JP3351834B2 - Chemical solution automatic preparation device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic preparation of a chemical solution, for example, for comparing the efficacy of a plurality of newly developed pesticides with each other or for determining a desired dilution ratio at the time of use. Related to the device.

[0002]

2. Description of the Related Art When conducting the above-mentioned drug efficacy test, it is common to prepare solutions of several tens of kinds of drugs at a time. Conventionally, the operation of dissolving and dispersing in a solution, the operation of diluting the dissolved chemical solution to a predetermined concentration, and the operation of subdividing the diluted chemical solution as needed have been performed entirely by hand. Unless this diluted drug solution is strictly adjusted to the prescribed concentration, and if care is not taken so as not to mix up the types of drugs, the reliability of the test results obtained by investing a lot of manpower and expense Can not be placed.

[0003]

As in the prior art, if the preparation of a drug solution relies entirely on humans, the measurement, dissolution,
It is almost impossible to completely eliminate errors in the dilution operation,
Further, there is a possibility that washing of the used equipment when changing the type of medicine is incomplete and different kinds of medicine are mixed. Furthermore, since many of the prototype drugs are extremely expensive, if they are discarded due to a measurement error or the like, a considerable economic loss is incurred. Since many drugs are harmful to the human body to varying degrees, it is never desirable to keep in contact with the drugs or their solvent vapors for a long time in order to prepare various types of drug solutions. Therefore, an object of the present invention is to prepare a drug stock solution having a predetermined concentration by dissolving a number of types of drugs which are individually weighed and sealed in individual containers with a solvent, and adding a diluting solution to each drug stock solution to prepare a diluted drug solution having a predetermined concentration. It is an object of the present invention to provide an automatic chemical liquid preparation apparatus that can perform a series of operations of subdividing each diluted chemical liquid without relying on humans.

[0004]

In order to achieve the above object, an automatic chemical liquid preparation apparatus according to the present invention is prepared by weighing and enclosing a plurality of types of drugs for a drug efficacy test in predetermined amounts in advance. In each of the plurality of containers, an operation of injecting a solvent to make each drug stock solution, an operation of diluting each drug stock solution to a predetermined concentration to make each diluted drug solution, and each of the diluted drug solutions in a plurality of containers. A series of subdividing operations are automated, and a plurality of dissolving containers 10 in which a weighed amount of drug is enclosed.
0, a predetermined amount of solvent is injected into each of the dissolving means A to form a drug stock solution, and the drug stock solutions in the plurality of dissolution containers 100 are transferred to the respective dilution containers 200 and the diluent is injected. A diluting means B for producing a diluted chemical solution having a predetermined concentration by means of a diluting solution, a diluting means C for dispensing the diluting chemical solution in the plurality of diluting containers 200 into a plurality of diluting containers 301 to 303, respectively, A washing means D for washing the subdivision means C each time the type of chemical solution is changed, an operation control section E for automatically proceeding the operation of each of the means A to D according to an operation program set arbitrarily, A weighing device for weighing each of a plurality of types of medicines, and weighing / storage means F for storing the weighed value and transmitting the weighed value to the operation control unit E are provided. The dissolving means A includes a second container chuck 27 for holding one of the plurality of dissolving containers 100 arranged in a standby state, and a solvent injection mechanism 28A, 28B for injecting a solvent into the held container. A rotating chuck 46 for receiving the dissolving container 100, gripping the bottom thereof, and rotating the dissolving XY hand 20;
A cap removing mechanism 50 for removing the cap 101, a container receiving stage 40 provided with a tilting chuck 60 for tilting the container, a second container chuck 74 for gripping the dilution container 200, and a diluent in the gripped container. And an XY hand 70 for diluting and subdivision having a diluting liquid injecting mechanism 80 for injecting the diluting liquid.
A second container chuck 74 attached to the Y hand 70 and holding one of the plurality of dilution containers 200 arranged in a standby state, and a predetermined amount of the diluted chemical solution in the held container is sucked up. The plurality of small containers 3 which are arranged in a standby state.
It is preferable to have a configuration including a dispensing mechanism 90 for transferring the data to 01 to 303. The cap 1 of the dissolving container 100
It is preferable that a window 103 closed by a rubber seal plate 103 is provided on the upper surface of the cover 01 so that the injection needles 35A and 35B constituting the solvent injection mechanisms 28A and 28B penetrate the seal plate 103. In the injection needle 35A,
It is preferable to attach a hollow ventilation needle 37 for communicating the inside of the melting container 100 to the atmosphere. The washing means D includes a drain tank 401 for discharging the diluted chemical remaining in the dispensing mechanism 90, and an overflow portion provided adjacent to the drain tank 401 and overflowing to the drain tank 401. And a fresh water tank 402 for washing the dispensing needle 93 of the dispensing mechanism 90. The dispensing needle 93 of the dispensing mechanism 90 is provided with a liquid attached to the needle downward. A blowing means 93A for blowing off may be provided.

