JP3507238B2 - Water-soluble cataplasm composition - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a water-soluble poultice composition, more specifically, a water-soluble poultice composition which is easy to handle and has good usability, and which is soluble in water and warm water when showering or bathing. It relates to a poultice composition.

[0002]

2. Description of the Related Art The effectiveness of the use of poultices for the treatment of bruise, low back pain, stiff shoulders, muscle aches, rheumatoid arthritis and the like has hitherto been known. That is, an excellent effect is recognized in addition to the effect of percutaneous absorption of the active ingredient from the adhesive plaster applied to the skin and the compressing effect due to the local cooling action of the plaster. Recently, a highly water-containing plaster mainly composed of water-soluble polymers such as polyacrylic acid, polyacrylic acid salt, sodium carboxymethylcellulose, and alginate has been developed. The release of components from the plaster and local cooling Excellent effects have been exhibited.

[0003]

[Problems to be Solved by the Invention] However, bruise, low back pain,
When the above-mentioned poultices are used for treatment of stiff shoulders, muscle aches, rheumatoid arthritis, etc., although a symptom-improving effect is observed, it is necessary to remove the poultice once applied, or if it is removed, In many cases, it was hard to say that it was uncomfortable because some parts and medicinal agents remained on the skin.

[0004]

[Means for Solving the Problems] The inventors of the present invention have diligently conducted research on the development of a new formulation in order to solve the above problems while enjoying the excellent therapeutic effects of poultices, and as a result, a water-soluble polymer has been obtained. By forming a poultice composition with two layers of an adhesive sheet layer containing the above and a non-adhesive water-soluble protective material, the poultice can be easily washed off with bath water or shower water at the time of bathing or showering. Find that you can
The present invention has been completed.

That is, the present invention provides a water-soluble poultice composition comprising two layers of (a) a water-soluble pressure-sensitive adhesive sheet and (b) a water-soluble protective material.
Furthermore, the present invention provides a water-soluble poultice composition comprising three layers of (c) a release sheet in addition to (a) the water-soluble pressure-sensitive adhesive sheet and (b) the water-soluble protective agent.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION Although the conventional poultices use a water-soluble polymer in the plaster, the plaster is not completely dissolved in water, and the non-woven fabric or woven fabric of the constituents of the poultice is used. Even when throwing away such things as trash, it becomes sticky and dirty, and the design itself does not envisage washing away.

The water-soluble pressure-sensitive adhesive sheet (a) used in the composition of the present invention is required to be water-soluble and have the pressure-sensitive adhesiveness to be applied to the skin. Here, the term "adhesiveness" means that the poultice composition of the present invention is adhered to the skin of the extension side part with the forearm of the person horizontal, and is left for at least 10 seconds when gently left with the application surface right below. Is preferred. If the adhesiveness is such that it peels off within 10 seconds, it may fall off even if it is attached to the skin.

Further, it is preferable that the pressure-sensitive adhesive sheet (a) contains a water-soluble polymer and water in order to achieve both tackiness and water solubility.

As the water-soluble polymer, a water-soluble polymer compound having a salt-forming group, a nonionic water-soluble polymer compound,
Examples thereof include emulsion polymers such as gelatin and acrylic resin emulsion. Among these, specific examples of the nonionic water-soluble polymer include polydimethylacrylamide, polyvinylpyrrolidone, polyethylene glycol monomethacrylate, poly-2-ethyl-2-oxazoline, polyvinyl alcohol, pullulan and the like. Also,
The water-soluble polymer compound having a salt-forming group is particularly preferable because it has high adhesiveness even when attached to wet skin. The salt-forming group of such a water-soluble polymer compound is not particularly limited as long as it is a group that forms a salt in the presence of an acid or a base, and any of anionic, cationic, and zwitterionic groups is used. May be Specific examples of such a salt-forming group include a carboxyl group, a sulfonic acid residue, a sulfuric acid residue, a phosphoric acid residue, a nitric acid residue, an amino group and an ammonium group. Two or more of these groups may be contained in one compound. Further, it is aesthetically preferable that these compounds have high water solubility, but even if they are cloudy, there is no particular problem.

