JP2002220304A - Whole heating type drug-containing body, container for the same and heating apparatus for drug transpiration - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a drug-containing body which enables stable drug transpiration for a long time. SOLUTION: The drug-containing body is smaller than the heating surface 15a of a heating body 15, has a thickness of 3 mm or more, and has a heat loss rate L (L=(h-t)/h×100) of 70% or less. In the foregoing equation, (h) is the heating temperature and (t) is the lowest temperature of the drug- containing body.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an overall heating type drug-containing substance for evaporating a drug by heating, a container for the drug-containing substance containing the drug-containing substance, and a drug-containing substance by heating the container for the drug-containing substance. The present invention relates to a chemical heating and evaporating apparatus for evaporating a chemical.

[0002]

2. Description of the Related Art As a chemical heating and evaporating apparatus which can be used for a long period of time, for example, longer than 12 hours, a liquid type is known.
This liquid-type drug heating and evaporation device dissolves the drug into the solution,
The drug is evaporated by sucking it into the heated part and heating it partially (hereinafter referred to as a partial heating method). In the case of the above-mentioned partial heating type, there is an advantage that a fresh chemical solution is always supplied, and the medicinal effect is easily maintained. However, there is a difference between a holding section (liquid container) for a drug solution in which a drug is dissolved in a solution and a heated section, and a point that the drug concentration of the drug solution is thin and the volume of the drug solution is large in order to keep the viscosity of the drug solution low for sucking up. From the two points, there is a disadvantage that the preparation is generally large.

[0003] As a drug heating and evaporating apparatus, there is known an overall heating type apparatus for evaporating a drug by heating an entire drug-containing body with a heating element. In the case of this whole heating type apparatus, the medicine storage section and the heated section are naturally integrated, and the formulation can be designed compact.

[0004] Further, in the above-mentioned partial heating method, unless the concentration of the drug is kept constant, the drug cannot be evaporated stably. That is, the solvent must be released into the air in addition to the drug. On the other hand, the whole heating method does not need the above-mentioned operation and does not evaporate excess solvent and the like, so that consideration is given to the environment.

[0005]

However, it has been very difficult to stably evaporate the medicine for a long time in the whole-heating-type medicine heating and evaporating apparatus using the above-mentioned whole-heating-type medicine-containing substance. That is, since the whole-heating-type drug-containing material used in the conventional whole-heating-type drug heating and evaporating apparatus has a thickness of about 2 mm, the drug content is limited, and the drug cannot be evaporated for a long time.

[0006] If the planar shape of the above-mentioned drug-containing body is increased, the drug content is increased. However, the drug heating and evaporating apparatus is used at home, and its size is limited to a planar shape in view of the space for carrying and placing. In addition, since the size of the planar shape of the heating element is limited due to the power consumption of the heating element, the size of the planar shape of the drug-containing body is limited.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a whole-heating type medicine-containing body, a medicine-containing body container, and a medicine heating and evaporating apparatus which can solve the above-mentioned problems.

[0008]

SUMMARY OF THE INVENTION The present inventors have developed an overall heating type that can stably evaporate a drug for more than 12 hours based on the size of the heating element, the heat generation temperature, the degree of drug evaporation from the drug-containing body, and the like. Drug-containing substances have been found through intensive studies and experiments.

The whole heating type drug-containing material of the present invention has a thickness of 3 mm or more, and the heat loss rate L obtained by the formula 1 from the heating temperature h and the minimum temperature t of the drug-containing material is 70% or less. It is a drug-containing substance of the whole heating type. Formula 1 L = (ht) / h × 100

[0010] The material of the drug-containing substance may be an adhesive and / or a sintered and / or tablet made mainly of an inorganic and / or organic powder, a paper and / or non-woven fabric made mainly of pulp, and a plastic. Non-woven fabric and / or woven fabric mainly composed of: non-woven fabric and / or woven fabric mainly composed of animal and plant-derived substances; foam mainly composed of plastic; kneaded plastic, dried plant, gel, gel, silica gel It is composed of one.

Preferably, the drug-containing substance is used by being enclosed in a container for the drug-containing substance having one or more air holes.

