JP3177525B2 - Method for supplying drug solution to hemodialysis machine - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a chemical disinfectant and cleaning supplies in dialysis treatment after completion within the dialysis apparatus, and a chemical liquid supply method for circulating the dialysis device to adjust its concentration.

[0002]

2. Description of the Related Art The purpose of hemodialysis treatment is to remove unnecessary substances from blood through a dialysate. Therefore, in a dialysis device that supplies a dialysate, unlike a disposable dialyzer or blood tube, washing and disinfection are indispensable every time one treatment is completed. Therefore, washing or disinfection using hot water flowing into a dialysis device or using a hypochlorite-based disinfectant has been conventionally performed. In recent dialysis treatments, a bicarbonate solution is often used as a dialysate. In this case, an acid solution such as acetic acid is used because a carbonate adheres to a dialysate flow path in a dialyzer. And we are removing it.

Conventionally, these chemicals for cleaning and disinfection have been prepared by mixing a concentrated solution and a dilution water at a fixed ratio by a dedicated metering pump provided in a dialysis machine to adjust the solution to a predetermined concentration. Alternatively, a method of introducing a solution prepared in advance to a predetermined concentration into a dialysis device has been adopted. Therefore, when cleaning and disinfecting is performed by a dedicated measuring pump in the dialysis device, it is necessary to add various components such as a mixing tank in addition to the measuring pump, which is a factor that hinders miniaturization and cost reduction of the device. I have. In addition, when introducing a drug solution prepared in advance to a predetermined concentration into a dialysis device, a dedicated mixing device is required separately, so that a complicated system including piping to the dialysis device and complicated operations become problems. I have.

[0004] Further, in these methods, a large amount of a chemical solution is required in order to constantly supply a concentration-adjusted drug solution, pass it through a dialysate circuit in a dialyzer, and discharge it to the outside as it is. However, for the purpose of remedying such inconvenience, a closed circuit is formed by the dialysate supply line and the drainage line of the dialysate circuit, and the internal liquid is circulated by the supply pump, and the drainage measurement pump is used. There has been proposed a method of adjusting the concentration of a chemical solution by draining an internal liquid from the above-described closed circuit and flowing a concentrated chemical solution through a chemical solution inlet connected to the closed circuit (Japanese Patent Publication No. 2-60345).

[0005]

In the above-mentioned method, no special measuring pump or mixing tank is required for adjusting the concentration of the chemical, and the chemical is circulated in a closed circuit, so that the chemical can be saved. It is more effective than the conventional method. However, since the diluted water in the closed circuit is discharged while circulating, and the concentrated chemical liquid is introduced into the closed circuit by the discharged amount, the chemical liquid is constantly discharged little by little. It takes extra time to reach a concentration of. Further, there is a problem that the adjustment to a predetermined density becomes ambiguous unless a density sensor or the like is provided.

In view of the above, it is an object of the present invention to provide a method for supplying a chemical solution in which the time required to reach a predetermined concentration is short and the chemical solution is less wasteful.

[0007]

SUMMARY OF THE INVENTION In order to solve the above-mentioned problems, the present invention provides a dialyser, which is provided with a liquid supply pump, a liquid supply line for supplying a dialysate to a dialyzer, and a drainage pump. Drain line for discharging dialysis waste liquid from the drain line, a water removal line whose flow rate is controlled by a water removal pump bypassing the drainage pump, and a chemical supply line connected to the liquid supply line or the drainage line If, for a hemodialysis apparatus comprising a bypass line for connecting an external connection terminal of the external connection end of the liquid supply line the discharge line dialysis Osamu
After the treatment, the dialyzer is removed and replaced with a bypass coupler.
In the method of supplying a cleaning / disinfecting chemical solution in a connected state, the external connection end of the liquid supply line is closed and the water removal pump is operated with the external connection end of the drain line opened. A predetermined concentrated chemical is introduced from the chemical supply line into the liquid supply line or the drainage line, and then the bypass line is opened to allow the introduced concentrated chemical to be supplied to the supply line and the drain through the bypass line. A method for supplying a drug solution to a hemodialysis apparatus, wherein the drug solution is circulated through a liquid line and the water removal line and mixed with a remaining liquid to dilute the concentrated drug solution to a predetermined concentration.

[0008]

With the external connection end of the liquid supply line closed and the external connection end of the drainage line opened, the water removal pump is operated to introduce a predetermined concentrated chemical from the chemical supply line to the liquid supply line or the drainage line. . At this time, the supply line and the drainage line are not in a closed circuit because the bypass line is closed,
An amount of concentrated drug solution calculated from the volume of the dialysate circuit and the target concentration of the drug solution is injected into the dialysate circuit. Next, the bypass line is connected to connect the external connection end of the liquid supply line to the external connection end of the drainage line, and a closed circuit is formed by the liquid supply line, the drainage line, and the water removal line, circulated and closed. The concentrated chemical can be diluted to a predetermined concentration by mixing with the liquid remaining in the circuit.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a method for supplying a chemical solution according to the present invention will be described in detail with reference to the drawings. FIG. 1 shows a dialysate circuit in a hemodialysis apparatus for explaining an embodiment of the present invention. In the figure, 7 is a dialyzer, 1 and 6 are feed lines, 8 and 9
Is a drainage line, 19 is a chemical supply line, 12 is a water removal line, 11 is a water removal pump, 13 is a bypass coupler that connects the supply line and the drainage line end of the dialyzer, 23
Is a bypass line connecting the external connection end of the liquid supply line and the external connection end of the drain line.

