed to the upper surface portion of the humidity sensitive film 6. Further, a polypropylene packing width 1 mm and a thickness 0.5 mm having closed cells as gas seal members 9 are disposed around the opening window 8 a on the fixed shutter portion 8. Reference numeral 10 denotes an outer main body container in which the inner main body container is accommodated, which is made of translucent polypropylene and having a thickness of 2 mm, and was processed by injection molding. The inner dimensions of the container are 76 × 48 × 27 mm. Reference numeral 11 denotes an outer lid for the outer main body container 10, which is also made of translucent polypropylene and has a thickness of 2 mm, and an opening 11 a of 67 × 39 mm is arranged at the center of the outer lid 11. Two fixed support shafts 12 are disposed on the inner wall surface of the outer main body container 10 between the outer lid 11 and the inner lid 4, and the movable support shaft 13 is held between the wire spring 14 and the shape memory wire spring 15. It has a configuration. FIG. 6 shows a top external view for showing the configuration of the movable shutter portion, the movable support shaft, the fixed support shaft, the wire spring, and the shape memory wire spring. FIG. 7 is a perspective view for easily explaining the movable shutter mechanism. The wire spring 14 is made of SUS having a diameter of 1 mm, and the shape memory wire spring 15 is made of a Ni-Ti alloy having a diameter of 1 mm. The wire spring 14 and the shape memory wire spring 15 are arranged in two places on the left and right as a pair. Specifically, the wire spring 14 is arranged to be an upper part of the fixed support shaft 12 and a lower part of the movable support shaft 13, and the shape memory line spring 15 is a lower part of the fixed support shaft 12 and an upper part of the movable support shaft 13. Are arranged as follows. In addition, a groove 13a is provided in a portion of the fixed support shaft 12 and the movable support shaft 13 in contact with the wire spring 14 or the shape memory wire spring 15, so that the position of the wire spring 14 or the shape memory wire spring 15 does not move in the left-right direction. It has become. FIG. 8 shows an enlarged cross-sectional view of the main part of the movable support shaft. A rectangular groove 13a is provided on each side of the movable support shaft 13, and the linear spring 14 or the shape memory linear spring 15 is half embedded in the rectangular groove 13a. The two movable support shafts 13 are connected to the movable shutter portion 16. The movable shutter portion 16 is made of an aluminum plate having a thickness of 1 mm and 67 × 34 mm. Opening windows 16 a are arranged at equal intervals in the movable shutter portion 16. The transformation end temperature during heating of the shape memory wire spring 15 is 45 ° C., and the transformation end temperature during cooling is 30 ° C.
[0027]
The sustained release mechanism of the volatile drug sustained release device will be described. First, at 30 ° C. or lower, the spring force of the wire spring 14 is superior to that of the shape memory wire spring 15, so that the aluminum plate serving as the movable shutter portion 16 is above the aluminum plate serving as the fixed shutter portion 8 as shown in FIGS. In the configuration of the movable shutter mechanism, which is located at a location away from the direction, the state a in FIG. Therefore, the movable shutter portion 16 does not hinder the release of allyl isothiocyanate from the inner body container 3. The allyl isothiocyanate vapor volatilized from the polyurethane continuous porous body 1 reaches the saturated vapor pressure concentration in the space 7. For example, since the vapor pressure of allyl isothiocyanate is about 5 mmHg at 25 ° C., the saturated vapor concentration in the space portion 7 is about 6600 ppm at the maximum. In the case of low humidity, the moisture sensitive film 6 suppresses the release of vapor of allyl isothiocyanate to some extent, so that the space 7 is maintained in a state close to the saturated vapor pressure concentration. However, when the humidity sensitive membrane 6 is sufficiently moistened, allyl isothiocyanate vapor passes through the humidity sensitive membrane 6. The humidity sensitive membrane 6 swells and becomes loose due to changes in humidity, and allyl isothiocyanate molecules are easily permeated and released to the outside. Thereafter, the light is discharged from the opening 11 a of the outer lid 11 through the opening window 8 a of the fixed shutter 8 and the opening window 16 a of the movable shutter 16.
[0028]
However, the transformation from the martensite phase to the parent phase of the shape memory wire spring 15 starts around 40 ° C., and the transformation ends at 45 ° C. The spring force of the shape memory wire spring 15 is now superior to that of the wire spring 14. become. As a result, the aluminum plate that becomes the movable shutter portion 17 is pressed downward by the spring force of the shape memory spring 15 as shown in FIGS. 4 and 5, and the movable shutter portion 16 and the fixed shutter portion 8 are interposed via the gas seal member 9. 7 is in the state of FIG. 7 in the configuration of the movable shutter mechanism. By making the opening window 8a and the opening window 16a non-overlapping each other, the release of allyl isothiocyanate from the inside of the inner body container 3 is completely suppressed.
Further, the external environment temperature gradually decreases, the transformation from the parent phase of the shape memory wire spring 15 to the martensite phase starts from around 35 ° C., the transformation ends at 30 ° C., and the spring force of the wire spring 14 again becomes the shape. Since it is superior to the memory wire spring 15, the movable shutter portion 16 moves upward and allyl isothiocyanate from the inner body container 3 is gradually released. As described above, the movable shutter portion 16 operates in the vertical direction while having temperature hysteresis. FIG. 9 shows a temperature-strain curve by a constant load test of the shape memory wire spring used in this example. Since shape memory wire springs generally have temperature hysteresis with respect to temperature rise and fall, it has been necessary to design the shape memory wire spring so that the intended drug sustained release function does not deteriorate.
[0029]
With such a configuration, it has a sustained release characteristic capable of handling humidity in which a drug is continuously released at a 30 mg / day level from a humidity sensitive film under conditions of 25 ° C. and relative humidity of 95% (hereinafter referred to as RH). The release of allyl isothiocyanate was completely suppressed above 30 ° C., and a volatile drug sustained release device having a temperature response function capable of releasing allyl isothiocyanate again below 30 ° C. could be provided.
