JP3422825B2 - Heat evaporation of chemicals - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for heat-evaporating a drug using a drug-containing body for heat-evaporation, and more specifically for the purpose of insecticidal, sterilizing, acaricidal, insect-proof, repellent, aroma, deodorant, etc. When heating the drug-containing body for heating and evaporation containing only the drug component or the drug together with the solvent and the additive with the heating element, the drug is indirectly heated through the heat conductive member, so that the drug can be used for a long period of time. The present invention relates to a heating evaporation method for stable and stable evaporation.

[0002]

2. Description of the Related Art Conventionally, as a heat-evaporative preparation, a method of heat-evaporating a solid, liquid or pasty medicine using a heating element has been known, and a typical example thereof is an electric mosquito trap. The electric mosquito repellent is an insecticidal mat containing a drug placed on a heating plate that is electrically heated to evaporate the drug and is used for insecticidal purposes. Further, a base material such as a fiberboard mainly composed of pulp or asbestos, which holds a chemical, is used.

In the heat evaporation method of this insecticidal mat represented by an electric mosquito trap, how to decompose the drug components and adjust the evaporation rate to stably evaporate the drug for a long time becomes a problem. . Therefore, various compounds have been conventionally known as sustained-release agents for stably evaporating a drug component over a long period of time. For example, piperonyl butoxide, butyl stearate and the like are actually used as sustained-release agents for pyrethroid insecticides, but the transpiration control of the drug is not sufficiently satisfactory. On the other hand, as a method for suppressing the decomposition of the active ingredient, it is generally known to blend an antioxidant, and Japanese Patent Application Laid-Open No. 53-121927 discloses various effective antioxidants. However, even if such a measure is taken, the residual rate of the active ingredient after heating and use is high, and a problem still remains in terms of sufficient effective use of the active ingredient. That is, in the conventional heating evaporation device, since the mat containing the drug is directly placed on the heating plate and heated, the entire mat is always kept in a higher temperature than necessary and is in contact with the heating plate. The active ingredient evaporates not only from the surface but also from the upper surface of the mat. Therefore, the amount of chemical vaporization in the early stage of heating is large, and after that, the amount of vaporization is significantly reduced
Stable transpiration cannot be obtained over a long period of time, the efficacy is reduced, and the residual rate of the drug is increased.

Further, when the temperature distribution of the heat generating plate is observed in detail, generally the surface temperature of the heat generating plate is not uniform, and there is a difference in surface temperature between the central part and the peripheral part. For example, the surface temperature of the central part of the heat generating plate is When the temperature is 170 ° C, the surface temperature of the peripheral portion is about 130 ° C. As a result, local heating of the central part of the mat occurs, which causes thermal decomposition of the active ingredient, and causes a decrease in drug evaporation efficiency and a decrease in efficacy. Further, in the conventional heat generating plate, since the surface temperature is not uniform as described above, the amount of chemical evaporation from the corresponding portion of the mat that contacts the central portion having a high surface temperature is large, and the concentration of the chemical in that portion is extremely dilute. . Therefore, most of the chemicals move to the central portion of the lower surface of the mat and evaporate. In this case, the chemicals need to move in the vertical and horizontal directions of the mat, and the moving distance becomes long, so that the chemical evaporation This is one of the factors that make it difficult to smoothly supply the drug and thus to stably evaporate the drug. Further, since the evaporation of the drug is concentrated in that portion, thermal decomposition of the drug is likely to occur, and a clogging phenomenon occurs, which hinders smooth evaporation of the drug thereafter.

As a measure for avoiding the above problems and obtaining stable drug evaporation over a long period of time, a part of the heating evaporator is immersed in the solution to absorb the solution into the heating evaporator. At the same time, various methods of heating and vaporizing the absorbed chemical liquid by heating the upper part thereof, so-called chemical liquid absorption type heat vaporization methods have been proposed. In such a chemical liquid absorption-type heat evaporation method, in order to heat the upper part of the heat evaporation body (liquid absorption core), a cylindrical heating element is surrounded by a space around the upper part of the liquid absorption core. It is installed like
1172). However, since the liquid absorbent core is indirectly heated by interposing air between the liquid absorbent core and the heating element, it slightly buffers the temperature distribution of the heating element itself, but the drug is located near the heating element, and it remains for a long time. When heated by heating, the drug is deteriorated in the heated portion above the liquid absorbent core, and a clogging phenomenon occurs due to accumulation over time, which tends to hinder the smooth evaporation of the drug near the end of evaporation. Also, the size of the absorbent core,
That is, since the surface area (heated area) of the chemical evaporation is limited by the shape of the heating element (diameter and length of the cylindrical heat radiating portion),
It has been practically difficult to increase the chemical vaporization area and to vaporize a large amount. Furthermore, in the case where a small amount of the drug is vaporized or the type of the drug is vaporized at a relatively low temperature, change the heating element temperature of the heating evaporation device or shorten the meshing distance between the heating element and the liquid absorption core to reduce the heated area. Had to be smaller. However, if the area to be heated is made small, the influence of the length of the liquid absorbent core and the temperature of the heating element on the amount of chemical evaporation will be great, and the yield will deteriorate considerably in order to guarantee the quality of the product. However, there was a limit to sharing the heating evaporation device. Even in the case of the above-described type in which the drug vaporizer is directly placed on the heat generating plate, the size of the drug vaporizer is limited by the shape of the heat generator.