Specific examples of the water-soluble polymer compound having such a salt-forming group include hyaluronic acid which is a mucopolysaccharide,
Sodium hyaluronate, chondroitin sulfate, sodium chondroitin sulfate, cation-modified pullulan, hemicelluloses alginic acid, sodium alginate, ammonium alginate, sodium carboxymethylcellulose, sodium carboxymethylamylose, cation-modified cellulose, etc. More preferable. As the synthetic system, one or two kinds of anionic, cationic or zwitterionic monomers are used.
Polymers of two or more kinds, or vinyl monomers of these monomers and carboxylic acids such as vinyl acetate, (meth) acrylates such as methyl methacrylate, alkyl vinyl ethers such as methyl vinyl ether, N-vinyl such as N-vinylpyrrolidone Examples thereof include copolymers with other general monomers having no salt-forming group such as cyclic amide, styrene and alkyl-substituted styrene, and a mixture of these polymers.

Examples of the anionic monomer include unsaturated carboxylic acid monomers such as acrylic acid, methacrylic acid, maleic acid and itaconic acid, their anhydrides or their salts; styrenesulfonic acid, 2-acrylamido-2-methyl. Examples thereof include unsaturated sulfonic acid monomers such as propanesulfonic acid and salts thereof; unsaturated phosphoric acid monomers such as vinylsulfonic acid and acid phosphoroxyethyl (meth) acrylate.

As the cationic monomer, dimethylaminoethyl acrylate, dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide,
(Meth) acrylic acid esters or (meth) acrylamides having a dialkylamino group such as dimethylaminopropylmethacrylamide; dimethylaminostyrene,
Styrenes having a dialkylamino group such as dimethylaminomethylstyrene; vinylpyridines such as 4-vinylpyridine and 2-vinylpyridine; or alkyl halides, benzyl halides, alkyl or aryl sulfonic acids or dialkyl sulfates thereof. And the like, which have been quaternized using a known quaternizing agent of.

As the zwitterionic monomer, N- (3
-Sulfopropyl) -N-acryloyloxyethyl-
N, N-dimethylammonium betaine, N- (3-sulfopropyl) -N-methacryloylamidopropyl-
N, N-dimethylammonium betaine, N- (3-carboxymethyl) -N-methacryloylamidopropyl-N, N-dimethylammonium betaine, N- (3-
Sulfopropyl) -N-methacryloyloxyethyl-
N, N-dimethylammonium betaine, N-carboxymethyl-N-methacryloyloxyethyl-N, N-
Examples thereof include dimethylammonium betaine.

When the salt-forming groups of these polymer compounds are not ionized, existing acids such as inorganic acids such as hydrochloric acid and sulfuric acid; acetic acid, propionic acid, lactic acid, succinic acid,
It is preferable to neutralize and ionize with an organic acid such as glycolic acid or a base, for example, tertiary amines such as trimethylamine and triethylamine; ammonia, sodium hydroxide and the like.

Among these water-soluble polymer compounds having a salt-forming group, those which are excellent in terms of low irritation to skin and ease of formulation are one or two cationic monomers. Examples thereof include polymers obtained by polymerizing one or more species, copolymers of these monomers with zwitterionic monomers and other general monomers having no salt-forming group, and mixtures of these polymers.

Among the cationic monomers, preferred are dimethylaminoethyl acrylate,
(Meth) acrylic acid esters or (meth) acrylamides having a dialkylamino group such as dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide and dimethylaminopropyl methacrylamide; alkyl halides, benzyl halides, alkyl or aryl sulfones Examples thereof include those quaternized with a known quaternizing agent such as acid or dialkyl sulfate. Among these, in particular, dimethylaminoethyl methacrylate and its quaternary compound; dimethylaminopropylacrylamide quaternary compound, or a copolymer of one or more of these monomers with the above-mentioned monomer, or a mixture thereof. Can be mentioned.

The water-soluble polymer compound having a salt-forming group has a molecular weight of 10,000 to 150 from the viewpoint of moldability.
The range of 10,000 is preferable, and the range of 100,000 to 1,000,000 is particularly preferable.

The water-soluble polymer compound having these salt-forming groups is contained in the adhesive sheet (a) in an amount of 1 to 99% by weight (hereinafter,
Simply referred to as "%"), preferably 5 to 99%.

