JP3610111B2 - Electrolyte solution analyzer and electrolyte solution analysis method - Google Patents

Description

[0001]
[Industrial application fields]
The present invention relates to an electrolyte solution analyzer used for quantitative analysis of electrolyte solutions such as urine and blood.
[0002]
[Prior art]
As a means of quantitative analysis of urine and blood collected as test samples, an electrolyte solution analyzer that quantitatively analyzes these sample solutions using an ion-selective electrode has been used. Used . As shown in FIG. 10, the electrolyte solution analyzer includes a flow type measurement cell 7, a sample pot 1 connected to the inlet side of the flow type measurement cell 7 via a sample solution introduction pipe 6, and the flow type A suction pump 9 connected to the outlet side of the measurement cell 7 via a suction pipe 8 having a small diameter (for example, an inner diameter of 1 mm or less), and an electrolyte solution such as a sample solution injected into the sample pot 1 is sucked into the suction pump 9. So that the electrolyte component in the electrolyte solution is quantitatively measured by the ion selective electrode provided in the flow type measurement cell and then drained into the waste liquid tank 25. It is configured. In the figure, 2 is a sample liquid injection nozzle for injecting a sample liquid into the sample pot 1, 3 is a standard liquid injection nozzle for injecting a standard liquid for calibration into the sample pot 1, and 4 is a dilution liquid into the sample pot 1 A dilution liquid injection nozzle 5 indicates a stirrer for stirring the sample liquid or the like injected into the sample pot 1.
[0003]
By the way, in the electrolyte solution analyzer configured as described above, when the electrolyte solution is introduced into the flow type measurement cell 7 and quantitative analysis is performed, accurate analysis data is obtained when air enters the flow type measurement cell 7. I can't do that. Therefore, conventionally, in order to prevent air from entering the flow type measurement cell 7 from the sample pot 1 through the sample liquid introduction tube 6, the electrolyte solution injected into the sample pot 1 is flow-type measured through the sample liquid introduction tube 6. After introduction into the cell 7, a part of the electrolyte solution is left in the sample pot 1 for quantitative analysis.
[0004]
[Problems to be solved by the invention]
However, if the electrolyte solution remains in the sample pot 1 and the quantitative analysis is performed, the residual solution in the sample pot 1 is added to the electrolyte solution in the flow type measurement cell 7 after the measurement in the flow type measurement cell 7 is completed. It is necessary to sequentially discharge the total amount, and it is not possible to inject the next sample liquid or the like into the sample pot 1 until the discharge of the residual liquid is completed, so it takes time to process a large number of samples continuously. There was a problem.
[0005]
The present invention has been made in view of the above-described problems, and an object thereof is to provide an electrolyte concentration analysis apparatus and an electrolyte concentration analysis method capable of processing a large number of samples in a short time without reducing analysis accuracy. It is in.
[0006]
[Means for Solving the Problems]
In order to solve the above-mentioned problem, the invention according to claim 1 includes a measurement unit having a flow type measurement cell, a sample storage unit connected to the inlet side of the flow type measurement cell via a sample solution introduction pipe, A suction means connected to the outlet side of the flow type measurement cell via a suction pipe, and the electrolyte solution injected into the sample container is introduced into the flow type measurement cell by the suction force of the suction means. In an electrolyte solution analyzer for quantitatively analyzing an electrolyte component in the electrolyte solution by an ion selective electrode provided in the flow type measurement cell , Above Through the bypass pipe connected to the sample solution introduction pipe, the electrolyte solution injected into the sample container is Electrolyte solution discharging means for discharging and , A control unit for controlling operations of at least the suction unit and the electrolyte solution discharge unit; , Is provided.
[0007]
According to a second aspect of the present invention, the electrolyte solution discharge means includes at least a switching valve for selectively blocking the flow upstream from the flow type measurement cell, and the sample container through a bypass pipe connected to the switching valve. A residual liquid discharging means for sucking and discharging the residual liquid therein, and the control unit is configured to control the switching valve and the residual liquid discharging means.
[0008]
According to a third aspect of the present invention, the electrolyte solution discharge means includes a switching valve for selectively blocking a flow upstream and / or downstream of the flow type measurement cell, and bypasses the flow type measurement cell. And a bypass pipe connected to the sample solution introduction pipe.