[0030]
The volatile drug sustained release device obtained in this example was used as a mildewproofing device for automobile car air conditioners. FIG. 10 shows a schematic diagram of a blower circuit of a car air conditioner. The outside air or the inside air of the automobile is blown to the evaporator 18 by the blower fan 17. A dust collection filter 19 and a volatile chemical sustained release device 20 are arranged on the upstream side of the evaporator 18 and can be replaced periodically. A heater core 21 and an air mix door 22 are arranged downstream of the evaporator 18, and after changing the mixing ratio of the cool air of the evaporator 18 and the warm air of the heater core 21 by the air mix door 22, a center register, a side register, a rear heater duct, Cold air or warm air is blown out from the front defroster, side defroster, or the like. During cooling, the operation is stopped in a state where the evaporator 18 retains condensed water. The condensed water re-evaporates to increase the humidity inside the blower circuit, so that an atmosphere in which mold is likely to occur is obtained. At this time, mildewproof performance could be exhibited by slow release of low-concentration allyl isothiocyanate from the humidity-sensitive membrane 6 by the volatile chemical sustained-release device. Specifically, by retaining about 0.3 to 1 ppm of allyl isothiocyanate, it had a sufficient fungicidal effect on common fungi such as Cladosporiaum, Alternaria, Aspergillus, Penicillium, Rhizopus.
[0031]
In the case of a car that is left under the hot sun in summer, the room temperature rises to about 60 ° C. Even in such a case, it is necessary to control the release of the medicine without causing the user to feel uncomfortable. Molds generally do not grow above 40 ° C., so the release of drugs at higher temperatures is wasteful. However, since the shape memory wire spring of this embodiment has a temperature hysteresis of about 15 ° C., the transformation end temperature accompanying the temperature rise was 45 ° C., and the transformation end temperature accompanying the temperature drop was 30 ° C. When a user drives a car and performs cooling operation, it is assumed that the temperature will always be 30 ° C. or lower. Therefore, the transformation end temperature of 30 ° C. accompanying the temperature drop is designed to be a volatile drug sustained release device design standard for car car air conditioners. It was. As a result, in the field test, even when nutrients were regularly given from the suction route, a sufficient fungicidal effect was confirmed.
[0032]
(Example 2)
FIG. 11 is a top external view of the volatile drug sustained-release device showing the present embodiment, FIG. 12 is a side cross-sectional configuration diagram of the volatile drug sustained-release device CC ′ line, and FIG. 13 is a volatile drug sustained-release device. Side surface block diagram with respect to the releasing device DD 'line is shown, These represent the sustained release state of a chemical | medical agent. FIG. 14 is a side cross-sectional configuration diagram of the volatile drug sustained release device CC ′ line, and FIG. 15 is a side cross-sectional configuration diagram of the volatile drug sustained release device DD ′ line, which controls the release of the drug. Represents a state. Reference numeral 23 denotes a tablet obtained by solidifying allyl isothiocyanate, which becomes a volatile chemical, with cellulose ethyl ether. Specifically, 15 g of cellulose ethyl ether powder (Nisshin Kasei; Etocel STD-100, weight average molecular weight 180,000) was put in a mold container, 30 g of ethanol was added and left for 2 hours, and then allyl isothiocyanate. By adding 30 g and vacuum drying at room temperature, ethanol was evaporated and allyl isothiocyanate was tableted with cellulose ethyl ether. Reference numeral 24 denotes a laminate film as a permeation control film for allyl isothiocyanate, a pillow package of 12 μm of polyethylene terephthalate and 70 μm of polyethylene. Reference numeral 25 denotes an inner main body container made of translucent polypropylene and a thickness of 2 mm for filling it, and the inner dimensions of the container are 71 × 43 × 15 mm. Reference numeral 26 denotes an inner lid for the inner body container 25, which is also made of translucent polypropylene and has a thickness of 2 mm. There is a large window at the center of the inner lid 26, and ribs 27 are formed on the large window. A 65 × 37 mm humidity sensitive film 28 is disposed in the center of the front side of the inner lid 26, and the same one as in Example 1 was used. Reference numeral 29 denotes a space formed by the pillow package 24, the inner main body container 25, and the inner lid 26. Reference numeral 30 denotes an outer main body container in which the inner main body container is accommodated, which is made of translucent polypropylene and having a thickness of 2 mm, and was processed by injection molding. The inner dimensions of the container are 76 × 48 × 27 mm. Reference numeral 31 denotes an outer lid for the outer main body container 30, which serves as a fixed shutter portion. It is made of translucent polypropylene and has a thickness of 2 mm. Opening windows 31 a are arranged on the outer lid 31 at equal intervals. A gas packing member 32 having a width of 1 mm and a thickness of 0.5 mm as a gas seal member 32 is provided around the opening window 31a on the lower surface of the outer lid 31 serving as a fixed shutter portion. Two fixed support shafts 33 are disposed on the inner wall surface of the outer main body container 30 between the outer lid 31 and the inner lid 26, and the movable support shaft 34 is sandwiched between the wire spring 35 and the shape memory wire spring 36. It has a configuration. FIG. 16 shows a top external view for illustrating the configuration of the movable shutter portion, the movable support shaft, the fixed support shaft, the wire spring, and the shape memory wire spring. FIG. 17 is a perspective view for easily explaining the movable shutter mechanism. The wire spring 35 is made of SUS having a diameter of 1 mm, and the shape memory wire spring 36 is made of a Ni-Ti alloy having a diameter of 1 mm. The wire spring 35 and the shape memory wire spring 36 are arranged in pairs at two locations on the left and right. Specifically, the wire spring 35 is arranged to be below the fixed support shaft 33 and above the movable support shaft 34, and the shape memory wire spring 36 is above the fixed support shaft 33 and below the movable support shaft 34. Are arranged as follows. Further, a groove 34a is provided in a portion of the fixed support shaft 33 and the movable support shaft 34 that contacts the linear spring 35 or the shape memory linear spring 36 so that the position of the linear spring 35 or the shape memory linear spring 36 does not move in the left-right direction. It has become. The structure of the groove 34a is the same as that of the first embodiment. Two movable support shafts 34 are connected to the movable shutter portion 37. The movable shutter portion 37 is made of a polyethylene terephthalate plate having a thickness of 4 mm and 67 × 34 mm, and opening windows 37 a are arranged at equal intervals in the movable shutter portion 37. The transformation end temperature during heating of the shape memory wire spring 36 is 45 ° C., and the transformation end temperature during cooling is 30 ° C.
[0033]
The sustained release mechanism of the volatile drug sustained release device will be described. First, at 30 ° C. or lower, the spring force of the wire spring 35 is superior to that of the shape memory wire spring 36, so that the polypropylene plate serving as the movable shutter portion 37 is lowered from the outer lid 31 serving as the fixed shutter portion as shown in FIGS. In the configuration of the movable shutter mechanism, the state shown in FIG. Therefore, the movable shutter portion 37 does not hinder the release of allyl isothiocyanate from the inner body container 25. The allyl isothiocyanate vapor volatilized from the tablet 23 was able to be gradually released while a permeation amount was regulated by the permeation control film 24 and the humidity sensitive film 28.