[0006]

As described above, when an electrically heated heating element is used, it is very difficult to uniformly heat the drug vaporizer, and a temperature distribution is likely to occur. , The drug is severely deteriorated in the high temperature part, and the drug that deteriorates with time accumulates in the drug vaporizer, which adversely affects the drug evaporation, so that the desired drug effect cannot be obtained for a long period of time, and the efficacy is high. And the residual rate of the drug also increased. Further, the drug to be evaporated and the amount of drug evaporated per unit time are also limited by the heating element. Further, with respect to the evaporated drug, there is a problem that the drug is likely to adhere to the low temperature portion of the surface of the device for heating and evaporating, and the substantial amount of the drug is reduced. In general, when the evaporated drug comes into contact with an object having a low temperature (such as the wall of a device), the drug condensation phenomenon is likely to occur, which eventually lowers the effective evaporation rate of the drug, and the desired drug effect cannot be obtained.

Therefore, the object of the present invention is to solve the above-mentioned problems in the heat evaporation of the drug, to uniformly heat the drug-containing body, and to prevent the thermal decomposition of the drug and the deterioration of the drug-containing body such as clogging. However, it is an object of the present invention to provide a method for heating and evaporating a drug which can stably and effectively evaporate the drug over a long period of time and has an excellent effective evaporation rate. Furthermore, the object of the present invention is not limited by the shape of the heating element or the shape of the heating evaporation device, the shape of the drug-containing body can be arbitrarily set, and the kind of the drug and the amount of the drug evaporated per unit time can be freely set. It is to provide a heating evaporation method.

[0008]

In order to achieve the above object, according to the present invention, when a drug-containing body containing a drug is heated by a heating element, heat conduction between the drug-containing body and the heating element is achieved. established a sexual member contact touch to the heating element, via a heat conductive member, i.e. a drug-containing body directly or indirectly heated by the heat transferred to the heat conductive member, Ru evaporate the drug in the heating transpiration method pharmacists, the heat conductive portion
The material is formed into divided bodies, and each divided segment of the heat conductive member is
The movable part is movable and can be heated by an elastic biasing force or gravity.
Heating steam characterized by being pressed or contacted
Dispersal methods are provided. Therefore, according to the present invention, there is provided a method for evaporating a drug in the shape of the drug-containing body which is not restricted by the shape of the heat generating body serving as a heat source. According to one preferred embodiment of the present invention, the periphery of the more drug-containing material to the heat conductive member outlined surrounds, downwardly around at least a portion of the surface of the drug-containing material during the heating and / or side the heat-conducting member such that heat rising air directed upward from the person occurs
Ru space communicating is formed within. More preferably, the heat conductive member is formed in a vertically split cylindrical body.

[0009]

According to the method of heating and evaporating a drug of the present invention, the base material containing the drug, such as a conventional insecticidal mat, is heated directly on the surface of the base material in direct contact with the base material. Unlike the configuration described above, the drug-containing body is substantially indirectly heated by using a heat conductive member and, if necessary, another protective member. Thermally conductive member is placed against touch to the heating element, since the drug-containing body heat of the heating body is heated via the heat conductive member that is transmitted, a so-called equalizing the heat conductive member to form The heating section allows for more uniform heating. In addition, the heat conductive member is
By adopting a movable split structure such as
While improving, pressure is applied to the heating element by elastic biasing force or gravity.
Since they are in contact with or in contact with each other, the heat transfer efficiency is improved. Furthermore,
Around the more drug-containing material to the heat conductive member outlined surrounds not only the heat generation body surface side of the drug-containing body, with the configuration that can be heated for multifaceted, a large heated area of the drug-containing body It becomes possible. That is, by increasing the heated area of the drug-containing body, the need for local high-temperature heating is eliminated, and the temperature of the heated part of the drug-containing body is much lower than the maximum temperature of the surface of the heating element. Can be set to.

As a result, thermal decomposition of the drug during heating can be suppressed, deterioration of the evaporation surface of the drug-containing body such as clogging can be suppressed, and stable drug evaporation can be achieved for a long period of time with a high effective evaporation rate. Become. Moreover, the drug-containing body, the thermally conductive member thus together is uniformly heated, has a structure to produce a high heating effect, it is possible to effectively evaporate the drug. Further, when the drug-containing body is heated, the heat of the heating element is transmitted through the heat conductive member, so that the shape and size of the drug-containing body can be arbitrarily set without being restricted by the shape of the heating element.
Moreover, since the amount of heat transferred from the heating element can be set arbitrarily, the type of drug and the amount of drug evaporated per unit time can be easily adjusted.