[0009]
According to a fourth aspect of the present invention, there is provided a measurement unit having a flow type measurement cell, a sample storage unit connected to an inlet side of the flow type measurement cell via a sample liquid introduction tube, and an outlet side of the flow type measurement cell. A suction means connected via a suction tube, and the electrolyte solution injected into the sample container is introduced into the flow type measurement cell by the suction force of the suction means, and is provided in the flow type measurement cell. In the quantitative analysis of the electrolyte component in the electrolyte solution by the ion-selective electrode, an excess amount of the electrolyte solution is supplied to the sample container, and a part of the electrolyte solution is filled in the flow type measurement cell. In this case, at least the electrolyte solution remaining in the container is discharged while maintaining the electrolyte solution in the mold measurement cell, and the electrolyte solution for the next measurement is supplied to the sample container.
[0010]
[Action]
According to the first to fourth aspects of the present invention, it is possible to inject another electrolyte solution into the sample storage portion while conducting the quantitative analysis by introducing the electrolyte solution into the flow type measurement cell. A large number of samples can be processed in a short time without degrading accuracy.
[0011]
【Example】
A first embodiment of the present invention will be described below with reference to FIG.
FIG. 1 shows a schematic configuration of an electrolyte concentration analyzer according to a first embodiment of the present invention. A liquid supply unit 31 of the electrolyte concentration analyzer is an electrolyte solution such as a sample solution or a standard solution derived from a patient. In a flow type measuring cell, specifically, a dispensing means comprising a known dispensing nozzle, syringe, transport tube, etc. capable of dispensing various electrolyte solutions, and dispensing by this dispensing means A sample storage unit that stores a sufficient amount of the electrolyte solution, and an electrolyte solution introduction pipe that communicates the sample storage unit and the flow-type measurement cell to introduce the electrolyte solution.
[0012]
The measurement unit 32 forms a flow type measurement cell having an ion selective electrode in which an upstream end communicates with an electrolyte solution introduction pipe so that the electrolyte solution can flow therethrough and an electrode part is exposed in the pipe. ing.
[0013]
Various ion-selective electrodes are known, and it is preferable to arrange a plurality of types of electrodes as necessary along the pipeline.
The suction means 33 is a means for transporting a known liquid, such as a pump or a syringe, and communicates with the downstream end (exit side) of the measurement pipe of the flow type measurement cell via the suction pipe, and a sample container The liquid contained in the container is transported into the flow type measurement cell through the electrolyte solution introduction pipe, and the measured electrolyte solution is discharged from the flow type measurement cell through the suction line.
[0014]
The electrolyte solution discharge means 34 is composed of at least one pipe, and discharges the liquid in the sample storage part without passing through the measurement part. The upstream end of the pipe is upstream of the measurement part 32, preferably for measurement. It is connected so as to be directly connected to the vicinity of the upstream end of the pipe line or through a switchable valve.
[0015]
The suction source of the electrolyte solution discharging means 34 can be used as a suction means or can be connected to a separate suction means.
When the downstream end of the conduit of the electrolyte solution discharge means 34 is connected to the suction pump connected to the downstream of the flow type measurement cell, a connecting portion is provided between the downstream end of the measurement conduit and the suction means 33.
[0016]
Here, when the upper end of the electrolyte solution discharging means pipe is directly connected without a valve, it is connected to the downstream side of the measuring unit 32 via a valve or a separate suction is provided. By connecting to the means, the liquid in the sample container is selectively transported to either the measuring part 32 or the electrolyte solution discharging means 34.
[0017]
On the other hand, the downstream end of the pipe line of the electrolyte solution discharge means can be directly connected to the downstream side of the measuring unit 32 without the valve when the upstream end is connected via the valve.
The control unit 35 is connected to the liquid supply unit 31, the measurement unit 32, the suction unit 33, and the electrolyte solution discharge unit 34 described above, and discharges the suction unit 33 and the electrolyte solution so as to correspond to the operations of the liquid supply unit 31 and the measurement unit 32. The operation of the means 34 is controlled. At this time, the control unit 35 controls the suction unit 33 and the electrolyte solution discharge unit 34 to selectively transport the liquid in the sample storage unit to either the measurement unit 32 or the electrolyte solution discharge unit 34. ing.
[0018]
The control of the electrolyte solution discharge means 34 is referred to as opening / closing switching of a valve or on / off switching of a separate suction means.