[0034]
However, the transformation of the shape memory wire spring 36 starts around 40 ° C., and the transformation ends at 45 ° C. This time, the spring force of the shape memory wire spring 36 is greater than that of the wire spring 35. As a result, the polypropylene plate serving as the movable shutter portion 37 is pressed upward by the spring force of the shape memory wire spring 36 as shown in FIGS. 14 and 15, and the movable shutter portion 37 and the outer lid 31 serving as the fixed shutter portion are gas sealed. It will be in the state which closely_contact | adhered through the member 32, and will be in the d state of FIG. 17 in the structure of a movable shutter mechanism. By making the opening window 31a and the opening window 37a not overlap each other in the vertical direction, release of allyl isothiocyanate from the inner body container interior 25 is completely suppressed.
[0035]
Further, the external environment temperature gradually decreases, the transformation of the shape memory wire spring 36 starts from around 35 ° C., the transformation ends at 30 ° C., and the spring force of the wire spring 35 again exceeds the shape memory wire spring 36. Therefore, the movable shutter portion 37 moves downward and allyl isothiocyanate from the inner body container 25 is gradually released. As described above, the movable shutter portion 37 operates in the vertical direction while having temperature hysteresis.
[0036]
With such a configuration, it has a sustained release property capable of handling humidity in which a drug is continuously released at a 30 mg / day level from a humidity-sensitive film under conditions of 25 ° C. and a relative humidity of 95% (hereinafter referred to as RH). The release of allyl isothiocyanate was completely suppressed above 30 ° C., and a volatile drug sustained release device having temperature responsiveness capable of releasing allyl isothiocyanate again below 30 ° C. could be provided.
[0037]
(Example 3)
18 is a top external view of the volatile drug sustained-release device showing the present embodiment, FIG. 19 is a side cross-sectional configuration diagram of the volatile drug sustained-release device EE ′ line, and FIG. 20 is a volatile drug sustained-release device. It is side surface sectional block diagram of the releasing device FF 'line, and represents the sustained release state of a chemical | medical agent. FIG. 21 is a top external view of the volatile drug sustained-release device showing the present embodiment, FIG. 22 is a side cross-sectional configuration diagram of the volatile drug sustained-release device EE ′ line, and FIG. 22 is a volatile drug. It is side surface block diagram of sustained release apparatus FF 'line, and represents the discharge | release suppression state of a chemical | medical agent. Reference numeral 38 denotes a polyurethane continuous porous material which swells by absorbing allyl isothiocyanate serving as a drug, and the same one as in Example 1 was used. 39 is a pillow package body of a laminate film that becomes an exterior of the polyurethane continuous porous body 38, and the same one as in Example 1 was used. 40 is an inner body container made of translucent polypropylene and a thickness of 2 mm for filling it, and was processed by injection molding. The inner dimensions of the container are 71 × 43 × 15 mm. 41 is an inner lid for the inner body container 40, which is also made of translucent polypropylene, thickness 2 mm, and has a large window at the center of the inner lid 41, and a rib 42 is formed in a cross shape with respect to the large window, A 65 × 37 mm permeation control film 43 is disposed at the center of the front side of the inner lid 41, and the polyurethane continuous porous body 38 is fixed to the bottom surface of the inner body container 40 by the ribs 42 and is reinforced to the permeation control film 43. It plays the role of The permeation control film 43 is a laminate film of polyethylene 40 μm / nylon 6 15 μm / polyethylene 40 μm. The outer peripheral portion of the permeation control film 43 is welded and joined to the inner lid 41 by heat sealing the polyethylene side. The heat seal width is 5 mm. The main body container 40 and the inner lid 41 are joined by ultrasonic joining. Reference numeral 44 denotes a space formed by the pillow package 39, the inner main body container 40, and the inner lid 41. Reference numeral 45 denotes a polyethylene terephthalate plate having a thickness of 4 mm, which serves as a fixed shutter portion. Opening windows 45a are arranged at equal intervals and bonded to the upper surface of the permeation control film 43. A gas seal member 46 is disposed around the opening window 45a on the fixed shutter 45 with a packing width made of ultra high molecular weight polyethylene of 1 mm and a thickness of 0.5 mm. 47 is an outer body container for accommodating the inner body container, which is made of translucent polypropylene and having a thickness of 2 mm, and was processed by injection molding. The inner dimensions of the container are 93 × 48 × 25 mm. The inner body container 40 is bonded and fixed at the bottom surface of the outer body container 47. Reference numeral 48 denotes an outer lid for the outer body container 47, which is also made of translucent polypropylene and has a thickness of 2 mm, and an opening 48a of 67 × 39 mm is disposed at the center of the outer lid 48. Reference numeral 49 denotes an aluminum plate serving as a movable shutter portion and a thickness of 0.4 mm. Further, a support portion 50 is provided at the left end of the movable shutter portion 49. The support portion 50 can guide the movement of the movable shutter portion in the left-right direction and regulate the movement amount. Specifically, it is a polyethylene terephthalate plate having a size of 47 × 6 mm and a thickness of 2 mm. The right end is connected to a support portion 53 joined to a movable support shaft 52 via a connecting shaft 51. The support 53 is also a polyethylene terephthalate plate having a size of 47 × 6 mm and a thickness of 2 mm. The movable support shaft 52 is disposed inside the fixed support shaft 54, and the fixed support shaft 54 is adhesively fixed to the outer lid 48 in the vertical direction. The wire spring 55 is located on the right side of the fixed support shaft 54 and is located on the left side of the movable support shaft 52. The shape memory wire spring 56 is positioned on the left side of the fixed support shaft 54 and is positioned on the right side of the movable support shaft 52. The transformation end temperature during heating of the shape memory wire spring 44 is 45 ° C., and the transformation end temperature during cooling is 30 ° C.
