JP4171630B2 - Ion introduction tool - Google Patents

Description

[0001]
[Technical field to which the invention belongs]
The present invention relates to an iontophoresis device, and more particularly, to an iontophoresis device that can be easily used, is not bulky as a whole, and hardly interferes with operations in daily life.
[0002]
[Prior art]
[Patent Document 1]
Japanese Patent No. 2797118 Specification
Iontophoresis (iontophoresis) is a method in which a physiologically active substance is administered transcutaneously by utilizing the electric repulsive force between a positively or negatively charged electrode and an ionic physiologically active substance. Unlike the above, in principle, it has characteristics that do not involve physical and mental pains such as pain and fear when administered. Many conventional iontophoresis devices were composed of a pair of electrodes, an oscillation circuit for applying a parallel or low-frequency pulse voltage to the electrodes, and a power supply circuit for energizing the oscillation circuit. Therefore, it is bulky as a whole, is difficult to handle in ordinary households, and requires a power source such as a battery or a power line. For this reason, there is a problem that when the battery is exhausted or taken out to an environment where a power line cannot be used, it is impossible to introduce ions at all.
[0004]
As a method for solving such a problem in the iontophoresis device, Patent Literature 1 proposes an iontophoresis device in which an anode mainly composed of a noble metal and a cathode mainly composed of a metal oxide semiconductor are connected by a conductive wire. Yes. Since this iontophoresis device uses the contact potential difference between a noble metal and a semiconductor, in principle, it does not require any power source such as a battery or a power line, which has been an indispensable element in conventional iontophoresis devices. There are advantages. However, even in such an iontophoresis device, since the matrix is provided so that the electrodes are connected to each other with a conducting wire or impregnated with a physiologically active substance on one side of the anode, the whole is easy to be bulky and comes into contact with the body surface. There was a problem that it was easy to disturb the operation in daily life.
[0005]
[Problems to be solved by the invention]
In view of such a situation, an object of the present invention is to provide an iontophoresis device that can be easily used, is not bulky as a whole, and hardly interferes with operations in daily life.
[0006]
[Means for Solving the Problems]
As a result of diligent investigation and research by the present inventors, a holding member, a foil-like cathode held on the holding member, and a cathode held via the foil-like conduction resistance member are held on the holding member. An iontophoresis device comprising a foil-like anode having a smaller ionization tendency than a cathode and a gel-like member held on the cathode and / or the anode can be easily used and is not bulky as a whole. It turned out to be difficult to interfere with the movement in daily life. In particular, for example, when the cathode and the anode are connected via a foil-like conduction resistance member, the conductive wire connecting the electrodes can be omitted, there is no contact failure, and the entire device including the electrode portion is lightweight and It has been found that an excellent advantage that it can be formed into a bendable sheet is obtained.
[0007]
That is, the present invention has the above-described problems, the holding member, the foil-like cathode held on the holding member, and held on the holding member, and connected to the cathode via the foil-like conduction resistance member. The problem is solved by providing an iontophoresis device comprising a foil-like anode having a smaller ionization tendency than the cathode, and a gel-like member held on the cathode and / or anode.
[0008]
Furthermore, the present invention provides the above-described object, in the iontophoresis device having such a configuration, in which the anode is a metal or a metal-based member (hereinafter referred to as “a metal or a metal-based material” unless otherwise specified). Simply abbreviated as “metal”), or an iontophoresis device which is a foil-like body obtained by vapor-depositing the metal on the holding member or another foil-like member different from the holding member To solve this problem.
[0009]
Furthermore, the present invention provides the above-described object, in the iontophoresis device having such a configuration, in which the cathode has a metal or a metal-based member having a higher ionization tendency than the anode, on the holding member or other than the holding member. This is solved by providing an iontophoresis device which is a foil-like body obtained by vapor deposition on the foil-like member.
[0010]
Furthermore, the present invention solves the above-mentioned problem by providing an iontophoresis device having such a configuration in which the resistance value of the conduction resistance member exceeds the resistance value in the skin of mammals including humans. It is.
