JP3267291B2 - Iontophoresis film - Google Patents

Description

Description: FIELD OF THE INVENTION The present invention relates to an iontophoresis treatment device for introducing a drug to a treatment site by using a weak current, and particularly to a simple disposable disposable device using a paper battery. The present invention relates to an iontophoresis film.

[Background Art] Iontophoresis is a method in which a direct current is continuously or intermittently conducted to a body, and an ionic chemical is absorbed into tissues and blood vessels near the skin through the skin by the electric electromotive force. This is an electrical iontophoresis therapy that has been gradually implemented since the beginning of this century. The advantages of this iontophoresis are that, first, there is no pain compared to the conventional drug administration by injection, etc., and second, because local drug administration is near the treatment site as compared to oral administration, systemic That is, it is possible to prevent an increase in the concentration of a drug.

Despite the above advantages, the reason that local therapy using iontophoresis is adopted only by specialized medical institutions seems to be the following three reasons.

First, the first point is that general iontophoresis treatment instruments are extremely expensive and difficult to handle, so that only specialists can use them.

The second point is that iontophoresis cannot be adopted for all drugs because the type of drug to be administered is limited to ionic drugs. Specifically, drugs administered to the skin from the positive electrode by iontophoresis include alkaloids such as copper, zinc, and morphine (morphine), and drugs administered to the skin from the negative electrode include salicylic acid and fluorine compounds. , Penicillin, insulin and the like.

The third point is that a change in PH near the electrode during iontophoresis and the occurrence of burns due to overcurrent have been regarded as problems.

However, this point is due to the improvement of the iontophoresis treatment device and the improvement of the handling work, which has made it possible to prevent the conduction of overcurrent, and there have been many improvements reported as a method of preventing the pH change near the electrode. Has been made. For example, the electrode is made of an ion exchange resin, allowing ions to pass selectively,
H ⁺ ions and OH in the skin around the region to be treated ^- such as how to prevent a large amount generation of ions (JP-A-1-32872) are known.

In addition, with respect to the fact that the types of drugs to be administered are limited, recently the drugs themselves have been considerably improved and have become more easily ionized.

Therefore, the biggest reason that iontophoresis is not widely used in various medical institutions is that the iontophoresis treatment device mentioned in the first point is very expensive and difficult to handle without advanced knowledge. It means that it can only be used by experts.

As a relatively simple iontophoresis therapy device to improve this point, a disposable iontophoresis therapy device that uses a flat small primary battery such as a button-type battery that is commonly available as a power source for iontophoresis (Japanese Patent Application Laid-Open No. 1-97475) and a thread-like stimulation electrode, an indifferent electrode, and a stimulation signal generating means provided between the two electrodes. The stimulation signal is generated using a sheet battery to treat the affected part. An electrical stimulation wound treatment device (Japanese Patent Laid-Open No. 63-229068) has been devised.

[Problem to be Solved by the Invention] However, in the case of using a general button-type battery, the small battery itself has a thickness and lacks flexibility, so that the usability is not good, and the battery is rough when actually used. It is very inconvenient to move while wearing.

In addition, at the time of iontophoresis, it is necessary to change the voltage value and the current value depending on the type of the drug, and to change the capacity of the battery so as to set the effective duration of the treatment. Then, such a response is difficult.

On the other hand, the electrical stimulation wound treatment device disclosed in Japanese Patent Application Laid-Open No. 63-229068 is very complicated because the device itself for generating a stimulation signal is an electrical circuit including an IC chip, a capacitor, and a diode. Similar to the treatment device of the above, it is not only inconvenient that it cannot move freely while being attached to the body, but also too expensive to disposable.

By the way, in iontophoresis therapy, 0.5 mA / cm ²
The become clear in 30 minutes or more locally conduction and burns happen clinical tests, etc., at present the number μA~ several mA about the current value at the time of iontophoresis therapy, several .mu.A / cm ² of about weak It is known that performing treatment with electric current for a long time is more effective for the human body and is more effective. Therefore, a power supply that provides such a weak electric current for a long time is required.

In recent years, the drug itself has been improved, and not only has it become easier to ionize, but also the current value during iontophoresis that is most effective depending on the type of drug has been clarified in clinical trials, etc. A power supply that can handle these types is required.

[Object of the Invention] The present invention has been made in order to solve the above-mentioned conventional problems, and an object of the present invention is to provide a safe and simple disposable iontophoresis treatment device which is free from skin disorders such as burns.