[0038]
The sustained release mechanism of the volatile drug sustained release device will be described. First, at 30 ° C. or lower, the spring force of the wire spring 55 is superior to that of the shape memory wire spring 56, so that the aluminum plate serving as the movable shutter portion 49 is positioned on the right side as shown in FIGS. The movable support shaft 52 is positioned on the right side by the action of the wire spring 55 and the shape memory line spring 56, and the movable shutter portion 49 is pulled to the right side from the support portion 53 joined to the movable support shaft 52 via the connecting shaft 51. become. At this time, when the movable shutter part 49 is pulled by the spring force of the line spring 55, the position of the movable shutter part 49 is regulated by the support part 50 colliding with the side wall surface of the fixed shutter part 45 and stopping. At this time, the opening window 45a provided in the fixed shutter portion 45 and the opening window 49a provided in the movable shutter portion 49 are located at a position where they overlap each other. As a result, release of allyl isothiocyanate from the inner body container 40 is not hindered. The allyl isothiocyanate vapor volatilized from the polyurethane continuous porous body 38 was able to be gradually released in a constant amount while the permeation amount was regulated by the permeation control film 39 and the permeation control film 43.
[0039]
However, the transformation of the shape memory wire spring 56 starts from around 40 ° C., and the transformation ends at 45 ° C. The spring force of the shape memory wire spring 56 now exceeds that of the wire spring 55. As a result, as shown in FIGS. 21 and 23, the aluminum plate serving as the movable shutter portion 49 is subjected to a force for moving the movable support shaft 52 in the left direction by the spring force of the shape memory linear spring 56. As a result, the movable shutter portion 49 is pushed to the left from the support portion 53 joined to the movable support shaft 52 via the connecting shaft 51. At this time, the moving position of the movable shutter portion 49 is regulated by the support portion 50 colliding with the inner side wall of the outer body container 47 and stopping. At this time, the opening window 45a disposed in the fixed shutter portion 45 and the opening window 49a disposed in the movable shutter portion 49 are structured so as not to overlap each other vertically, thereby releasing allyl isothiocyanate from the inside of the inner body container 40. Is completely suppressed. Accordingly, the distance between the opening windows 49a disposed in the movable shutter section 49 is larger than the width of the opening windows 45a disposed in the fixed shutter section 45, so that the fixed shutter depends on the moving distance of the movable shutter section 49. The opening window 45a disposed in the portion 45 is completely sealed.
[0040]
Further, the external environment temperature gradually decreases, the transformation of the shape memory wire spring 56 starts from around 35 ° C., and the transformation ends at 30 ° C. so that the spring force of the wire spring 55 is greater than that of the shape memory wire spring 56 again. Therefore, the movable shutter portion 49 moves from the right to the left, and allyl isothiocyanate from the inner main body container 40 is gradually released. As described above, the movable shutter portion 49 slides in the left-right direction while having temperature hysteresis. At this time, the outer dimensions of the support portion 50 and the movable shutter portion 49 are set to the inner wall size of the outer body container 47 and the lower surface of the outer lid 48. On the other hand, by adopting a structure having a clearance of about 0.5 mm, it was possible to accurately guide the direction in which the movable shutter portion 49 slides to the left and right.
[0041]
With such a configuration, it has a sustained release property that allows the drug to be continuously released at a 20 mg / day level from the permeation control membrane at 25 ° C., and completely suppresses the release of allyl isothiocyanate at 45 ° C. or higher. A volatile drug sustained-release device having temperature responsiveness capable of releasing allylisothiocyanate again at a temperature below ℃ could be provided.
[0042]
(Example 4)
FIG. 24 is a top external view of the volatile drug sustained release device showing the present embodiment, FIG. 25 is a side sectional configuration diagram of the volatile drug sustained release device GG ′ line, and FIG. It is side surface sectional block diagram of release apparatus HH 'line, and represents the sustained release state of a chemical | medical agent. FIG. 27 is a top external view of the volatile drug sustained-release device showing this embodiment, FIG. 28 is a side cross-sectional configuration view of the volatile drug sustained-release device GG ′ line, and FIG. 29 is a volatile drug. It is a side cross-section block diagram of sustained-release apparatus HH 'line, and both represent the discharge | release suppression state of a chemical | medical agent. 57 is a polyurethane continuous porous material which swelled by absorbing allyl isothiocyanate as a drug, and the same one as in Example 1 was used. 58 is a pillow package body of a laminate film that becomes the exterior of the polyurethane continuous porous body 57, and the same one as in Example 1 was used. 59 is an inner body container made of translucent polypropylene and a thickness of 2 mm for filling it, and was processed by injection molding. The inner dimensions of the container are 71 × 43 × 15 mm. Reference numeral 60 denotes an inner lid for the inner body container 59, which is also made of translucent polypropylene and has a thickness of 2 mm. There is a large window at the center of the inner lid 60, and ribs 61 are formed in a cross shape on the large window. The inner lid 60 has a 65 × 37 mm humidity sensitive 62 disposed in the center on the surface side, and the rib 61 fixes the polyurethane continuous porous body 57 to the bottom surface of the inner body container 59 and reinforces the humidity sensitive membrane 62. It plays the role of The same humidity sensitive film 62 as in Example 1 was used. The outer peripheral portion of the humidity sensitive film 62 is welded and joined to the inner lid 60 by heat sealing the polyethylene side. The heat seal width is 5 mm. The inner body container 59 and the inner lid 60 are joined by ultrasonic joining. 63 is a space formed by the pillow package 58, the inner main body container 59, and the inner lid 60. Reference numeral 64 denotes a polyethylene terephthalate plate having a thickness of 4 mm, which serves as a fixed shutter portion. Opening windows 64a are arranged at equal intervals and bonded to the upper surface of the humidity sensitive film 62. A gas seal member 65 and a nylon 66 packing width of 1 mm and a thickness of 0.5 mm are disposed around the opening window 64 a on the fixed shutter portion 64. Reference numeral 66 denotes an outer body container in which the inner body container 59 is accommodated, which is made of translucent polypropylene and has a thickness of 2 mm and is processed by injection molding. The inner dimensions of the container are 99 × 48 × 23 mm. Reference numeral 67 denotes an outer lid for the outer body container 66, which is also made of translucent polypropylene and has a thickness of 2 mm, and an opening 67a of 67 × 39 mm is arranged in the approximate center of the outer lid 67. Reference numeral 68 denotes an aluminum plate serving as a movable shutter portion and a thickness of 0.4 mm. A support portion 69 that guides the movement of the movable shutter portion in the left-right direction and restricts the amount of movement is disposed at the left end of the movable shutter portion 68. Specifically, it is a polyethylene terephthalate plate having a size of 47 × 6 mm and a thickness of 2 mm. The right end is connected to a support portion 72 joined to a movable support shaft 71 via a connection shaft 70. The support 72 is also a polyethylene terephthalate plate having a size of 47 × 6 mm and a thickness of 2 mm. The movable support shaft 71 is disposed inside the fixed support shaft 73, and the fixed support shaft 73 is adhesively fixed to the outer lid 67 in the vertical direction. The wire spring 74 is located on the left side of the fixed support shaft 73 and is located on the right side of the movable support shaft 71. The shape memory wire spring 75 is positioned on the right side of the fixed support shaft 73 and is positioned on the left side of the movable support shaft 71. As the shape memory wire spring 62, one that causes a transformation between a parent phase and an R phase (Rhombohedral, rhombohedral) was used. Therefore, the transformation end temperature during heating is 40 ° C., and the transformation end temperature during cooling is 36 ° C.