[0005]

First, a predetermined amount of a solvent is sequentially injected into each of a plurality of dissolution containers 100 in which a weighed drug is enclosed by a dissolving means A, and the drug is dissolved and dispersed to prepare a drug stock solution. Next, the drug stock solution in each dissolution container 100 is
By the diluting means B, the liquid is transferred into each of the diluting containers 200 and the diluting liquid is injected to prepare a diluting drug solution having a predetermined concentration. Subsequently, the diluent solution in each dilution container 200 is divided into a plurality of subdivision containers 301 to 30 by the subdivision means C.
Dispense into 3. Each time the type of the diluted chemical solution to be subdivided is changed, the subdivision unit C is washed by the cleaning unit D. The operation of each of the units A to D automatically proceeds according to an operation program arbitrarily set in the operation control unit E. The weighing values of the respective medicines weighed by the weighing / storing means F are input to the operation control unit E, and the amounts of the solvent and the diluent for the respective medicines are corrected according to the dispersion of the respective weighing values. .

[0006]

An embodiment of the present invention will be described below with reference to the drawings. As shown in FIG. 1 as a front view and FIG. 2 as a plan view, a schematic configuration of a main body portion of the automatic drug solution preparation device is a drug dissolving means A sequentially from the left side to the right side of the figure. A portion serving as a diluting means B for a dissolved drug stock solution, a portion serving as a dispensing means C for dispensing a diluted drug solution into a small dispensing container, and a washing means for washing the small dispensing device each time the type of the diluted drug solution is changed The part to be D is installed on the device base 1. The four circumferences of the device base 1 are surrounded by a transparent peripheral wall 2 as shown in FIG. An operation control unit E (not shown) of the apparatus is provided outside the peripheral wall 2.

[0007] In the dissolving means A, a basket 110 for accommodating a plurality of dissolving containers (vial bottles) 100 in an aligned manner is provided. This dissolving container 100
As shown in FIG. 7, a screw-type cap 101 is provided, and a window 102 provided on the upper surface of the cap is closed with a rubber-like elastic seal plate 103 such as a silicon rubber plate. A plurality of dilution containers (test tubes) 200, a small container (kuda bottle) 301, a small container (beaker) 302,
And baskets 210, 311, and 31 each containing three types of containers, namely, a small container (sample bottle) 303 in an aligned manner.
312 and 313 are provided.

In addition, as shown in FIG. 3, a weighing device including an electronic balance 3 for weighing a medicine is provided at a location away from the main body of the apparatus.
Storage means F is provided. The weighing / storage means F includes a personal computer (hereinafter, referred to as a personal computer) 4 for inputting each weighed value of each medicine weighed by the electronic balance 3, a disk device 5 for storing the input data on a floppy disk, FI for storing the above data in FI card
It comprises a card making device 6 and a printer 7 for printing input data as required.

Next, the detailed configuration of the main body of the apparatus will be sequentially described. Basket 11 containing melting container 100
Numeral 0 is vertically provided in an ultrasonic water tank 10 for vibrating water filled in the tank by an ultrasonic generator as shown in FIG.
The gantry 11 on which the ultrasonic water tank 10 is mounted has its four corners supported by cylinders N1. A swash plate cam 12 having a sliding inclined surface is mounted laterally below the gantry 11. When the movable cam of the swash plate cam 12 is reciprocated in the horizontal direction by the cylinder N2, the gantry 11 is swung up and down with a predetermined amplitude and cycle as shown by a dashed line in the figure. The operating rod of the cylinder N2 is
As shown in FIG. 6, it is connected to the swash plate cam 12 via the connecting plate 13. A plurality of cylinders N3 are erected on the edge of the gantry 11, and the basket 110
Is vertically movably supported by a support member 14 attached to the top end of the support member.