Another object of the present invention is to provide an iontophoresis treatment device which is lightweight and flexible, has good usability, can freely move around without any discomfort, and is easy to manufacture.

Furthermore, the present invention shows an effective voltage value and current value according to the kind of the drug used, and can freely change the capacity of the battery so as to correspond to the optimal duration for the treatment. An object is to provide a high iontophoresis treatment device.

[Means for Solving the Problems] An iontophoresis film of the present invention that achieves the above object has an insulating base material having an adhesive layer on one surface and electrodes on both surfaces, and is provided outside the adhesive layer. A paper battery in which one electrode is adhered to the adhesive layer except for a peripheral portion, a conductive treatment agent laminated on the other electrode of the paper battery, and the one electrode is insulated from the other electrode. And a terminal for electrically connecting the paper battery to the skin surface, and the paper battery is cut into a desired size, and a necessary number of the battery cells are stacked so as to have an electric capacity according to the conductive therapeutic agent. It consists of.

Here, as the paper battery, a cutable battery using a polymer solid electrolyte as an electrolyte is preferable. As such a paper battery, the one already proposed by the present inventor (JP-A-1-130473) is particularly preferable. This paper battery is extremely lightweight and flexible, and can be manufactured thin.In addition, since it uses a solid electrolyte, there is no liquid leakage and safety is high, and it also has a stable super power. By stacking, a desired voltage can be obtained, and a desired size, that is, a desired capacity can be used depending on the application and as needed.

[Action] The iontophoresis film is applied so that the surface to which the conductive therapeutic agent is applied is in direct contact with the skin surface of the affected part. Then, a weak current flows between the portion of the skin surface that is in contact with the conductive therapeutic agent and the portion of the skin surface that is in contact with the terminal from the other electrode, and the electromotive force causes the conductive current to flow. The ionic chemicals in the drug are absorbed through the skin into nearby tissues and blood vessels. In this case, a paper battery using a solid polymer electrolyte composed of an amorphous polymer compound and an alkali metal salt has an area as required, and also has a capacity and a capacity according to the ionic chemical by being laminated. It can be a voltage value or a current value, and the current continues to flow by the capacity, and the therapeutic effect is maintained during that time.
That is, the treatment can be performed for a long time with a weak current, the safety to the human body is high, and iontophoresis can be performed effectively.

EXAMPLES Hereinafter, an example of the iontophoresis film of the present invention will be described with reference to the drawings.

As shown in FIG. 1, iontophoresis film A
Is a flexible paper battery 1 having both poles, which can be freely cut; a terminal 3 connected to one pole 11 of the paper battery 1 and insulated from the other pole 13; The conductive therapeutic agent 7 provided on the substrate, the adhesive substrate 4 for fixing the conductive therapeutic agent 7 and the terminal 3 to the skin as the contacted part, and the conductive therapeutic agent 7, the terminal 3, and the adhesive substrate 4 The laminated peeling member 5 is laminated and integrated.

To insulate the terminal 3 from the other pole 13 of the paper battery 1 and the conductive therapeutic agent 7 provided on the other pole 13,
As shown in FIG. 3, one side edge 1a of the paper battery 1
The insulating film 2 is laminated so that the portion (shaded portion in FIG. 3) is covered including its thickness. A metal foil one size smaller than the paper battery 1 is used as the terminal 3, and a part of the metal foil is laminated and stuck so as to come off the paper battery 1 and the insulating film 2.

Further, as shown in FIG. 4, the conductive therapeutic agent 7 provided on the other pole surface of the paper battery 1 and the metal foil 3 as a terminal drawn out from one pole are securely attached to the affected part skin surface. An adhesive substrate 4 having a size capable of covering the paper battery 1, the insulating film 2 and the metal foil 3 is laminated so as to be attached.

Examples of the conductive therapeutic agent 7 include agents administered to the skin from the positive electrode, such as copper, zinc, and alkaloids such as morphine (morphine). Examples of the agents administered to the skin from the negative electrode include salicylic acid, fluorine compounds, penicillin, Insulin and the like. More specifically, the following agents can be used as components for iontophoresis.

