JP3349483B2 - Agaricus extract granules and production method thereof - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a composition comprising an agaricus extract and / or a dry powder of agaricus, in particular its granules and a process for its production.

[0002]

2. Description of the Related Art Agaricus is attracting attention as a mushroom having high anticancer activity and bioregulatory function. In particular, high molecular weight polysaccharides and glycoproteins such as (1-3) and (1-6) -β-glucan contained in Agaricus are important for anticancer activity, and activate the host immune system. Has been reported to have anticancer activity (THE CHEMICAL TIMES, 131,12-
21 (1989), ANTICANCER RESEARCH, 17,277-284 (1997), Ca
ncer Immunol Immunother, 46, 147-159 (1998), Biosci.
Biotechnol. Biochem., 62, 434-437 (1998)), the use of agaric extract-containing granules, tableted products, liquids, agaric dried forms, and agaricus dry powders as foods and health food materials is currently progressing. JP-A-02-2
11848, JP-A-06-128164, JP-A-07-128
258107, JP-A-10-182577, JP-A-11
-32723, JP-A-11-80014, JP-A-11-0014
113531, JP-A-11-155518).

However, such Agaricus products have some problems. Agaricus extract is very hygroscopic and has a poor taste. Therefore, in the Agaricus granule product, the content of the Agaricus extract is low, and the treatment taking into account the hygroscopicity and taste peculiar to Agaricus has not been performed. Therefore, the agaricus extract-containing granules of the type that can be dissolved in water and drinkable are still insufficiently soluble in water. On the other hand, in the case of swallowable agaricus extract-containing granules and agaricus dry powder, the problem is that the agaricus-specific bad taste is directly felt when put in the mouth, it can be clogged in the throat, and it can not be dissolved in water to drink There is a point. In addition, in tableted products, due to its high hygroscopicity, the compounding amount of excipients is inevitably increased, and a large number of particles must be drunk in order to ingest an effective amount. On the other hand, in the case of liquid, there is a problem that portability is inferior, the dried form cannot be used as it is, and it is necessary to boil in water in advance.

[0004]

DISCLOSURE OF THE INVENTION The present invention provides a granule containing a high amount of agaricus extract and / or agaricus dry powder, which is hardly soluble in water and can be clogged in the throat in the mouth.
An object of the present invention is to provide an agaricus extract-rich granule in which problems such as the unpleasant taste unique to agaricus in the mouth are directly felt.

[0005]

Means for Solving the Problems In order to solve these problems, the present inventors added a predetermined amount of a starch degradation product and crystalline cellulose to agaricus extract and / or agaricus dry powder, and performed a stepwise granulation treatment. It has been found that it is effective to perform the present invention, and the present invention has been completed. That is, the present invention relates to a composition characterized by containing agaric extract and / or agaric dry powder, a starch decomposed product, crystalline cellulose, granules thereof, and an agaric extract and / or agaric dry powder, a starch degraded product, and crystalline cellulose. In a first step, 0.05 to 0.4 parts by mass of an aqueous alcohol solution containing 80 to 99.5% of alcohol is uniformly impregnated with respect to 1 part by mass of the mixture, and then, as a second step, an aqueous alcoholic solution is again added to 0.1 part by mass. 05-0.4
It is a method for producing granules, which comprises impregnating parts by mass and drying, and then pulverizing the particles to a particle size of 1 mm or less.

[0006]

DETAILED DESCRIPTION OF THE INVENTION The Agaricus extract or Agaricus dry powder used in the present invention is generally Agaricus bla
Use fruit bodies and mycelium of zei Murill (Kawariharatake). The extract can be obtained as a hot water extract or a hydrous ethanol extract by extracting with water or a hydrophilic organic solvent such as ethanol. The extract is used in the form of a liquid as it is, or dried as it is, or powdered by mixing and drying an excipient. The dry powder is used by drying and pulverizing mycelia and fruiting bodies as they are. As an example, it is obtained by pulverizing after drying with low-temperature hot air. The agaricus extract or agaricus dry powder thus obtained contains major bioactive ingredients such as β-glucan, α-glucan, β-galactoglucan, xyloglucan, peptide glucan and nucleic acid.