The dissolving XY hand 20, which is the main body of the dissolving means A, includes a fixed hand 20A arranged along the side of the basket 110 as shown in FIG.
And a movable hand 20B reciprocally movable in parallel with the fixed hand 20A. As shown in FIG. 9, a screw 21 that is turned by a pulse motor M1 attached to one end is incorporated in the inside longitudinal direction of the fixed hand 20A having a rectangular tubular shape. This screw 2
The sliding member 22 screwed to the first member 1 has a leg member 23 for mounting the movable handle 20B at a portion where the upper portion protrudes from the upper surface of the fixed hand 20A. A screw 24 that is turned by a pulse motor M2 (FIG. 2) attached to one end of the movable hand 20B is incorporated in the inside longitudinal direction of the movable hand 20B. The sliding body 25 screwed to the screw rod 24 has one side surface protruding to the side of the movable hand 20B, and the mounting base 26 is attached to this protruding portion.

A first container chuck 27 and first and second solvent injection mechanisms 28A and 28B are attached to the mounting base 26 as shown in FIG. As shown in FIGS. 7 and 8, the first container chuck 27 is attached to the lower end of an elevating body 30 that moves up and down along a rail member 29 that is vertically attached to the mounting base 26. The elevating body 30 is moved up and down by the cylinder N4. First container chuck 2
7 is, for example, as shown in FIG.
It has a pair of gripping arms 31 whose opposing distance can be changed by a set of cylinders N5 and N5. Also, as shown in FIG. 8, in order to prevent the cap 101 of the dissolving container 100 from rotating, two rotation-stopping needles 32 piercing the seal plate 103 are provided on the upper base of the container chuck 27. It is protruding.

The first and second solvent injection mechanisms 28A and 28B, which are arranged vertically, have substantially the same structure. That is,
As shown in FIG. 8, the first solvent injection mechanism 28A attaches an injection needle 35A downward to an elevating body 34 that moves up and down along a rail member 33 that is vertically attached to the mounting base 26. ing. Then, as shown in FIG.
Is connected to the first solvent tank T1 by a hose 36A with a pump P1 interposed. The solvent in this case is a mixture of acetone and water. The elevating body 34 is moved up and down by the cylinder N6. And cap 10
A venting needle 37 is attached to the lower end of the injection needle 35A so that the inside of the dissolution container 100 sealed with 1 communicates with the atmosphere when the solvent is injected. The upper end of the injection needle 35B of the second solvent injection mechanism 28B is connected to the second solvent tank T2 by a hose 36B with a pump P2 interposed. The solvent in this case is an aqueous solution of a surfactant.
The ventilation needle 37 is omitted.

Next, the structure of the dilution means B will be described. The diluting unit B receives a dissolving container 100 filled with the drug stock solution prepared by the dissolving unit A from the dissolving XY hand 20 and temporarily mounts the container receiving stage 40.
And a cap removing mechanism 50 attached to the container receiving stage 40 for removing the cap 101 of the dissolving container 100, and tilting the container to transfer the stock drug solution in the container 100 to the diluting container 200. Chuck 6
0, a diluting liquid injecting mechanism 71 attached to the diluting / dispensing hand 70, and a second container chuck 74 for gripping the diluting container 200. In this case, the dilution container 2
00 is a test tube.

The container receiving stage 40 is, as shown in FIGS. 11 and 12, a base 4 which is raised and lowered by a cylinder N7.
It is installed on 1 On the base 41, a movable plate 43 that can move up and down with its four corners supported by telescopic columns 42 is placed. The movable plate 43 is moved up and down by the action of a rotary swash plate cam 45 attached to the lower end of the drive shaft of the rotary actuator 44. On the movable plate 43, a rotating shaft 47 having a rotating chuck 46 attached to the upper end thereof for gripping the bottom of the vertically oriented melting container 100 is provided upright. The rotation of the rotary actuator 44 is transmitted.

As shown in FIGS. 11 and 12, the cap removing mechanism 50 includes a combination of a rotary chuck 46, a first container chuck 27, a rotary actuator 44, and others. That is, the bottom of the melting container 100 is gripped by the rotary chuck 46, and the cap 101 is gripped by the first container chuck 27 lowered from above. At this time, the rotation preventing needle 32 pierces the seal plate 103. When the rotary actuator 44 is operated in this state, the rotary chuck 46 holding the melting container 100 is lowered while rotating, and the cap 1 is rotated.
01 is removed.

In order to remove the cap 101 that has come off, the base 41 is also provided with a cap removing mechanism 51. As shown in FIGS. 11 and 13, the cap removing mechanism 51 includes a cap 10 into which the non-rotating needle 32 is pierced.
1, a cylinder N8 for moving the holding plate 52 up and down, and a cap 101 that has fallen off the rotation-stopping needle 32 when the holding plate 52 is pressed down to receive a desired one. Shoot 53 to guide to the place
It is composed of

The tilting chuck 60 for discharging the undiluted drug solution from the dissolving container 100 is, as shown in FIGS. 11 to 14, a leg member 61 erected on one end side of the base 41 of the container receiving and mounting stage 40. A pair of gripping arms 63 are assembled to the drive shaft of an air-type rotary cylinder 62 attached to the container. The gripping arms 63 are arranged so as to grip the body of the melting container 100. I have.