[0011]
Further, according to the present invention, in the iontophoresis device having such a configuration, the conductive resistance member is one or two selected from conductive carbon, conductive ceramic, conductive plastic, and conductive metal. The problem is solved by providing an iontophoresis device comprising one or more selected from at least one species.
[0012]
Furthermore, this invention solves the said subject by providing the iontophoresis device which hold | maintains a foil-shaped release member on a gel-like member in the iontophoresis device of such a structure.
[0013]
Furthermore, this invention solves the said subject by providing the iontophoresis device whose release member is a transparent or opaque release member in the iontophoresis device of such a structure.
[0014]
Furthermore, this invention solves the said subject by providing the iontophoresis device whose form is a sheet form in the iontophoresis device of such a structure.
[0015]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described with reference to illustrated examples. FIG. 1 is a plan perspective view of an embodiment of the iontophoresis device of the present invention, and FIG. 2 is a longitudinal sectional view of the embodiment shown in FIG. 1 taken along a cutting line AA ′. 1 and 2, reference numeral 1 denotes a holding member, which is generally used in skin patches and has flexibility, such as paper, cloth, non-woven fabric, wood, bamboo, plastic, polymer, and laminates thereof. A foil-like non-conductive material such as the above is used, and this is cut into a shape and size corresponding to a portion of the body surface to be ion-introduced. On the holding member 1 in contact with the body surface of the living body, one or more of natural, synthetic or semi-synthetic adhesive polymer bases that are generally used for skin patches are used as an adhesive, and if necessary. In addition, one or more of a viscosity imparting agent, a softening agent, an inorganic filler, an absorption accelerator, a solubilizer, a fragrance, a pigment, and the like are blended into this. One or more of (plaster) or the like can be partially spread.
[0016]
In FIG. 1 and FIG. 2, reference numeral 2 denotes an anode made of metal or a metal-based member, and usually a thin precious metal such as gold, silver, platinum, or an alloy thereof, or a material based on them is spread thinly. A linear or flat strip made of these metals or a metal-based material is woven by a general-purpose method and held on the holding member 1 by a general-purpose method, or the holding member 1 or the holding member The film is deposited on a foil-like holding member different from 1 by a general-purpose method such as sputtering, vacuum deposition, or chemical vapor deposition, and has a thickness of 1,000 μm or less, preferably 1 to 500 μm, more preferably 1 The anode 2 can be formed as a foil having a thickness of 100 μm. In this example, the anode 2 is held on the holding member 1 by appropriately laminating a gold foil on the holding member 1 via an adhesive. The anode 2 is usually composed of an electrode having a smaller ionization tendency than the cathode 3 described later. Further, the anode 2 is different from the holding member 1 as a non-conductive material, for example, on a part or the whole surface of another member (base) mainly composed of a foil-like plastic or a foil-like non-conductor. If necessary, a linear or flat band-shaped body made of such a member may be formed by laminating a metal constituting the metal or covering with a member constituting the anode 2 by a general-purpose method such as sputtering, vacuum vapor deposition, or chemical vapor deposition. Alternatively, the anode 2 can be blended with a chemical fiber or the like by a general-purpose method and woven. The electrode 2, the holding member 1 as the base of the electrode 2, the other foil-like member different from the holding member, and the cathode 3 are each independently usually at a thickness of 1,000 μm or less, preferably 1 to It is formed into a foil shape of 500 μm, more preferably 1 to 100 μm. When the electrode 2 is disposed on the base, the total thickness thereof is preferably in the range of 1 to 1,000 μm. Moreover, the thickness of the holding member 1, the electrode 2, and the cathode 3 may be comprised uniformly throughout, and thickness can also be changed arbitrarily partially.