[0011] Further, in the periphery of the more drug-containing material to the heat conductive member to the structure outlined surrounds the lower or lateral side of the thermally conductive member is opened, by opening the drug transpiration opening upward By forming a space that communicates with the periphery of the drug-containing body, a heat rising airflow can be generated smoothly, and the evaporated drug can be effectively diffused (evaporated). Moreover, the high insulation thermal conductivity member has, transpiration agent is prevented from adhering to the heating transpiration instrument surface, no contamination of the instrument, the effective transpiration rate of the drug is also improved, a long period of time The desired drug transpiration effect can be maintained. Moreover, the drug-containing body, since the heat is more schematic surrounded configurations to the conductive member, directly at and during storage use, can ensure not touch the drug-containing body, children (infants) are drug-containing material It is also possible to prevent accidental ingestion or accidental ingestion, and the child-proof property is improved. In addition, it is safe to handle because it does not require direct contact with the drug-containing body (medicine), especially for children with sensitive skin, and it is also safe from shocks. It is strong and advantageous in terms of drug protection. Furthermore, the surface of the drug-containing body that is directly exposed to sunlight can be reduced, the light resistance during use and storage is improved, and the drug is prevented from being decomposed by light, resulting in a stable drug evaporation effect over a long period of time. Is obtained.

[0012]

DETAILED DESCRIPTION OF THE INVENTION As the heat conductive member which can be used in the present invention, any member can be used as long as it can transfer the amount of heat necessary for evaporation of the drug, and silver, copper, gold, aluminum, brass, tungsten, iron, nickel, cobalt. Examples include metals such as zinc, manganese, duralumin, stainless steel, brass, and ceramics such as aluminum oxide, silicon oxide, magnesium oxide, and barium oxide. Further, depending on the type of the medicine and the position where the medicine is installed on the heating element, the materials mentioned below as the protective member may be used as the heat conductive member. The shape of the thermally conductive member is set arbitrarily by the heating element the shape of the drug-containing body and the heating transpiration apparatus, at least a portion of the thermally conductive member to come in contact to the heating element indirectly drug-containing material Any structure may be used as long as it can be heated selectively. Further, in order to effectively use the heat from the heating element, it is possible to prevent the heat loss and improve the thermal efficiency by covering the surface of the heat conductive member with a heat insulating material or the like.

The material of the protective member used in the present invention is desired to have heat resistance and chemical resistance depending on the chemicals used. For example, polypropylene, polyethylene, polyamide, polyethylene terephthalate, polybutylene terephthalate, polysulfone, polyacetal, melamine resin, polytetrafluoroethylene, phenol resin, unsaturated polyester resin, epoxy resin, urethane resin, methacrylic acid resin, polyarylate, Examples thereof include polyketone, polyamideimide, polyallyl sulfone, polyphenylene sulfide, polyphenyl sulfone, and polyether nitrile. In addition, a material obtained by kneading a metal powder of aluminum or the like or vapor-depositing a metal can also be used.

The method of heating and evaporating via the heat conductive member of the present invention is a method in which the drug-containing body is placed on a heating plate to evaporate the drug, or a part of the heat-evaporator is immersed in a chemical solution. It is possible to apply the method of evaporating the chemical solution by absorbing the chemical solution and heating the upper part thereof, and moreover, regardless of these methods, it is possible to use heating elements of various shapes. is there. Speaking of a more preferable evaporation method of the heating evaporation method of the present invention, only the drug, or a drug-containing body containing the drug together with the minimum necessary solvent and additives, the heat-generating body as a heat source, heat conductivity A method of uniformly heating through a member may be mentioned, but the shape of the heating element at this time is not limited as described above.

In this way, it is possible to evaporate a high-concentration drug containing only the drug component or the minimum necessary solvent.
It is more preferable because it has better thermal efficiency than the conventional chemical vapor absorption type heating evaporation method. That is, in the case of the chemical liquid absorption type, not only the evaporation of the drug but also the evaporation of the solvent is required, so unnecessary heat is used, and it takes time to reach the amount of evaporation to obtain the desired effect. On the other hand, in the method of evaporating the drug only with the drug or with the minimum solvent, the heat is required only for the evaporation of the drug, so that the thermal efficiency is very good, and the drug can be evaporated with a smaller amount of heat, and the heat generation is reduced. The power consumption of the body is low, and it is possible to save energy, and the drug-containing body is quickly heated immediately after the heating element is energized, and the rise of drug evaporation becomes very good. For example, in the case of heating and evaporating an insecticide, , A stable insecticidal effect is obtained from the beginning of use. In addition, since the solvent is not used unnecessarily, liquid leakage does not occur, and a very compact design is possible, and even when only the drug component or the solvent is used, it is used only at the minimum necessary. In the sense that it is possible to significantly reduce the adverse effect on the atmosphere due to evaporation of the solvent.

