JP3446295B2 - Urinary stone dissolver for flushing laboratory animal breeding stand and urinary stone prevention method - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dissolver for urinary stone inhibitors for laboratory animals, and more specifically, a flush-type experiment in which flush water is made to flow at regular intervals to wash away the excrement of feces and urine discharged from the laboratory animals. The present invention relates to a dissolver for a drug that effectively prevents urine stones from adhering to the "toy" of the urine receiver of the gantry by adding minute amounts to the wash water of the gantry gantry.

[0002]

2. Description of the Related Art Laboratory animals are housed in a cage with a bottom, and this cage is installed on a pedestal equipped with a "toy" that receives the excrement of the animal excreted by the animal. The method of flushing the excrement of excrement discharged into the urine is widely adopted as a method for raising experimental animals.

However, when this gantry is used for a long time, scales called urinary stones produced by the decomposition of urine adhere firmly to the "toys" to generate a foul odor and increase the propagation of various bacteria, thus raising experimental animals. It is known to worsen the environment. Conventionally, the urinary stones had to be dissolved and removed with a strongly acidic cleaning agent at regular intervals, or physically removed by daily polishing with a steel scoop.

The inventors of the present invention also added a mixture of an acidic substance and a surfactant to the wash water of the "Toy" in minute amounts to prevent the adherence of urinary stones to the "Toy" (Japanese Patent Laid-Open No. Hei 10 (1999) -242977). No. 5-317886) and its agent are effectively dissolved in washing water (Japanese Patent Laid-Open No. 5-321314), and some of them are put to practical use.

[0005]

The method of dissolving and removing urinary stones adhering to the "toy" of a water-washable laboratory animal breeding platform with a strongly acidic detergent is a irritating gas due to the reaction between the urine stone and the detergent. The work cannot be carried out in the state where the experimental animals are bred because they generate mist or mist. In addition, when carrying out the work, it is difficult to carry out the work frequently because it is necessary to move the laboratory animals being raised to other facilities, and it is necessary to move to the “toy” for a certain period after removal. Although urinary stones are attached in a very small amount, after that, experimental animals must be kept with a large amount of attached urine stones.

On the other hand, the method of manually polishing the "toy" with a steel scraper every day is effective and has little effect on the experimental animals, but a large number of breeding personnel are required to completely carry out this work. There are few economic problems and the actual implementation.

[0007] Further, by adding a small amount of an acidic substance alone or a mixture of an acidic substance and a surfactant, which the present inventors have proposed and put into practical use, to the "Toy" by adding a minute amount to the washing water of the "Toy". The chemicals that prevent the adherence of urinary stones and the dissolver that effectively dissolves the chemicals in the wash water have no effect on the laboratory animals and are excessively labor intensive for the workers compared to the above method. It is an excellent method to prevent urinary stones, but since the dissolver is of a type that is installed and used in the wash water tank, it is not suitable for a washable laboratory animal breeding stand that does not have a wash water tank. I can not use it.

An object of the present invention is to provide a dissolver which can be installed even in a washable laboratory animal breeding stand having no wash water tank and which effectively dissolves the urolith inhibitor and adds it to the wash water.

[0009]

[Method for Solving Problems] As a result of earnest research, the present inventors installed a dissolver for storing a solid drug at the top of the "toy" of a water-washing type laboratory animal breeding stand, and It is possible to prevent the generation of urinary stones adhering to the "toy" by introducing the part into the dissolver to dissolve the drug and flowing the drug solution in which the drug is dissolved to the "toy". "
The structure is such that the dissolved water flows into the dissolver while flowing into the dissolver, and the chemical solution flows out from the dissolver after the wash water has finished flowing. The present invention has been completed based on the finding that urine stones in the "toys" can be effectively prevented because they can be poured into the "toys" without being diluted with washing water. Hereinafter, the present invention will be described in detail.

The solubilizer of the present invention is provided in the main body for accommodating a solid or liquid drug and a drug solution which is an aqueous solution in which the drug is dissolved or diluted, and the bottom or side lower part of the main part or the lower part inside the main part, and one Part into the dissolver to dissolve the drug and then to let the drug solution flow out to the "Toy" surface.

The main body may have any shape as long as it can store a medicine and a fixed amount of liquid medicine, and a preferable shape such as a cylindrical shape or a rectangular parallelepiped shape is selected depending on the structure of the gantry and the installation place.