Next, the subdivision means C uses the XY hand 70 for dilution / subdivision as its main body. The XY hand 70 for diluting / dispensing, as shown in FIG.
Fixed hand 70A arranged along the rear of 0,312
And a movable hand 70B arranged in a direction orthogonal to the fixed hand 70A and capable of reciprocating in a direction along the fixed hand 70A. Its configuration is substantially the same as that of the XY hand 20 for melting. As shown in FIGS. 16 and 17, a mounting base 73 is attached to a portion where a sliding body 72 screwed to a screw rod 71 of a movable hand 70B protrudes to the side of the movable frame. The mounting container 73 has a dilution container 200
, A diluting liquid injecting mechanism 80, and a dispensing mechanism 90 that sucks up the diluent solution in the diluting container 200 and dispenses the diluent into the small dispensing containers 301 to 303.
And is attached.

The second container chuck 74 is shown in FIGS.
As shown in the figure, at the lower end of an elevating body 76 that is vertically movably attached to a rail member 75 that is vertically attached to the mounting base 73,
A pair of chucks 77 for holding the dilution container 200 are attached. The elevating body 76 is moved up and down by a cylinder N9. Further, the diluent injection mechanism 80 is mounted on the mounting base 7.
20 and a diluent tank T3 for supplying diluent to the pump P3 via a hose 81 as shown in FIG. 82 is a pump P3
Is an injection nozzle connected to the discharge port.

The dispensing mechanism 90 includes a rail member 91 vertically attached to the mounting base 73, a lifting / lowering body 92 which can be moved up and down along the rail member 91 by the cylinder N10, and is vertically attached to the lifting / lowering body 92. Dispensing needle 93. As shown in FIG. 22, the dispensing needle 93 has a blowing tube 93A for blowing compressed air coaxially built therein. The upper end of the dispensing needle 93 is connected to a purified water tank T4 by a water supply hose 94 with a pump P4 and a solenoid valve V1 interposed. The water supply hose 94 has a function of temporarily storing the diluted chemical solution sucked up from the dilution container 200 and a function of flowing the washing water to the dispensing needle 93. Fumarolic tube 93A
Is connected to a compressor 96 by a hose 95 with an electromagnetic valve V2 interposed.

Next, as shown in FIG. 19, after the dispensing needle 93 has finished sucking and dispensing, the dispensing mechanism 90 is operated.
A drain tank 401 for discharging the diluted chemical liquid remaining therein and a fresh water tank 402 provided adjacent to the drain tank 401 for cleaning the dispensing needle 93 are provided. Then, as shown in FIG. 21, the drainage in the drainage tank 401 flows into the waste liquid tank T5 via a pipe, and the freshwater tank 402 passes from the clean water tank T4 via a pipe via an electromagnetic valve V3. Purified water is supplied. The purified water supplied to the fresh water tank 402 overflows and flows into the drainage tank 401,
The water level of both tanks is set. Reference numeral 403 denotes a water purification source such as a well, which supplies purified water to each of the water purification tank T4 and the ultrasonic water tank 10 via pipes having electromagnetic valves V4 and V5 interposed therebetween. In FIG. 21, reference numeral 404 denotes a heater for heating water in the ultrasonic water tank 10.

The apparatus main body is provided with an operation control unit (not shown) for fully automatically operating the apparatus main body in accordance with an arbitrarily set operation program. Each cylinder N1 to N10, each pump P1 to P4, each solenoid valve V1 to V
5, and a series of operations of the rotary actuator 44, the rotary cylinder 62, and the like are all performed according to the above operation program. In addition, when weighing each of a plurality of types of drugs, it is inevitable that the weighed amount of each drug varies, so that this variation is corrected, and all of the prepared drug stock solutions have the same drug content. Based on the input information from the weighing / storage means F, the operation control unit controls the injection amount of the solvent into each of the dissolution containers 100 and the injection of the diluent into the dilution container 200 so that the concentration becomes the concentration. A correction device for correcting the amount is incorporated. Further, the concentration of the diluted stock solution and the amount to be dispensed to the small containers 301 to 303 can be arbitrarily set by an attached operation panel.