In the heat evaporation method of the present invention, the drug-containing body for heat evaporation that is preferably used is obtained by impregnating or coating a drug with an inorganic powder and / or an organic powder as a base material. As calcium hydrogen phosphate and its anhydride, calcium phosphate, calcium phosphate-based apatite, magnesium metasilicate aluminate, hydrotalside, aluminum hydroxide gel, alumina hydroxide magnesium, calcium carbonate, aluminum silicate, magnesium silicate, anhydrous silicic acid Inorganic powder such as clay, diatomaceous earth, kaolin, colloidal silica, water glass, aluminum phosphate, magnesium phosphate, gypsum, magnesia cement, tungsten, zinc oxide, red iron oxide, tungsten trioxide, zirconium oxide, and PT
Fluorine-based resins such as FE (tetrafluoroethylene resin) and PVdF (vinylidene fluoride resin), polyacetal, polyarylate, polyetheretherketone, polyethylene, polyethylene terephthalate, polycarbonate,
Nylon 6, Nylon 66, Nylon 11, Nylon 1
2. Polyamide, polyimide, polyamide-imide, polysulfone-based resin such as polysulfone / polyethersulfone, polyphenylene ether, polyphenylene sulfide, polybutylene terephthalate, polypropylene, polymethylpentene, AES resin , AS resin, ABS resin, MBS resin, crystalline cellulose, CMC, MC, starch, HPMC,
Organic powders such as HPC and HPS are exemplified. The drug-containing body for heat evaporation is a mixture of inorganic powder and / or organic powder,
It can be prepared by methods such as compression molding and extrusion molding, but the molding method is not particularly limited.
The shape of the drug-containing body for heat evaporation of the present invention is arbitrary such as flat plate, donut shape, and columnar shape.

Among the organic powders, particularly when a thermoplastic resin powder is used, the strength of the drug-containing body is improved by molding the drug-containing body and then heat-sealing it near the melting point of the thermoplastic resin powder. You can also That is, by melting the contact portion of the thermoplastic resin powder in close contact with the inorganic powder and / or the organic powder, the strength against breakage and cracking can be obtained without losing the porosity. Furthermore, since the thermoplastic resin powder has excellent water resistance and moisture resistance, it does not exhibit strength reduction even at high humidity.
It is possible to mold a drug-containing body for heat vaporization of stable quality which maintains a constant strength even under an environment of general use. Further, since the thermoplastic resin powder is stable to water, by using the chemical substance for heat evaporation of the present invention, water-based deodorant, antibacterial and fungicide, insecticide, fragrance, etc. It is possible to evaporate the liquid medicine and the emulsified drug solution.

In addition, the drug substance for heat evaporation of the present invention contains the fluidity and lubricity of powder during compression molding and extrusion molding.
In order to improve the lubricity, if necessary, as a lubricant and a lubricant within a range that does not impair the characteristics of the agent containing heat for evaporation,
Talc, stearates such as magnesium stearate and sodium stearate, amino acid lubricants such as N-lauryl-DL-aspartic acid-β-lauryl ester and N ⁶ -lauroyl-L-lysine, boric acid, liquid paraffin It is also possible to add waxes such as sodium benzoate and carbowax. Further, fibrous powder such as glass fiber or carbon fiber may be added to improve the strength of the drug-containing body for heat evaporation.