Disinfectants include phenol, ethanol, acrinol, oxidol, benzalkonium chloride, benzathonium chloride, mercurochrome, iodotin, sodium hypochlorite, cresol, etc., and anti-inflammatory agents such as salicylic acid, naphazoline hydrochloride, etc. Anti-histamines, ointment bases, fragrances, etc., such as camphor, dibucaine hydrochloride, lidocaine hydrochloride, antibiotics, chloramphenicol, kanamycin sulfate, gentamicin sulfate, etc .; hormones, prednisone, prednisolone, etc. Is, for example, sulfadiazine, sulfadimethoxine, vitamins such as vitamin A-balmitin ester, vitamin D2, vitamin E acetate, and sugars such as glucose,
As the inorganic components such as fructose and maltose, potassium, sodium and many other agents can be used as the components of the conductive therapeutic agent 7 of the iontophoresis film A of the present invention.

Needless to say, these must be provided at predetermined poles according to their ionic characteristics. Such a therapeutic agent may be applied in powder or liquid form on the electrode of the paper battery 1, or may be impregnated with a sterilized gauze or the like and affixed on the electrode. In this case, if the therapeutic agent does not have powder or conductivity, a known solution containing a conductive substance that does not have a negative effect on the human body is injected or added.

Further, a gel-like wet pad may be provided on the conductive therapeutic agent 7 for iontophoresis, depending on the location and state of the iontophoresis film A to be applied. The use of a gel-like wet pad provides a good feeling of adhesion when applied to a curved surface such as an elbow or other joint or a region where movement is severe, and the iontophoresis film A is not easily shifted, and thus is not easily shifted. Burns that may occur when the vehicle is damaged can be avoided.

The flexible paper battery 1 having both poles and which can be freely cut is not particularly limited, but a paper battery using a polymer solid electrolyte composed of an amorphous polymer compound and an alkali metal salt is preferable. FIG. 5 shows an example of such a paper battery. This paper battery is formed by sequentially laminating a layer (positive electrode) 11 composed of a positive electrode material dispersed in a polymer, a solid polymer electrolyte layer 12 and a negative electrode 13 on an insulating film 10. The layer (positive electrode) 11 composed of the positive electrode material dispersed in the polymer may be separated from the current collecting layer 11-1 of the positive electrode and the active material layer 11-2 of the positive electrode.

The non-crystalline polymer compound is a polymer compound having a glass transition point lower than room temperature and under active molecular motion at room temperature, such as polyethylene oxide (PEO),
Polymethoxy polyethylene glycol methacrylate,
At least one polymer compound selected from polyvinyl pyridine, polysiloxane, polypropylene oxide, segmented polyurethane, polyurethane urea, polyphosphazene, cellulose, polystyrene, and polypeptide is used. Desirably, polymethoxy polyethylene glycol methacrylate, poly Phosphazen is used.

Further, the alkali metal salt is LiClO ₄ , LiBr, LiSC
At least one lithium metal salt selected from N, LiCl, LiBr ₄ and LiPF ₆ , preferably LiClO ₄ .

Paper battery using the above polymer solid electrolyte,
It is extremely lightweight and can be manufactured thinly, has no liquid leakage, and is not only highly safe, but also has a stable electromotive force. It can be used as a desired size, that is, a capacity as needed.

When a paper battery using the above polymer solid electrolyte is used, the insulating film 10 is peeled off to expose both electrode surfaces before use.

Thereafter, the conductive therapeutic agent 7 is applied to either the positive electrode or the negative electrode of the paper battery 1 depending on the ionicity of the agent.

The paper batteries 1 are stacked, if necessary, to obtain a desired voltage so as to exhibit an optimum voltage value suitable for the type of the conductive therapeutic agent 7.

Further, it is desirable that the paper battery 1 be cut into an appropriate size and shape with disinfected scissors or the like so that the affected skin area and the treatment duration are most effective. For example, in the case of a wound such as a finger, a band may be formed as shown in FIG.

As the insulating film 2, a plastic film,
Any insulating sheet such as laminated paper or synthetic paper can be used, but a sterilized sheet that has been sterilized in advance is desirable.

As the metal foil 3, aluminum, copper, nickel or the like can be used, but an aluminum foil which is highly safe, mass-produced and inexpensive is preferable.

The adhesive base material 4 is not particularly limited as long as an adhesive sheet is provided on one side with an insulating sheet such as a plastic film, a laminated paper, or a synthetic paper, but is not particularly limited. Although it is preferable to use a color that does not cause discomfort during use, it is preferable to use a sterilized product that has been sterilized in advance.

After the peeling member 5 is peeled off, the iontophoresis film A configured as described above is affixed so that the application surface of the conductive therapeutic agent 7 directly contacts the affected part skin surface 6.