Next, the operation of the above configuration will be described. First,
As described above, different types of chemicals are weighed into a plurality of, for example, 100 dissolving containers 100 by the weighing / storage means F, covered with caps 101, and housed in a basket 110 in an aligned manner. Then, it is set in the ultrasonic water tank 10 (see the flow sheet in FIG. 23). And
Turn on the power switch of the apparatus main body, and by the operation control unit, input the selected numerical values such as the number of the dissolving containers 100, the concentration of the diluent stock solution, the concentration and injection amount of the solvent and the diluent, the dispensed amount of the diluent solution, Set the operation mode of the device.

When the operation start switch is turned on, the dissolving means A starts operating. That is, the dissolving XY hand 20 brings the injection needle 35A of the first solvent injection mechanism 28A right above the first dissolving container 100 out of 100 as shown on the left end side of FIG. And lower it. Therefore, the injection needle 35A and the attached ventilation needle 37 protrude into the container through the rubber elastic sealing plate 103 sealing the window 102 of the container cap 101, and the inside of the sealed container is communicated with the atmosphere. You. In this state, the pump P1 operates to inject a predetermined amount (for example, 2 cc) of the first solvent into the container. Hereinafter, similarly, the amount of the solvent corresponding to the amount of the drug in each container is calculated and then injected into all the dissolving containers 100. After injecting the solvent into all 100 dissolving containers 100, the ultrasonic generator and the cylinder N2 attached to the ultrasonic water tank 10 are operated, for example, for about 10 minutes, and the dissolving containers 100 in the basket 110 are operated. The ultrasonic wave is applied to the substrate and it is swung up and down to promote the dissolution and dispersion of the drug.

Next, in the same manner as above, the second solvent supply mechanism 28B injects, for example, 6 cc of the second solvent into each of the dissolving containers 100, and then operates the ultrasonic water tank 10 to make the first solvent. Completely dissolves and disperses the drug that could not be dissolved and dispersed with only the solvent. In this case, the injection needle 3
The position where 5B penetrates is shifted from the position of injection needle 35A so that the hole made by injection needle 35A can be used effectively.
The holes made by the injection needles 35A and 35B in the seal plate 103 are as follows.
Since the plate is closed due to its original shape restoring property, the solvent is not lost by evaporation (see the flow sheet of FIG. 23).

With the start of the operation of the dissolving means A, the diluting means B also starts operating at the same time. That is, as a pre-stage for dilution, the XY hand 70 for dilution / subdivision is operated, and the injection nozzles 82 of the diluting liquid injection mechanism 80 are sequentially moved to the respective 100 dilution containers 200 and 302. The pump is brought directly above, and each time, the pump P3 is operated to inject a predetermined amount of the diluent. Next, the process proceeds to this stage of the dilution operation. First, the second container chuck 74 attached to the XY hand 70 for dilution / small portion
14 and 18, the first diluting container 200 into which the diluting liquid has been injected is gripped and moved to a position adjacent to the container receiving stage 40, as shown in FIGS. (See FIG. 23).

On the other hand, the cap 101 of the first dissolving container 100, which is housed in the basket 110 and contains the undiluted drug solution, is attached to the first dissolving XY hand 20.
Of the container receiving stage 40
To the position. At the time of this holding, the two rotation preventing needles 32 pierce the seal plate 103. After the bottom of the dissolving container 100 transferred onto the container receiving stage 40 is gripped by the rotary chuck 46, the rotary actuator 44 operates to rotate the main body of the dissolving container 100 and move it down. At this time, the cap 101 remains held by the first container chuck 27 in a non-rotating state. Next, when the presser plate 52 of the cap removing mechanism 50 which is normally in the ascending position is moved down, the cap 101 is moved.
Is depressed and detached from the detent needle 32, and falls into the cap collecting chute 53. Then, the first container chuck 27 is moved to hold the next melting container 100.

When the cap 101 is removed, the gripping of the rotary chuck 46 is released, and the tilting chuck 60 grips the body of the melting container 100 instead. Then, as shown in FIG. 14, the tilting chuck 60 is rotated by a predetermined angle around the horizontal axis, and the opening of the dissolving container 100 turned downward is set in the dilution standby state adjacent to the container receiving stage 40. The drug stock solution brought directly above the container 200 is transferred into the container 200.