The dissolution water inflow / outlet port is provided on the bottom surface or lower portion of the side surface of the dissolver, and may have any structure as long as the dissolution water is taken into the main body to dissolve the medicine and then the medicine solution is discharged to the "toy" surface. Can be taken. Further, it is also preferable to adopt a structure in which a tube is inserted not from the wall surface of the main body but from the upper part and the opening is the lower part of the dissolver.

In the dissolver of the present invention, if a certain amount of dissolved water flows into the main body of the dissolver at an inlet / outlet of the dissolved water, the inflow of the dissolved water is stopped, and after the outflow of the washing water flowing through the "toy" surface is stopped, the main body is stopped. It is possible to provide an opening / closing valve having a structure for allowing the drug solution therein to flow out, and a drug solution spraying device for uniformly spraying the drug solution flowing out of the dissolver onto the “toy” surface.

The on-off valve closes when a certain amount of dissolved water flows into the main body and stops the inflow of the dissolved water, and opens after the outflow of the washing water flowing on the "toy" side is stopped and the chemical liquid in the main body flows out. Although any structure can be adopted as long as it is a structure that allows the valve and the float inside the main body to be connected, and when the dissolved water in the main body reaches a certain level, the valve operates due to the buoyancy of the float and the wash water dissolver. A valve having a structure in which the inflow pressure disappears when the outflow pressure of the dissolving water is closed by the inflow pressure into the dissolving water to stop the outflow of the washing water on the “Toy” surface, and the chemical solution in the dissolving device flows out is particularly preferably used.

Since the chemical solution flowing out from the dissolver flows out due to the head pressure in the dissolver, the outflow speed is slow, and it is difficult to spread the chemical solution to the entire “Toy” surface just by letting it flow out to the “Toy” surface. is there.

There are many types of washing-type laboratory animal breeding racks, and the washing water is made to flow out from a pipe having a plurality of pores installed across the "toy" at the top of the "toy". In the case of a stand, if a chemical solution is supplied into the wash water supply pipe without installing a special device, even if the chemical solution has a slow flow rate, the chemical solution can flow out so that it spreads on the “toy” surface. It is possible to use the existing wash water outflow pipe as a chemical spraying tool without installing such a tool. However, in the case of a stand that allows flush water to flow from a thick pipe to the "Toy" at a high flow rate and then spread over the entire "Toy" surface, the chemical liquid flowing out from the dissolver can be removed from the "Toy".
It is preferable to let the drug solution flow to the "toy" side through the drug solution sprayer that spreads over the entire surface.

The drug solution sprayer used in the present invention is as follows:
Any structure can be adopted as long as it can widely spread the chemical solution on the "toy" side. A pipe having a plurality of pores installed across the "toy" at the top of the "toy" described above, a pipe having narrow slits installed in the same shape, etc. are preferably adopted.

The present invention will be described in more detail below with reference to the examples of FIGS. 1 to 27 showing one embodiment of the present invention. Figure 1,
2 and 23, the dissolver of the present invention is used to wash the "toy" by letting wash water flow out from the hole of the washing pipe installed at the top of the "toy" so as to cross the "toy" at regular intervals. FIG. 3 is an exemplary diagram when installed and used on a type of flush-type experimental animal breeding platform (hereinafter referred to as platform A). The feature of this type of breeding platform is that it requires less washing water, Since it is not possible to sufficiently wash off the excrement of animals of the "Toy" by itself, the washing water is flushed from the washing water pipe to the "Toy" and at the same time the "Toy" side is attached to the chains on both sides of the "Toy". Often used in combination with a device that automatically scrubs with a rubber wiper to wash the excrement from the "toy" and discharge it to a downstream excrement receiver, and the "toy" is often tilted at a small angle. Is mentioned.

FIG. 10, FIG. 15 and FIG. 16 are washing-type washing machines of the type in which the dissolver of the present invention is used to wash the “toy” by flowing washing water from a thick pipe installed at the top of the “toy” at regular intervals. FIG. 3 is an exemplary diagram when installed and used on a laboratory animal breeding stand (hereinafter referred to as a stand B). A feature of this type of breeding stand is that a large amount of washing water is poured on the “Toy” surface in a short time, and Since it is a method of washing the toys' manure with the force of running water and discharging it to the downstream manure receiver, there is no need for a device such as a brush or wiper, but it is necessary to forcefully flush a large amount of washing water onto the toys. "Toys" often have a relatively large inclination angle.