Then, the skin surface 6 in contact with the conductive therapeutic agent 7
A weak current flows between the portion B of FIG. 2 and the portion C of the skin surface 6 which is in contact with the metal foil 3 which is the terminal electrode from the other electrode 11 (near the arrow in FIG. 2). Sex chemicals can be absorbed through the skin into nearby tissues and blood vessels. That is, ions having a positive charge move into the skin on the positive electrode side of the paper battery 1, and ions having a negative charge move into the skin on the negative electrode side. As a result, the ionic drug is absorbed into tissues and blood vessels near the skin.

In this case, the current continues to flow by the capacity of the paper battery 1 using the solid polymer electrolyte composed of the amorphous polymer compound and the alkali metal salt, and the therapeutic effect is maintained during that time. That is, the treatment can be performed for a long time with a weak current, the safety to the human body is high, and iontophoresis can be performed effectively.

Specific symptoms in which the therapeutic effect of the iontophoresis film of the present invention is recognized include cuts, abrasions,
Cutaneous wounds, cutaneous wounds, cutaneous wounds, etc., suppurative skin diseases such as tobi, melancholy, folliculitis, eczema, dermatitis, soreness, rash, rash, itch, soybean burn, insect bite, hives Such as integumental pain, itching, inflammation, etc., but in addition to the various symptoms for which conventional iontophoresis therapy can be used, of course, use the iontophoresis film A of the present invention for treatment. It goes without saying that it can be done.

Example First, a flexible paper battery 1 having both poles and used for the iontophoresis film of the present invention, which can be freely cut, was prepared by the following procedure. As the insulating film 10 shown in FIG.
m), the composition having the following formulation was dispersed and mixed by a ball mill for 24 hours to obtain a coating solution, and the coating solution was applied to a dry weight of 20 μm with a Mayer bar at 100 ° C.
For 5 minutes to form a current collecting layer 11-1 of the positive electrode.

Conductive carbon black (Vulcan XC-72 Cabot) 6 parts by weight Dispersant (Roma PW Sannopco) 1 part by weight Water 81 parts by weight Aqueous polyurethane resin (Necarez R960 Polyvinyl Chemicals) 12 parts by weight When the surface resistance of the electric layer 11-1 is 15 cm × 15 cm,
The 4-terminal method was 5 × 10 ² Ωcm ⁻¹ .

Next, on the current collecting layer 11-1 of the positive electrode, a mixture having the following formulation was dispersed and mixed by a ball mill for 24 hours to obtain a coating solution.
The coating solution was applied using a Mayer bar so that the dry film thickness became 20 μm, dried at 100 ° C. for 5 minutes, and dried on a positive electrode active material layer 11−.
And 2.

Manganese dioxide 24 parts by weight Dispersant (Roma PW Sannopco) 1 part by weight Isopropyl alcohol 5 parts by weight Water 60 parts by weight Water-based polyurethane resin (Permarin UA500 Sanyo Chemical Industries, Ltd.) 10 parts by weight Created as follows.

First, a polymer of the monoester methacrylate of the formula I (where n = 4) was polymerized as follows.

Monoester methacrylate (NK
A solution in which ester M-40G (manufactured by Shin-Nakamura Chemical Co., Ltd.) was dissolved was stirred in a polymerization tube under a nitrogen stream. Thereafter, a solution prepared by dissolving 1 g of azoisobutylnitrile in 10 g of methylene chloride was added dropwise, and the mixture was stirred at 50 ° C. for 45 minutes.

After allowing the reaction solution to cool at room temperature, it was added to 500 ml of methanol with stirring to precipitate the desired polymer. The polymer was redissolved in methylene chloride, purified by repeating reprecipitation with methanol again, and dried in vacuo at 70 ° C. to obtain a crude polymer.

The viscosity of a 70% by weight methylene chloride solution of this polymer was 500 cps (25 ° C.) using a B-type viscometer.

25.5 g of this polymer, 4.5 g of LiClO ₄ , and 70 g of methylene chloride were stirred and mixed to form a coating solution, which was uniformly coated on the positive electrode active material layer 11-2 so as to have a dry film thickness of 15 μm. After drying for 5 minutes, a polymer solid electrolyte layer 12 was obtained.

Further, a 15 μm-thick aluminum foil was laminated as the negative electrode 13 on the polymer solid electrolyte layer 12 to produce the paper battery 1.

Here, the performance of the paper battery 1 was measured, and safety to a human body was confirmed.

First, we considered how much the resistance value of the human skin surface was actually within.

