JP3725409B2 - Blood viscometer - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a blood viscometer that measures the viscosity of blood.
[0002]
[Prior art]
Conventionally, when grasping blood viscosity, blood is collected every time measurement is performed, and blood viscosity is measured using a viscometer, and line measurement is performed by a so-called invasive method. As the viscometer, a rotary viscometer, a capillary viscometer, or the like is used.
[0003]
[Problems to be solved by the invention]
The conventional method for measuring blood viscosity using the open blood method has the following problems.
[0004]
(1) It was necessary to collect blood for each measurement, which put a burden on the person being measured.
[0005]
(2) It took time because the measurement took time.
[0006]
(3) Since blood quickly solidifies, it was necessary to pay attention to the preservation of blood until it was measured with a viscometer.
[0007]
(4) When measuring with a conventional viscometer, it is necessary to make measurement conditions such as environment constant in order to ensure accuracy.
[0008]
(5) Viscometers based on the principle of stirring blood and measuring the force at that time, such as rotational viscosity, are accurate for measuring blood viscosity because blood cells collapse when blood is stirred. Was lacking.
[0009]
Accordingly, an object of the present invention is to provide a blood viscometer that can solve the above-described problems of the prior art and can easily and accurately measure blood without having to collect blood for each measurement.
[0010]
[Means for Solving the Problems]
In order to achieve the above object, the blood viscometer of the present invention comprises the blood characteristic value formed by associating the blood viscosity value with each of a plurality of blood characteristic values of the blood characteristic having a correlation characteristic with respect to the blood viscosity, and the blood characteristic value A correlation data storage unit that stores correlation data between blood viscosity values, a blood characteristic measurement unit that measures blood characteristic values, and a blood characteristic value that is initially measured by the blood characteristic measurement unit for each user Under the same conditions, the blood viscosity value is measured with an existing viscometer, the measured blood characteristic value and the blood viscosity value are stored, the personal condition storage unit, the blood characteristic value and the blood viscosity value stored in the personal condition storage unit, , Referring to the correlation data stored in the correlation data storage unit, identifying personal correlation data between the blood characteristic value and blood viscosity value applicable to the user, and refer to the identified personal correlation data Blood A viscosity extracting means for obtaining a blood viscosity value corresponding to a blood characteristic value measured by the sex measuring means,
It is characterized by providing.
[0011]
The blood characteristic is an aging value (APGindex) of acceleration pulse wave, and the blood characteristic measuring means is a measuring means of an aging value of acceleration pulse wave.
[0012]
The blood characteristic is a blood flow velocity, and the blood characteristic measurement means is a blood flow velocity measurement means.
[0013]
Further, the blood characteristic is a blood flow rate, and the blood characteristic measuring means is a blood flow measuring means.
[0014]
The apparatus further comprises a water content calculating means for calculating information on a water content necessary for ingestion in the body from a blood viscosity value obtained by the viscosity extracting means according to a predetermined program.
[0015]
In the above-described invention, blood characteristics such as the aging value (APG index) of the acceleration pulse wave, the blood flow velocity, and the blood flow volume have correlation characteristics unique to each individual with respect to the blood viscosity. That is, there is a unique relationship between blood characteristics and blood viscosity for each individual, and personal correlation data is formed. Therefore, for a large number of individuals, data relationships between blood characteristic values and blood viscosity values are collected, and correlation data is formed as a set of personal correlation data.
[0016]
A person using a blood viscometer according to the present invention needs to specify which personal correlation data should be applied to him only once at the beginning. The identification of the personal correlation data is performed by measuring the blood characteristic value using the blood characteristic measuring means provided in the blood viscometer according to the present invention and using the existing blood viscometer such as an open blood type and the blood characteristic value and blood viscosity value. And the corresponding personal correlation data is selected from the correlation data using the measured blood characteristic value and blood viscosity value.
[0017]
Once the personal correlation data is specified, the blood viscosity value can be obtained using the personal correlation data of the user by simply measuring the blood characteristic value using the blood characteristic measuring means.
