JP3419728B2 - Food composition - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a food composition that is extremely effective and safe for reducing hair loss and that is effective for growing hair.

[0002]

2. Description of the Related Art It is considered that the cause of alopecia is a complex intertwining of factors such as hormonal imbalance, stress, aging, poor blood circulation, and various hair cosmetics and hair nourishing agents have been conventionally used. Has been used. In these hair cosmetics and hair nourishing agents, all of the scalp skin cell activators such as senburi extract and ginseng extract, scalp blood circulation-promoting substances such as capsicum extract and nicotinic acid derivative, and female hormones such as estradiol and estrone are included. It has been used for external use.

However, the cell activating substances which have been conventionally used as cosmetics for hair and hair nourishing have a problem that their permeability to the skin is low at a low concentration, and that they are not sufficiently effective alone. Further, the blood circulation-promoting substances used in the same manner have the drawbacks that they have strong skin irritation, their amount is limited, and the duration of blood circulation promotion is short. In addition, the female hormone drug is concerned about the systemic effect, and its compounding amount is limited, so that it cannot exert a sufficient effect.

[0004] Recently, plant extracts such as herbs have been attracting attention as a cosmetic for hair and a hair nourishing agent from the viewpoint of safety.
For example, those containing horseradish extract as an active ingredient (Japanese Patent Application Laid-Open No. 11-242242)
-124318, 10-265347), those containing Ginkgo biloba extract as an active ingredient (Registered 2811479, 2835970, JP-A-10-287531, 3-133919) and the like. be able to. The horse mackerel extract has been used as a good herb for nails in Europe since ancient times (published by Shogakukan Herb Taizen p.61 1990), and ginkgo biloba extract is known to promote blood circulation. However, even if an external preparation containing these is used, there is a problem of contact dermatitis and the drawback of falling off by washing hair and sweating, and it is not practically sufficiently satisfactory in terms of effectiveness. It was

In addition, for the disruption of hormone balance, which is considered to be one of the causes of hair loss, a female hormone such as estradiol is added as an active ingredient (Registration No. 28.
No. 35970). However, female hormone preparations are not possible to exert a sufficient effect due to concern about systemic effects such as breast cancer and the limited amount of the combination.

Various nutritional supplements are also required for hair growth and hair growth. In this regard, keratin, which is known as a hair composition, and pantothenic acid, which is known as a hair loss preventive, are added as active ingredients (JP-A-10-17427). However, nutritional supply to cells is carried out via peripheral blood, and sufficient effects cannot be obtained even when these nutritional components are supplemented externally.

Up to now, agents for promoting hair growth and hair growth have been used as external preparations under the names such as hair cosmetics and hair nourishing agents. However, the hair is originally generated by the command from the papilla in the dermis, which is in contact with the capillaries,
Focusing on such a mechanism, even if the active ingredient is applied externally, few ingredients reach the dermal papilla, and it is considered that it is effective by taking it internally.

As a health food for hair to be taken internally, one containing a millet extract as an active ingredient (Registration 1688371) can be mentioned. However, there are many patients suffering from hair loss and alopecia who have poor peripheral blood circulation, and therefore, even if an active ingredient is supplemented in the state of poor peripheral blood circulation, it does not reach the dermal papilla under the scalp. Vitamin E is known as a blood circulation promoting component, and wheat germ oil is blended to contain this component. The amount of vitamin E in wheat germ oil is 1 g per 1 g.
It is a very small amount of 1.5 mg, and wheat germ oil must be taken in large amounts even to obtain the required amount of vitamin E. Further, androgenetic alopecia is considered to be mainly caused by dihydrotestosterone which is reduced by the male hormone testosterone by 5-α reductase.
There is a patent (Registered 2791673) that contains isoflavone as a 5-α-reductase inhibitor, but the fact is that even if this component is supplemented in the state of poor peripheral blood circulation, it does not reach the dermal papilla.

[0009]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a food for hair which has a safe and highly effective hair-growth effect and which overcomes the drawbacks of the external preparation.