Although the surface resistance of the skin surface of the human body varies from person to person, for example, the sweat line activity is always active in the palm and the like, and the skin surface sweats considerably immediately after marathon or when sleeping in a futon. As a result, the surface resistance decreases.

By the way, when a 24-year-old, medium-thick, medium-thick healthy man measures the surface resistance of the human body after running a marathon for 30 minutes, the neck part where sweat is shining is about 2 kΩ, and the slippery part of the shoulder It was about 150 kΩ with a sweaty appearance.

When the skin surface is relatively dry or when it has humidity, the surface resistance of the human skin is set to 150 kΩ and 2 kΩ, respectively, and the environment is frozen in the cold wind. Assuming the extreme cases of the skin surface inside the futon while sleeping, the temperature was set to 20 ° C / 60% and 40 ° C / 95%.

The maximum current value of the paper battery 1 having a size of 86 mm × 54 mm was measured in the above environment, and the results were as shown in the table below.

Normally, under the environmental conditions in which we live, it is easily presumed that the current value is approximately within the range shown in the table.

The maximum current value in the table is 40 ° C. 2kΩ under 95% environment
And the maximum current density is calculated to be 0.005 mA / cm ² .

By the way, in iontophoresis therapy, usually several μA
It is known that treatment can be performed safely and effectively by conducting a weak current of about several mA to the human body for a long time,
Conversely, it is known that a skin injury such as a burn occurs when a current of 0.5 mA / cm ² is conducted for 30 minutes or more.

The calculated value of 0.005 mA / cm ² is about 1/100 of the current density compared to 0.5 mA / cm ² , which is the limit at which skin damage such as the above-mentioned burn occurs, and is about 100 times that of 3000 mA. It is safe to conduct for a minute.

Fig. 7 shows the paper battery 1 of the same size at 40 ° C and 95%.
As a result of measuring the discharge characteristics when a load resistance of 2 kΩ was connected under the environment described above, the relationship between current-voltage-time is shown. As is clear from the figure, the current value is the maximum current value after several hours.
It indicates 0.25 mA, after which the current and voltage values decrease. Therefore, even if the paper battery 1 is continuously applied in an environment of 40 ° C. and 95%, there is no possibility of causing a burn, and the treatment can be performed safely and effectively.

Hereinafter, the results of treatment with the iontophoresis film A of the present invention using the paper battery 1 obtained in the above example will be described.

Case 1 (51 years old, office worker) When falling down on a bicycle, the length is about 2 cm above the knee and the length is 5
He suffered a tear 2 cm in depth and 2 cm in depth.

When a commercially available acrinol gauze was applied to the wound for a while and observed, a few days later, the symptoms seemed to be apparent suppuration, and the pus oozed out even if the acrinol gauze was replaced every few hours when the stench was severe I felt pain.

Thereafter, a commercial mercurochrome solution was immersed in the disinfected gauze and replaced every few hours, but no significant effect was observed.

(Results of treatment) One piece of the paper battery was cut into a size of 7 cm x 3 cm so that the wound was completely hidden, and one electrode was provided with benzathonium chloride as a disinfectant component.
Nafazoline hydrochloride as an anti-inflammatory agent, disinfected gauze containing an appropriate amount of dibucaine hydrochloride as a local anesthetic was applied, and an iontophoresis film was applied together with the other electrode so that the gauze adhered to the wound, saw.

However, the wound did not improve and suppuration advanced. Therefore, three pieces of the paper battery cut into a size of 7 cm × 3 cm were laminated so as not to be short-circuited, and an iontophoresis film obtained by applying an ointment containing sulfadimethoxine as a sulfa agent to one electrode of the paper battery was used. It was applied to the wound. It was replaced every 5 hours. The current between both electrodes is about 50
It was confirmed that the current value was stable at μA and the current value was favorable for iontophoresis. At the time of the third replacement after the application of the iontophoresis film coated with the sulfa drug, the odor of the wound was almost completely eliminated, and the amount of pus was considerably reduced.

Therefore, the replacement time of the iontophoresis film was changed from 5 hours to 10 hours, and the film was further replaced four times. The current value was also stable at about 50 μA from the time of attachment to the time of replacement.

Forty-five hours after applying the iontophoresis film coated with the sulfa drug to the affected skin, almost no pus became oozed by the edge of the iontophoresis film, so the drug of the iontophoresis film was re-benzathonium chloride, Nafazoline hydrochloride, dibucaine hydrochloride as a main component disinfectant disinfectant, the same size of the battery using iontophoresis film using only one, using a new one several times a day, treatment was continued However, about one week later, the wound was completely closed.