According to this configuration, the following effects are achieved. That is, various electrolyte solutions such as a sample solution and a standard solution are stored in the liquid storage unit of the liquid supply unit 31 according to a command from the control unit 35. Here, the order of storing the electrolyte solution to be stored, the pretreatment such as dilution and stirring, or the amount of each dispensing is determined according to the contents set in advance in the control unit 35.
[0019]
Next, a part of the electrolyte solution in the sample storage part is guided to the measurement pipe of the flow type measurement cell through the electrolyte solution introduction pipe by the operation of the suction means 33. Here, in the flow type measurement cell, at least the measurement pipe line is filled with the electrolyte solution to be measured at this time, preferably at a flow rate at which the measurement pipe line, particularly the ion-selective electrode is sufficiently familiar. However, since the excess electrolyte solution still remains in the sample container, there is no possibility that air bubbles may be mixed into the measurement pipe.
[0020]
Next, the control unit 35 controls the electrolyte solution discharging unit 34 and the suction unit 33, so that the electrolyte solution in the sample storage unit and the electrolyte solution introduction tube is removed from the electrolyte solution discharging unit 34 while maintaining the electrolyte solution in the measurement pipe line. It discharges through the pipe line. Subsequently to this, the control unit 35 controls the liquid supply unit 31 for the next electrolyte solution according to the predetermined measurement contents until the measurement of the current electrolyte solution is completed in the flow type measurement cell. Next, the next electrolyte solution is placed in a standby state in which the sample solution is accommodated in the sample container and the electrolyte solution introduction tube.
[0021]
On the other hand, the electrolyte solution in the measurement cell is measured within an appropriate measurement time so that an output corresponding to the concentration related to a predetermined ion species can be obtained by the ion selective electrode. Here, the measurement time by the ion selective electrode is appropriately determined according to the type of the electrode, the exposed area of the sensitive film, and the like. Therefore, the control of the electrolyte solution discharge means 34 and the suction means 33 is set according to the measurement time in the control unit 35. Thereby, the measurement process of the ion concentration by the measurement unit 32, the discharge of the electrolyte solution for the current measurement by the electrolyte solution discharge means 34, and the standby of the electrolyte solution for the next measurement by the liquid supply unit 31 are efficiently processed in parallel.
[0022]
When the ion measurement in the measurement unit 32 is completed, the control unit 35 performs suction so that the electrolyte solution in the measurement pipe is discharged downstream of the measurement cell while the operation of the electrolyte solution discharge means 34 is stopped. The means 33 is controlled. At this time, the electrolyte solution for the next measurement that has been waiting in the sample storage portion and the electrolyte solution introduction pipe is introduced into the measurement pipeline following the electrolyte solution measured this time.
[0023]
As described above, a plurality of electrolyte solutions can be continuously and rapidly measured under high-precision measurement conditions by the same operation.
Next, a second embodiment of the present invention will be described with reference to FIGS. In FIG. 2, 1 is a sample pot as a sample container, 2 is a sample solution injection nozzle for injecting a predetermined amount of sample solution into the sample pot 1, and 3 is a standard solution injection for injecting a predetermined amount of standard solution into the sample pot 1 Nozzle 4 is a diluent injection nozzle for injecting a predetermined amount of diluent into the sample pot 1, and 5 is a stirrer for stirring the sample liquid injected into the sample pot 1. One end of the liquid introduction pipe 6 is connected.
[0024]
The other end of the sample solution introduction tube 6 is Na contained in the sample solution. ⁺ Are connected to an inlet portion of a known flow type measurement cell 7 for measuring at least one kind of ion concentration by an ion selective electrode, and injected into the sample pot 1 at the outlet portion of the flow type measurement cell 7. A suction pump 9 as a suction means for sucking the sample solution and standard solution is connected via a suction tube 8.
[0025]
Reference numeral 10 denotes an electrolyte solution discharge unit that discharges the sample solution and standard solution injected into the sample pot 1 by bypassing the flow type measurement cell 7, and this electrolyte solution discharge unit 10 is provided in the middle of the sample solution introduction pipe 6. And a bypass pipe 12 connected to the switching valve 11 and a residual liquid discharge pump 13 that sucks and discharges the residual liquid in the sample pot 1 through the bypass pipe 12. Further, the suction pipe 8 and the bypass pipe 12 are both connected to a common waste liquid tank 26 downstream of the pumps 9 and 13.