[0017]
1 and 2, reference numeral 3 denotes a foil-like cathode, which is a cathode made of one or more materials selected from metals, conductors other than metals, and semiconductors, which have a high ionization tendency with respect to the anode 2. Yes, usually generates electric potential in contact with metal, such as carbon, conductive plastic, conductive ceramic, titanium, iron, nickel, zinc, aluminum, carbon, tin, antimony, bismuth, or alloys thereof Conductor or thinly spread semiconductors such as zinc oxide, tin oxide, antimony oxide, bismuth oxide, or linear or flat strips made of these semiconductors, if necessary, with chemical fibers, etc. The cathode 3 is mixed or woven by the method described above, or further, a part of or the whole of the cathode 3 based on a foil-like plastic or a foil-like non-conductor different from the holding member 1. The member to be formed is laminated by a known method, or further, the member is deposited on a part or all of the base by a general method such as sputtering, vacuum deposition, chemical vapor deposition, etc., and the thickness is 1,000 μm or less. The foil-like cathode 3 is preferably 1 to 500 μm, more preferably 1 to 100 μm or less. In this example, two pieces of rectangular aluminum foil are used as the cathodes 3 and 3 and are laminated on the holding member 1 through a binder as appropriate. The anode 2 and the cathodes 3 and 3 are connected via the conduction resistance members 4 and 4. In this example, the foil-like conduction resistance members 4 and 4 are partially laminated on the anode 2 and the cathodes 3 and 3, but the gaps X and X located between the anode 2 and the cathodes 3 and 3 are used. In addition, a member that is the same as or different from the conductive resistance members 4 and 4 can be disposed, and a short circuit between these electrodes can be substantially eliminated. Further, in the conductive resistance members 4 and 4, preferably, a non-conductive member is disposed by a general-purpose method at a portion in contact with the biological skin surface so that the conductive resistance members 4 and 4 are connected to the biological skin surface. Avoid direct contact. The resistance of the conductive resistance members 4 and 4 for connecting the anode 2 and the cathodes 3 and 3 is the type, nature, introduction time, and ion introduction tool of the ionic physiologically active substance to be ion-introduced. It can be set as appropriate according to the living body including humans, and is usually set so as to exceed the resistance value of the skin of mammals including humans. Moreover, it is not preferable that the resistance of the conduction resistance members 4 and 4 is less than the resistance value in the skin of mammals including human beings because unfavorable stimulation may be given to the skin of the living body. Furthermore, although there is no upper limit of the resistance of the conduction resistance members 4 and 4, it should be set in consideration that the ion introduction rate of the ionic physiologically active substance to be ionized decreases as the resistance increases. In general, the resistance of the conductive resistance members 4 and 4 is usually more than 0 kΩ and 1,000 kΩ or less, preferably more than 10 kΩ and 500 kΩ or less, more preferably more than 50 kΩ and 100 kΩ or less. Such conduction resistance members 4 and 4 are appropriately selected from one or more of metals such as iron, gold, and aluminum, carbon, carbon nanotubes, conductive plastics, conductive ceramics, conductive pastes, conductive coating agents, and the like. It mix | blends and processes by a general purpose method, It is set as the conduction | electrical_connection resistance members 4 and 4 which have the said resistance value. At this time, one or more of a diluent, an antistatic agent, an overcoat agent, a binder, a paint, a polymer, and the like can be blended. In addition, as the conductive resistance members 4 and 4, a linear member that causes disconnection is excluded.
[0018]
In FIG. 1 and FIG. 2, reference numeral 5 denotes a gel-like member held on the anode 2, which can normally be brought into safe contact with the skin without any side effects, and should be introduced subcutaneously by the iontophoresis device of the present invention. Any member can be used as long as it can stably hold the ionic physiologically active substance, and one or more of natural, synthetic or semi-synthetic adhesive polymer bases can be used in appropriate combination. Examples of the adhesive polymer base include agar, alginic acid, carrageenan, farcellulan, gelatin, pectin, starch, xanthan gum, gellan gum, guar gum, locust bean gum, gum arabic, tamarind seed gum, curdlan, carrageenan, gellan gum, Examples thereof include polysaccharides such as pullulan and derivatives thereof, and acrylic-based, rubber-based, and silicon-based water-containing members. These adhesive polymer bases may be appropriately blended with one or more of a viscosity imparting agent, a softening agent, an inorganic filler, an absorption accelerator, a solubilizer, a fragrance, and a pigment as necessary. it can.