[0043]
The sustained release mechanism of the volatile drug sustained release device will be described. First, at 36 ° C. or lower, the spring force of the wire spring 74 is superior to that of the shape memory wire spring 75, so that the aluminum plate serving as the movable shutter portion 68 is located on the left side as shown in FIGS. The movable support shaft 71 is positioned on the left side by the action of the wire spring 74 and the shape memory line spring 75, and the movable shutter portion 68 is pushed to the left side via the connecting shaft 70 from the support portion 72 joined to the movable support shaft 71. That's right. At this time, the movement position of the movable shutter portion 68 is regulated by the support portion 69 colliding with the inner side wall of the outer body container 66 and stopping. In addition, the opening window 64a disposed in the fixed shutter portion 64 and the opening window 68a disposed in the movable shutter portion 68 are located in a place where they overlap each other. As a result, release of allyl isothiocyanate from the inner body container 59 is not prevented. The allyl isothiocyanate vapor volatilized from the polyurethane continuous porous body 57 was able to be gradually released while a permeation amount was regulated by the permeation control film 58 and the humidity sensitive film 62.
[0044]
However, the transformation from the R phase to the parent phase of the shape memory wire spring 75 starts from around 37 ° C., and the transformation ends at 40 ° C., so that the spring force of the shape memory wire spring 75 now exceeds that of the wire spring 74. Become. As a result, as shown in FIGS. 27 and 29, the aluminum plate that becomes the movable shutter portion 68 is subjected to a force that moves the movable support shaft 71 in the right direction by the spring force of the shape memory wire spring 75. The movable support shaft 71 is positioned on the right side by the action of the wire spring 74 and the shape memory line spring 75, and the movable shutter portion 68 is pulled to the right side from the support portion 72 joined to the movable support shaft 71 via the connecting shaft 70. become. When the movable shutter portion 68 is pulled by the spring force of the wire spring 74, the position of the movable shutter portion 68 is regulated by the support portion 69 colliding with the side wall of the fixed shutter portion 64 and stopping. At this time, the opening window 64a disposed in the fixed shutter portion 64 and the opening window 68a disposed in the movable shutter portion 68 are structured so as not to overlap each other vertically, thereby releasing allyl isothiocyanate from the inside of the inner body container 59. Is completely suppressed. Accordingly, the distance between the opening windows 68a disposed in the movable shutter section 68 is larger than the width of the opening windows 64a disposed in the fixed shutter section 64, so that the fixed shutter depends on the moving distance of the movable shutter section 68. The opening window 64a disposed in the portion 64 is completely sealed.
[0045]
Further, the external environment temperature gradually decreases, the transformation from the mother phase to the R phase of the shape memory wire spring 75 starts from around 39 ° C., the transformation ends at 36 ° C., and the spring force of the wire spring 74 becomes the shape memory again. Since it becomes superior to the wire spring 75, the movable shutter portion 68 moves from the right to the left and the allyl isothiocyanate from the inner body container 59 is gradually released. As described above, the movable shutter portion 68 slides in the left-right direction while having a very small temperature hysteresis. At this time, the outer dimensions of the support portion 69 and the movable shutter portion 68 are set to the inner wall size of the outer body container 66 and the outer lid 67. By taking a clearance of about 0.5 mm with respect to the lower surface, it was possible to guide the direction in which the movable shutter portion 68 slides to the left and right. FIG. 16 shows a temperature-strain curve obtained by a constant load test of the shape memory wire spring used in this example. The shape memory wire spring was able to make the temperature hysteresis with respect to the temperature rise and fall extremely small by repeating the transformation between the parent phase and the R phase. As a result, it has become possible to provide a volatile drug sustained-release device capable of stopping the sustained release of the drug at about a predetermined temperature or higher and continuing the sustained release of the drug at a predetermined temperature or lower.
[0046]
The volatile drug sustained release device obtained in this example was used as an anti-fungal device for a car air conditioner for automobiles similar to Example 1. When the cooling operation is stopped, the condensed water of the evaporation re-evaporates to increase the humidity inside the blower circuit, so that an atmosphere is likely to generate mold. However, at this time, mildewproofing performance was able to be exerted by slow release of allyl isothiocyanate at a low concentration from the humidity sensitive membrane by the volatile drug sustained release device. Also, in summer, the release of the drug could be suppressed by the movable shutter portion and the fixed shutter portion at 40 ° C. or higher, and it was possible to return to the sustained release state again at 36 ° C. or lower. Since the temperature hysteresis is also small, the drug can be effectively released as expected.
[0047]
In the embodiment, the description has been made by using the wire spring and the shape memory wire spring exclusively. However, it is also possible to constitute the movable shutter mechanism by combining the leaf spring and the shape memory leaf spring. It is also possible to combine a wire spring and a shape memory leaf spring or a leaf spring and a shape memory leaf spring. What is necessary is just to select the optimal combination in consideration of each spring force.
[0048]
In the embodiment, a polyethylene terephthalate plate and an aluminum plate are used as the material of the fixed shutter portion or the movable shutter portion, but those that can be used in the present invention are not limited to this. If the fixed shutter part or the movable shutter part is thick, a resin plate may be used, but if it is thin, a material excellent in gas barrier properties is preferable. For example, a metal plate, a laminate plate with an aluminum inner layer, and the like can be used. It is also possible to select a material other than aluminum as the metal for the laminated plate.
[0049]
In the embodiment, the case where the gas seal member is applied between the movable shutter portion and the fixed shutter portion has been described, but when the area where the movable shutter portion and the fixed shutter portion overlap is small and the gas barrier property is also desired to be improved. The gas seal member is effective. However, if the movable shutter portion and the fixed shutter portion have a sufficient area to overlap, and the release of the drug can be structurally suppressed, the gas seal member becomes unnecessary. For example, when the movable shutter portion operates in the vertical direction, this can be achieved by taking a sufficient overlapping area. Moreover, although polypropylene, polyethylene, ultrahigh molecular weight polyethylene, and nylon 66 having closed cells are used as the gas seal member, those that can be used in the present invention are not limited thereto. For example, when the movable shutter portion operates in the vertical direction, the gas barrier property can be improved by using a gas seal member having elasticity. For this purpose, the gas seal member has 30 vol% or more independent bubbles. I liked it. Further, when the movable shutter portion slides in the left-right direction, the sliding characteristics are regarded as important, and a resin material having a small surface roughness and good sliding properties is preferred. For example, polypropylene and polyethylene terephthalate could be used.