If necessary, pigments, dyes, preservatives, antioxidants, ultraviolet absorbers, flame retardants, and accidental food inhibitors are added to the heat-transpiration agent-containing body as long as its characteristics are not impaired. You may mix | blend an agent. As an antioxidant that can be blended, stearyl-β- (3,5-di-t-butyl-4
-Hydroxyphenyl) propionate, 2,2'-methylenebis (4-methyl-6-t-butylphenol), 2,2'-methylenebis (4-ethyl-6-t-)
Butylphenol), 4,4'-methylenebis (2,6
-Di-t-butylphenol), 4,4'-butylidenebis (3-methyl-6-t-butylphenol), 4,
4'-thiobis (3-methyl-6-t-butylphenol), 1,3,5-trimethyl-2,4,6-tris (3,5-di-t-butyl-4-hydroxybenzyl)
Benzene, 1,1,3-tris- (2-methyl-4-hydroxy-5-t-butylphenyl) butane, tetrakis- [methylene-3- (3 ', 5'-di-t-butyl-
4'-hydroxyphenyl) propionate] methane,
2-mercaptobenzimidazole, 1,1-bis (4
-Hydroxyphenyl) cyclohexane, N-phenyl-β-naphthylamine, N, N'-diphenyl-p-phenylenediamine, 2,2,4-trimethyl-1,2-
Dihydroquinoline polymer, 6-ethoxy-2,2,4
-Trimethyl-1,2-dihydroquinoline, 2-t-butyl-6- (3-t-butyl-2-hydroxy-5-methylbenzyl) -4-methylphenyl acrylate,
3,5-di-t-butyl-4-hydroxy-benzylphosphonate-diethyl ester, bis (3,5-di-t-butyl-4-hydroxybenzylphosphonate ethyl) calcium, tris [2- (3 ', 5'-di-t-
Butyl-4'-hydroxyhydro-cinnamoyloxyl) ethyl] isocyanurate, tris- (4-t-butyl-2,6-di-methyl-3-hydroxybenzyl)
Isocyanurate, 3,9-bis [1,1-di-methyl-2- {β- (3-t-butyl-4-hydroxy-5-
Methylphenyl) propionyloxy} ethyl] -2,
4,8,10-tetraoxaspiro [5.5] undecane, ditridecyl-3,3'-thiodipropionate,
Dimyristyl-3,3'-thiodipropionate, distearyl-3,3'-thiodipropionate, triethylene glycol-bis [3- (3-t-butyl-5-methyl-4-hydroxyphenyl) propionate ],
1,6-hexanediol-bis [3- (3,5-di-
t-Butyl-4-hydroxyphenyl) propionate], N, N′-hexamethylenebis (3,5-di-t
-Butyl-4-hydroxy-hydrocinnamamide),
2,2-thio-diethylenebis [3- (3,5-di-t
-Butyl-4-hydroxyphenyl) propionate], N, N'-bis [3- (3,5-di-t-butyl-4-hydroxyphenyl) propionyl] hydrazine, tris- (3,5-di-t -Butyl-4-hydroxybenzyl) -isocyanurate, 2,4-bis- (n
Examples thereof include compounds such as -octylthio) -6- (4-hydroxy-3,5-di-t-butylanilino) -1,3,5-triazine. These may be used alone or in combination of two or more. By adding these antioxidants, effects such as prevention of thermal deterioration during heating, prevention of oxidation, decomposition of chemicals, prevention of polymerization, and improvement of long-term stability over time can be obtained.

Further, antioxidants generally called peroxide decomposers, such as dilauryl thiodipropionate (DLTP) and distearyl thiodipropionate (D
STP) and the like may be used in combination with the antioxidant. Further, by using an ultraviolet absorber as a stabilizer, the light resistance during storage and use can be further improved.

The heating temperature of the heating and vaporizing method of the present invention is selected depending on the drug to be contained, but it is usually preferable to maintain the surface temperature of the heated portion of the drug-containing body for heating and vaporizing at 40 ° C to 200 ° C. . In addition, as a heat generation method of the heating element, a resistance heater (nichrome wire or the like), semiconductor (PTC)
A method of energizing a heater using, oxidation reaction (oxidation of metals such as iron and magnesium), hydrolysis reaction (reaction of quicklime and water, etc.), combustion heat of alcohol, gas, kerosene, wax, etc., and platinum catalyst A method of utilizing the combustion heat of the used alcohol or gas, a method of directly or indirectly utilizing other heat source, or the like is used.

The heat-evaporative drug-containing body of the present invention may contain various evaporative drugs depending on the purpose of use. For example, when used for the purpose of insecticidal, as the insecticide, it is possible to use various transpiration insecticides that have been conventionally used, such as pyrethroid insecticides, carbamate insecticides, organophosphorus insecticides and the like. You can Generally, a pyrethroid insecticide is preferably used because it is highly safe, and examples thereof include allethrin, d1 · d-T80-allethrin, d · d-T80-allethrin, and d · d-T8.
Various conventionally known pyrethroid insecticides such as 0-praletrin, phthalthrin, d-T80-resmethrin, d-T80-flamethrin, permethrin, phenothrin, fenvalerate, cypermethrin, cifenotrin, empentrin, terrarethrin, etofenprox, benfluthrin and the like. Can be used. Similarly, when used for the purpose of aroma, various natural and artificial flavors can be used, for example, animal or plant natural flavors, hydrocarbons, alcohols, phenols, aldehydes, ketones, lactones, oxides. , Artificial flavors such as esters, etc., and one of these can be used alone,
It is also possible to use a mixture of two or more kinds. Furthermore, various chemicals such as deodorants, germicides, antibacterial agents, rust preventives, acaricides, and repellents can be used depending on the purpose, as long as they can be evaporated by heating.