[0007] The present invention is characterized in that the agaric extract and / or the agaric dry powder contains a starch degradation product and crystalline cellulose. The degraded starch used in the present invention is a product obtained by degrading starch which is generally stored in large amounts in tissues such as corn, potato, sweet potato, tapioca and the like. As an example, it is obtained by hydrolyzing starch, purifying it by decolorization, desalting, sterilization and the like, and then pulverizing it by a spray dryer. However, this is only an example,
The starch decomposition product is not limited by this production method.

The crystalline cellulose used in the present invention is obtained, for example, by subjecting high-purity natural cellulose to acid hydrolysis, removing non-crystalline regions, extracting only pure crystalline portions, purifying and drying the crystalline cellulose. All crystalline cellulose that can be used in food. If no starch degradation product is contained, final granules having the desired function cannot be formed. When no crystalline cellulose is contained, the hardness of the final granules becomes extremely high, and the solubility becomes extremely poor. Therefore, it is necessary to include the starch degradation product and the crystalline cellulose.

In the present invention, more preferably, 0.1 part by mass or more and 1.5 parts by mass or less of a starch decomposed product is contained with respect to 1 part by mass of agaricus extract and / or agaricus dry powder, and crystalline cellulose is added at 0.1 part by mass. It is contained in an amount of from 01 parts by mass to 0.5 parts by mass. However, when the agaric extract is liquid, the dry base is used, and excipients are not included in the calculation. If the starch hydrolyzate is less than 0.1 part by mass, the moldability is deteriorated. Conversely, if it exceeds 1.5 parts by mass, the granular properties are affected and the hardness of the final granules is increased to dissolve. Worse. On the other hand, when the crystalline cellulose is less than 0.01 part by mass, similarly, the hardness of the final granules is increased and the solubility is deteriorated. Conversely, if it exceeds 0.5 part by mass, the moldability is affected, There are problems such as clogging the throat when put in the mouth and poor dispersibility of the granules when dissolved in water. Therefore, in the present invention, it is desirable to mix at the above mixing ratio.

The production of the granules of the present invention is characterized in that the following steps are performed. Agaricus extract and / or
Alternatively, a starch decomposed product, crystalline cellulose, and other excipients as described below are added to the Agaricus dry powder and mixed with stirring, and then an aqueous alcohol solution is first added. The alcohol concentration of the alcohol aqueous solution is 80 to 99.
5%, and the amount of addition was 0.1% with respect to 1 part by mass of the powder mixture.
It is 0.5 to 0.4 parts by mass. The alcohol aqueous solution may be one in which lactose or the like is dissolved as described later, and the alcohol concentration in this case is based on the total amount of the alcohol solution.
This step is the first step of the production method of the present invention. Thereafter, as a second step, an aqueous alcohol solution is added and mixed while the granules are kept wet. By passing through the first step, it is possible to obtain a wet powder having a uniform particle size without forming a cage. This allows
Granules having appropriate hardness and moldability can be easily produced. Preferably, the alcohol concentration used in the first step is higher than the alcohol concentration used in the second step. This is to improve the uniform dispersibility of the aqueous alcohol solution in the powder.

In the production method of the present invention, preferably, the process proceeds to the third step using the dried granules. In the third step, 1 part by mass of the granules obtained in the second step is uniformly impregnated with 0.05 to 0.4 parts by mass of an aqueous alcohol solution and dried, and then pulverized so that the particle size becomes 1 mm or less. .
If the granules containing the agaric extract and / or agaric dry powder, starch degradation product and crystalline cellulose are sized to a predetermined particle size before performing the third step, the particle size of the resulting granules becomes more uniform. As the particle size of the granules, it is desirable that the average particle size is 1 mm or less, and if the average particle size exceeds 1 mm, the impregnation of the hydroalcoholic in the third step becomes uneven, and the particle size distribution of the resulting granules becomes wider. Therefore, the object of the present invention cannot be satisfied.

[0012] More preferably, as a fourth step after the third step, the wet granules are subjected to crushing granulation or extrusion granulation through a screen of 6 mm or less and then dried, so that the granules are dried. Can be prevented from binding, and the particle size of the final granules becomes more uniform.

The point of the present invention is to impregnate the composition containing agaric extract and / or agaric dry powder, starch degradation product and crystalline cellulose stepwise and uniformly with a predetermined amount of an aqueous alcohol solution having a predetermined concentration. The physical properties of the resulting granules are not affected by the method or drying method.