[0050]
In the examples, polypropylene resin was used as the container for filling the drug. However, what can be used in the present invention is not limited to this. In addition, a material having no problem may be selected in view of chemical resistance with the medicine to be filled.
[0051]
In the examples, the drug is used by being absorbed in a liquid absorber, or mixed with a solid polymer material and used as a tablet. However, the form that can be used in the present invention is not limited to this. What is necessary is just the structure which is filled with the chemical | medical agent inside the container. However, in consideration of physical distribution as a volatile drug sustained-release device, it is necessary to consider that the liquid drug does not flow outside.
[0052]
In the embodiment, the case where the permeation amount control film or the humidity sensitive film is disposed in the opening of the container filled with the medicine has been described. However, the present invention includes a container in which only the opening is disposed. By configuring a movable shutter mechanism with a fixed shutter part and a movable shutter part in the opening, and arranging the medicine in a tablet form inside the container, it is possible to prevent medicine outflow in physical distribution.
[0053]
In the examples, allyl isothiocyanate was exclusively used, but the present invention is not limited to this. Essential oils such as lavender oil and rosemary oil can also be used as a fragrance. Antibacterial and antifungal effects can also be obtained with a low concentration of volatilization using tea tree oil, eucalyptus oil or the like.
[0054]
【The invention's effect】
As is apparent from the above embodiment, according to the first aspect of the present invention, the spring force of the wire spring or the leaf spring exceeds the spring force of the shape memory wire spring or the shape memory leaf spring below a predetermined temperature. By configuring the shape memory wire spring or the shape memory leaf spring to exceed the spring force of the wire spring or the leaf spring above the temperature, the shape memory wire spring or the shape memory leaf spring, the wire spring or the leaf spring, Thus, a movable shutter mechanism including a movable shutter unit can be provided. As a result, it was possible to effectively utilize the required amount of the drug gradually released from the container filled with the volatilizing drug having antifungal property, fragrance and the like, and contributed to extending the life of the drug. In addition, users no longer feel uncomfortable due to unnecessary drug release.
[0057]
  further,As a movable shutter mechanism, a fixed support shaft and a movable support shaft are arranged in parallel with an opening surface of a container filled with a medicine or a permeation amount control film surface, and a shape memory wire spring or a shape memory leaf spring and a wire spring or In combination with a leaf spring, the spring force of the wire spring or leaf spring is superior at low temperatures depending on the temperature range, and the spring force of the shape memory wire spring or shape memory leaf spring is superior at high temperatures. By operating downward, the opening of the inner body container or the drug permeation control membrane part could be completely sealed. As a result, it was possible to provide a volatile drug sustained release device that sufficiently suppresses release of a drug in a high temperature range by a sufficient spring force of a shape memory wire spring or a shape memory leaf spring.
[0058]
  Claim2According to the described invention, as the movable shutter mechanism, the fixed support shaft and the movable support shaft are arranged in parallel with the opening surface or the permeation amount control film surface of the container filled with the medicine, and the shape memory wire spring or the shape is arranged. A combination of a memory leaf spring and a wire spring or a leaf spring. Depending on the temperature range, the spring force of the wire spring or leaf spring is superior at low temperatures, and the spring force of the shape memory wire spring or shape memory leaf spring is superior at high temperatures. Thus, the movable shutter portion was moved from the bottom upward, and the opening of the outer body container or the opening window of the fixed shutter portion could be completely sealed. As a result, it was possible to provide a volatile drug sustained release device that sufficiently suppresses release of a drug in a high temperature range by a sufficient spring force of a shape memory wire spring or a shape memory leaf spring.
[0059]
  Claim3According to the described invention, the fixed support shaft and the movable support shaft are arranged perpendicularly to the opening surface of the container filled with the medicine or the permeation amount control film surface as the movable shutter mechanism, and the movable support shaft is the connecting shaft. The shape memory wire spring or a combination of shape memory leaf spring and wire spring or leaf spring, the spring force of the wire spring or leaf spring is superior at low temperatures depending on the temperature range, and shape at high temperatures The movable shutter part can be operated from the left to the right or from the right to the left by utilizing the spring force of the memory wire spring or the shape memory leaf spring, and the moving distance is optimized by the structure of the movable shutter part. By doing so, it was possible to design from an open state to a closed state. As a result, it was possible to provide a volatile drug sustained-release device that sufficiently releases the drug at high temperatures.
[0060]
  Claim4According to the described invention, the fixed shutter portion is disposed between the movable shutter portion and the opening portion or between the movable shutter portion and the transmission amount control film, and both the fixed shutter portion and the movable shutter portion have the opening window. The opening portion of the movable shutter portion was moved up and down or left and right to open and close the portion that gradually released the drug. At that time, it was possible to design a sufficiently large open portion necessary for the gradual release of the volatile drug while reducing the moving distance of the movable shutter portion by the spring action of the shape memory wire spring or the shape memory leaf spring.
[0061]
  Claim5According to the described invention, the shape memory wire spring or the shape memory plate is provided by providing the groove-shaped recess in the portion where the wire spring or the leaf spring and the shape memory wire spring or the shape memory leaf spring are in contact with the movable support shaft. The spring action of the spring and the wire spring or the leaf spring is sufficient to cope with repeated cycles due to temperature changes without causing positional deviation.
[0062]
  Claim6According to the described invention, the support portion is disposed at the end of the movable shutter portion, and the moving distance when the movable shutter portion is operated by the action of the shape memory wire spring or the shape memory leaf spring and the wire spring or the leaf spring is reduced. If it is configured to be regulated, that is, if the support portion collides with the inner wall surface of the outer container or the side wall surface of the fixed shutter portion, the shape memory wire spring or the spring of the shape memory leaf spring Accurate positioning that maintains the relationship between the opening window of the movable shutter part and the opening window of the fixed shutter part when moving in the left-right direction by virtue of the force or the spring force of the wire spring or leaf spring. I was able to.