[0026]
In the above configuration, for example, the sample liquid injected into the sample pot 1 is stirred and mixed with the diluent, and then introduced into the flow type measurement cell 7 by the suction force of the suction pump 9, and then the switching valve 11 is switched. When the residual liquid discharge pump 13 is driven, the residual liquid in the sample pot 1 is bypassed through the sample liquid introduction pipe 6, the switching valve 11, the bypass pipe 12 and the residual liquid discharge pump 13 and discharged to the waste liquid tank 26.
[0027]
Therefore, in this embodiment, since the standard solution or the sample solution to be measured next can be injected into the sample pot 1 while the measurement is performed in the flow type measurement cell 7, a large number of samples can be obtained without reducing the analysis accuracy. The sample can be processed in a short time.
[0028]
FIG. 3 is a time chart showing operating states of the sample liquid injection nozzle 2, the standard liquid injection nozzle 3, the dilution liquid injection nozzle 4, the agitator 5, the suction pump 9, the switching valve 11 and the residual liquid discharge pump 13. As shown in the figure, at time t1, injection of the sample liquid and diluent into the sample pot 1 is started, and stirring is performed by the stirrer 5 from time t2 to time t3 when a predetermined time has elapsed from time t1, and time t3 Then, the suction pump 9 is operated, and the sample liquid injected into the sample pot 1 is introduced into the flow type measurement cell 7. At time t4 when a predetermined time has elapsed from time t3, the suction pump 9 is stopped and the introduction of the sample liquid into the flow type measurement cell 7 is completed.
[0029]
At a time t4 when a predetermined time has elapsed from the time t3, the switching valve 11 is switched and the residual liquid discharge pump 13 is operated, so that the sample liquid remaining in the sample pot 1 is passed through the sample liquid introduction pipe 6, the switching valve 11, and the bypass. The liquid is discharged to the waste liquid tank 26 through the pipe 12 and the residual liquid discharge pump 13. When the time t5 at which the discharge of the sample liquid remaining in the sample pot 1 ends is reached, the residual liquid discharge pump 13 stops. At this time, the switching valve 11 is switched and the standard solution injection nozzle 3 is operated to inject the standard solution as the next measurement sample into the sample pot 1 from time t5 to time t6. At time t7 when a predetermined time has elapsed from time t5, the suction pump 9 is activated again, and the standard solution injected into the sample pot 1 is introduced into the flow type measurement cell 7 and at the same time stays in the flow type measurement cell 7. The sample liquid that has been discharged is discharged to the waste liquid tank 26. In this way, the injection and stirring of the standard solution is started before the sample solution is discharged from the flow-type measurement cell 7, and if the control is preferably completed until stirring, the next solution to be measured is measured at the end of one measurement. Therefore, it is preferable in that the processing efficiency can be further improved. Hereinafter, the measurement of the sample solution and the standard solution is alternately repeated by repeating the above-described operation.
[0030]
It should be noted that at least the diluent injection nozzle 4, preferably each of the nozzles 2, 3 and 4 has a liquid flow caused by an appropriate discharge momentum or discharge angle, and there is little variation in the measured value between samples, so the influence of contamination. In the case of analysis items that can be ignored, the stirrer 5 is not necessarily required, and the processing efficiency can be further increased by that amount.
[0031]
In the second embodiment described above, the standard solution or sample solution to be measured next is injected into the sample pot 1 while the sample solution is introduced in the flow type measurement cell 7 and the electrolyte component of the sample solution is quantified. Therefore, a large number of samples can be processed in a short time without degrading the analysis accuracy.
[0032]
When serum is quantitatively analyzed, the concentration of the standard solution at the normal serum level is affected by the contamination of the sample solution and the like measured last time without particularly washing the sample pot 1 with the washing solution. The sample solution can be analyzed quantitatively.
[0033]
Next, a third embodiment of the present invention will be described with reference to FIG. In FIG. 4, 1 is Sample container As a sample pot, 2 is a sample solution injection nozzle for injecting a predetermined amount of sample solution into the sample pot 1, 3 is a standard solution injection nozzle for injecting a predetermined amount of standard solution into the sample pot 1, and 4 is diluted in the sample pot 1 A diluent injection nozzle 5 for injecting the liquid is a stirrer for agitating the sample liquid or the like injected into the sample pot 1, and one end of the sample liquid introduction tube 6 is connected to the bottom of the sample pot 1.