[0018]
In the present invention, attention is paid to APG index, blood flow velocity, blood flow volume, and the like as blood properties having a correlation characteristic with respect to blood viscosity. Correspondingly, APG index measuring device, blood flow velocity measurement are used as blood characteristic measuring means. Either a device, a blood flow measuring device or the like is used.
[0019]
DETAILED DESCRIPTION OF THE INVENTION
Embodiments of a blood viscometer according to the present invention will be described below with reference to the drawings.
[0020]
First, focusing on APGindex as a blood characteristic, a case where an APGindex measuring device is used as a blood characteristic measuring means will be described.
[0021]
FIG. 1 is a block diagram in the case of configuring a blood viscometer using the APGindex measuring apparatus 10.
[0022]
As shown in FIG. 3, the blood viscometer has a device main body 1, a pulse wave sensor 3, and a conductive wire 4 that connects the device main body 1 and the pulse wave sensor 3. The pulse wave sensor 3 is formed in a sack shape and is used by being attached to the finger 5 of the hand. On the surface of the apparatus main body 1, there are provided a switch unit 6 for switching the data input mode, turning on the power, and the like, and a display unit 7 for displaying measurement results and the like. The example shown in FIG. 3 is merely an example, and other configurations may be used. For example, a type in which the pulse wave sensor 3 is attached to the earlobe and the apparatus main body 1 is attached to the wrist may be used. A type in which the wave sensor 3 is wound around an arm with a cuff like a blood pressure monitor may be used.
[0023]
As shown in FIG. 1, the blood viscometer of this embodiment includes an APG index measuring device 10 as blood characteristic measuring means. The APG index measuring apparatus 10 includes a light emitting unit such as an LED and a light receiving unit composed of a photodiode or a phototransistor and the like, and detects a change in blood flow due to the pulsation of the heart by a change in the amount of transmitted light and the amount of scattered light. An amplifying circuit 22 for amplifying an analog signal from the pulse wave sensor 3; and differential circuits 23 and 24 connected in two stages for differentiating the analog signal from the amplifying circuit 22 twice to convert it into a pulse wave acceleration signal; An A / D conversion circuit 25 for converting an analog signal from the differentiation circuit 24 into a digital signal, and a blood characteristic calculation means provided in the CPU 11 for calculating an APGindex as a blood characteristic from data in the A / D conversion circuit 25 26.
[0024]
Next, the operation of the APGindex measuring apparatus 10 will be described.
The signal from the light receiving unit is amplified by the amplifier circuit 22 to obtain a waveform signal as shown in FIG. 6A. This waveform signal is differentiated twice by passing through the differentiation circuits 23 and 24 in two stages. A waveform signal as an acceleration pulse wave of the pulse wave is obtained as shown in FIG. 6B, and then digitally converted by the A / D conversion circuit 25. The digitally converted signal is calculated as APGindex by the blood characteristic element calculating means 26 in the CPU 11. As shown in the waveform diagram of the acceleration pulse wave in FIG. 6B, the waveform signal of the acceleration pulse wave appears at peak heights such as a, b, c, and d with reference to the base line L. The change in the acceleration pulse wave is considered to represent the force applied to the blood in the blood vessel, and strongly reflects the ability of the heart, which has a large difference among individuals. APGindex is calculated and calculated by the formula of APGindex = (b + c + d) / a.
[0025]
The blood viscometer of the present embodiment includes, in addition to the APGindex measuring device 10, a correlation data storage unit 15 that stores correlation data formed by collecting data between APGindex and blood viscosity values for a large number of individuals, A personal condition storage unit 13 for storing personal conditions for specifying personal correlation data applicable to each person using the blood viscometer of the present embodiment from the correlation data, and an individual stored in the personal condition storage unit 13 Viscosity extraction means 17 is provided that refers to the conditions and correlation data, and thereafter obtains a blood viscosity value from the APGindex measured by the user using the APGindex measuring device 10.
[0026]
The blood viscometer according to the present embodiment further includes a water content calculating unit 19 that calculates information on the amount of water necessary for ingestion from the blood viscosity value obtained by the viscosity extracting unit 17 according to a predetermined program. The viscosity extraction means 17 and the water content calculation means 19 are provided in the CPU 11, and the personal condition storage unit 13 and the correlation data storage unit 15 are provided in the storage unit 12.