The container for a drug-containing substance of the present invention has at least one vent hole, is large enough to contain the drug-containing substance, and has a distance of 1 to 10 mm between the inner surface and the surface of the drug-containing substance. A container for a drug-containing body, which is characterized in that:

According to a fourth aspect of the present invention, there is provided an apparatus for heating and evaporating a medicine, comprising a heating element on which the container for a medicine-containing body according to claim 4 is mounted, wherein an angle of a heating surface of the heating element is 0 to 70 degrees. It is a chemical heating and evaporation device.

[0014]

[Action] According to the drug substance of the present invention which is entirely heated,
Can evaporate drugs stably for a long period of time.

According to the container for a drug-containing body of the present invention, the drug vapor smoothly passes between the inner surface of the container and the surface of the drug-containing body, and diffuses outside from the vent hole.

According to the drug heating and evaporating device of the present invention, the entire drug-containing body can be heated by the heating element. In addition, a compact design can be achieved by inclining the heating surface of the heating element.

[0017]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A chemical heating and evaporating apparatus will be described with reference to FIG. The medicine heating and evaporating apparatus 1, the medicine-containing body container 2, and the whole heating-type medicine-containing body 3 form a medicine heating and evaporating apparatus. The drug heating and evaporation device 1 has a shape in which a lower device 10 and an upper device 11 are connected by a screw 12. The lower device 10 has a drug-containing body insertion portion 13 opened on one side.
And an air intake section 14 opening the lower part of the medicine-containing body insertion section 13 on the lower surface, and a heating element 15 is attached. The heat generating surface 15a of the heat generating body 15 is oblique to the horizontal and opens to the medicine-containing body insertion portion 13. A switch unit 16, a push button 17, and a lamp 18 are attached to the lower device 10. When the push button 17 is pressed, the switch section 16
N, the heating element 15 is energized to generate heat, and the lamp 18 is turned on.

As shown in FIGS. 2 to 7, the medicine-containing container 2 has a substantially box-like shape including an upper plate 20, a lower plate 21, a front plate 22, a rear plate 23, and both side plates 24. An outlet-side vent hole 25 is formed in the rear panel 23, and an inlet-side vent hole 26 is formed in the rear face plate 23. The lower plate 21 and the front plate 22
And a lower surface plate 21 thereof is detachable. A plurality of protrusions 21a are integrally provided on the inner surface of the lower plate 21 in the front-rear direction. A plurality of front vertical pieces 22a are integrally provided on the inner surface of the front plate 22. An indicator 28 is attached to the surface of the front plate 22.
A plurality of rear vertical pieces 23a are integrally provided on the inner surface of the rear plate 23. Thereafter, the vertical piece 23a contacts the rear portion of the protruding piece 21a. A round bar-shaped rod 20a is integrally provided downward on both sides of the inner surface of the upper surface plate 20. The medicine-containing body container 2 includes a medicine-containing body insertion portion 13.
And the lower surface plate 21 is connected to the heating surface 15 a of the heating element 15.
And contacts the stopper 19. The medicine-containing body holding container 2 is inserted into the medicine-containing body insertion portion 13, and the lower surface plate 21 contacts the heat-generating surface 15 a of the heat-generating body 15 and hits the stopper 19.

The medicine-containing body 3 has a rectangular plate shape impregnated with a medicine that evaporates when heated, and is provided in the medicine-containing body container 2 by removing the lower plate 21. As shown in FIG. 8, the surface of the drug-containing body 3 has a front vertical piece 22a and a rear vertical piece 2a.
3a, there is a gap between the inner surface (inner wall) of the container 2 for the drug-containing body and the surface of the drug-containing body 3 in contact with the rods 20a on both sides. The lower surface of the drug-containing body 3 contacts the projection 21a. The amount of drug evaporation is adjusted by changing the distance between the heating element 15 and the drug-containing body 3 according to the projection size of the projection 21a. Although not shown, it is also possible to adjust the amount of chemical vaporization by providing a projection or the like below the lower plate 21 to change the distance from the heating element 15.