Although FIG. 10, FIG. 15 and FIG. 16 describe an apparatus for flowing the cleaning water by opening and closing the solenoid valve, the cleaning water can also be supplied to the upper portion of the pedestal. The tank is installed, and the cleaning water is poured little by little into the tank and the cleaning water is flushed with a siphon when the amount of water reaches a certain level.The cleaning water is stored in the tank and the float valve is operated with a solenoid valve or electromagnet at a certain time. The gantry B also includes a gantry that allows the washing water in the tank to flow by being operated.

Incidentally, FIGS. 1, 2, 23, 10, and 1
FIGS. 5 and 16 exemplify a method in which a part of the “Toy” surface is taken into the dissolver as dissolved water when the washed water flows, but as a method for supplying the dissolved water, the above-mentioned wash water storage tank is used. It is possible to adopt a method of taking a part of the water supplied to the dissolver into the dissolver, a method of attaching a solenoid valve to a dedicated pipe separate from the cleaning water, and supplying the water at regular intervals.

5 to 9 and 24 to 27 are cross-sectional views for explaining the function of the dissolver of the present invention. Either dissolver can be mounted on any of the mounts A and B depending on the installation method and the water intake method. Can also be used.

5 to 9 and 24 to 27, the shape of the main body (1) is not particularly limited as long as it is a structure capable of accommodating a drug and temporarily storing a drug solution in which the drug is dissolved.
5 to 9 and FIGS. 25 to 27, preferred shapes include a rectangular parallelepiped shape and a cylindrical shape, and in FIG. 24, a rectangular parallelepiped shape having an opening at the top and a horizontally long shape.

The capacity of the main body (1) varies depending on the width and length of the "toy", but a capacity of about 0.5 to 10 liters is preferably used. The capacity of the main body is 0.
If it is less than 5 liters, the amount of chemical solution that flows out to the “Toy” surface after the wash water has finished will be small, and the “Toy” surface will not be able to be sufficiently covered with the chemical solution, and there will be parts where urinary stones cannot be prevented. When the capacity of the main body becomes too large,
After the washing water has finished flowing out, the concentration of the chemical liquid flowing out of the dissolver on the "toy" surface decreases, and the chemical effect decreases, which is not preferable.

The dissolved water inflow / outflow port (2) is shown in FIGS.
5 and the dissolver illustrated in FIG. 26, the main body (1)
In the dissolver illustrated in FIGS. 8 and 24, it is provided at the bottom of the main body (1) below the side surface of the main body (1), and in the dissolver illustrated in FIGS. Although it is the opening of the tube inserted in (1), any structure can be adopted as long as it can take the dissolved water into the main body (1) and discharge the drug solution in which the drug is dissolved.

In each of the drawings, the case where the inflow port of the dissolved water and the outflow port of the chemical solution are integrated is shown, but the main body (1)
If the structure is such that the dissolved water is taken into the inside and the chemical liquid is discharged after a certain period of time, it is possible to adopt even if the dissolved water inlet and the chemical liquid outlet are separate. When the dissolved water inlet and the chemical solution outlet are separate, the flow of the dissolved chemical solution inflowing the chemical solution is controlled by a timer that controls the solenoid valve provided at each port, and the valve that interlocks the dissolved water inlet and the chemical solution outlet is opened and closed. Various known methods such as a method of doing can be adopted.

In FIGS. 5 to 9 and 24 to 27, the position of the dissolved water outflow port (2) is illustrated as being fixed, but in any of the dissolvers, a drug dissolution adjusting pipe ( 22) etc. are installed, the position of the dissolved water outflow inlet is adjusted according to its shape and length, the amount of dissolved water remaining in the main body after the outflow of the drug solution is adjusted, and the method of adjusting the dissolved amount of the drug is preferably adopted. It

In FIG. 5, FIG. 6, FIG. 25, and FIG. 26, an on-off valve female (5) is installed at the dissolved water inflow / outflow port,
The amount of dissolved water in the main body (1) becomes a fixed position. The buoyancy of the float (7) in the main body activates the on-off valve male (6) to close the on-off valve female (5), and the dissolved water dissolves over a certain amount. It is possible to stop the flow into the container.