After that, the tilting chuck 60 once returns to the original position for vertically gripping the container, and then is rotated again. If the drug stock solution remains in the dissolving container 100, After being transferred into the dilution container 200, it returns to the original position. At this time, the injection nozzle 82 of the diluent injection mechanism 80 is provided immediately above the dissolving container 100, and in order to wash the inside of the container, the numerical correction corresponding to the weighed amount of the drug is performed as described above. A predetermined amount (several cc) of the diluted liquid is injected. Then, the washing liquid is supplied to the dissolving container 10.
By completely tilting 0 twice as described above, the sample is completely transferred to the dilution container 200. Thereafter, the gripping of the tilting chuck 60 is released, and the empty melting container 100 is placed in the first position.
The container is returned to a predetermined position in the basket 110 by the container chuck 27. The dilution container 200 containing the prepared diluent solution is held by the second container chuck 74,
It is returned to its original position in the basket 210. Thereafter, in the same manner as described above, the drug stock solutions in all the dissolving containers 100 are diluted with a predetermined amount of the diluting solution.
Transferred to 0 to prepare a diluted drug solution. FIG. 24 is a flow sheet showing a process for preparing the diluted chemical solution.

Next, the operation of the subdividing means C will be described. First, the dispensing needle 93 of the dispensing mechanism 90 attached to the dilution / small XY hand 70 is brought directly above the first dilution container 200 and inserted into this container. Immediately after that,
The solenoid valve V2 is opened for a predetermined time, and the fumarolic tube 93A
Compressed air is blown into the diluted drug solution from below to uniformly disperse the drug if it has settled. Next, the pump P4 is operated to draw a predetermined amount of the diluted chemical solution into the water supply hose 94, and then the dispensing needle 93 is pulled up. Thereafter, the dispensing needle 93 is moved to the position immediately above the first dispensing container 301 to inject a predetermined amount of the diluted drug solution. After the injection, the solenoid valve V2 is momentarily opened, and the droplets attached to the tip of the dispensing needle 93 are blown down into the container by the force of the compressed air. Subsequently, the dispensing needle 93 is moved to the position immediately above the first of the dispensing container 302, and a predetermined amount of the diluted drug solution is injected into this container. Subsequently, the dispensing needle 93 is moved to the position immediately above the first position of the dispensing container 303, and a predetermined amount of the diluted drug solution is injected into this container (see the flow sheet in FIG. 25).

After dispensing the diluted drug solution into each of the dispensing containers 301 to 303, the dispensing needle 93 is washed by the washing means D as a preparation operation for sucking up different kinds of diluted drug solution. . To do this, as shown in FIG. 19, the dispensing needle 93 is moved immediately above the drainage tank 401, and the pump P4 is operated to discharge the remaining diluent liquid in the water supply hose 94. Subsequently, the electromagnetic valve V1 is opened, and the purified water in the purified water tank T4 is flown into the dispensing needle 93 by the pump P4 to be washed. The washing liquid is dropped into a waste liquid tank T5. Subsequently, the dispensing needle 93 is moved right above the fresh water tank 402 to be immersed in this tank, and the outside of the dispensing needle 93 is also washed. At this time, the electromagnetic valve V3 is opened, and the purified water in the purified water tank T4 is supplied into the fresh water tank 402. The fresh water overflowing from the fresh water tank 402 flows into the drain tank 401 and is collected in the waste liquid tank T5. Finally, if the clean water adhering to the dispensing needle 93 is blown off by injecting the compressed air, the preparation for dispensing the second kind of the diluted chemical liquid into the small containers 301 to 303 is ready (the flow sheet in FIG. 25). reference).

Thereafter, the remaining kinds of the diluted chemicals are also subdivided into the respective small containers 301 to 303 in the same manner as described above.

[0033]

As is apparent from the above description, the automatic chemical liquid preparation apparatus according to the present invention has various practically excellent effects as listed below. (A) Since operations other than the weighing of the drug are performed fully automatically, the preparation of various types of diluted drug solutions can be performed extremely efficiently. (B) Of course, the preparation of the drug stock solution and the preparation and subdivision of the diluted drug solution can be performed simultaneously, so that the preparation of the drug solution can be performed quickly from this point as well. (C) Since no manual intervention is required in the operation of preparing the chemical solution, any human operation error can be eliminated. (D) Therefore, the prepared chemical solution has no error in the composition and concentration, and the reliability of the drug efficacy test result can be ensured. (E) An extremely expensive drug prototyped for a drug efficacy test
It is possible to almost completely eliminate the economical loss that has conventionally been achieved, in which the operation has to be discarded due to an operation error at the time of preparing the chemical solution by hand. (F) Since the first and second container chucks, the solvent injection mechanism, the diluent injection mechanism, and the dispensing mechanism are rationally arranged on the two XY hands, the external shape of the automatic chemical liquid preparation device is compactly arranged. As a result, the installation space can be saved and a large number of chemical solutions can be quickly prepared. (G) Injecting the solvent into the dissolving container is performed by inserting an injection needle with a ventilation needle through a rubber elastic seal plate sealing a window provided in the cap. In addition to saving the trouble of opening and closing the cap, the injection can be performed smoothly. (H) The dispensing needle of the dispensing mechanism is provided with a blowing means so that the liquid remaining on the needle is blown down, and the washing means is for washing the dispensing needle in addition to the drainage tank. Since the fresh water tank is provided, it is possible to reliably eliminate the possibility of mixing different types of chemicals due to insufficient washing when switching the type of chemical.