As shown in FIG. 1, by heating the heating element 15 with the medicine-containing body container 2 provided in the medicine heating and evaporating apparatus 1, air flows in from the air intake section 14 and is indicated by an arrow. As shown, the gas flows into the above-mentioned gap from the vent hole 26 on the inlet side, flows out of the vent hole 25 on the outlet side, and flows out of the appliance. That is, as the heating element 15 generates heat, an upward airflow of air is generated as shown by an arrow, and the evaporated medicine is smoothly diffused.

Next, the medicine-containing container 2 will be described in detail. The shape only needs to be able to accommodate the drug-containing body 3 and have one or more air holes. That is, any shape may be used as long as air can flow through the vent hole in the medicine-containing body container 2. The material is at least one selected from polyolefin, polyester, polyamide, and polysulfone. The size of the gap between the surface of the drug-containing body 3 and the inner surface of the container, that is, the distance is 1 to 10 mm, preferably 1 to 5 m
m. In other words, if there is no gap, the medicine vapor will not pass, and if the gap is too large, it will not be possible to secure heat retention. 1-10m to do
m, preferably in the range of 1 to 5 mm.

Next, a description will be given of a test example in which the distance between the surface of the drug-containing body 3 and the inner surface of the container was changed, and the amount of drug evaporation was measured according to the distance under the following conditions. (Conditions) As the drug-containing material 3, a tableting product containing 3000 mg of praletrin as an active ingredient was used. The amount of the medicinal component was determined by distilling off the component trapped on silica gel with acetone and gas chromatography. In the evaluation, 90% or more of the specified amount of the drug transpiration with respect to the specified amount was passed. The test results were as shown in Table 1 below.

[0023]

[Table 1]

From this test result, it was found that the distance between the surface of the drug-containing material 3 and the inner surface of the container was in the range of 1 to 10 mm.

The indicator 28 displays the heating time, that is, the remaining amount of the medicine, using a substance that changes color by heating. This indicator is mounted at a position that is easily visible from the outside, is not easily affected by the outside air temperature, and is not likely to hinder the evaporation of the drug.

Next, a second embodiment of the chemical heating and evaporating apparatus 1 will be described with reference to FIGS. A concave portion 30 opened on the surface, a lid 31 for opening and closing the concave portion 30,
A power supply plug 32 is provided. The recess 3
0 is inclined with respect to the horizontal, and its bottom surface 30a
The heat generating surface 15a of the heat generating body 15 protrudes. The concave portion 30 is opened at the lower surface by a ventilation portion 33.

As shown in FIG. 11, the medicine-containing container 2 is opened and inserted into the recess 30 by opening the lid 31, and the lower plate 21
Is in contact with the heating surface 15a of the heating element 15. By generating heat from the heating element 15, a flow of air is generated as shown by an arrow, and the medicine evaporates smoothly.

Since the heating element 15 is inclined with respect to the horizontal as described above, the apparatus can be designed to be compact. The reason is that if there is an obstacle on the rising airflow carrying the medicine generated when heated, disadvantages such as loss of medicine and contamination of equipment will occur, and when placed on a horizontal heating element, the airflow will be smoother This is because an arch for passing through is required, and the equipment becomes large. The maximum angle of the heating element 15 is 70 degrees. The heating element 15 may be horizontal if the size of the appliance is not considered. Therefore, the fixing angle of the heating element 15 to the appliance is:
The angle may be in the range of 0 to 70 degrees.

[0029] The shell temperature during use of the device is 60 ° C or less.

Next, the whole heating type drug-containing body 3 will be described. As shown in FIG. 12, the medicine containing body 3 has a rectangular plate shape, and the plane size is smaller than the plane size of the heating surface 15 a of the heating body 15. As a result, the entire medicine-containing body 3 can be directly or indirectly heated by the heating element.

The drug containing body 3 is made of a material capable of containing a drug, for example, a binder and / or a sintered body and / or a tableted body mainly containing inorganic and / or organic powder, and a paper mainly containing pulp. And / or non-woven fabrics, non-woven fabrics and / or fabrics mainly composed of plastics, non-woven fabrics and / or fabrics mainly composed of animal and plant-derived substances, foams mainly composed of plastics, kneaded plastics, dried plants, gels , Gel and silica gel.