The gelatin is more preferably hydrolyzed to a molecular weight of 20,000 to 100,000 to a high molecular weight gelatin having a normal molecular weight of about 300,000. It is also one of the preferable methods to control the solubility by appropriately blending high molecular weight gelatin and low molecular weight gelatin. A low molecular weight gelatin having a molecular weight of 20,000 or less has a low gelling ability and is preferably used in combination with a high molecular weight gelatin. The blending amount of these gelatins is preferably 1 to 70% in the adhesive sheet (a),
40% is more preferable in terms of solubility and moldability.

The polyvinyl alcohol is preferably a partially saponified product in order to increase the water solubility, but there is no problem even if modified polyvinyl alcohol modified with itaconic acid or various compounds is used. The content of polyvinyl alcohol in the adhesive sheet (a) is preferably 1 to 60%,
30% is more preferable in terms of solubility and moldability.

The pressure-sensitive adhesive sheet (a) can exhibit pressure-sensitive adhesiveness by controlling the amount of water, but when completely dried, it loses its adhesiveness, and when the amount of water is too large, it has moldability and stability. May not be retained,
Not preferable. The water content of the adhesive sheet (a) was 0.
It is preferably 1 to 60%, more preferably 1 to 30%.
As a method for measuring the water content, there are a weight reduction by drying at 80 ° C. and a test method by the Karl Fischer method, but it is preferable to measure by the Karl Fischer method in order to obtain accurate data.

If desired, polyols can be added to the pressure-sensitive adhesive sheet (a). By adding a polyol, a plasticizing effect can be obtained, which is useful for increasing the flexibility and moldability of the plaster. Here, as the polyol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, glycerin, sorbitol,
Mannitol, saccharose, diglycerin and the like can be mentioned, but propylene glycol, butylene glycol, glycerin, sorbitol and mannitol are preferable. These polyols may be used alone or in combination of two or more, and the compounding amount of the adhesive sheet (a) is preferably 1 to 80%, more preferably 1 to 50%.

The thickness of the water-soluble adhesive sheet (a) of the present invention is preferably 5 to 10000 μm, more preferably 10 to 500.
0 μm is preferable, and 20 to 1000 μm is particularly preferable.

The water-soluble protective material (b) in the present invention is preferably a water-soluble film, a water-soluble nonwoven fabric, a water-soluble woven fabric, or a water-soluble nonwoven fabric or a water-soluble woven fabric laminated with a water-soluble film. It is attached to one surface of the pressure-sensitive adhesive sheet (a). Examples of the material include a film made of gelatin, polyvinyl alcohol, pullulan, etc., a non-woven fabric, and a woven fabric. For example, polyvinyl alcohol may be mixed with a modified product of a copolymer of vinyl acetate and a vinyl monomer such as olefin or vinyl carboxylate. A modified polyvinyl alcohol derivative in which a water-soluble or water-dispersible block copolymer is mixed with polyvinyl alcohol or a compound such as itaconic acid or maleic acid is copolymerized can be used.
Denatured polyvinyl alcohol using gelatin, water-soluble protein, or polysaccharides such as dextrin and pullulan may be used. If necessary, polyvinyl alcohol may be modified by a suitable method to obtain gelatin or water-soluble protein. It may be used by enhancing the miscibility with polysaccharides such as dextran, dextrin and pullulan. That is, it is sufficient that the water-soluble protective material (b) has no tackiness by itself, can protect one surface of the water-soluble adhesive sheet (a), and can be formed into a film. In addition, the processing form is not limited, as well as the additive and the modification method for improving the solubility and stability in bath water.