[0034]
The other end of the sample solution introduction tube 6 is Na contained in the sample solution. ⁺ Are connected to an inlet portion of a flow type measurement cell 7 for measuring an ion concentration by an ion selective electrode, and a sample solution or a standard solution injected into the sample pot 1 is connected to an outlet portion of the flow type measurement cell 7. A suction pump 9 is connected as a suction means for sucking air through a suction pipe 8.
[0035]
Reference numeral 10 denotes an electrolyte solution discharge unit that discharges the sample solution and the standard solution injected into the sample pot 1 by bypassing the flow type measurement cell 7. The electrolyte solution discharge unit 10 is an inlet of the flow type measurement cell 7. An on-off valve 14 provided on the side, a branch pipe 15 branched from the sample liquid introduction pipe 5 on the upstream side of the on-off valve 14, and a residual liquid discharge for sucking and discharging the residual liquid in the sample pot 1 through the branch pipe 15 And a pump 16. Further, a waste liquid tank 26 communicates with the downstream of the suction pipe 8 and the branch pipe 15 as in the first embodiment.
[0036]
In the above configuration, for example, when the sample liquid injected into the sample pot 1 is introduced into the flow type measurement cell 7 by the suction force of the suction pump 9, the on-off valve 14 is closed and the residual liquid discharge pump 16 is driven. The sample liquid remaining in 1 is bypassed through the sample liquid introduction pipe 6, the branch pipe 15, and the residual liquid discharge pump 16 and discharged to the waste liquid tank 26. Thereby, not only can the standard solution or the sample solution to be measured next be injected into the sample pot 1 while the sample solution is analyzed in the flow type measurement cell 7, but also the next solution to be measured is already measured after the measurement is completed. Is in a state of waiting in the sample pot 1 and the sample liquid introduction pipe 6, so that a large number of samples can be continuously processed in a short time without lowering the analysis accuracy.
[0037]
When serum is quantitatively analyzed, the concentration of the standard solution at the normal serum level is affected by the contamination of the sample solution, etc. measured last time, even without washing the sample pot 1 with a washing solution. The sample solution can be analyzed quantitatively.
[0038]
Next, a fourth embodiment of the present invention will be described with reference to FIGS. In FIG. 5, 1 is a sample pot as a sample container, 2 is a sample liquid injection nozzle that injects a predetermined amount of sample liquid into the sample pot 1, and 3 is a standard solution injection that injects a predetermined amount of standard solution into the sample pot 1 The nozzle 4 is a diluent injection nozzle for injecting a diluent into the sample pot 1, and 5 is a stirrer for stirring the sample solution and the like injected into the sample pot 1. One end of 6 is connected.
[0039]
The other end of the sample solution introduction tube 6 is Na contained in the sample solution. ⁺ Are connected to an inlet portion of a flow type measurement cell 7 for measuring an ion concentration by an ion selective electrode, and a sample solution or a standard solution injected into the sample pot 1 is connected to an outlet portion of the flow type measurement cell 7. A suction pump 9 is connected as a suction means for sucking air through a suction pipe 8.
[0040]
Reference numeral 10 denotes an electrolyte solution discharge unit that discharges the sample solution and standard solution injected into the sample pot 1 by bypassing the flow type measurement cell 7. The electrolyte solution discharge unit 10 is connected to the sample solution introduction pipe 6. A first switching valve 17 provided in the middle, a second switching valve 18 provided in the middle of the suction pipe 8, and the first switching valve 17 and the second bypassing the flow type measurement cell 7. And a bypass pipe 19 connected to the switching valve 18. Further, the suction pipe 8 is connected to the waste liquid tank 27 downstream of the suction pump 9.
[0041]
In the above configuration, for example, after the sample liquid injected into the sample pot 1 is introduced into the flow type measurement cell 7 by the suction force of the suction pump 9, the first switching valve 17 and the second switching valve 18 are switched and sucked. When the pump 9 is driven, the sample liquid remaining in the sample pot 1 is bypassed through the first switching valve 17, the bypass pipe 19, the second switching valve 18 and the suction pump 9 and discharged to the waste liquid tank 27. The As a result, the standard solution or sample solution to be measured next can be injected into the sample pot 1 while analyzing the sample solution in the flow type measurement cell 7, so that a large number of samples can be obtained without reducing the analysis accuracy. It can be processed in a short time.