In the dissolver illustrated in FIGS. 7 to 9, 24, and 27, since the dissolution water stop device is not installed, the amount of dissolution water taken into the main body is the dissolution water intake tool. It is adjusted by the structure of (8) and the thickness of the dissolved water inflow / outflow pipe. It is also preferable to install a flow control cock or the like in the middle of the dissolved water inflow / outflow pipe.

The overflow port (11) in the dissolvers shown in FIGS. 7 to 9, 24, and 27 is for preventing the surroundings from being contaminated by the overflowed chemical liquid when the inflow amount of the dissolved water is too large. The chemical liquid that has overflowed is installed in the "Toy" surface through the overflow pipe (12).

The overflow port (11) and the overflow pipe (12) should be installed as a measure against valve failure even in the dissolver having the dissolving water inflow stop valve shown in FIGS. 5, 6, 25 and 26. You can

The dissolved water intake tool (8) is not particularly limited as long as it has a structure for taking a part of the wash water, and various known structures are used according to the structure of the wash water outflow pipe. In the stand A, the washing water flows out from the small holes of the washing water outflow pipe, so that the inside of the washing water pipe is in a pressurized state.
As shown in Figure 4, it is possible to take in the wash water to the dissolver without using a special device simply by branching from the middle of the wash water pipe. It is possible to collect the wash water without any work.

In the gantry B, if the outflow speed of the wash water becomes slow, the effect of cleaning the excrement on the "toy" decreases, so an orifice for limiting the outflow speed of the wash water is installed at the outlet of the wash water outflow pipe. It is not preferable to adopt a structure in which a part of the wash water is taken in by increasing the pressure, and a structure that does not limit the wash water outflow rate such as installing an intake pipe with a receiving port in running water as shown in FIG. 11 is preferably adopted. It However, even if it has a structure that restricts the outflow of the wash water to the outlet of the wash water outlet pipe, as shown in FIGS. Any structure can be used as long as it has a structure that does not spread and the effect of cleaning the manure is not reduced.

The dissolved water intake pipe (9) is installed to introduce a part of the wash water taken by the dissolved water intake tool (8) into the dissolved water inlet (2) as dissolved water, and the dissolved water inflow is performed on the way. A quantity adjuster can be provided.

As the dissolved water intake pipe (9), various known pipe materials can be used, and a soft vinyl pipe, a soft rubber pipe, a hard vinyl chloride pipe and the like are preferably used because of easy installation.

As the medicine (4), a molded body containing an acidic substance as a main component is preferably used, but when it is added to washing water,
The component is not particularly limited as long as it is a drug that can prevent urine stones from adhering to the "toy" surface, and any drug can be used.

The drugs can be placed in the dissolver side by side one by one inside the dissolver body as shown in FIG. 23, or as shown in FIGS. It is also possible to install (3) and stack several medicines vertically. Although only one drug holder is installed in FIGS. 5 to 9, a plurality of drug holders can be installed.

The medicine holder (3) may have any structure as long as it has an opening at the bottom for allowing the dissolved water and the medicine to come into contact with each other and a guide for preventing the medicines stacked on top from falling. . The shape thereof is not limited, such as a basket-like tube and a box-like shape having slits.

The dissolution rate of the drug is controlled by the solubility of the drug, the presence or absence of the drug solution constantly stored in the dissolver, the amount of the drug solution accumulated, and how much the drug is immersed in the accumulated drug solution. It is adjusted by a method such as whether or not to allow it.
Normally, washing of the water-washing type experimental animal breeding platform is performed at intervals of 1 to 4 hours, so if the drug is immersed in the pooled water in the dissolver, the pooled water will have a saturated concentration of the main component of the drug, In the case of a drug with an appropriate saturation solubility, the dissolver should be constructed so that a part of the drug solution is always stored in the dissolver, the drug is installed in a immersed state, and the amount of the drug solution constantly stored in the dissolver is adjusted. The method of adjusting the drug dissolution rate is preferably adopted.