[0027]
Next, a method for creating correlation data between the APGindex stored in the correlation data storage unit 15 and the blood viscosity value will be described. Here, the correlation data is already incorporated in the blood viscometer of the present embodiment when the product is shipped from the factory.
[0028]
As described above, APGindex has a correlation characteristic unique to each individual with respect to blood viscosity, and there is a unique relationship between APGindex and blood viscosity for each individual. Therefore, using an APG index measuring device and an existing open-type viscometer, various body conditions are changed for each individual to obtain various APG indexes, and simultaneously, blood viscosity values are obtained for blood giving each APG index. The personal correlation data obtained in this way is obtained for a set of a large number of individuals, and the correlation data is formed as a set of a large number of personal correlation data. Here, as the APG index measuring device to be used, the APG index measuring device 10 itself in the blood viscometer of the present embodiment may be used, or another highly accurate APG index measuring device may be used.
[0029]
FIG. 4 shows correlation data between a blood characteristic value (APGindex in this embodiment) and a blood viscosity value. Row Ym (m = 1, 2,...) Shows a symbol for identifying personal correlation data, and column An shows a blood characteristic value (APGindex). Once row Ym (m = 1, 2,...) Is identified as Yk, blood is represented by column An (n = 1, 2,...) Corresponding to the measured blood characteristic value (APGindex) and its row Yk. The viscosity value is determined.
[0030]
FIG. 5 is a graph in which the correlation data shown in the matrix in FIG. 4 is classified into a plurality of personal correlation data. One individual correlation data corresponds to one row Ym (m = 1, 2,...).
[0031]
The personal correlation data is specified as follows from the correlation data shown in FIG.
As shown in FIG. 3, the pulse wave sensor 3 is mounted on a finger, the apparatus main body 1 is placed on a table or the like, and a pulse wave is measured by starting operation by the switch unit 6. At the same time, the blood viscosity value is measured using an existing viscometer by the open blood method, and these data are input by the switch unit 6. This data is registered in the personal condition storage unit 13 as a personal condition. In addition, measuring a blood viscosity value using an existing viscometer by an open blood method is usually performed in a medical institution such as a hospital.
[0032]
For example, as an individual condition, it is assumed that APGindex is A3 and the blood viscosity value is ρ33. In this case, in FIG. 4, a set of data [(A1, ρ31), (A2, ρ32),... (An, ρ3n) specified by the row Y3 corresponding to A3 and ρ33 is specified as the personal correlation data. This personal correlation data corresponds to the data line of row Y3 in FIG.
[0033]
By referring to the personal conditions registered in the personal condition storage unit 13 and the correlation data stored in the correlation data storage unit 15, the personal correlation data is specified in the viscosity extracting means 17.
[0034]
After the personal condition is registered in the personal condition storage unit 13, the APG index is measured using the APG index measuring device 10, and the viscosity extracting means 17 refers to the specified personal correlation data and blood corresponding to the measured APG index. The viscosity value is extracted.
[0035]
Next, the water content calculation means 19 will be described.
With reference to the blood viscosity value obtained by the viscosity extracting means 17, the water amount calculating means 19 can calculate information on the water amount necessary for ingestion in the body, for example, according to the following program expression.
[0036]
The amount of water S required for ingestion in the body is determined by the relationship with various factors such as height L, weight W, age Ag, sex S, fat percentage B, blood viscosity value P, and intracellular / external fluid ratio IO.
[0037]
Therefore, the moisture content information is calculated by the following formula.
[0038]
Water amount required for ingestion S = coefficient K {(1-fatty ratio B) × weight W × height L × age Ag × sex coefficient MF × blood viscosity change ΔP × intracellular fluid ratio IO}
Or you may calculate using the following functions.
[0039]
Water amount required for ingestion in the body S = f1 (B) × f2 (L) × f3 (W) × f4 (Ag) × (MF) × f5 (P) × f6 (IO)
Here, the functions f1, f2, f3, f4, f5, f6, etc. may be determined based on experimental or various medical knowledge.