The binder and / or tablet containing the inorganic and / or organic powder as a main component is described in JP-A-6-192008.
The solid described. In addition to calcium phosphates, which are the main ingredients, excipients (crystalline cellulose) and binders (CMC) required for caking, binders (plastic powder, nylon powder) required for sintering, tableting Sometimes contains necessary lubricants (magnesium stearate).

The paper and / or non-woven fabric containing pulp as a main material is generally referred to as paper, but may be mixed with plastic. As for the manufacturing method, there is a method of bonding with heat or glue other than water.

The nonwoven fabric and / or woven fabric mainly composed of plastic is a so-called nonwoven fabric and woven fabric. Nonwoven fabric manufacturing methods are roughly classified into a dry method using heat or glue, and a wet method in which fibers are entangled with water or an organic solvent.

In addition, the nonwoven fabric and / or woven fabric mainly composed of an animal-derived substance is a material using so-called nonwoven fabric and woven fabric, such as silk, cotton, hemp, kenaf, and gelatin.

The foam mainly composed of plastic is as follows.
Polyurethane foam, polyethylene foam, polypropylene foam and styrofoam, which are mainly used as cushioning materials and sponges, are basically shown, but in a broad sense they mean all kinds of porous plastics. In other words, it is a plastic with holes that can be impregnated with a drug.

The plastic kneaded body is a chemical compound and a plasticizer compounded as necessary for evaporation and internalization.
It is mixed with plastic and molded.

The dried plant refers to so-called dried flowers and dried fruits, and examples thereof include potpourri, hemp, and wood.

Gels include those solidified by gelling agents such as gelatin, carrageenan and gellan gum, as well as those solidified by polymer water-absorbing agents and polymer oil-absorbing agents.

Gel is a paste obtained by mixing an inorganic and / or organic powder with a drug and a solvent to increase the viscosity and paste. Since the drug and the solvent evaporate by heating and return to the original powder and disintegrate, the end point (when the medicinal effect has disappeared) is clear.

The drug contained in the drug substance 3 is an insecticide having a vapor pressure of 1.0 × 10 ⁻⁵ mmHg or more, mainly a pyrethroid insecticide, a bactericide, a repellent,
Growth regulators, fragrances, deodorants and the like. The substances to be mixed with the medicine in the medicine containing body 3 include a heat stabilizer, an antioxidant, an ultraviolet absorber, a dye, a pigment, an aroma / deodorant, and various synergists.

Next, a description will be given of the main object of the present invention, in which a drug can be evaporated for a long time (more than 12 hours) by heating. (1) The thickness of the drug-containing body 3 is 3 mm or more. (2) The heat loss rate L (L = (ht) / h × 100) is 70
% Or less. Here, h is the heating temperature, and t is the lowest temperature of the drug substance 3.

The above-mentioned heating and transpiration means that the medicine is heated so that the maximum temperature of the object to be heated is 5 ° C. or more higher than the ordinary temperature and the medicine is released into the air. The thickness of the drug-containing body 3 is a dimension from a surface closest to the heating element (lower surface) to a surface farthest away (top surface). Not the thinnest part of the drug substance. For example, as shown by a virtual line in FIG. 12, when the thin side surface 3a of the medicine-containing body 3 is used on the heating element 15, the length 1 of the thick side surface 3b is the thickness. What is important is the material and physical properties of the drug-containing substance having high thermal efficiency that does not lose heat even when it is separated from the heating element.

The heat loss ratio is synonymous with the thermal conductivity.
The temperature of the heating element to be used may be set according to the chemical to be evaporated, but the heat loss rate needs to be 70% or less in order to efficiently use energy without waste. The heating temperature h, which is a reference for calculating the heat loss rate, is the maximum surface temperature of the heating element.