Adjustment of the amount of drug solution accumulated in the dissolver at all times is as follows.
As illustrated in FIG. 7 and FIG. 9, in addition to the position of the dissolved water inflow / outflow port, a drug dissolution control pipe (2
2) is installed and the amount of the drug solution that constantly accumulates in the dissolver is adjusted according to its length and shape. As shown in FIG. 6, a plurality of dissolution adjusting holes (15) are provided between the dissolved water outlet and the drug installation part. It is preferable to employ a method of providing a drug solution storage wall (14) having the same and adjusting the amount of the drug solution that is always accumulated in the drug solution storage tank (13) by opening and closing the solution adjusting plug (16) that closes the solution adjusting hole.

In the dissolver of FIG. 6, 1 inflow of dissolved water is used.
The part has a stirring water supply pipe (2) having an air hole (21) at the top.
It is supplied to the lower part of the chemical solution storage tank (13) by 1) and has a function of stirring the highly concentrated chemical solution in the chemical solution storage tank with the inflowing dissolved water to uniformly dilute it.

The dissolver of the present invention is intended to prevent the generation of urinary stones on the "Toy" surface by dissolving a solid urine stone inhibitor in a part of the washing water and flowing it out as a chemical solution onto the "Toy" surface. When used in combination with a device that supplies a fixed amount of drug into the dissolver at regular time intervals, it can be used in the same manner as a solid drug for powder or liquid drugs.

In this case, it is preferable that a certain amount of the chemical solution always remains in the dissolver. When a liquid drug is supplied into the dissolver by a pump, etc., the amount of residual water in the dissolver due to the supply of the drug may cause the drug solution containing the drug component to flow out of the drug solution outflow hole due to overflow when it is not intended. In order to prevent this, as shown in FIGS. 25 and 26, a chemical liquid storage tank (13) having a siphon pipe (19).
A dissolver provided in the dissolver or a system in which dissolved water flows in and out by a siphon phenomenon as shown in FIG. 27 is preferably used. In the dissolver having these structures, even if a liquid drug is supplied into the dissolver, the residual drug solution in the dissolver does not flow out due to overflow from the drug solution outflow hole.

The liquid medicine supply pipe (1
8) is installed on the upper part of the main body, but the structure and installation position of the liquid drug supply pipe (18) can be adopted without particular limitation as long as the drug can be supplied to a predetermined position in the dissolver. .

The chemical solution sprayer (10) is installed when the flow rate of the chemical solution flowing out of the dissolver on the gantry B is low and the chemical solution does not spread on the "toy" surface. The chemical solution sprayer can have any structure as long as it can spray the chemical solution flowing out from the dissolver so as to spread on the “toy” surface, but usually has a pipe having a plurality of narrow holes or a narrow slit. A pipe or the like is preferably used.

When the amount of the chemical liquid to be sprayed is small, the size of the fine holes of the pipe, the interval and the width of the slits are set so that the chemical liquid is evenly distributed over the entire surface. It is preferable to have a structure in which the size is reduced, the interval is increased, or the width of the slit is reduced.

When the position of urination is habituated by the experimental animal and the portion to which the urinary stone adheres is biased, the size and intervals of the small holes and the slits are adjusted so that a large amount of the medicinal solution flows to the portion where the urine stone easily adheres. You can also adjust the width of the.

FIG. 15 and FIG. 16 are exemplary views when the dissolver having the chemical liquid spraying tool (10) is installed on the gantry B. FIG. 15 shows the position of the dissolved water intake tool (8) and the spraying tool. This is a case of a structure in which the liquid medicine flowing out of the dissolver does not flow to the water intake device but to the liquid medicine spraying device by making it higher than the branch point of the device, and FIG. 16 shows a flow path switching valve (17) at the branch of the water intake device and the spraying device. ) Is installed, the flow path to the drug sprayer (10) is closed when the dissolved water flows from the dissolved water intake device (8) into the dissolver, and the dissolved water is discharged when the drug solution flows out of the dissolver. This is a case where the flow path is closed to the water intake tool (8) and the flow path to the chemical liquid spraying tool (10) is open.

The flow path switching valve (17) may have any known structure as long as it has the above-described function, and examples thereof include the structures shown in FIGS.

[0050]

[Function] The urinary stones generated on the "toy" of the water-washable experimental animal breeding stand are those in which calcium compounds in the urine take in organic matters and feces in the urine and adhere to the "toy" surface in a scale form. Since the "Toy" is washed once every 1 to 4 hours, manure is decomposed by the action of microorganisms or dried and solidified until it is washed and removed, and it adheres to the "Toy" little by little. However, it adheres as a thick scale over time.