If necessary, other excipients may be mixed with the composition containing agaricus extract and / or agaricus dry powder, starch degradation product and microcrystalline cellulose, or may be added to an aqueous alcohol solution such as lactose, xylitol, maltitol. , Lactitol, starch and the like are preferably used for controlling the formability of the granules such as the particle size, hardness and bulk density of the final granules. The granules produced by the present invention are those in which the moisture absorption and fluidity of the Agaricus extract are greatly improved. Therefore, the use is not limited to granules, but is also suitable for the production of tableted products, capsules and the like.

[0015]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.
In the examples, a stirring granulation method and a hot air shelf drying method were employed.

Example 1 The following raw materials were prepared. Agaricus extract 1.00 part by mass Starch decomposed product 0.25 part by mass Crystalline cellulose 0.05 part by mass After mixing the above raw materials, 95% ethanol was mixed with stirring and 0.15 part by mass with respect to 1 part by mass of the raw material mixed powder. Dripping,
92% ethanol in the wet state of granules 1
0.3 parts by mass was added dropwise to parts by mass. Hot air shelf dryer 60
After drying for 2 to 5 hours at 10 ° C. so that the loss on drying was 10% or less, pulverization was performed so that the particle size became 1.0 mm or less to obtain granules.

Example 2 The following raw materials were prepared. Agaricus extract 1.00 part by mass Starch decomposed product 0.25 part by mass Crystalline cellulose 0.05 part by mass After mixing the above raw materials, 95% ethanol was mixed with stirring and 0.15 part by mass with respect to 1 part by mass of the raw material mixed powder. Dripping,
92% ethanol in the wet state of granules 1
0.3 parts by mass was added dropwise to the parts by mass. Hot air shelf dryer 6
After drying at 0 ° C. for 2 to 5 hours so that the loss on drying was 10% or less, pulverization was performed so that the particle size became 0.5 mm or less. 1 part by mass of the obtained granules is uniformly impregnated with 0.2 part by mass of 94% ethanol and dried at 60 ° C. in a hot-air shelf drier for 2 to 5 hours so that the loss on drying is 10% or less. The powder was pulverized to a particle size of 1 mm or less to obtain granules.

Example 3 The following raw materials were prepared. Agaricus extract 1.00 part by mass Starch decomposed product 0.25 part by mass Crystalline cellulose 0.05 part by mass After mixing the above raw materials, 95% ethanol was mixed with stirring and 0.15 part by mass with respect to 1 part by mass of the raw material mixed powder. Dripping,
92% ethanol in the wet state of granules 1
0.3 parts by mass was added dropwise to parts by mass. Hot air shelf dryer 6
After drying at 0 ° C. for 2 to 5 hours so that the loss on drying was 10% or less, pulverization was performed so that the particle size became 0.5 mm or less. The wet mass obtained by uniformly impregnating and mixing 0.2 parts by mass of 94% ethanol with 1 part by mass of the obtained granules was mixed with 3 parts by mass.
crushed granules popping out from a screen of 2 mm, dried for 2 to 5 hours at a hot-air shelf dryer at 60 ° C. so that the loss on drying is 10% or less, and then pulverized so that the particle size becomes 1 mm or less. Granules were obtained.

Comparative Example 1 Granules were obtained in the same manner as in Example 1 except that the following raw materials were used. Agaricus extract 1.00 part by mass Starch decomposed product 1.00 part by mass Comparative example 2 A granule was obtained in the same manner as in Example 2 except that the following raw materials were used. Agaricus extract 1.00 part by mass Starch degradation product 1.00 part by mass Comparative example 3 A granule was obtained in the same manner as in Example 3 except that the following raw materials were used. Agaricus extract 1.00 parts by mass Starch decomposed product 1.00 parts by mass

Comparative Example 4 Granules were obtained in the same manner as in Example 1 except that the following raw materials were used. Agaricus extract 1.00 part by mass Crystalline cellulose 0.50 part by mass Comparative example 5 A granule was obtained in the same manner as in Example 2 except that the following raw materials were used. Agaricus extract 1.00 part by mass Crystalline cellulose 0.50 part by mass Comparative example 6 A granule was obtained in the same manner as in Example 3 except that the following raw materials were used. Agaricus extract 1.00 parts by mass Crystalline cellulose 0.50 parts by mass

Evaluation Example 1 The following tests were performed on the granules of Examples 1 to 3 and Comparative Examples 1 to 6. The results are shown in Table 1 for Examples 1 to 3, and Table 2 for Comparative Examples 1 to 6. Test method (1) Particle size The particle size of the final granules was measured with a particle size distribution meter. In Tables 1 and 2, (-) is added to those having a distribution rate of granules having a particle size of 0.149 to 0.500 mm of less than 50% by mass, and 50 to 70%.
(+) Is indicated for those that are 70% by mass, and (++) is indicated for those that exceed 70% by mass.