Then, at the time of incorporating the drug into the drug substance for heat evaporation, the minimum necessary solvent can be used for the purpose of improving the permeability or diffusibility of the drug. An aliphatic saturated hydrocarbon solvent can be used as the solvent. Examples of commercially available products include No. 0 solvent H (manufactured by Nippon Oil Co., Ltd.), No. 0 solvent M (manufactured by Nippon Oil Co., Ltd.), normal paraffin (Mitsuishi / Texaco Chemical Co., Ltd.), IP solvent 2028 (made by Idemitsu Petrochemical Co., Ltd.) and the like. Moreover, an unsaturated aliphatic hydrocarbon solvent can also be used. In addition, water, alcohols, glycol ethers such as ethylene glycol monobutyl ether, glycols, and esters such as IPM can be used.

[0024]

EXAMPLES Hereinafter, various aspects of the heat evaporation method of the present invention will be described.
Will be described in detail. 1 and 2 show an example in which a heating element having a heater eccentric type ring-shaped heat radiation portion is used, and the heat conductive member has a movable split structure. That is, the heat conductive member 3 has a structure in which the divided segments 25a and 25b that are vertically divided into two parts form a tubular body having an upper small diameter portion and a lower large diameter portion as a whole,
The upper divided end surface of each of the divided segments 25a and 25b is an inclined surface 26 so that a cutout portion that expands toward the upper end surface is formed. In addition, each divided segment 25a, 2
A taper 27 is attached to the outer surface of the upper end of 5b.
The heat conductive member 3 having such a movable two-division structure is used as a heating element.
When it is mounted on the ring-shaped heat radiation tube 28 of No. 12 , the heating element 1 has a taper 27 on the outer surfaces of the upper ends of the two divided segments 25a and 25b for easy insertion.
It can be easily inserted into the second ring-shaped heat radiation tube 28. At the time of insertion, the upper small diameter portions of the divided segments 25a and 25b slide on the inner peripheral edge of the lower end of the ring-shaped heat radiation cylinder 28, and when a lateral force is applied above the fulcrum S, the divided segments 25a and 25b fall inward. Therefore, it is easily inserted into the ring-shaped heat dissipation cylinder 28. When the insertion is further advanced, a lateral force is applied by the lower edge of the heating element below the fulcrum S to the widened portion of the lower portion of the upper small diameter portion of the divided segments 25a and 25b, so that the segment is upright. Return to the original state, both split segments 25
The outer surfaces of the upper small-diameter portions of a and 25b come into contact with the inner surface of the ring-shaped heat dissipation cylinder 28, and efficient heat conduction is performed.

It should be noted, by the shape of the divided segments of the thermally conductive member, when placed on a horizontal plane of each divided segment alone, but collapse occurs depending on the position of the center of gravity of the divided segments themselves, indicating the center of gravity is in Figure 3 When it is in the upright position or is tilted outward (indicated by the hollow arrow in the figure), it is tilted inward when it is inserted into the ring-shaped heat radiation tube of the heating element in the same manner as described above, but gravity after insertion. Stops at the most stable position, resulting in the segment 25a '
The outer surface of the upper small-diameter portion (the other divided segment is not shown) contacts the inner surface of the ring-shaped heat dissipation tube of the heating element (even if the center of gravity is in a position tilted outward, it can be maintained by the container 2 ). Further, the central portions of the two divided segments 25a and 25b are pivotally connected by a suitable connecting means (not shown) such as a pin, and the both divided segments 25a are connected by a suitable biasing means (not shown) such as a spring. , 25b, the upper small diameter portion may be urged to expand.
Also in the case of such a thermally conductive member having a movable two-divided structure, since the outer surfaces of the upper ends of the two divided segments 25a and 25b are provided with the taper 27, the biasing force in the direction of expanding the two is increased. It can be easily pushed into the ring-shaped heat dissipation tube 28, and once installed, it is attached in a direction in which the upper small diameter portions of the two divided segments 25a, 25b of the heat conductive member 3 are expanded by the elastic biasing force. It is urged and pressed against the inner surface of the ring-shaped heat dissipation cylinder 28 of the heating element 12 , and more efficient heat conduction becomes possible.

On the other hand, the container 2 is composed of a container-shaped protective member 9 having a cylindrical portion 30 projecting inwardly at the center of the bottom plate 29, and the protective member 9 is vertically arranged at the engaging step portion 7 . It has a structure that can be divided. The drug-containing body 1 is placed on the upper end surface of the cylindrical portion 30 in the container 2 , and the heat conductive member 3 having the movable two-division structure is housed so as to surround the drug-containing body 1. . In addition, an indicator function member 31 is fitted into the cylindrical portion 30 of the container 2 and has an indicator function that functions in accordance with the end of the evaporation of the drug and notifies the end of the evaporation of the drug. As such an indicator function member 31, various materials that cause a color tone change by heating can be used. For example, an electron-donating color-developing organic compound that exhibits a color tone change over time with heating, a material containing a dye that causes a color tone change by evaporation or sublimation, a sublimation agent, and the like can be used. Also, anthraquinone-based oil-soluble dyes, monoazo-based oil-soluble dyes, disazo-based oil-based dyes, triallylmethane-based oil-based dyes, naphthalimide-based oil-based dyes, anthraquinone-based disperse dyes, basic dyes, etc. Using a material containing a migration dye that migrates through the container 2
It is also possible to use a synthetic resin for the bottom plate 29 of the above, and to transfer the above migration dye to the bottom plate 29 of the container 2 by heating and to exhibit an indicator function by the change of the color tone of the bottom plate 29. As described above, the container 2 in which the drug-containing body 1 and the thermally conductive member 3 having the movable two-divided structure is housed is the middle plate portion 33 of the dome-shaped heating evaporation device 32.
It is mounted in the inwardly recessed portion formed in the above, and as described above, the upper small-diameter portion of the heat conductive member 3 is mounted in the ring-shaped heat radiation tube 28 of the heating element 12 . As a method of mounting the container 2 and the middle plate portion 33 of the heating evaporation device 32, an arbitrary method such as screwing or snap fitting can be adopted.