[0019]
In the present invention, the arrangement and shape of the anode 2 and the cathode 3 on the support member 1 are not limited to those shown in FIGS. 1 and 2, and in short, the anode 2 and the cathode 3 are held by the support member 1. In this state, when both electrodes are connected via the conductive resistance member 4 and the gel-like member 5 held on the anode 2 and / or the cathodes 3 and 3 is brought into contact with the body surface of the living body, As long as a difference in contact potential between the cathode 3 and the ionic physiologically active substance held in the gel member 5 can be administered subcutaneously, their arrangement and shape are not limited. Further, the shape and size of the anode 2 and the cathode 3 on which the gel-like member 5 is arranged can be devised according to the shape and size of the part of the body surface on which the gel-like member 5 is brought into contact. A part of the side in contact with the body surface may be covered with an insulating member. In FIG. 1 and FIG. 2, the gel-like member 5 is disposed only on the anode 2, but may be disposed on the anode 2 and the cathode 3 or only on the cathode 3 as necessary. it can. In the iontophoresis device of the present invention, an anionic physiologically active substance is ion-introduced from the anode 2 side and a cationic physiologically active substance is ion-introduced from the cathode 3 side to the skin. Further, the arrangement of the anode 2 and the cathode 3 in FIGS. 1 and 2 can be reversed as necessary.
[0020]
In the embodiment shown in FIG. 1 and FIG. 2, the lead wire for connecting the anode and the cathode, which is an indispensable element in the conventional ion introduction tool, can be omitted, and the ion introduction tool is made flexible, It is possible to reduce the bulk of the ion conductor and to substantially eliminate the failure of the iontophoresis device due to the corrosion of the conductive wire. Depending on the site to which ions are introduced, if the application time is long, the skin may become stuffy or itchy due to sweating, and the contact resistance with the body surface may be extremely reduced. When the body surface of the electrode is relatively wide, for example, a plurality of through holes are formed at appropriate positions of the holding member 1, the anode 2, the cathode 3, the conduction resistance member 4, or the gel-like member 5, or one of these electrodes. It is also optional to form a part or the whole so as to form a mesh-like foil.
[0021]
Further, if necessary, the gel-like member 5 on the side contacting the body surface of the living body is protected from dust, external impact, etc. during the storage period, and included in the gel-like member 5 A release member can also be arranged as a member for suppressing evaporation of a solvent such as moisture. Examples of the release member include transparent or opaque release members such as water / solvent-impermeable paper, addition polymerization plastic, polycondensation plastic, addition condensation plastic, polyaddition plastic, and ring opening. It is prepared by processing and chopping into a shape and size that can cover the entire surface of the gel-like member 5 using a polymerized plastic or the like as a material. Typical examples of the plastic include polyethylene, polystyrene, polypropylene, polyvinyl chloride, and polyvinylidene chloride. In addition, such a release member peels off from the gel-like member 5 before using the ion introduction tool of the present invention, and when the ion introduction by the ion introduction tool of the present invention is temporarily interrupted, The gel-like member 5 can be prevented from being deteriorated by placing it on the member-like member 5 again.
[0022]
Each member constituting the iontophoresis device of the present invention can be independently formed as a single layer or a multilayer structure of two or more layers as necessary. For example, in the case of a gel-like member having a multi-layer structure, and different ionic physiologically active substances of different types are blended in each layer, the time timing for ion introduction of the individual ionic physiologically active substance into the skin is changed. be able to. If necessary, the conductive resistance member has a multilayer structure, and the conductive resistance member having the lowest resistance value is arranged on the outermost side in contact with the body surface of the living body. The conductive resistance members are arranged in this order, and conductive peelable foil-like conductive members are arranged between the respective layers, and the resistance value of the conductive resistance member can be changed by peeling one layer at a time. By arranging, the introduction rate of the ionic physiologically active substance to be ionized can be adjusted. Furthermore, the shape and size of each constituent member may be set according to the shape and area of the body surface of the living body to which the ionic physiologically active substance is to be introduced by the ion introduction tool, and is not limited to that shown in FIG. It is not limited.