[0010]

Under the above circumstances, the present inventor has conducted diligent research, and as a result, a food composition containing a combination of specific ingredients has an unparalleled effectiveness overcoming the drawbacks of external preparations. Moreover, they have found that they are extremely safe and have completed the present invention. That is, the present invention is a food composition containing millet, ginkgo biloba extract and isoflavone. Preferably, 0.1-5 parts by mass of ginkgo biloba extract and 0.001-3 parts by mass of isoflavone per 1 part by mass of millet, and more preferably 0. Four
-4 parts by mass and isoflavone 0.02-2 parts by mass, which is a food composition.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Millet (Panicum milliaceum L) is rich in various minerals and has been a staple food for a long time as a nutritious food, but it has not been eaten much recently. In Europe, it is a herb that has been traditionally applied externally or internally as a good herb for hair and nails. In the present invention, millet means, for example, millet (Panicum milliaceum
L) seeds or fruits or millet (Panicum milliaceum)
It is an extract extracted from the seed or fruit of L).
As the extraction solvent, water, hot water, or monohydric alcohols such as methanol, ethanol, propanol, isopropanol, butanol or an aqueous solution thereof, or acetone, hexane, etc., conventionally known as an edible plant extraction solvent. If it is present, it is not particularly limited and can be used. As the millet in the present invention, those obtained by crushing millet seeds or fruits as they are, separating and concentrating the extract of ripe millet dry seeds, adding an excipient and drying, or a powder thereof. The one that is converted is used.

[0012] Ginkgo biloba extract is Ginkgo bil.
oba L) is obtained by extraction from leaves. For example, an extract obtained by extracting ginkgo biloba leaves with water, an organic solvent or a water-organic solvent mixed solvent, or a powder thereof is used. The ginkgo biloba extract used in the present invention is
Any flavonoids containing 20% or more, terpenoids containing 5% or more, or both as the main components can be used. Such ginkgo biloba extract can be produced by any known technique. For example, it is produced by a known method in which dried ginkgo leaves are extracted with a hydrous lower alcohol, and then low polar compounds are removed from the obtained extract by using a fat-soluble organic solvent, or by extraction with an organic solvent which is not mixed with water. can do.

The ginkgo biloba extract contains flavone glycosides, terpenes and the like, and is said to be effective for vasodilation, increase of blood flow, prevention of aging of vascular system, and antitussive, expectorant,
It is used as a folk medicine for detoxification and nutrition.
It is also used as a cerebral circulation improving drug in Europe. The intake of medicines is 40 times, 3 times a day
-80 mg is set, and its efficacy on peripheral vasodilation has been confirmed.

The isoflavone in the present invention is a compound having an isoflavone skeleton, such as daidzin and glyciti.
n, genistin, daidzein, glycitein, genistein, 6 ”-o
-acetyl-daidzin, 6 ”-o-acetyl-glycitin, 6” -o-ace
tyl-genistin, 6 ”-o-malonyl-daidzin, 6” -o-malonyl
-glycitin, 6 "-o-malonyl-genistin, etc., and those modified by microbial fermentation such as succinylation and hydroxylation, or those modified by enzymatic treatment or other methods In the present invention, at least 0.1% by mass of isoflavone is used.
Those containing above are preferable, for example, soybean or soybean hypocotyl,
Kuzu, red clover, sugi which are dried and crushed as they are, and those which have been separated and purified through an extraction step from them, or soybeans, soybean hypocotyls, kuzu, red clover, sugi which have been crushed, and microorganisms such as natto Alternatively, those fermented with Aspergillus niger, Aspergillus niger, or Aspergillus oryzae may be pulverized by an appropriate means, or may be separated and purified from them through an extraction step, etc. It can be used as a raw material of the invention. For example, defatted soybean and soybean germ can be steamed, cooled, seed koji is added and mixed, and koji-making is performed, followed by hydrolysis, sterilization, drying and crushing.

Isoflavones are known to have various physiological actions such as estrogen-like action, anticholesterol action, anticancer action and prevention of osteoporosis. The average isoflavone intake of the Japanese is 18 mg per day, which is higher than that of other countries (FFIJ., 172,83-89 1997), and it is considered to be the main cause of the relatively mild menopause in Japanese women. (Lance
It has been pointed out that the isoflavone intake (32 mg per day) is a major cause of cancer in Okinawa, which is the longevity region of Japan, and the frequency of cancer is low. (Will
cox, B, J., et al: Am. J.Clin.Nutr., 61,901 1995) Ipriflavone, a therapeutic drug for osteoporosis containing isoflavone as an active ingredient, has a daily intake of 600 mg.
Usually 30 to 100 mg to adjust hormone balance
It is thought that the intake of is effective.