[0042]
FIG. 6 is a time showing operating states of the sample liquid injection nozzle 2, the standard liquid injection nozzle 3, the diluent injection nozzle 4, the agitator 5, the suction pump 9, the first switching valve 17 and the first switching valve 18 described above. As shown in the figure, at the time t1, the injection of the sample liquid and the dilution liquid into the sample pot 1 is started, and at the time t2 when the injection ends, the sample liquid is stirred until the time t3, and the time t2 At a time t3 when a predetermined time has elapsed, the suction pump 9 is activated, and the sample liquid injected into the sample pot 1 is introduced into the flow type measurement cell 7. At time t4 when a predetermined time has elapsed from time t3, the suction pump 9 is stopped and the introduction of the sample liquid into the flow type measurement cell 7 is completed.
[0043]
At a time t4 when a predetermined time has elapsed from the time t3 when the introduction of the sample liquid into the flow type measurement cell 7 is completed, the suction pump 9 is actuated again and the first switching valve 17 and the second switching valve 18 are switched, and the sample is switched. The liquid introduction pipe 6 and the suction pipe 8 communicate with each other through the bypass pipe 19. Thereby, the sample liquid remaining in the sample pot 1 passes through the sample liquid introduction pipe 6, the first switching valve 17, the bypass pipe 19, the second switching valve 18 and the suction pump 9 by the suction force of the suction pump 9. And discharged to the waste liquid tank 27. At time t5 when the discharge of the sample liquid remaining in the sample pot 1 is completed, the suction pump 9 is stopped and the first switching valve 17 and the second switching valve 18 are switched, and the sample liquid introduction pipe 6 and The suction tube 8 communicates with the flow side measurement cell 7. At the same time, the standard solution injection nozzle 3 operates to inject the standard solution into the sample pot 1. Thereafter, the measurement of the sample solution and the standard solution is alternately repeated by repeating the above-described operation.
[0044]
In the fourth embodiment described above, the standard solution or sample solution to be measured next can be injected into the sample pot 1 while the sample solution is introduced in the flow type measurement cell 7 and the electrolyte component of the sample solution is quantified. A large number of samples can be processed in a short time without degrading the analysis accuracy.
[0045]
When serum is quantitatively analyzed, the concentration of the standard solution at the normal serum level is affected by the contamination of the sample solution and the like measured last time without particularly washing the sample pot 1 with the washing solution. The sample solution can be analyzed quantitatively.
[0046]
Next, a fifth embodiment of the present invention will be described with reference to FIG. In FIG. 7, 1 is a sample pot, 2 is a sample solution injection nozzle for injecting a predetermined amount of sample solution into the sample pot 1, 3 is a standard solution injection nozzle for injecting a predetermined amount of standard solution into the sample pot 1, and 4 is a sample. A diluent injection nozzle 5 for injecting a diluent into the pot 1 is a stirrer for stirring the sample solution or the like injected into the sample pot 1. One end of a sample solution introduction pipe 6 is connected to the bottom of the sample pot 1. Has been.
[0047]
The other end of the sample solution introduction tube 6 is Na contained in the sample solution. ⁺ Are connected to an inlet portion of a flow type measurement cell 7 for measuring an ion concentration by an ion selective electrode, and a sample solution or a standard solution injected into the sample pot 1 is connected to an outlet portion of the flow type measurement cell 7. A suction pump 9 is connected via a suction pipe 8.
[0048]
Reference numeral 10 denotes an electrolyte solution discharge unit that discharges the sample solution and standard solution injected into the sample pot 1 by bypassing the flow type measurement cell 7, and this electrolyte solution discharge unit 10 is an outlet of the flow type measurement cell 7. The switching valve 20 is provided on the side, and the switching valve 20 is bypassed by the flow type measurement cell 7 and connected to the inlet side of the flow type measurement cell 7. Further, the suction pipe 8 is connected to the waste liquid tank 27 downstream of the suction pump 9.
[0049]
In the above configuration, for example, after the sample liquid injected into the sample pot 1 is introduced into the flow type measurement cell 7 by the suction force of the suction pump 9, the switching valve 20 is switched to drive the suction pump 9. The remaining sample liquid is discharged to the waste liquid tank 27 through the sample liquid introduction pipe 6, the bypass pipe 21, the switching valve 20, and the suction pump 9. As a result, the standard solution or sample solution to be measured next can be injected into the sample pot 1 while analyzing the sample solution in the flow type measurement cell 7, so that a large number of samples can be loaded in a short time without degrading the analysis accuracy. Can be processed.
[0050]
When serum is quantitatively analyzed, the concentration of the standard solution at the normal serum level is affected by the contamination of the sample solution and the like measured last time without particularly washing the sample pot 1 with the washing solution. The sample solution can be analyzed quantitatively.