[0040]
The amount of water S required for in-body intake calculated by the water amount calculating means 19 is displayed on the display unit 7 together with the blood viscosity value or individually.
[0041]
Next, focusing on blood flow velocity as a blood characteristic, a case where a blood flow velocity measuring device is used as blood characteristic measuring means will be described.
[0042]
FIG. 2 is a block diagram in the case of configuring a blood viscometer using the blood flow velocity measuring device 40 as blood characteristic measuring means.
[0043]
As shown in FIG. 2, the blood flow velocity measuring device 40 includes a light emitting unit such as an LED and a light receiving unit including a photodiode or a phototransistor. A blood flow sensor 43 that detects the change of the blood flow, an amplification circuit 44 that amplifies the analog signal from the blood flow sensor 43, an A / D conversion circuit 45 that converts the analog signal from the amplification circuit 44 into a digital signal, The frequency analysis means 46 which fast Fourier-transforms (FFT) the signal from the data in the D conversion circuit 45, and the blood characteristic calculation means 47 provided in CPU11 in order to calculate the blood flow velocity as a blood characteristic.
[0044]
Next, the operation of the blood flow velocity measuring device 40 will be described.
Laser light in a wavelength region that is strongly absorbed or scattered by hemoglobin in the blood is emitted from the light emitting portion of the blood flow sensor 43. Here, the blood flow velocity measuring device 40 detects the blood flow velocity based on the detection of the Doppler effect or the detection of speckle. The reason why the laser beam is used as the irradiation light is that the wavelength width is narrow and it is effective for detecting the Doppler effect and speckle. This laser light is applied to the fingertip, undergoes a Doppler shift in accordance with the speed of hemoglobin in the blood, and then is scattered by each tissue. The scattered light has a spread in the frequency spectrum due to its randomness. Therefore, the detection light received by the light receiving unit has a spread in the frequency spectrum. This frequency spectrum distribution is detected by the frequency analysis means 46, and can be grasped as the amount of change in blood from the slope of f of this frequency spectrum.
[0045]
The signal from the light receiving unit is amplified by the amplification circuit 44 and then digitally converted by the A / D conversion circuit 45. This digitally converted signal is subjected to FFT by the frequency analysis means 46 in the CPU 11, as shown in FIG. Converted.
[0046]
Then, the blood characteristic calculation means 47 calculates the blood flow velocity. As shown in FIG. 7, the blood flow velocity is calculated by obtaining the slope of f of the frequency spectrum from the FFT conversion processing result according to the equation (P2-P1) / (f2-f1).
[0047]
The blood viscometer using the blood flow velocity measuring device 40 as the blood characteristic measuring means can function in the same manner as the blood viscometer using the blood flow velocity measuring device 40 described above.
[0048]
Alternatively, a blood flow measuring device may be used as the blood characteristic measuring means by paying attention to the blood flow as the blood characteristic. In this case, the blood flow velocity calculation method in the blood characteristic calculation means 47 when measuring the blood flow velocity can be handled as follows. That is, it calculates according to the formula of 1/2 * (P2-P1) * (f2-f1) from the result of the FFT conversion process in the frequency analysis means 46. FIG. Other than this, it is the same as the case of measuring the blood flow velocity.
[0049]
As described above, according to the embodiment of the present invention, it is only necessary to collect blood once at the beginning of use, and blood viscosity can be measured without placing a burden on the measurement subject. it can.
[0050]
Moreover, since it is not necessary to collect blood after the beginning, the measurement can be easily performed in a short time.
[0051]
Moreover, since it does not depend on blood collection fundamentally, it is not necessary to pay attention to the blood preservation performed in order to prevent blood from solidifying as in the prior art.
[0052]
In addition, it is possible to eliminate the necessity of making measurement conditions such as the environment constant in order to ensure measurement accuracy as in the prior art.
[0053]
Also, for example, a viscometer based on the principle of stirring the blood and measuring the force at that time, such as rotational viscosity, causes the blood cells to collapse when the blood is stirred. The problem of lacking can be eliminated.
[0054]
In addition, according to the embodiment of the present invention, since the moisture amount calculating means 19 is provided, it is possible to calculate information on the amount of moisture necessary for ingestion in the body and manage the replenishment amount of moisture necessary for the body. It can be useful for health management and health promotion.