Regarding the result of this treatment, conventional injection and incision (suture)
It was clear that the results were the same or faster as compared with the bactericidal treatment using the method described above.

Case 2 (25 years old, housewife) Caring for the roses in the garden caused numerous scratches on both hands.

Therefore, an iontophoresis film of the present invention (see FIG. 6) prepared by selecting several points having the same length and depth in the form of a band in accordance with the length of the wound, and acrinol gauze in the center The placed general first aid tape was applied several times to portions where the degree of scratches seemed to be the same, and the healing speed was compared.

The iontophoresis film was obtained by using one piece of the paper battery obtained in the above example for one sheet of the iontophoresis film, and affixing acrylol gauze to one of the electrodes.

(Treatment Result) The degree of healing of the wound by the iontophoresis film of the present invention was clearly faster than that of a general emergency treatment tape.

It seems that healing was accelerated due to the high rate of absorption of acrinol by the affected area of the skin due to iontophoresis.

Case 3 (63-year-old, housewife) Complained of severe itchiness due to moisturization during this treatment because of cold and susceptibility to morbidity.
He always used a commercially available ointment containing an antihistamine, but complained that healing was slow.

(Treatment results) An ointment containing a commercially available antihistamine, which was conventionally used by the subject, was applied to one electrode of the iontophoresis film of the present invention, and was used in several affected parts of the limbs with severe morbidity. As a result, healing was faster than usual.

One paper battery was used for one iontophoresis film.

In addition, once at a place where the iontophoresis film of the present invention was used, the result was that it became difficult to cause bruise for a while.

This is presumably because the iontophoresis film of the present invention promotes blood circulation in the affected skin, improves the physical properties such as coldness for a while, and makes it less likely to cause bruising.

In the treatment of various symptoms in addition to the above treatment results, several layers of the iontophoresis film of the present invention may be laminated depending on the degree of each symptom, or the area of the paper battery may be increased to extend the duration of the treatment effect. In most cases, the speed of treatment could be confirmed.

[Effects of the Invention] As is clear from the above examples, the iontophoresis film of the present invention is easy to manufacture and inexpensive, can be easily handled by anyone, and is safe without skin damage such as burns. It is a disposable iontophoresis treatment device.

In addition, the iontophoresis film of the present invention is lightweight and flexible, so that it has a good feeling of use and can freely move around without any discomfort. Furthermore,
The effective voltage and current values and the effective duration of the treatment can be freely adjusted according to the type of the therapeutic agent for iontophoresis, and the therapeutic effect is high.

In particular, when the iontophoresis film of the present invention is used in combination, the treatment can be performed clearly and safely, as compared with the case where a household medicine that can be purchased at a pharmacy or the like can be used as it is.

Furthermore, infants and children often dislike injections and incisions (associations), but if the iontophoresis film of the present invention is used, treatment of wounds and the like can be easily advanced and there is no concern about side effects.

As described above, the iontophoresis film of the present invention is medically very valuable.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing one embodiment of the iontophoresis film of the present invention, FIG.
3 and 4 are views showing the structure of the iontophoresis film of the present invention, FIG. 5 is a sectional view of a paper battery used for the iontophoresis film of the present invention, and FIG.
The figure shows a use example of the iontophoresis film of the present invention, and FIG. 7 shows the discharge characteristics of a paper battery. A ... Iontophoresis film 1 ... Paper battery 2 ... Insulating film 3 ... Terminal 4 ... Adhesive base material 5 ... Peeling member 6 ... Skin surface 7 ... Conductive therapeutic agent 10 ... Insulating film 11: The other electrode (positive electrode) 12: Polymer solid electrolyte layer 13: One electrode (negative electrode)

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. ⁷ , DB name) A61N 1/30 A61N 1/04

Claims (1)

(57) [Claims] 1. An insulative base material having an adhesive layer on one surface, and a paper battery having electrodes on both surfaces, and one electrode stuck to said adhesive except for an outer peripheral portion of said adhesive layer. ,
A conductive therapeutic agent laminated on the other electrode of the paper battery, and a terminal insulated from the other electrode and having a terminal for electrically connecting the one electrode to the skin surface, An iontophoresis film, which is obtained by laminating a necessary number of pieces cut into a desired size so as to have an electric capacity suitable for the conductive therapeutic agent.