[0023]
The method of using the iontophoresis device of the present invention shown in FIGS. 1 and 2 will be described. The gel-like member 5 is brought into contact with the body surface of a living body to which an ionic physiologically active substance is to be introduced, and one side surface of the cathode 3 is provided. The part or the whole is used in contact with a part of the body surface of the living body. Thus, an electric path composed of the anode 2, the cathodes 3, 3, the conduction resistance members 4, 4, and the skin is formed, and the anode 2, the cathodes 3, 3 are charged negatively and positively, respectively. That is, the anode 2 is negatively charged by electrons supplied from the cathodes 3 and 3, and an anionic physiologically active substance contained in the gel-like member 5 placed on the anode 2 is caused by the electric repulsive force. It will penetrate into the skin of the living body. On the other hand, when the gel-like member 5 containing a cationic physiologically active substance is provided on the cathodes 3 and 3, the cationic physiologically active substance can be permeated subcutaneously. Further, when the cathodes 3 and 3 and the gel-like member 5 are brought into contact with the body surface of the living body, by pre-wetting the body surface to be treated with, for example, a solution, an ointment or a gel-like conductive medium, The ion introduction efficiency of the ionic physiologically active substance contained in the gel member 5 can be increased.
[0024]
The iontophoresis device of the present invention is a lightweight sheet-like device as a whole, and the gel-like member 5 can be in close contact with or close to the body surface of a living body. It can be held on the treated body surface. In addition, depending on the part of the living body to be treated with the iontophoresis device of the present invention, in order to hold the iontophoresis device at a predetermined site, it is optionally fixed using an auxiliary tool such as an adhesive tape, a bandage, or a supporter. is there.
[0025]
The iontophoresis device of the present invention is positively or negatively charged, for example, anesthetic agent, hypnotic analgesic agent, anxiolytic agent, antidepressant agent, antipyretic analgesic / antiinflammatory agent, stimulant agent, stimulant agent, antiparkinsonian agent, neuropsychiatric agent , Central nervous system agent, skeletal muscle relaxant, autonomic agent, antispasmodic agent, ophthalmic agent, otolaryngological agent, antipruritic agent, cardiotonic agent, arrhythmic agent, diuretic, antihypertensive agent, vasoconstrictor, coronary vasodilator Agent, peripheral vasodilator, hyperlipidemia agent, circulatory organ agent, respiratory accelerator, antitussive expectorant, bronchodilator, allergic agent, antipruritic agent, intestinal adjuster, peptic ulcer agent, healthy stomach digester Antacids, laxatives, astringents, pituitary hormones, salivary hormones, thyroid hormones, antithyroid hormones, anabolic steroids, corticosteroids, male hormones, follicular / luteal hormones, Mixed hormone preparations, genitourinary / anal preparations, outer skin Bactericidal disinfectant, wound protection agent, external preparation for purulent diseases, analgesic / antipruritic / astringent / anti-inflammatory agent, parasitic skin disease agent, emollient / corrosive agent, dental / oral agent, vitamin, inorganic preparation, Hemostatic agent, anticoagulant agent, liver disease agent, antidote, habitual addiction agent, gout treatment agent, enzyme preparation, diabetes agent, antineoplastic agent, radiopharmaceutical, antihistamine agent, stimulant therapy agent, herbal medicine, Chinese medicine Medicinal properties of pharmaceuticals such as prescription drugs, antibiotics, chemotherapeutic agents, biological agents, anthelmintic / antiprotozoal agents, X-ray contrast agents, diagnostic drugs, narcotics, cell utilization agents, treatment aids, In cosmetics such as basic cosmetics, hair cosmetics, oral hygiene products, for example, L-ascorbic acid and its salts and derivatives, esthiol, ellagic acid, carpronium chloride, caffeine, photosensitizer, oxalic acid, salicylic acid, Tokov Rolls, nicotinic acid, lactic acid, riboflavin, terpene compounds derived from animals and plants, lipids, nutrients such as bioactive proteins, moisturizing ingredients, emollient ingredients, keratin softening ingredients, blood circulation promoting ingredients, whitening ingredients, hair growth ingredients, hair growth It can be applied to various physiologically active substances including components, bad breath suppressing components, hypersensitivity suppressing components, and bactericidal components. However, these are merely examples, and the physiologically active substance administered subcutaneously by the iontophoresis device of the present invention should never be limited to the above.