In the case of the configuration shown in FIGS. 1 and 2 , the heating element 1
As the internal temperature of the container 2 rises due to the heat generation of 2 ,
As shown by the arrow in the figure, a heat rising airflow is generated from the ventilation port 8 formed in the bottom plate 29 of the container 2 to the evaporation port 10 through the periphery of the drug-containing body 1 and is formed at the bottom of the peripheral wall of the heating evaporation device 32. A heat rising airflow is also generated from the formed ventilation port 34 to the evaporation port 10 through the ventilation port 35 formed in the middle plate portion 33, and the evaporation / diffusion of the drug can be performed more smoothly, and the drug-containing body 1 The heat conductive member 3 heats almost the entire circumferential surface of the heat conductive member 3 for more uniform heating, and since these are housed in the container 2 composed of the protective member 9, the heat insulating effect is excellent. Further, the elapsed time of use, the end point, or the expiration of the use period can be displayed by the indicator function member 31 with the progress of the evaporation of the drug. Further, by using the heat conductive member having the movable two-divided structure as in the above-mentioned configuration example, advantages such as improvement of the attachment property to the heating evaporation device (heating element) and improvement of heat conduction efficiency can be obtained. In particular, when a heat conductive member is inserted into a ring-shaped heat dissipation tube as shown in FIG. 2 , when the heat conductive member is a single member, or when a plurality of members are fixed, the ring is attached because of its mountability. It is necessary to configure the heat conductive member with a diameter smaller than that of the heat dissipation tube, and it is difficult to closely contact the heat generating member and the heat conductive member. On the other hand, by adopting a movable split structure as shown in FIG. 1 and FIG. 2 , the heat conductive member has improved wearability, and at the same time, the heat conductive member moves to a predetermined position so that the ring-shaped heat radiating cylinder can be moved. , Or when the divided segments are connected to each other via spring means or the like, a part of the heat conductive member is urged toward the heat generating element at the end of the attachment and is pressed against the heat generating element. As a matter of course, the heat conduction efficiency is improved by directly contacting the heat generating member and the heat conductive member, rather than by interposing the space therebetween.

The configuration example described the following is a few examples of the heating transpiration method of the invention and are not intended that the present invention is not limited to these are well, various heating transpiration apparatus, the drug-containing The structure and configuration of the body and container are arbitrary,
Various forms are available.

The following, shows the test examples, the thermally conductive member using
Concrete will be described with the effects. Test Example 1 Each of a heat-resistant plastic plate (made of polyphenylsulfone), a copper plate and an aluminum plate (24 × each) was placed on a plate-shaped heating element using a positive temperature coefficient thermistor of a commercially available heating evaporation device.
36 mm, thickness 1 mm) was placed on each plate, and the surface temperature of the upper surface of each plate was measured with a thermocouple type surface thermometer. The surface temperature of the heating element was also measured in the same manner. In addition, the temperature measuring unit has five points (FIG. 4) that divide the diagonal line of each plate or heating element into six equal parts.
Measurement) under the condition of room temperature of 25 ° C. The measurement results are shown in Table 1 and FIG.

[0030]

[Table 1]

Test Example 2 A heat-resistant plastic plate (made of polyphenylene ether), a copper plate and an aluminum plate 51 (60 × 36 mm each) were placed on a plate-shaped heating element 50 using a positive temperature coefficient thermistor of a commercially available heating evaporation device. , Thickness 1m
established m) a as shown in FIGS 6, and each plate 51
A commercially available mosquito catching mat 52 is placed on the upper surface of the heating element 50 opposite to the above, and heat evaporation is performed, and the insecticidal active ingredient that is volatilized every 3 hours is sucked and collected on silica gel, and this is collected for 12 hours. Repeated to the eye and for each sample solution extracted with acetone was quantitatively analyzed by gas chromatography. Next, the drug-containing body after heat evaporation for 12 hours was extracted with acetone, and the active ingredient was quantitatively analyzed in the same manner.
In addition, d.d-T80-praletrin was used as the insecticidal active ingredient. The results of each are shown in Table 2.