[0063]
  Claim7According to the described invention, the opening windows are provided at equal intervals in the movable shutter portion, and the interval width of the opening windows is larger than the opening window provided in the fixed shutter portion, so that the movable shutter portion is fixed when moved. The overlap part which overlaps with a shutter part can be provided reliably, As a result, the volatile chemical | medical agent sustained release apparatus which suppresses discharge | release of a chemical | medical agent fully in a closed state at high temperature was able to be provided.
[0067]
  Claim8According to the described invention, by using a humidity sensitive film as a permeation control film, it is possible to sufficiently exhibit antifungal properties under high humidity conditions, and unnecessary release of volatile chemicals under low humidity conditions. It was possible to provide humidity responsiveness that sufficiently regulated the amount.
[0068]
  Claim9According to the described invention, allyl isothiocyanate, tea tree oil, and eucalyptus oil can be used as chemicals, and an environment-friendly antibacterial and antifungal effect can be provided at a low concentration using natural ingredients.
[0069]
  Claim10According to the described invention, a humidity-sensitive film sensitive to humidity can be provided by using a laminate structure containing viscose-processed paper as a humidity-sensitive film. It was possible to effectively and slowly release a drug having a concentration, and the membrane was densified at low humidity, and the release of the drug could be sufficiently suppressed.
[0070]
  Claim11According to the described invention, by selecting a material whose spring characteristics can be controlled by repetitive transformation between the mother phase and the R phase with respect to the shape memory wire spring or the shape memory leaf spring, the temperature hysteresis is 1 to 2 ° C. I was able to get something very small. As a result, it is possible to provide a sustained-release device that can suppress the release of the volatile drug from a lower temperature, and it is possible to effectively use the drug and extend its life.
[Brief description of the drawings]
FIG. 1 is an external view of the top surface of a volatile drug sustained-release device of Example 1. FIG.
2 is a side cross-sectional configuration diagram with respect to the line AA ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 1 is in an open state; FIG.
FIG. 3 is a side cross-sectional configuration diagram with respect to the line BB ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 1 is in an open state.
4 is a side cross-sectional configuration diagram with respect to the line AA ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 1 is in a closed state; FIG.
5 is a side cross-sectional configuration diagram with respect to the line BB ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 1 is in a closed state. FIG.
6 is a top external view for showing the configuration of a movable shutter portion, a movable support shaft, a fixed support shaft, a wire spring, and a shape memory wire spring as a movable shutter mechanism of the volatile drug sustained release device in Embodiment 1. FIG.
7 is a perspective view illustrating an operation mechanism as a movable shutter mechanism of the volatile drug sustained release device in Embodiment 1. FIG.
8 is an enlarged cross-sectional view of the main part of the movable support shaft of the volatile drug sustained-release device in Example 1. FIG.
FIG. 9 is a temperature-strain curve obtained by a constant load test of the shape memory wire spring of Example 1.
FIG. 10 is a schematic configuration diagram in which the volatile drug sustained-release device of Example 1 is used in a blower circuit of a car air conditioner.
11 is an external view of the top surface of the volatile drug sustained-release device of Example 2. FIG.
FIG. 12 is a side cross-sectional configuration diagram with respect to the line CC ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 2 is in an open state.
13 is a side cross-sectional configuration diagram with respect to the line DD ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 2 is opened. FIG.
14 is a side cross-sectional configuration diagram with respect to the line CC ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 2 is closed. FIG.
15 is a side cross-sectional configuration diagram with respect to the line DD ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 2 is closed. FIG.
FIG. 16 is a top external view showing the configuration of a movable shutter mechanism, a movable support shaft, a fixed support shaft, a wire spring, and a shape memory wire spring as a movable shutter mechanism of the volatile drug sustained release device in Example 2;
FIG. 17 is a perspective view for explaining an operation mechanism as a movable shutter mechanism of the volatile drug sustained release device in Example 2.
FIG. 18 is an external view of the upper surface when the movable shutter mechanism of the volatile drug sustained-release device in Example 3 is opened.
FIG. 19 is a side cross-sectional configuration diagram with respect to the EE ′ line when the movable shutter mechanism of the volatile drug sustained-release device in Example 3 is in an open state.
FIG. 20 is a side cross-sectional configuration diagram with respect to the FF ′ line when the movable shutter mechanism of the volatile drug sustained-release device in Example 3 is in an open state.
FIG. 21 is an external view of the upper surface when the movable shutter mechanism of the volatile drug sustained-release device in Example 3 is closed.
FIG. 22 is a side cross-sectional configuration diagram with respect to the EE ′ line when the movable shutter mechanism of the volatile drug sustained-release device in Example 3 is in a closed state;
FIG. 23 is a side cross-sectional configuration diagram with respect to the FF ′ line when the movable shutter mechanism of the volatile drug sustained-release device in Example 3 is closed.
FIG. 24 is an external view of the upper surface when the movable shutter mechanism of the volatile drug sustained-release device in Example 4 is in an open state.
25 is a side cross-sectional configuration diagram with respect to the GG ′ line when the movable shutter mechanism of the volatile drug sustained-release device in Example 4 is in an open state. FIG.
FIG. 26 is a side cross-sectional configuration diagram with respect to the line HH ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 4 is in the open state.
FIG. 27 is an external view of the upper surface when the movable shutter mechanism of the volatile drug sustained-release device in Example 4 is closed.
FIG. 28 is a side cross-sectional configuration diagram with respect to the GG ′ line when the movable shutter mechanism of the volatile drug sustained-release device in Example 4 is in a closed state;
29 is a side cross-sectional configuration diagram with respect to the line HH ′ when the movable shutter mechanism of the volatile drug sustained-release device in Example 4 is in a closed state. FIG.
30 is a temperature-strain curve diagram of the shape memory wire spring of Example 4 by a constant load test. FIG.