[Brief description of the drawings]

FIG. 1 is a side view of an apparatus main body.

FIG. 2 is a plan view of an apparatus main body.

FIG. 3 is a front view of the weighing / storage means.

FIG. 4 is a front view of the ultrasonic water tank.

FIG. 5 is a side view of the ultrasonic water tank.

FIG. 6 is a partial view of a swinging mechanism of the ultrasonic water tank.

FIG. 7 is a longitudinal sectional view of a dissolving container and a partial view of a container chuck.

FIG. 8 is a front view of first and second solvent injection mechanisms and a first container chuck attached to a dissolving XY hand.

FIG. 9 is a longitudinal sectional view illustrating the structure of an XY hand for melting.

FIG. 10 is a solvent supply system diagram for supplying first and second solvents to first and second solvent injection mechanisms, respectively.

FIG. 11 is a front view including a partial vertical cross section of the container receiving station in which the cap removing mechanism and the container tilting chuck are assembled.

FIG. 12 is a partial perspective view of the same.

FIG. 13 is a perspective view showing a cap removing mechanism portion.

FIG. 14 is a perspective view showing a state where the dissolving container is tilted.

FIG. 15 is a front view of a diluting liquid dispensing mechanism, a second container chuck, and a dispensing mechanism attached to an XY hand for dilution / small dispensing.

FIG. 16 illustrates the structure of the XY hand for dilution / subdivision.
It is a partial front view including a longitudinal section.

FIG. 17 is a vertical sectional side view illustrating the structure of the XY hand for dilution / small fractionation.

FIG. 18 is a partial front view illustrating a dispensing operation by the dispensing mechanism.

FIG. 19 is a partial front view showing the arrangement and structure of a dispensing mechanism and its cleaning means, including a longitudinal section.

FIG. 20 is a diluent supply system diagram for supplying a diluent to a dispensing mechanism.

FIG. 21 is a diagram illustrating a supply system of purified water to a cleaning unit and an ultrasonic water tank.

FIG. 22 is a supply system diagram of purified water and compressed air for dispensing mechanism cleaning.

FIG. 23 is a flowchart showing the operation steps of each of the weighing / storing means, the dissolving means and the diluting means of the medicine.

FIG. 24 is a flowchart showing each of a dissolving container moving and cap removing step, a diluting container moving step, and a diluting means operating step.

FIG. 25 is a flowchart showing operation steps of the subdivision unit and the cleaning unit.

[Explanation of symbols]

 Reference Signs List A dissolving means B diluting means C small dispensing means D washing means E operation control part F weighing / storing means 100 dissolving container 101 cap 102 window 103 seal plate 200 diluting container 301-303 small dispensing container 110, 210, 311 313 Basket 1 Device main body 2 Perimeter wall 3 Electronic balance 4 Personal computer 5 Disk device 6 FI card 7 Printer 10 Ultrasonic water tank 11 Mount 12 Swash plate cam 13 Connecting plate 14 Support member 20 XY hand for melting 20A Fixed hand 20B Movable hand 21,24 Screw 22, 22 Sliding body 23 Leg member 26 Mounting base 27 First container chuck 28A First solvent injection mechanism 28B Second solvent injection mechanism 29, 33 Rail member 30, 34 Elevating body 31 Holding arm 32 Non-rotating needle 35A, 35B Injection needle 36A, 36B Hose 37 Ventilation Needle 40 Container receiving stage 41 Base 42 Telescopic column 43 Movable plate 44 Rotary actuator 45 Swash plate cam 46 Rotating chuck 47 Rotating shaft 50 Cap removal mechanism 51 Cap elimination mechanism 52 Holding plate 53 Chute 60 Tilt chuck 61 Leg member 62 Rotary Cylinder 63 Gripping arm 70 XY hand for dilution / small portion 70A Fixed hand 70B Movable hand 71 Screw rod 72 Sliding 73 Mounting base 74 Second container chuck 75 Rail member 76 Elevating body 77 Gripping member 80 Diluent injection mechanism 81 Hose 82 Injection nozzle 90 Dispensing mechanism 91 Lay member 92 Elevating body 93 Dispensing needle 93A Fumarizing nozzle (foaming means) 94 Water supply hose 95 Hose 96 Compressor 401 Drainage tank 402 Fresh water tank 403 Purified water source 404 Heater T1 First melting Tank T2 second solvent tank T3 diluent tank T4 water tank T5 waste tank N1~N10 cylinder P1~P4 pump V1~V5 solenoid valve