Although urinary stones that have grown to a thick scale over time are difficult to remove as described above, the amount of urinary stones generated in each washing is very small, and even a drug with a thin concentration is sufficient. Focusing on the fact that urine stones can be removed and the generation of urinary stones is suppressed by the presence of the chemical liquid on the "toy" surface, the urinary stones on the "toy" surface can be dissolved by dissolving a small amount of an acidic substance in the wash water. The agent for preventing the adherence of urine is a urinary stone inhibitor proposed by the present inventors.

That is, when the chemical dissolver of the present invention is installed on a water washing stand and used, a part of the washing water is taken by the water intake tool (8) every time the washing water is flown (or at regular intervals through a dedicated pipe). Is supplied to the dissolver main body (1) through the dissolved water inlet pipe (9) and the dissolved water inlet (2) into the main body of the dissolver (1) to dissolve the drug (4) installed in the dissolver. Alternatively, the high-concentration drug solution which is obtained by dissolving the drug in the dissolver is diluted to be a drug solution having an appropriate concentration and stored in the dissolver body. When the wash water stops flowing and the inflow pressure of the dissolved water to the dissolver disappears, the chemical solution flows out of the dissolver and flows out to the "toy" surface from the wash water outflow pipe or the chemical solution spraying tool (10), and the action of the chemical agent. Prevents the adherence of urinary stones, which are a mixture of calcium compounds and organic compounds, which have deteriorated the urine of experimental animals, which adhere to the "toy" surface.

Further, the inflow amount of the dissolved water into the dissolver is controlled to an appropriate amount by an on-off valve interlocked with the float, the structure of the dissolved water intake tool, and a flow rate adjusting cock provided in the middle of the dissolved water inflow / outflow pipe. Therefore, it is possible to maintain the concentration of the chemical solution at an appropriate level, and the chemical solution that flows out of the dissolver flows to the "Toy" surface immediately after the washing water is washed. Manure is washed away with wash water and is a toy
The chemical solution that is not diluted with the washing water directly contacts the urine stone with the minute amount of the urine stone adhering to the surface exposed. Therefore, urine stones can be effectively removed, and a high-concentration drug solution remains on the "toy" side, so that the generation of urine stones can be suppressed to a minimum even if the animal manure is discharged again. Is.

[0054]

EXAMPLES The present invention will be described in more detail by way of examples. However, the scope of the present invention is not limited to the following examples.

1) Dissolver and drug (Example 1) A dissolver having a structure of FIG. 6 and having a capacity of 5 liters was installed on the stand A by the water intake system of FIG. The drug was set by vertically stacking six succinic acid tablets, each of which was press-molded into a disk shape having a diameter of 5 cm and a thickness of 3 cm, in a drug holder.

Example 2 A dissolver having a capacity of 5 liters and having the structure shown in FIG. 7 was set on the pedestal A by the water intake system shown in FIG. The drug was set by vertically stacking six succinic acid tablets, each of which was press-molded into a disk shape having a diameter of 5 cm and a thickness of 3 cm, in a drug holder.

Example 3 A dissolver having a structure of FIG. 24 and having a capacity of 1 liter was installed on the stand A by the water intake system of FIG. As the drug, three succinic acid tablets, which were pressure-molded into a disk shape having a diameter of 5 cm and a thickness of 3 cm, were set side by side in a dissolver.

(Example 4) A dissolver having a structure of FIG. 27 and having a capacity of 3 liters was installed on the stand A by the water intake system of FIG. A mixed aqueous solution containing 10% malic acid, 1% ethylene oxide propylene oxide block polymer, and 0.3% sorbitan monooleate was fed into the dissolver at a rate of 15 ml / hour from a metering pump.

(Embodiment 5) A dissolver having a structure shown in FIG. 25 and having a capacity of 3 liters was installed on the pedestal B by the method of FIG. 15 with the water intake tool of FIG. A mixed aqueous solution containing 10% malic acid, 1% ethylene oxide propylene oxide block polymer, and 0.3% sorbitan monooleate was fed into the dissolver at a rate of 15 ml / hour from a metering pump.