[0026]
Such an ionic physiologically active substance is usually blended in the gel-like member 5 after being dissolved or dispersed in an appropriate medium or base such as water, ethanol, glycerin, ethylene glycol, or polyethylene glycol. The site to which the iontophoresis device of the present invention is applied may be applied simultaneously or sequentially to one site or a plurality of sites on the body surface of a living body. When applied to the face, the holding member is, for example, a face pack shape corresponding to the unevenness of the face, and the anode and the cathode are formed in an appropriate shape according to the application site. Although depending on the purpose of application and the type of ionic physiologically active substance, the time of ion introduction is usually 0.1 hours or more, up to 24 hours, while carefully observing the symptom of the subject and the state of the application site. Preferably, it is adjusted in the range of 0.5 to 5 hours. When iontophoretic substances such as peptide hormones and cytokines, bioactive substances that are weakly charged, or bioactive substances in which only part of the molecule is charged, are necessary to promote ion introduction. Accordingly, an absorption promoter containing a chelating agent such as ethylenediaminetetraacetic acid, ethylene glycol bis (2-aminoethyl ether) -N, N, N ′, N′-tetraacetic acid, and the like, together with such a physiologically active substance. You may use together simultaneously or sequentially.
[0027]
【The invention's effect】
As explained above, the iontophoresis device of the present invention is connected to the cathode through the holding member, the foil-like cathode held on the holding member, and the foil-like conduction resistance member. A light-weight and sheet-like iontophoresis device comprising a foil-like anode having a smaller ionization tendency than the cathode and a gel-like member held on the cathode and / or the anode. It has the advantage that it has moderate flexibility, and can be shaped and sized according to the shape and size of the surface of the living body that comes into contact with it. ing. The ionic physiologically active substance contained in the gel-like member can be easily and efficiently introduced into the skin simply by bringing the gel-like member into contact with a predetermined part of the body surface of the living body with the anode or the cathode. Unlike the conventional apparatus, the tool does not have a conductive wire for connecting the electrodes to each other, so that there is an actual benefit that the ion introduction tool can be substantially free of corrosion due to corrosion.
[0028]
It can be said that the present invention having such a remarkable effect is a very significant invention that contributes to the world.
[Brief description of the drawings]
FIG. 1 is a plan perspective view of an embodiment of an iontophoresis device according to the present invention.
2 is a side sectional view of the iontophoresis device shown in FIG. 1 taken along a cutting line AA ′. FIG.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Holding member 2 Anode 3 Cathode 4 Conduction resistance member 5 Gel-like member X Gap between anode and cathode Y Gap between gel-like member and conduction resistance member

Claims (6)

Ionized from a cathode formed by connecting a holding member, a foil-like cathode held on the holding member, and a foil-like conductive resistance member having a peelable multilayer structure held on the holding member. A flexible sheet-like iontophoresis device comprising a foil-like anode having a small tendency and a cathode and / or a gel-like member held on the anode.   A foil obtained by evaporating a metal or a metal-based member or a metal or metal-based member on the holding member or another foil-like member different from the holding member. The iontophoresis device according to claim 1 which is a body.   The cathode is a foil-like body obtained by vapor-depositing a metal having a higher ionization tendency than the anode or a metal-based member on the holding member or another foil-like member different from the holding member. The iontophoresis device according to 1.   4. The iontophoresis device according to claim 1, wherein the resistance value of the conduction resistance member exceeds the resistance value of the skin of a mammal including a human.   The conductive resistance member is composed of one or more selected from conductive carbon, conductive ceramic, conductive plastic, and conductive metal, according to any one of claims 1 to 4. Ion introducer.   The iontophoresis device according to any one of claims 1 to 5, wherein a foil-like release member is held on the gel-like member.

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