[Table 2]

As is clear from the results shown in Table 1 and FIG. 5 , the temperature distribution on the upper surface of the heating element is highest at the central portion of the heating element and lowers toward the ends. The temperature difference between the maximum temperature and the minimum temperature of the upper surface of the heating element is about 40 ° C. or higher. When a plate made of polyphenylsulfone, which has a relatively low thermal conductivity, is placed on the heating element, the on-board temperature is generally lower than the heating element surface temperature, and the temperature difference between the maximum temperature and the minimum temperature is also Although it was somewhat relaxed, it was thought that a considerable thickness was required to eliminate the temperature difference, heat loss was large, and it was unsuitable for evaporating the chemicals of a commercially available mosquito repellent mat. However, in the case of a copper plate and an aluminum plate (thickness 1 mm) having good thermal conductivity, the temperature difference was alleviated and a substantially uniform temperature distribution was obtained. Furthermore, the temperature is not entirely lowered, and the temperature of the portion located at the highest temperature portion of the heating element surface is lowered, and the temperature of the low temperature portion is raised, resulting in an overall uniform temperature. ing. Therefore, the amount of heat is sufficient to evaporate the drug on the commercially available mosquito repellent mat, and by installing the heat conductive member on the upper surface of the heating element, the drug-containing body can be uniformly heated and the heat loss is reduced. It is also very effective in evaporating the drug.

Next, as is clear from the results shown in Table 2, the heat conductive member was made larger than in Test Example 1 described above, and the drug (d.d-T80-praletrin) was placed at a position separated from the heating element plate. 2) is evaporated, the plate made of polyphenylene ether does not evaporate the drug at any time, and the heat from the heating element is not effectively used. On the other hand, when a member with high thermal conductivity (copper plate, aluminum plate) was used, the desired effective chemical evaporation was obtained.
Furthermore, compared with the case where the mosquito repellent mat is placed directly on the heating element, the decrease in the amount of drug evaporated in the latter half of use is suppressed, and the amount of drug evaporated tends to be maintained for a relatively long time. The estimated unrecovered rate of the drug was also low. It is presumed that this is because the temperature distribution on the heating surface was uniform and the heating surface was not subjected to local heating, so that the decomposition of the drug was suppressed. Moreover, by using the heat conductive member, it is possible to evaporate the drug at any place regardless of the shape and the place of the heating element.

[Brief description of drawings]

FIG. 1 is a schematic cross-sectional view showing one structural example of a method for heating and evaporating a drug according to the present invention.

2 is a main part schematic cross-sectional view of the configuration example shown in FIG. 1.

FIG. 3 is a schematic cross-sectional view showing another example of the shape of divided segments of the heat conductive member.

FIG. 4 is a plan view showing a temperature measuring unit of each plate used in Test Example 1.

FIG. 5 is a graph showing the relationship between the measurement part and the measurement temperature of each plate used in Test Example 1.

FIG. 6 is a perspective view showing a heating mode of a mosquito catching mat through each plate used in Test Example 2.

[Explanation of Codes] 1 drug-containing body, 2 container, 3 heat conductive member,
8,34 Vent, 9 Protection member, 10 Evaporator,
12 heating elements, 25a, 25b, 25a 'divided segments, 28 ring-shaped heat dissipation tube, 31 indicator functional member

Continuation of the front page (56) Reference JP-A-1-153032 (JP, A) Actually open 5-80 (JP, U) Actually open 53-132884 (JP, U) Actually open 63-53277 (JP , U) Actual Kaihei 4-127181 (JP, U) (58) Fields investigated (Int.Cl. ⁷ , DB name) A01N 25/18 103 A01N 25/18 101 A01M 13/00

Claims (4)

(57) [Claims] In claim 1 is heated by the heating element a drug-containing body containing the agent, a heat conductive member between the drug-containing body and the heating element provided come in contact to the heating element, the drug-containing body heat It was heated with intervening conductive member, the heating transpiration method pharmacists that Ru was evaporated and drug, divided like body the thermally conductive member
And each segment of the heat conductive member is movable.
To press or contact the heating element by elastic biasing force or gravity
A method of heating and evaporating, characterized in that 2. A schematic surrounds the periphery of the more drug-containing material to the heat conductive member, heat rise toward upward from below and / or laterally around at least a portion of the surface of the drug-containing material upon heating heating transpiration method according to claim 1, characterized in that the formation of the space communicating with the heat conductive portion member as the air flow occurs. 3. The heat evaporation method according to claim 2, wherein a drug evaporation port is provided at least at one position substantially above the drug containing body. 4. A heating transpiration method according to any one of claims 1 to 3, characterized in that the formation of the heat conductive member in a longitudinal split split cylindrical body.