Also, a sheet obtained by processing polyvinyl alcohol into a fibrous shape and subjecting it to a non-woven fabric processing or a spinning processing can protect one side of the water-soluble pressure-sensitive adhesive sheet (a) of the present invention, and therefore it can be mentioned as a preferred example. it can. When processing polyvinyl alcohol into a fibrous form, necessary modifications and conditions of additives are in conformity with the above polyvinyl alcohol film, and it does not have tackiness by itself and dissolves in cold water to warm water to give an adhesive sheet (a Needless to say, it is acceptable if the protection of () is possible. Examples of the sheet obtained by processing polyvinyl alcohol into a fibrous shape and subjecting it to non-woven fabric processing or woven fabric processing are disclosed in JP-A-7-42019 and JP-A-5-32.
1105, JP-A-3-86530, JP-A-3-27
9410, JP-A-3-199408, JP-A2-1
Examples of the water-soluble polyvinyl alcohol fiber are shown in No. 12406 and the like. That is, a non-woven fabric or a woven fabric which is excellent in water solubility, dissolution rate and water dispersibility at low temperature, and which does not shrink even in a high humidity state and does not shrink is preferable.

The water-soluble protective material (b) is preferably as thin as possible if it can be dissolved in cold water to hot water to protect the adhesive sheet (a). The thickness of the film is 1 to 30.
00 μm is preferable, and 10 to 1000 μm is more preferable. Needless to say, a film or a non-woven fabric surface that is appropriately embossed to improve solubility and the like is preferable for the purpose of the present invention.

The water-soluble poultice composition of the present invention comprises (a)
It consists of two layers of water-soluble adhesive sheet and (b) water-soluble protective material, but when washed with bath water or shower water,
It is desirable not to block the drain of the washbasin or bathroom. Water-solubility of the sheet (a) and the protective material (b) of the present invention means that 1 to 50 g of the poultice composition is added to 5 L of normal water at 40 ° C. and lightly stirred within 20 minutes. It is preferably dispersed, mixed or dissolved and passed through the Japanese Pharmacopoeia Standard Sieve No. 1.

The water-soluble poultice composition of the present invention also comprises
A water-soluble pressure-sensitive adhesive sheet (a) having a water-soluble protective material (b) on one surface thereof, and a release sheet (c) added to the other surface of the water-soluble pressure-sensitive adhesive sheet (a) to form a three-layer structure. By doing so, the usability is further improved. This release sheet (c)
Examples of the material include a film made of polyethylene, polyethylene terephthalate, polypropylene, polystyrene, polyvinyl chloride, polyvinyl alcohol, saran, or the like, or a material in which paper or an aluminum thin film is surface-treated with silicon on these resins. Of these, a film made of a resin such as polyethylene or saran is preferable. The thickness of the release sheet (c) is preferably 1 to 500 μm, and 5 to 100 μm from the viewpoint of ease of use and economy.
Is particularly preferable.

The water-soluble poultice composition of the present invention also comprises
It is preferable to add a cooling sensation agent and / or a warming sensation agent as a component of the water-soluble adhesive sheet (a). Examples of the cooling sensation agent used in the present invention include the following. (1) l-menthol, camphor, thymol (2) menthol derivative

[0030]

[Chemical 1]

(Wherein A represents a single bond or an alkylene group having 1 to 8 carbon atoms, R ² represents an alkyl group having 1 to 8 carbon atoms) or HOOC- (CH ₂ ) _m -CO- (formula Where m represents a number from 0 to 6)] (3) The following compounds

[0032]

[Chemical 2]

(In the formula, R ³ and R ⁴ each represent a hydrogen atom or an alkyl group having 1 to 8 carbon atoms or a hydroxyalkyl group) (4) Monocyclic compound

[0034]

[Chemical 3]

(R ³ and R ⁴ have the same meanings as described above)
R ⁵ represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n represents an integer of 0 to 5] (5) Bicyclic compound

[0036]

[Chemical 4]

(In the formula, Y is --OH, --COOH or --COOR ² (R
² has the same meaning as above), R ⁶ represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and l represents 1 or 2) (6) Tricyclic alcohol

[0038]

[Chemical 5]

(In the formula, R ⁷ represents a hydrocarbon group having 1 to 8 carbon atoms, and the dotted line represents a single bond or a double bond)

[0040]

[Chemical 6]

(In the formula, one of R ⁸ and R ⁹ is a hydrogen atom and the other is a hydrocarbon group having 1 to 8 carbon atoms, or both are hydrocarbon groups having 1 to 8 carbon atoms, Or R ⁸ and R ⁹
Together form a ring having 2 to 6 carbon atoms. R ¹⁰ represents a hydrogen atom or a hydrocarbon group having 1 to 8 carbon atoms.) (7) Tricyclic amide