The amount of each component in the composition of the present invention is preferably 0.
1-5 parts by mass and 0.001-3 parts by mass of isoflavone, more preferably 0.4-4 parts by mass of ginkgo biloba extract and 0.02-2 parts by mass of isoflavone. In this range, the synergistic effect of millet, ginkgo biloba extract and isoflavone is more remarkably exhibited. For 1 part by mass of millet,
If the ginkgo biloba extract is less than 0.1 parts by mass, the effect of the present invention is not sufficient, and if it exceeds 5 parts by mass, no further effect can be expected. Similarly, if the amount of isoflavone is less than 0.001 part by mass, the effect aimed at by the present invention is not necessarily sufficient, and if it exceeds 4 parts by mass, no further effect can be expected. If necessary, biotin, pantothenic acid and derivatives thereof, keratin and the like may be added to the composition of the present invention.

To produce the food composition of the present invention, for example, when encapsulating, for example, millet, ginkgo biloba extract, isoflavone and beeswax are mixed, and the mixture is filled in a capsule base mixed with gelatin and glycerin. . The food composition of the present invention is not limited to capsules, and can be made into any food such as tablets, granule foods, general beverages, etc. by a conventional method.

The food composition of the present invention exerts an effect of improving thinning hair and loss of hair much more effectively than ingesting millet, ginkgo biloba extract and isoflavone alone. Although the mechanism is not clear, it is considered that the active ingredient is surely delivered to the hair root by improving the poor peripheral blood circulation in the scalp, and the hair loss due to the disruption of the hormone balance is prevented by the weak estrogenic action.

[0019]

The present invention will be described in detail below with reference to examples, but the technical scope of the present invention is not limited thereto.

Examples 1 to 3 and Comparative Examples 1 to 6 According to the formulations shown in Table 1, ginkgo biloba extract containing millet, flavonoid 24% and terpene lactone 6%, and a raw material consisting of isoflavone were mixed, and gelatin and glycerin were mixed. It was filled in the capsule base to obtain soft capsules.
The evaluation method was determined by the number of hair loss before and after using the sample. For each of 10 examples (5 males and 5 females) of each of the Examples and Comparative Examples, 1.6 g of the sample was ingested per day for 2 months, and hair loss before and after ingestion of the sample was washed. It was collected and the number was counted. The judgment of the effect was displayed as follows from the difference of each period.

Judgment: Criterion 0: The number of hair loss is less than 10 and cannot be said to be effective. 1: The number of hair loss was reduced by 10 or more, and a slight effect was recognized. 2: The number of hair loss was reduced by 40 or more, and a considerable effect was recognized. 3: The number of hair loss was reduced by 70 or more, and a remarkable effect was recognized.

Table 2 shows the judgment scores of 10 panelists and their totals. As a result, as shown in Table 2, it was 9 in Example 1 containing millet, ginkgo biloba extract and isoflavone.
Hair loss in a relatively small number of subjects was significantly reduced. When the amount of Ginkgo biloba extract and isoflavone exceeded a certain level, the effect reached the ceiling as shown in Examples 2 and 3. Comparative examples 1, 2 of millet, ginkgo biloba extract and isoflavone alone
In Comparative Examples 4, 5 and 6 including 3 and 2 out of 3 types, the number of hair loss is slightly decreased depending on the person, but the overall improvement has not been achieved.

[0023]

[Table 1]

[0024]

[Table 2]

[0025]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, it is possible to provide a food composition which is extremely effective in reducing hair loss and safe and which is effective in growing hair.

─────────────────────────────────────────────────── ─── Continuation of the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) A23L 1/29-1/308 A23L 1/10 A61K 35/78

Claims (5)

(57) [Claims] 1. A food composition comprising millet, ginkgo biloba extract and isoflavone as active ingredients for hair growth . 2. 1 part by mass of millet and 0.1 ginkgo biloba extract
~ 5 parts by mass and isoflavone 0.001 to 3 parts by mass
A food composition comprising: Wherein millet, also claim 1, wherein the fruit of millet, it is pulverized or each extract these seeds
Is a food composition of 2 . 4. Isoflavone is soybean, fermented soybean, fermented soybean hypocotyl, fermented soybean hypocotyl, kudzu, fermented kudzu, red clover, fermented red clover, ougi, fermented ougi,
Soybean extract extracted from each of these, soybean fermented extract, soybean hypocotyl extract, soybean hypocotyl fermented extract, kudzu extract,
Kudzu fermentation extract, red clover extract, red clover fermented extract according to claim 1, characterized in that it contains as more than one selected from the Radix Astragali extract and Radix Astragali fermented extract, 2 or 3 Food composition. 5. The food composition according to claim 1, which is for growing hair.