[0051]
Further, in this embodiment, unlike the third embodiment shown in FIG. 4, there is no need to provide a switching valve on the inlet side of the flow type measurement cell 7, so that a large number of samples can be processed in a short time with a simple configuration. can do.
[0052]
Next, a sixth embodiment of the present invention will be described with reference to FIG. In FIG. 8, 1 is a sample pot, 2 is a sample solution injection nozzle for injecting a predetermined amount of sample solution into the sample pot 1, 3 is a standard solution injection nozzle for injecting a predetermined amount of standard solution into the sample pot 1, and 4 is a sample. A diluent injection nozzle 5 for injecting a diluent into the pot 1 is a stirrer for stirring the sample solution or the like injected into the sample pot 1. One end of a sample solution introduction pipe 6 is connected to the bottom of the sample pot 1. Has been.
[0053]
The other end of the sample solution introduction tube 6 is Na contained in the sample solution. ⁺ Are connected to an inlet portion of a flow type measurement cell 7 for measuring an ion concentration by an ion selective electrode, and a sample solution or a standard solution injected into the sample pot 1 is connected to an outlet portion of the flow type measurement cell 7. A suction pump 9 is connected via a suction pipe 8.
[0054]
Reference numeral 10 denotes an electrolyte solution discharge unit that discharges the sample solution and the standard solution injected into the sample pot 1 by bypassing the flow type measurement cell 7. The electrolyte solution discharge unit 10 is an inlet of the flow type measurement cell 7. The switching valve 22 provided on the side and a bypass pipe 23 that bypasses the flow type measurement cell 7 and connects to the outlet side of the flow type measurement cell 7. Further, the suction pipe 8 is connected to the waste liquid tank 27 downstream of the suction pump 9.
[0055]
In the above configuration, for example, after the sample liquid injected into the sample pot 1 is introduced into the flow type measurement cell 7 by the suction force of the suction pump 9, the switching valve 22 is switched to drive the suction pump 9. The remaining sample liquid is discharged to the waste liquid tank 27 through the sample liquid introduction pipe 6, the switching valve 22, the bypass pipe 23, the suction pipe 8, and the suction pump 9. As a result, the standard solution or sample solution to be measured next can be injected into the sample pot 1 while the sample solution is analyzed in the flow type measurement cell 7, so that a large number of samples can be loaded in a short time without reducing the analysis accuracy. Can be processed.
[0056]
When serum is quantitatively analyzed, the concentration of the standard solution at the normal serum level is affected by the contamination of the sample solution and the like measured last time without particularly washing the sample pot 1 with the washing solution. The sample solution can be analyzed quantitatively.
[0057]
Further, in this embodiment, unlike the third embodiment shown in FIG. 4, there is no need to provide a switching valve on the outlet side of the flow type measurement cell 7, so that a large number of samples can be processed in a short time with a simple configuration. can do.
[0058]
Next, a seventh embodiment of the present invention will be described with reference to FIG.
In the seventh embodiment, the sample pot 1 and the flow-type measurement cell 7 are arranged close to each other in the vertical direction, and these are covered with a thermostatic block 28 made of a heat conductive member, thereby completing a small analysis unit that can be controlled easily. Can do.
[0059]
The constant temperature block 28 brings both the sample pot 1 and the flow type measurement cell 7 into a constant temperature state by a known means for raising or lowering temperature (not shown) such as a heater. If necessary, the ion-selective electrodes for a plurality of items may be stacked vertically in the flow type measurement cell 7 along the pipeline. Here, the connection part of the bypass pipe 21 and the sample liquid introduction pipe 6 adopts a configuration in which no valve is interposed, thereby providing a distribution unit that has high temperature control efficiency, high accuracy, small size, and easy manufacture. Further, if such an analysis unit is configured to be removable, the analysis units for measuring the same or different ions can be appropriately replaced.
[0060]
In addition, this invention is not limited to the Example mentioned above, A various change is possible. For example, although the dilution process is performed in the above-described embodiment, the configuration for dilution process and dilution may be omitted in the case where dilution is performed in advance or measurement is performed with a stock solution.