[0042]

[Chemical 7]

(In the formula, R ¹¹ and R ¹² are the same or different and each is a hydrogen atom, a hydrocarbon group which may be substituted with a hydroxy group, a lower alkoxy group or a lower alkoxycarbonyl group, or a hydroxy group or a lower alkoxy group. A phenyl group substituted with a group, or R ¹¹ and R ¹² together form a ring having 2 to 6 carbon atoms which may further contain an oxygen atom together with the adjacent nitrogen atom)

These cooling sensitizers are preferably added in the composition of the sheet (a) in an amount of 0.01 to 5%, particularly 0.1 to 2%.

As the warming agent, capsicum tincture,
Capsicum extract, vanillyl nonanoate, benzyl nicotinate, methyl nicotinate, phenyl nicotinate,
Examples thereof include nicotinic acid derivatives such as tocopherol nicotinate, capsaicin, Dutch pepper extract, salamander extract, and ginger extract. The blending amount of these warming agents in the sheet (a) is preferably 0.0001 to 15%, more preferably 0.0005 to 5%.

In the composition of the water-soluble pressure-sensitive adhesive sheet (a), general-purpose raw materials usually used for poultices can be added. Such raw materials include steroidal anti-inflammatory drugs such as prednisolone and dexamethasone; indomethacin, flufenamic acid, mefenamic acid, ibuprofen,
Non-steroidal anti-inflammatory drugs such as methyl salicylate, glycol salicylate and acetylsalicylic acid; antihistamines such as triterenamine, chlorpheniramine maleate and diphenhydramine; sulfa drugs such as sulfamonomethoxine and sulfamethizole; penicillin, cephalospo Antibiotics such as phosphorus, erythromycin, tetracycline, chloramphenicol, streptomycin;
Antifungal agents such as naphthiomate and clotrimazole; 5-
Anti-neoplastic agents such as fluorouracil, cyclophosphamide, busulfan and actinomycin; narcotics and analgesics such as morphine, codeine, nalorphine and pentazocine;
Psychoactive drugs such as prostaglandins, chlorpromazine, reserpine; sojutsu, juniper, valerian, kaygai, koboku, senkyu, spruce, touki, jasmine, ginger, carrot, cinnamon, peony, mint, sardine, sardine, butterbur,
Dokukatsu, Shobu, Gayou, Matsuba, Jakushi,
Deer, camphor, saffron, psyllium, fennel,
Chimpi, can peel, chamomile, peach leaf, rosemary,
Herbs such as melissa, horse chestnut, arnica, and sage, herbal medicines, and herbs are included. In addition, drugs used for systemic drug delivery systems (drug delivery systems, DDS) can also be used. Examples of such drugs include angina drugs, antiarrhythmic drugs, cardiovascular drugs such as antihypertensive drugs, and hormone preparations. Other than these, all drugs that can be used for poultices can be used.

To prepare the water-soluble poultice composition of the present invention, for example, the water-soluble adhesive sheet (a) is prepared by adding purified water to gelatin to swell it, and then heating and dissolving it to give polyglycerin. A mixture of a solvent and a medicinal component such as is spread on a horizontal plate to a thickness of 1 to 2 mm, a polyvinyl alcohol water-soluble film having a thickness of about 40 μm is laminated on one surface, and after cooling, If necessary, the release sheet (c) can be laminated on the other surface of the sheet (a) and cut into an appropriate size to be manufactured. Industrially, a plaster machine is required,
For example, it can be produced by coating the water-soluble protective material (b) made of a water-soluble film of polyvinyl alcohol on the water-soluble protective material (b), cooling it, and then cutting it into a suitable size.