[Explanation of symbols]
1 Polyurethane continuous porous body
2 Pillow package
3 Inner body container
4 Inner lid
5 ribs
6 Humidity sensitive membrane
7 space
8 Fixed shutter
9 Gas seal member
10 Outer body container
11 outer lid
12 Fixed support shaft
13 Movable support shaft
14 wire spring
15 Shape memory wire spring
16 Movable shutter
17 Blower fan
18 Evaporator
19 Dust collection filter
20 Volatile drug sustained release device
21 Heater core
22 Air mix door
23 tablets
24 pillow package
25 Inner body container
26 Inner lid
27 Ribs
28 Humidity sensitive membrane
29 Space
30 Outer body container
31 outer lid
32 Gas seal member
33 Fixed support shaft
34 Movable support shaft
35 wire spring
36 Shape Memory Wire Spring
37 Movable shutter
38 Polyurethane continuous porous body
39 Pillow packaging
40 Inner body container
41 Inner lid
42 Ribs
43 Permeation control membrane
44 Space
45 Fixed shutter
46 Gas seal member
47 Outer body container
48 outer lid
49 Movable shutter
50 Supporting part
51 connecting shaft
52 Movable support shaft
53 Supporting part
54 Fixed support shaft
55 Wire spring
56 Shape Memory Wire Spring
57 Polyurethane continuous porous body
58 pillow package
59 Inner body container
60 Inner lid
61 Ribs
62 Humidity sensitive membrane
63 Space
64 Fixed shutter
65 Gas seal member
66 Outer body container
67 outer lid
68 Movable shutter
69 Supporting part
70 connecting shaft
71 Movable support shaft
72 Supporting part
73 Constant support shaft
74 wire spring
75 Shape memory wire spring

Claims (11)

A container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug are provided in the container, and a movable shutter mechanism is disposed on the outer surface of the permeation amount control film. The movable shutter mechanism includes at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion, and the pair of shape memory wire springs. Or a pair of shape memory leaf springs and a pair of wire springs or a pair of leaf springs in a volatile drug sustained release device in a parallel relationship,
Said movable shutter mechanism comprises a pair of fixed support shaft and the pair of movable support shaft is arranged in parallel relationship with the transmission amount control film surface, the movable shutter is fixedly supported by the movable support shaft, the movable support axis is positioned inside the stationary support shaft with respect to the transmission amount control film surface, wherein the shape memory wire spring or said shape memory plate spring below the fixed support shaft with respect to the transmission amount control film surface, wherein are arranged so as to be above the movable support shaft, the wire spring or the leaf spring above the stationary support shaft, the disposed so as to be below the movable support shaft, the wire spring or the at least a predetermined temperature by the movable shutter portion by the action of the leaf spring shape memory wire spring or the shape memory plate spring is operated downward from the top, volatility, characterized in that the opening is a mechanism in the closed state Agent sustained release devices. A container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug are provided in the container, and a movable shutter mechanism is disposed on the outer surface of the permeation amount control film. The movable shutter mechanism includes at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion, and the pair of shape memory wire springs. Or a pair of shape memory leaf springs and a pair of wire springs or a pair of leaf springs in a volatile drug sustained release device in a parallel relationship,
Said movable shutter mechanism comprises a pair of fixed support shaft and the pair of movable support shaft is arranged in parallel relationship with the transmission amount control film surface, the movable shutter is fixedly supported by the movable support shaft, the movable support axis is positioned inside the stationary support shaft with respect to the transmission amount control film surface, wherein the shape memory wire spring above the stationary support shaft, is arranged so as to lower the movable support shaft, the wire spring Alternatively the leaf spring is below the fixed support shaft with respect to the transmission amount control film surface, the is arranged to be above the movable support shaft, wherein the shape memory and the line spring or the leaf spring at a predetermined temperature or higher by the movable shutter portion by the action of the wire spring or the shape memory plate spring operates the upward direction, volatile sustained drug release device, characterized in that the opening is a mechanism in the closed state. A container filled with a volatile drug and an opening provided with a permeation amount control film for controlling the permeation amount of the drug are provided in the container, and a movable shutter mechanism is disposed on the outer surface of the permeation amount control film. The movable shutter mechanism includes at least a pair of shape memory wire springs or a pair of shape memory leaf springs, a pair of wire springs or a pair of leaf springs, and a movable shutter portion, and the pair of shape memory wire springs. Or a pair of shape memory leaf springs and a pair of wire springs or a pair of leaf springs in a volatile drug sustained release device in a parallel relationship,
It said movable shutter mechanism comprises a pair of fixed support shaft and the pair of movable support shaft is disposed in the transmission amount control film surface perpendicular relationship, fixed support the movable support shaft to the movable shutter portion through the connecting shaft is located inside the fixed support shaft movable support shaft to the transmission amount control film surface, wherein the shape memory wire spring or said shape memory plate spring right of the fixed support shaft, of the movable support shaft It is arranged so as to be left, the wire spring or the leaf spring is the left side of the stationary support shaft, wherein are arranged such that the right side of the movable support shaft, or said shape memory wire spring or said shape memory plate spring left of the stationary support shaft, it is arranged so that the right side of the movable support shaft, the wire spring or the leaf spring is right of the fixed support shaft, wherein are arranged such that the left side of the movable support shaft, predetermined Warm The wire the movable shutter portion by the action of the spring or the leaf spring and the shape memory wire spring or the shape memory plate spring is from right to left, or by operation from left to right, the closed state from the open in the above A volatile drug sustained-release device characterized by the following mechanism. A fixed shutter portion is disposed between the movable shutter portion and the opening portion, or between the movable shutter portion and the transmission amount control film, and a plurality of opening windows are disposed in both the fixed shutter portion and the movable shutter portion. The volatile drug sustained release device according to any one of claims 1 to 3 , wherein the opening window portion of the movable shutter portion is opened and closed by operating in an up-down direction or a left-right direction. The volatilizing drug slowdown according to any one of claims 1 to 4, wherein the movable support shaft is provided with a recess in a portion in contact with the wire spring or leaf spring and the shape memory wire spring or shape memory leaf spring. Release device. A support portion is disposed at the end of the movable shutter portion, and the movement distance when the movable shutter portion operates is controlled by the action of the shape memory wire spring or the shape memory leaf spring and the wire spring or the leaf spring. The volatile chemical | medical agent sustained release apparatus of Claim 3 characterized by these. The volatile drug sustained release device according to claim 4 , wherein opening windows are provided at equal intervals in the movable shutter portion, and an interval width of the opening windows is larger than that of the opening window provided in the fixed shutter portion. . The volatile drug sustained-release device according to any one of claims 1 to 7, wherein the permeation amount control membrane is a humidity sensitive membrane. The volatile drug sustained-release device according to any one of claims 1 to 8, wherein the drug is allyl isothiocyanate, tea tree oil, or eucalyptus oil. 9. The volatile drug sustained-release device according to claim 8, wherein the humidity-sensitive film has a laminate structure containing viscose-processed paper. The volatility drug sustained release device according to any one of claims 1 to 10, wherein the spring characteristics of the shape memory wire spring or the shape memory leaf spring are controlled by repeated transformation of the parent phase and the R phase.

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