[0061]
Even if the inner diameter of the branch pipe 15 or the bypass pipes 12, 19, 21, and 23 is larger than that of the sample introduction pipe 6 (for example, 1.5 to 2 mm), a burden is imposed on the discharge of the sample liquid from the sample pot 1. Rather, it is preferable in that the pressure balance in the pipe is improved and the discharge efficiency is increased. Here, if necessary, even if a bypass pipe is provided at the bottom of the sample pot 1 or a plurality of pipes are provided in the middle of the sample introduction pipe and the drainage operation is performed simultaneously or alternately, the processing efficiency can be further improved. Good.
[0062]
Further, if the discharge of the sample solution or the standard solution is completed during each measurement and the dispensing and discharge of only the diluted solution is also performed, contamination can be prevented more reliably. Moreover, although the suction pump is used as the suction means, other suction members such as a syringe may be used.
[0063]
【The invention's effect】
As described above, according to the present invention, it is possible to provide an electrolyte solution analysis apparatus and an electrolyte solution analysis method that can process a large number of samples in a short time without reducing the analysis accuracy.
[Brief description of the drawings]
FIG. 1 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a first embodiment of the present invention.
FIG. 2 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a second embodiment of the present invention.
FIG. 3 is a time chart for explaining the operation of the electrolyte solution discharge section of the embodiment.
FIG. 4 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a third embodiment of the present invention.
FIG. 5 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a fourth embodiment of the present invention.
FIG. 6 is a time chart for explaining the operation of the electrolyte solution discharge section of the embodiment.
FIG. 7 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a fifth embodiment of the present invention.
FIG. 8 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a sixth embodiment of the present invention.
FIG. 9 is a diagram showing a schematic configuration of an electrolyte solution analyzer according to a seventh embodiment of the present invention.
FIG. 10 is a diagram showing a schematic configuration of a conventional electrolyte solution analyzer.
[Explanation of symbols]
1 ... Sample pot
2 ... Sample liquid injection nozzle
3. Standard solution injection nozzle
4 ... Diluent injection nozzle
5 ... Agitator
6 ... Sample solution introduction tube
7 ... Flow type measurement cell
8 ... Suction tube
9 ... Suction pump
10 ... Electrolyte solution discharge part
11, 17, 18, 20, 22 ... switching valve
12, 19, 21, 23 ... Bypass pipe
13, 16 ... Residual liquid discharge pump
14 ... Open / close valve
15 ... Branch pipe

Claims (4)

A measurement part having a flow type measurement cell; a sample storage part connected to the inlet side of the flow type measurement cell via a sample liquid introduction pipe; and a suction pipe connected to the outlet side of the flow type measurement cell. The electrolyte solution injected into the sample container is introduced into the flow-type measurement cell by the suction force of the suction means, and the ion-selective electrode provided in the flow-type measurement cell In the electrolyte solution analyzer for quantitatively analyzing the electrolyte component in the electrolyte solution ,
An electrolyte solution discharging means for discharging the electrolyte solution injected into the sample container through a bypass pipe connected to the sample solution introduction pipe ;
A control unit for controlling the operation of at least the suction unit and the electrolyte solution discharging unit ;
An electrolytic solution analyzer characterized by comprising: The electrolyte solution discharge means sucks and discharges the residual liquid in the sample storage through a switching valve for selectively blocking the flow upstream from the flow type measurement cell and a bypass pipe connected to the switching valve. The electrolyte solution analyzer according to claim 1, further comprising: a residual liquid discharging unit configured to control the switching valve and the residual liquid discharging unit. The electrolyte solution discharge means includes a switching valve for selectively blocking the flow upstream and downstream of the flow type measurement cell, and the sample solution introduction pipe bypassing the flow type measurement cell. The electrolyte solution analyzer according to claim 1, further comprising a bypass pipe connected to the pipe. A measurement unit having a flow-type measurement cell; a sample storage unit connected to the inlet side of the flow-type measurement cell via a sample liquid introduction tube; and a suction tube connected to the outlet side of the flow-type measurement cell. The electrolyte solution injected into the sample container is introduced into the flow-type measurement cell by the suction force of the suction means, and the ion-selective electrode provided in the flow-type measurement cell In quantitative analysis of the electrolyte components in the electrolyte solution, an excess amount of the electrolyte solution is supplied to the sample container, and a part of the electrolyte solution is filled in the flow type measurement cell, and then the electrolyte solution is placed in the flow type measurement cell. An electrolyte solution analysis method characterized by discharging at least the electrolyte solution remaining in the container while maintaining the above and supplying an electrolyte solution for the next measurement to the sample container.

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