[0048]

According to the present invention, by designing a water-soluble adhesive sheet and a water-soluble protective material into two layers, it is soluble in water or warm water and has a tackiness even if it is a finger when handling. It is possible to obtain a water-soluble poultice composition which is excellent in usability without sticking to the skin. In addition, the release sheet (c) is added to the back surface of the water-soluble pressure-sensitive adhesive sheet (a) to form three layers, so that the usability is further improved.
When the water-soluble adhesive sheet and the water-soluble protective material are designed for two layers, the adhesive surface is attached to the inside of the packaging bag, making it easier to handle when opening and removing unnecessary dust such as release paper. It has the effect of not releasing it. The water-soluble poultice of the present invention can be peeled off or stuck on the site of stiff shoulders, low back pain, and muscle pain, and after a predetermined time to bring an effect, like a conventional poultice, or a patch is applied. It can also be dissolved in bath water or shower water as it is. Unlike conventional poultices and plasters, the water-soluble poultice of the present invention saves the trouble of peeling the plaster from the skin after use, and for the rest of the plaster or the medicinal agent when peeled off, use a shower or bath water. It can be easily washed off and can provide a preparation which is comfortable and has a good feeling in use.

[0049]

EXAMPLES Next, the present invention will be described with reference to examples, but the present invention is not limited to these examples.

Formulation Example (Examples 1, 2 and 5) Purified water was added to gelatin according to the formulation shown in Table 1 (a) and allowed to swell sufficiently at room temperature, then heated to 60 ° C and stirred. While the remaining components shown in (a) were added and mixed, the mixture was spread into a sheet having a thickness of about 1.5 mm. After spreading, the polyvinyl alcohol film shown in (b) prepared to have a thickness of 30 μm or the polyvinyl alcohol nonwoven fabric prepared to have a thickness of 150 μm is laminated, solidified, and then cut into 7 × 12 cm (a) water-soluble About 11.7 g of (1) adhesive sheet, and
About 12 g of a water-soluble poultice consisting of 3 g was prepared and packaged in a bag made of an aluminum laminated film.

Example 3 Purified water was added to gelatin according to the formulation shown in (a) of Table 1 to allow it to swell sufficiently at room temperature, and then the mixture was heated to 60 ° C. and stirred with an aqueous polyacrylic acid solution ( (10% of pure content) and sodium polyacrylate were added, the viscosity was increased with stirring, the remaining components shown in (a) were added and mixed, and then spread into a sheet having a thickness of about 1.5 mm. . After spreading, the polyvinyl alcohol film shown in (b) prepared to have a thickness of 30 μm was laminated, and after solidification, 7 ×
The same water-soluble poultice as in Examples 1, 2 and 5 was prepared by cutting it into 12 cm pieces and packaged in a bag made of an aluminum laminated film.

Example 4 Purified water was added to the polyvinyl alcohol shown in (a) of Table 1 to swell it, and the mixture was heated to 70 ° C. and thickened with stirring, and then shown in (a). The remaining components were added and mixed, and then spread into a sheet having a thickness of about 1.5 mm. After spreading, the polyvinyl alcohol films shown in (b) having a thickness of 30 μm were laminated, solidified, and then cut into 7 × 12 cm to prepare water-soluble poultices similar to those in Examples 1, 2 and 5. Then, it was packaged in a bag made of an aluminum laminated film.

[0053]

[Table 1]

(Examples 6 to 10) As to Examples 1 to 5, (a) a water-soluble adhesive sheet was spread on a polyethylene film of a protective material (thickness: 50 μm) of (c),
(B) Covering with a water-soluble release sheet, a water-soluble poultice composition was prepared, solidified, cut into 7 × 12 cm, and packaged in a bag made of an aluminum laminated film.

(Comparative Examples 1 to 5) Regarding Examples 1 to 5,
A water-soluble poultice composition was prepared without being covered with the protective material of (b), solidified, cut into 7 × 12 cm, and packaged in a bag made of an aluminum laminated film.

Comparative Example 6 A commercially available poultice (New Patex A; manufactured by Daiichi Pharmaceutical Co., Ltd.) was cut into 7 × 12 cm and used.

Experimental Examples For the water-soluble poultices of Examples 1 and 10 and Comparative Example 1 and the commercially available poultice (New Patex A) of Comparative Example 6, 1
We asked 0 subjects to actually use it, and examined the effect and feeling of use. (Usage) A bag made of an aluminum laminated film is broken, and the water-soluble poultices of Example 1 and Comparative Example 1 and a commercially available poultice (New Patex A) are taken out from the bag and attached to a shoulder, and after 8 hours, After being washed off with a shower at 35 to 40 ° C. on the skin, the effect on stiff shoulders, the solubility in the shower, and the usability were investigated.