(2) Ease of Drinking Sensory tests were conducted on the feeling of melting in the mouth when the granules were contained in the mouth, clogging in the throat, and ease of pouring with water. Tables 1 and 2 show that there are no problems with taking (○), those that dissolve immediately in the mouth and directly feel the unpleasant taste unique to agaricus, those that are clogged in the throat and difficult to drink, etc. (×) is displayed.

(3) Solubility 2.5 g of the granules were placed in a beaker containing 100 ml of water, and the solubility when stirred with a spoon was visually inspected. Tables 1 and 2 show (○) for those that dissolve completely quickly.
(X) is shown when the precipitate does not disappear even after stirring for 1 minute or more. In addition, (△) is indicated when the granules floated on the surface of the water but were difficult to stir due to adhesion to the wall surface or spoon of the beaker at the time of stirring, although they were dissolved by stirring for 1 minute.

[0024]

【table 1】

[0025]

[Table 2]

[0026]

[Effects of the Invention] Although a graded granulation process is performed,
In Comparative Examples 1 to 3 in which crystalline cellulose was not blended,
Particle size is 1m after drying due to too strong bonding force between particles
m, the final granules were uneven in particle size. As a result, the bad taste peculiar to Agaricus was reduced, but hard granules were clogged in the throat, making it difficult to drink and poorly soluble. In addition, although it has undergone a stepwise granulation process in the same manner, in Comparative Examples 4 to 6, in which the starch degradation product is not blended, the final granules are all fine powders, so that they are hard to drink in the throat, and in the mouth. It melted quickly, and the unpleasant taste unique to Agaricus was directly felt. Further, regarding the solubility, the granules floated on the water surface and adhered to the wall surface of the beaker or the spoon during stirring, which made stirring difficult.

On the other hand, in Examples 1 to 3 in which a starch extract and / or crystalline cellulose were blended in a predetermined amount with an agaricus extract and / or agaricus dry powder and a stepwise granulation process was performed, all of these performances were excellent. ing. Therefore, the granules obtained according to the present invention do not directly feel the taste of agaricus when placed in the mouth and do not cause the throat to jam. Conversely, when it is dissolved in water for drinking, it also has the contradictory characteristics that it dissolves in water smoothly, which can be said to be granules with excellent continuity for the user.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Masaaki Ono 12-13, Kaminano, Totsuka-ku, Yokohama-shi, Kanagawa Prefecture Inside the FANCL Central Research Laboratory Co., Ltd. No. FANCL Central Research Laboratory Co., Ltd. (56) References JP-A-11-266832 (JP, A) JP-A-11-8014 (JP, A) Registered utility model 3053921 (JP, U)

Claims (4)

(57) [Claims] Agaric extract and / or 1 part by weight of dry powder of agaricus is used in an amount of 0.1% by weight of starch decomposed product.
~ 1.5 parts by weight, and 0.01 ~ crystalline cellulose
A granule comprising 0.5 parts by mass. 2. An alcohol aqueous solution containing 80 to 99.5% by mass of alcohol as a first step with respect to 1 part by mass of a mixture of agaricus extract and / or agaricus dry powder, a starch degradation product, and crystalline cellulose.
After uniformly impregnating 0.4 parts by mass, 0.05 to 0.4 parts by mass of an aqueous alcohol solution having a lower concentration than that used in the first step is further impregnated as the second step. And then pulverizing so that the particle size becomes 1 mm or less. 3. An alcohol aqueous solution is added as a third step to 1 part by mass of the granules produced by the production method according to claim 2 .
A method for producing granules, comprising uniformly impregnating and drying from 0.5 to 0.4 parts by mass, and then pulverizing the particles to a particle size of 1 mm or less. 4. An alcohol aqueous solution is added as a third step to 1 part by mass of the granules produced by the production method according to claim 2 .
The wet mass, which is uniformly impregnated with 0.5 to 0.4 parts by mass, is subjected to crush granulation or extrusion granulation by passing through a screen of 6 mm or less, then dried, and then crushed so that the particle size becomes 1 mm or less. A method for producing granules.