Continuing on the front page (72) Inventor Katsuhiro Fujita 1041-3-1, Noshu-cho, Yasu-cho, Noshu-gun, Shiga Prefecture (72) Inventor Fujio Wakabayashi 1041-Noshu, Yoji-cho, Yasu-cho, Noshu-gun, Shiga Within Sankyo Co., Ltd. (72) Inventor Kenji Sato 27-28, Daikancho, Higashi-ku, Nagoya-shi Within Aichi Electric Trading Co., Ltd. (Int.Cl. ⁷ , DB name) A01M 7/00 B05B 12/02 B65B 3/00 B65B 3/04 B65B 3/26 B65B 3/30

Claims (6)

(57) [Claims] 1. Each of a plurality of types of drugs for a drug efficacy test is
An operation of injecting a solvent into each of a plurality of containers prepared by weighing and enclosing a predetermined amount in advance and preparing each drug stock solution, and an operation of diluting each drug stock solution to a predetermined concentration to prepare each diluted drug solution. A series of operations for subdividing each of the diluted drug solutions into a plurality of containers is automated, and a predetermined amount of a solvent is injected into each of the plurality of dissolving containers 100 in which the weighed drugs are sealed. Dissolving means A for producing a drug stock solution; diluting means B for transferring the drug stock solutions in the plurality of dissolution containers 100 to the respective dilution containers 200 and injecting the diluent to produce a diluted drug solution of a predetermined concentration; A dispensing means C for dispensing the diluting liquid in the plurality of diluting containers 200 into a plurality of dispensing vessels 301 to 303, respectively; and Cleaning means D for cleaning; An operation control unit E that automatically advances the operations of A to D according to an operation program set arbitrarily; a weighing device that weighs each of the plurality of types of medicines; An automatic chemical liquid preparation device comprising: a weighing / storage means F for communicating to a section E. 2. The dissolving means A includes a second container chuck 27 for holding one of the plurality of dissolving containers 100 arranged in a standby state, and a solvent injection mechanism 28A for injecting a solvent into the held container. , An XY hand for dissolving 20 attached to the dissolving XY hand 20. The diluting means B includes a rotary chuck 46 for receiving the dissolving container 100, holding and rotating the bottom thereof, and a cap removing mechanism 50 for removing the cap 101. A container receiving stage 40 provided with a tilting chuck 60 for tilting the container; and a second container chuck 74 for gripping the dilution container 200.
And a diluting / subdivision XY hand 70 to which a diluting liquid injecting mechanism 80 for injecting diluting liquid into the gripped container is provided. A second container chuck 74 that holds one of the plurality of dilution containers 200 that is attached and arranged in a standby state, sucks up a predetermined amount of the diluted chemical solution in the held container, and waits in an aligned state. The chemical liquid automatic preparation device according to claim 1, further comprising a dispensing mechanism (90) that transfers the liquid to the plurality of small containers (301 to 303). 3. The cap 101 of the dissolving container 100.
On the upper surface of the window 1, a window 1 sealed with a rubber seal plate 103
3. The automatic chemical liquid preparation apparatus according to claim 1, wherein an injection needle 35 </ b> A, 35 </ b> B constituting the solvent injection mechanism 28 </ b> A, 28 </ b> B is penetrated through the seal plate 103. 4. The injection needle 35A has a hollow ventilation needle 37 that allows the inside of the dissolution container 100 to communicate with the atmosphere.
4. The automatic chemical liquid preparation apparatus according to claim 3, further comprising: 5. The cleaning means D includes a drainage tank 401 for discharging a diluent solution remaining in the dispensing mechanism 90, and a cleaning tank D provided adjacent to the drainage tank 401 for discharging the diluted chemical solution. The automatic chemical liquid preparation apparatus according to any one of claims 1 to 4, further comprising a fresh water tank (402) having an overflow part and washing the dispensing needle (93) of the dispensing mechanism (90). 6. The dispensing needle 93 of the dispensing mechanism 90 is provided with a blowing means 93A for blowing down liquid adhering to the needle downward. Automatic chemical solution preparation device.