2) Performance test-1 Fifteen rabbit cages for rabbits were installed in each row, and feces and urine were received in a "toy" provided under the cage, and 20 liters of washing water was applied by a solenoid valve once every 4 hours for 120 hours. At the same time as flowing for 2 seconds, the "Toy" surface is automatically cleaned with a brush, and excrement and urine are discharged into the drain pipe installed on the side opposite to the wash water outflow pipe. Rabbits were raised for 30 days with the drug set. In Examples 1 and 2, six drugs were replenished once every 12 days, in Example 3, three drugs were replenished once every 6 days, and in Example 4, the drug in the liquid drug tank was replenished so as not to run out. In addition, rabbits were bred on the same rack without a drug (Comparative Example 1). In addition, "Toy" completely removed urinary stones with a chemical at the start of the test.

3) Performance test-2 15 cages of rabbit cages for each stage were installed, and feces and urine were received in a "toy" provided under the cage, and 30 liters of washing water was applied by a solenoid valve once every 4 hours for 20 hours. The dissolver and the drug of Example 5 were set on the cradle B of a system in which the excrement was flowed for 2 seconds to discharge the excrement into the drain pipe installed on the opposite side of the wash water outflow pipe, and the rabbit was bred for 30 days. During the test period, the liquid in the liquid drug tank was replenished so as not to run out. In addition, rabbits were bred on the same rack without a drug (Comparative Example 2). "Toys"
Completely removed urinary stones with a drug at the start of the test.

4) Evaluation method The concentration of the drug in the waste water flowing out from the "toy" and the end of the cleaning 10 days after the start of the test and before the additional injection of the drug 6 days or 12 days after the test was started, After a minute, the concentration of the drug in the residual water of the "Toy" side was measured. In addition, the state of urinary stone adherence on the "toy" surface after 30 days was visually observed.

5) Test Results The test results are shown in Table 1, and the symbols in the table indicate the following items. Note that the drugs of Examples 1 to 3 were always left during the test period when additional drugs were added.・ Urethane attachment: After 30 days, the urinary stone adhered to the "Toy" surface ◎: No urinary stone adhered ○: Little urine stone adhered △: Urine stone adhered ×: Large urine stone adhered

[0064]

[Table 1]

[0065]

As described above, the urinary stone preventive agent dissolver for experimental animals of the present invention, as shown in Table 1, efficiently delivers a drug and a fixed amount of the drug regardless of the time after the drug is added. It is dissolved in washing water to effectively prevent urinary stones on the "Toy" side of the washing-type laboratory animal breeding stand.

INDUSTRIAL APPLICABILITY The present invention is a simple and efficient dissolver of a drug for preventing the generation of urinary stones which are generated in a "toy" of a water-washing type laboratory animal breeding stand and deteriorate the breeding environment of the laboratory animal due to the development of malodor and various bacteria. And its usage, the scientific and industrial significance is extremely great due to the improvement of test accuracy and the reduction of breeding labor.

[Brief description of drawings]

FIG. 1 shows an example of installation of a drug dissolver of the present invention (dissolver B) on an actual mount (mount A).

FIG. 2 shows an example of installation of a drug dissolver (dissolver C) of the present invention on an actual mount (mount A).

FIG. 3 is an example of a water intake tool from a wash water pipe of a gantry A.

4 is a cross-sectional view of the water intake tool of FIG.

FIG. 5 is a cross-sectional view of an example (dissolver A) of the drug dissolver of the present invention.

FIG. 6 is a cross-sectional view of another example (dissolver B) of the drug dissolver of the present invention.

FIG. 7 is a cross-sectional view of another example (dissolver C) of the drug dissolver of the present invention.

FIG. 8 is a cross-sectional view of another example (dissolver D) of the drug dissolver of the present invention.

FIG. 9 is a cross-sectional view of another example (dissolver E) of the drug dissolver of the present invention.

FIG. 10 is an example in which the dissolver B is installed on an actual stand (stand B).

FIG. 11 is a cross-sectional view of an example of a water intake tool from the wash water pipe of the gantry B.

FIG. 12 is another example of the water intake tool from the wash water pipe of the gantry B.

13 is a view showing a cross-sectional view of the water intake tool of FIG.

14 is a sectional view of the water intake device of FIG. 12 in a direction perpendicular to FIG.