Reference numeral 5 denotes a double pump, which comprises a feed pump for supplying dialysate and a drain pump for discharging waste dialysate with one pump. Further, the liquid sending pump 10 is used as a pressurizing pump in order to make operating conditions of the double pump 5 constant and improve accuracy. The operation of the dialysis device in normal dialysis treatment is as follows. Water subjected to various purification treatments is supplied from a liquid supply line 1 by a liquid supply pump 2, and a dialysis stock solution supplied by a stock solution pump 3 and a mixing tank 4.
And a constant concentration dialysate is sent to the double pump 5. Usually, acetate dialysate or bicarb dialysate is used for dialysis treatment.In the case of acetate dialysis, one dialysis stock solution is diluted and used. Another set of the stock solution pump 3 and the mixing tank 4 is required, but they are omitted in FIG. The dual pump 5 supplies the diluted dialysate to the dialyzer 7 through the liquid supply line 6, and aspirates an equal amount of the dialysis waste liquid from the dialyzer 7 through the drain line 8, and from the drain line 9 to the outside. Drain. On the other hand, the water removal pump 11 sends the dialysis waste liquid from the drainage line 8 to the drainage line 9 via the water removal line 12 and discharges it to the outside. As described above, the amount of dialysate delivered by the dual pump 5 and the amount of dialysis waste fluid to be sucked are equal. Therefore, the amount delivered by the water removal pump 11 was sucked from the blood of the patient M through the dialysis membrane of the dialyzer 7. By controlling the water removal pump 11, which is equal to the amount of water, that is, the amount of water removal, water removal, which is one of the objectives of dialysis treatment, can be controlled.

In such a hemodialysis apparatus, the following operation is performed when cleaning and disinfecting the liquid circuit after completion of the dialysis treatment. First, at the time of washing and disinfection, the dialyzer 7 is removed, and a bypass coupler 13 is connected instead. The undiluted solution connection port 21 is detached from an undiluted undiluted solution tank and connected to a rinse port 18 provided on the drainage line 9. These connections are shown in dashed lines in FIG. And water supply valve 1
4. Close the bypass valve 16 and open the drain valve 15 and the chemical valve 17. Further, only the water removing pump 11 is operated, and the liquid sending pump 2, the liquid sending pump 10, the double pump 5,
The stock pump 3 is stopped. With this setting, the water removal pump 11 discharges the dialysis waste liquid remaining in the drainage line 8. At this time, the supply line 6 and the drainage line 8 have a negative pressure. A concentrated chemical for cleaning and disinfection is sucked from a chemical tank 20 via a chemical line 19. The water removal pump 11 is a pump having a quantitative property, and by this operation, it is possible to accurately aspirate an amount necessary for a target concentration (calculated from the total volume of the dialysate circuit). Further, the volumes of the water removal line 12 and the drainage line 9 are larger than the amount of the concentrated chemical required for the target concentration, and the inhaled chemical is not discharged to the outside.

Next, the drain valve 15 and the chemical liquid valve 17 are closed, the bypass valve 16 is opened to open the connection line 23, and all the pumps are operated. At this time, the dialysate circuit becomes a closed circuit, and the remaining dialysate and chemicals begin to circulate in the circuit while being mixed. And all pumps and lines can be disinfected and cleaned. As described above, although one embodiment of the present invention has been described, what is added in the present invention other than the components necessary for normal dialysis treatment is only a few valves and piping as is clear from the above description, and the minimum The chemical liquid supply mechanism can be configured with limited parts. Further, since there is no leakage of the chemical solution, consumption of the concentrated chemical solution can be minimized. The concentrated chemical for disinfection and cleaning described in the above description, usually, sodium hypochlorite or acetic acid is used,
Various chemicals such as other inorganic or organic acid solutions and chlorine-based disinfecting chemicals are applied within the range of the purpose.

[0013]

According to the present invention, in a hemodialysis apparatus,
Compared cleaning and disinfection of the dialysis fluid circuit in the conventional method, more efficient, Ru can be done simpler.

[Brief description of the drawings]

FIG. 1 is a diagram showing one embodiment of a hemodialysis apparatus of the present invention.

[Description of sign]

 1, 6 supply line 2, 10 supply pump 3 stock solution pump 4 mixing tank 5 double pump 7 dialyzer 8, 9 drainage line 11 water removal pump 12 water removal line 13 bypass coupler 14 water supply valve 15 drainage valve 16 bypass valve 17 Chemical solution valve 18 Rinse port 19 Chemical solution line 20 Chemical solution tank 21 Undiluted solution connection port 22 Blood circuit 23 Bypass line M Patient

Claims (1)

(57) [Claims] 1. A liquid supply line provided with a liquid supply pump for supplying dialysate to a dialyzer, a drainage line provided with a drainage pump for discharging dialysis waste liquid from the dialyzer, and the drainage pump A water removal line whose flow rate is controlled by a water removal pump while bypassing a chemical solution supply line connected to the liquid supply line or the drainage line, an external connection end of the liquid supply line, and the drainage line against the external connection terminal to the hemodialysis apparatus including a bypass line connecting the dialysis
After the treatment is completed, the dialyzer is removed and the bypass coupler is replaced.
In the method of supplying the cleaning / disinfecting chemical solution with the liquid connected, the external connection end of the liquid supply line is closed and the water removal pump is operated with the external connection end of the drain line opened. A predetermined concentrated chemical solution is introduced from the chemical solution supply line to the liquid supply line or the drainage line, and then the concentrated chemical solution introduced by opening the bypass line is supplied to the supply line and the liquid supply line via the bypass line. A method for supplying a drug solution to a hemodialysis apparatus, wherein the drug solution is circulated through a drain line and the water removal line and mixed with a remaining liquid to dilute the concentrated drug solution to a predetermined concentration.