(Results) The results are shown in Tables 2 to 5. Numerical values in the table indicate the number of panelists who answered as in each evaluation item.

[0059]

[Table 2]

[0060]

[Table 3]

[0061]

[Table 4]

[0062]

[Table 5]

As is clear from the above results, the water-soluble poultice composition of the present invention had an extremely high effect on stiff shoulders as compared with commercially available poultices. Also,
By covering with a protective material composed of a water-soluble film or a non-woven fabric, it was easy to stick to the skin and was extremely easy to use.

(Examples 11 to 19) Purified water was added to each polymer and swollen at room temperature according to the formulation shown in (a) below, and the remaining components shown in (a) were stirred while stirring. In addition, after mixing, it was spread on a polyethylene film whose surface was treated with silicon into a sheet having a thickness of about 1.5 mm. After spreading, put it in a dryer at 110 ° C, take samples over time during drying, measure the water content by the Karl Fischer method, and dry it so that the water content of the spread plaster is 15%. did. Water-soluble non-woven fabric composed of maleic acid-modified polyvinyl alcohol (polymerization degree: 1400) on the surface of the semi-cured dried material (fiber thickness: 15 μm, fiber melting temperature: 1
℃, Nonwoven fabric thickness: 170μm, Nonwoven fabric weight: 25g
/ M ² ) of polyvinyl alcohol film (degree of polymerization: 1
Sheets obtained by laminating 500) were laminated, cut into 10 × 7 cm, and then loaded into a packaging material made of a polyethylene film laminated with aluminum foil to manufacture.

[0065]

[Table 6]

Examples 11 and 18 Poly-2-acrylamido-2-methylpropanesulfonic acid (molecular weight 500,000) Examples 12 and 19 Polymethacryloyloxymethylsuccinic acid (molecular weight 20)
Example 13 Na Styrene Sulfonate Polymer (Molecular Weight 100,000) Example 14 Methacrylic Acid Polymer (Molecular Weight 200,000) Example 15 Polymethacryloyloxyethyltrimethylammonium Chloride (Molecular Weight 400,000) Example 16 Polymethacryloyloxy Ethyldimethylammonium diethylsulfate (molecular weight 300,000) Example 17 Polymethacryloylamidopropyltrimethylammonium chloride (molecular weight 300,000) / Polyacrylamidopropyltrimethylammonium chloride (molecular weight 3)
0,000) Copolymer

Each of the water-soluble poultices of Examples 11 to 19 had high adhesiveness to the skin and good solubility in the shower, and was extremely easy to use.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Keiko Morioka, 2606, Akabane, Kai-cho, Haga-gun, Tochigi Prefecture, Kao Institute of Stock Companies (72) Inventor, Hidenori Man, 2606, Akabane, Kai-cho, Haga-gun, Tochigi, Institute of Kao Stock Companies (72) Inventor Michitaka Sawada 1334 Kao Co., Ltd., Minato, Wakayama City, Wakayama Prefecture (72) Inventor Tadashi Iwasaki 1334 Kao Co., Ltd., Minato, Wakayama City, Wakayama Prefecture (56) Reference JP-A-3-66775 (JP, A) ( 58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K 9/70 405 A61K 47/10

Claims (6)

(57) [Claims] 1. A water-soluble adhesive sheet and (b)
A water-soluble poultice composition comprising two layers of a water-soluble protective material. 2. The water-soluble poultice composition according to claim 1, wherein the water-soluble adhesive sheet (a) contains a water-soluble polymer and water. 3. The water-soluble poultice composition according to claim 2, wherein (a) the water-soluble pressure-sensitive adhesive sheet further contains a polyol. 4. The water-soluble poultice composition according to claim 2, wherein the (a) water-soluble pressure-sensitive adhesive sheet further contains a cooling sensation agent and / or a warming sensation agent. 5. The water-soluble poultice composition according to any one of claims 1 to 4, wherein the water-soluble protective material (b) is a water-soluble film, a water-soluble nonwoven fabric or a water-soluble woven fabric. 6. A water-soluble poultice composition comprising three layers: (a) a water-soluble adhesive sheet, (b) a water-soluble protective material, and (c) a release sheet.