FIG. 15 is an example of installing the dissolver on an actual mount (mount B) when using the chemical liquid sprayer.

FIG. 16 is an example of installation of the dissolver on an actual frame (frame B) when using the chemical solution sprayer and the flow path switching valve.

FIG. 17 is a state diagram at the time of inflow of washing water into the dissolver of the example of the flow path switching valve.

FIG. 18 is a state diagram in which the chemical solution flows out from the dissolver of the flow path switching valve of FIG.

FIG. 19 is a state diagram at the time of inflow of washing water into a dissolver of another example of the flow path switching valve.

20 is a state diagram in which the chemical solution flows out from the dissolver of the flow path switching valve of FIG.

FIG. 21 is a state diagram when wash water flows into a dissolver of another example of the flow path switching valve.

22 is a state diagram in which the chemical solution flows out from the dissolver of the flow path switching valve of FIG. 21.

FIG. 23 is an example in which one example of the drug dissolver of the present invention (dissolver F) is installed on an actual mount (mount A).

FIG. 24 is a sectional view of the dissolver F of the present invention.

FIG. 25 is a cross-sectional view of an example (dissolver G) of a dissolver for a liquid drug.

FIG. 26: Another example of dissolver for liquid drug (dissolver H)
FIG.

FIG. 27: Another example of dissolver for liquid drug (dissolver I)
FIG.

[Explanation of symbols]

(1): Main body (2): Dissolved water outflow inlet (3): Drug holder (4): Drug (5): Open / close valve female (6): Open / close valve male (7): Float (8): Dissolved water intake tool (9): Dissolved water inflow and outflow pipe (10): Chemical spray device (11): Overflow port (12): Overflow pipe (13): Chemical solution storage tank (14): Chemical liquid storage wall (15): Dissolution control hole (16): Dissolution control plug (17): Flow path switching valve (18): Liquid drug supply pipe (19): Siphon tube (20) Stirring water supply pipe (21) Air hole (22) Drug dissolution control pipe (23) O-ring (24) Wire (A): "Toys" (B): Washing water outflow pipe of the stand A (C): Wash water outflow solenoid valve (D): Washing water outflow pipe of pedestal B

─────────────────────────────────────────────────── ─── Continuation of the front page (56) References Japanese Patent Laid-Open No. 5-321314 (JP, A) Actual Development 3-31845 (JP, U) (58) Fields investigated (Int.Cl. ⁷ , DB name) A01K 1/01 A01K 1/03 B01F 1/00 C02F 5/00 C02F 5/10

Claims (4)

(57) [Claims] 1. A main body for accommodating chemicals and dissolved water, a bottom of the main body, a dissolved water outflow inlet provided at a lower part of the main body side surface or a lower part inside the main body, and part of the cleaning water is dissolved at the time of cleaning the "toy" surface. For a washable laboratory animal breeding stand characterized by having a structure in which it is taken in as water from the dissolution water inflow port into the main body, and after the outflow of washing water is stopped, the drug dissolution water is allowed to flow out from the dissolution water inflow port to the "toy" surface. Urine stone inhibitor dissolver. 2. When the amount of dissolved water in the main body reaches or exceeds a certain water level, the dissolved water inflow / outflow port is closed, and a "toy" is provided.
The urine stone inhibitor dissolver for a water-washable laboratory animal breeding stand according to claim 1, further comprising an opening / closing valve that opens the dissolution water inflow port after the outflow of the washing water flowing through the surface is stopped. 3. An on-off valve for the dissolved water inflow port is connected to a float inside the main body, and when the level of the dissolved water inside the main body reaches a certain amount, it operates by the buoyancy of the float and blocks the dissolved water outflow port with the inflow pressure of washing water, Stop the flow of wash water into the body,
It is a valve with a structure that opens when the outflow of washing water to the "Toy" side stops and the wash water inflow pressure into the main body of the dissolver disappears, and the chemical solution inside the main body flows out to the "Toy" side. The urine stone inhibitor dissolver for a water-washable laboratory animal breeding stand according to claim 2. 4. The urine stone inhibitor dissolver for a water-washable laboratory animal breeding stand according to claim 1, further comprising a drug sprayer for flowing the drug solution flowing out from the dissolution water inflow port to the "toy" surface. .