[0055]
【The invention's effect】
As described above, according to the configuration of the present invention, it is possible to easily measure the blood viscosity thereafter by collecting blood only once.
[0056]
In addition, since it has a water content calculation means, it can calculate information on the amount of water required for ingestion in the body, can manage the amount of water supply necessary for the body, and can be useful for health management and health promotion. it can.
[Brief description of the drawings]
FIG. 1 is a block diagram showing a schematic configuration of an embodiment of a blood viscometer according to the present invention.
FIG. 2 is a diagram showing a schematic configuration of another embodiment of a blood viscometer according to the present invention.
FIG. 3 is a diagram showing a schematic configuration of an apparatus configuration of a blood viscometer according to the present invention.
FIG. 4 is a diagram showing correlation data composed of a row number indicating classification of personal correlation data and a blood viscosity value obtained by column numbers indicating various blood characteristic values.
FIG. 5 is a graph showing blood characteristic values (APGindex) classified by line numbers indicating the classification of personal correlation data.
FIG. 6A is a diagram showing a signal waveform of a pulse wave, and FIG. 6B is a diagram showing a signal waveform of an acceleration pulse wave obtained by differentiating the signal waveform shown in FIG.
FIG. 7 is a view showing a frequency spectrum distribution obtained by FFT processing.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Apparatus main body 3 Pulse wave sensor 10 APGindex measuring apparatus 11 CPU
13 Personal condition storage unit 15 Correlation data storage unit 17 Viscosity extraction unit 19 Moisture content calculation unit

Claims (7)

Correlation data storage unit for storing correlation data between the blood characteristic value and the blood viscosity value formed by associating the blood viscosity value with each of a plurality of blood characteristic values of the blood characteristic having a correlation characteristic with respect to the blood viscosity When,
Blood characteristic measuring means for measuring blood characteristic values;
Personal conditions for measuring the blood characteristic value by the blood characteristic measuring means at the beginning for each user and measuring the blood viscosity value with an existing viscometer under the same conditions and storing the measured blood characteristic value and blood viscosity value A storage unit;
With reference to the blood characteristic value and blood viscosity value stored in the personal condition storage unit and the correlation data stored in the correlation data storage unit, between the blood characteristic value and blood viscosity value applicable to the user Viscosity extracting means for identifying the blood correlation value corresponding to the blood characteristic value measured by the blood characteristic measuring means with reference to the identified personal correlation data,
A blood viscometer comprising: 2. The blood viscometer according to claim 1, wherein the blood characteristic is an aging value of an acceleration pulse wave, and the blood characteristic measurement unit is a measurement unit of an aging value of an acceleration pulse wave. 2. The blood viscometer according to claim 1, wherein the blood characteristic is a blood flow velocity, and the blood characteristic measurement means is a blood flow velocity measurement means. 2. The blood viscometer according to claim 1, wherein the blood characteristic is a blood flow volume, and the blood characteristic measurement means is a blood flow volume measurement means. 5. The apparatus according to claim 1, further comprising: a water amount calculating unit that calculates information on a water amount necessary for ingestion in the body from a blood viscosity value obtained by the viscosity extracting unit according to a predetermined program. The blood viscometer described. The water amount calculating means is set such that the amount of water necessary for ingestion in the body is S, the coefficient is K, the fat percentage is B, the weight is W, the height is L, the age is Ag, and the gender coefficient is MF, The amount of change in blood viscosity is ΔP, the intracellular / external fluid ratio is IO,
S = K {(1-B) × W × L × Ag × MF × ΔP × IO}
The blood viscometer according to claim 5, wherein the formula represented by: The water content calculation means sets the water content necessary for ingestion in the body as S, functions as f1, f2, f3, f4, f5, f6, fat percentage as B, height as L, weight as W, age Is Ag, gender coefficient is MF, blood viscosity is P, intracellular / external fluid ratio is IO,
S = f1 (B) × f2 (L) × f3 (W) × f4 (Ag)
× MF × f5 (P) × f6 (IO)
The blood viscometer according to claim 5, wherein the formula represented by:

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