JP3421355B2 - 置換三環式化合物を調製するのに有用な中間体の酵素的で動的な分割 - Google Patents

置換三環式化合物を調製するのに有用な中間体の酵素的で動的な分割

Info

Publication number
JP3421355B2
JP3421355B2 JP50449699A JP50449699A JP3421355B2 JP 3421355 B2 JP3421355 B2 JP 3421355B2 JP 50449699 A JP50449699 A JP 50449699A JP 50449699 A JP50449699 A JP 50449699A JP 3421355 B2 JP3421355 B2 JP 3421355B2
Authority
JP
Japan
Prior art keywords
formula
compound
alkyl
acylating agent
acylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50449699A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000512862A (ja
Inventor
ウイリアム ブライアン モーガン，
ジンチュ リュ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2000512862A publication Critical patent/JP2000512862A/ja
Application granted granted Critical
Publication of JP3421355B2 publication Critical patent/JP3421355B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50449699A 1997-06-17 1998-06-15 置換三環式化合物を調製するのに有用な中間体の酵素的で動的な分割 Expired - Fee Related JP3421355B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87767597A 1997-06-17 1997-06-17
US08/877,675 1997-06-17
PCT/US1998/011501 WO1998058073A1 (en) 1997-06-17 1998-06-15 Enzymatic kinetic resolution of an intermediate useful for preparing substituted tricyclics

Publications (2)

Publication Number Publication Date
JP2000512862A JP2000512862A (ja) 2000-10-03
JP3421355B2 true JP3421355B2 (ja) 2003-06-30

Family

ID=25370483

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50449699A Expired - Fee Related JP3421355B2 (ja) 1997-06-17 1998-06-15 置換三環式化合物を調製するのに有用な中間体の酵素的で動的な分割

Country Status (9)

Country Link
EP (1) EP1002123A1 (enrdf_load_stackoverflow)
JP (1) JP3421355B2 (enrdf_load_stackoverflow)
AR (1) AR015892A1 (enrdf_load_stackoverflow)
AU (1) AU8058398A (enrdf_load_stackoverflow)
CA (1) CA2293708C (enrdf_load_stackoverflow)
IN (1) IN187248B (enrdf_load_stackoverflow)
MY (1) MY133532A (enrdf_load_stackoverflow)
WO (1) WO1998058073A1 (enrdf_load_stackoverflow)
ZA (1) ZA985217B (enrdf_load_stackoverflow)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002519419A (ja) * 1998-07-02 2002-07-02 シェーリング コーポレイション （８−クロロ−３，１０−ジブロモ−６，１１−ジヒドロ−５ｈ−ベンゾ［５，６］シクロヘプタ［１，２−ｂ］ピリジン−１１−イル）−１−ピペリジンを生成するためのプロセス
US6706883B1 (en) 1998-07-02 2004-03-16 Schering Corporation Process for producing (8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-B]pyridin-11-YL)-1-piperdine
ATE346159T1 (de) * 2000-05-08 2006-12-15 Pfizer Prod Inc Enzymatische spaltung von selektiven modulatoren des östrogenrezeptors

Also Published As

Publication number Publication date
ZA985217B (en) 1999-01-07
JP2000512862A (ja) 2000-10-03
IN187248B (enrdf_load_stackoverflow) 2002-03-09
WO1998058073A1 (en) 1998-12-23
EP1002123A1 (en) 2000-05-24
CA2293708A1 (en) 1998-12-23
AU8058398A (en) 1999-01-04
AR015892A1 (es) 2001-05-30
MY133532A (en) 2007-11-30
CA2293708C (en) 2004-05-11

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