Next, a description will be given of a test example in which the drug evaporation time was measured under the following conditions while changing the thickness and the heat loss rate of the drug containing material 3. (Conditions) A mat-type heat evaporation device was used. The drug substance was placed directly on the heating element. A thermocouple thermometer was used for the measurement. The measurement was performed under constant temperature conditions.
In the evaluation, a case where the prescribed amount of the drug evaporation amount is 90% or more and the drug evaporation time is longer than 12 hours is indicated by “○”. As the drug-containing material, a pulp mat mixed with terrareslin as an active ingredient was used. The amount of the active ingredient was determined by distilling off the component trapped on the silica gel with acetone and measuring with gas chloro. The test results were as shown in Table 2 below.

[0046]

[Table 2]

From this test result, a sufficient amount of drug evaporation can be obtained if the thickness is less than 3 mm.
Even when the heat loss was shorter than 2 hours and the heat loss was 75.1% (70% or more) even when the thickness was 13.8 mm (3 mm or more), a sufficient amount of drug evaporation could not be obtained. From this, it has been found that by setting the thickness of the drug-containing material to 3 mm or more and the heat loss rate to 70% or less, the drug can stably evaporate for more than 12 hours.

[0048]

According to the whole heating type drug-containing material of the present invention, the drug can be evaporated stably for a long period of time.

According to the container for a drug-containing body of the present invention, the drug vapor smoothly passes between the inner surface of the container and the surface of the drug-containing body, and diffuses outside from the vent hole.

According to the medicine heating and evaporating apparatus of the present invention, the whole medicine-containing body can be heated by the heating element. In addition, a compact design can be achieved by inclining the heating surface of the heating element.

[Brief description of the drawings]

FIG. 1 is a sectional view of a chemical heating and evaporating apparatus.

FIG. 2 is a plan view of a medicine-containing body container.

FIG. 3 is a front view of the medicine-containing container.

FIG. 4 is a right side view of the medicine-containing container.

FIG. 5 is a rear view of the medicine-containing container.

FIG. 6 is a bottom view of the medicine-containing body container.

FIG. 7 is a sectional view taken along the line AA of FIG. 3;

FIG. 8 is a sectional view in a use state.

FIG. 9 is a plan view showing a second embodiment of the drug heating and evaporation device.

FIG. 10 is a sectional view taken along line BB of FIG. 9;

FIG. 11 is a cross-sectional view of a state in which a container for a drug-containing body is set.

FIG. 12 is a perspective view of a drug containing body.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Drug heat evaporation apparatus, 2 ... Drug-containing body container, 3 ... Drug-containing body, 15 ... Heating element, 15a ... Heating surface.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 2B121 CA04 CA53 CA54 CC02 CC03 CC13 FA05 FA08 4C080 AA03 BB02 BB03 HH02 KK02 NN06 NN22 QQ14 4H011 AA01 AB03 AC02 AC06 BA01 BB15 BC19 BC22 DA09 DB04 DD05 DE04 DF03 DF04 DH04

Claims (5)

[Claims] 1. A general heating type drug-containing substance having a thickness of 3 mm or more for evaporating a drug for a long time by heating, wherein a heating temperature [h] and a minimum temperature [t] of the drug-containing substance are used to obtain an equation (1).
The heat loss factor [L] obtained by the method is 70% or less. Formula 1 L = (ht) / h × 100 2. The material of the drug-containing body is made of an adhesive and / or a sintered body mainly composed of an inorganic and / or organic powder and / or
Or tableting body, paper and / or non-woven fabric mainly composed of pulp,
Non-woven fabric and / or woven fabric mainly composed of plastic, non-woven fabric and / or woven fabric mainly composed of animal and plant-derived substances,
The whole-heating-type drug-containing substance according to claim 1, wherein the substance is composed of at least one of a foam mainly composed of plastic, a kneaded body of plastic, a dried plant, gel, gel, and silica gel. 3. The whole-heating-type drug-containing substance according to claim 1, wherein the drug-containing substance is used by being enclosed in a container for the drug-containing substance having one or more air holes. 4. A drug-containing material having at least one air hole and having a size capable of containing the drug-containing material, wherein the distance between the inner surface and the surface of the drug-containing material is 1 to 10 mm. Container. 5. A heating element on which the container for a medicine-containing body according to claim 4 is placed, wherein the angle of the heating surface of the heating element is 0 to 5.
An agent for heating and evaporating a medicine characterized by being at 70 degrees.