JP3136310B2 - Carriers suitable for chewing clothing - Google Patents
Carriers suitable for chewing clothingInfo
- Publication number
- JP3136310B2 JP3136310B2 JP04075149A JP7514992A JP3136310B2 JP 3136310 B2 JP3136310 B2 JP 3136310B2 JP 04075149 A JP04075149 A JP 04075149A JP 7514992 A JP7514992 A JP 7514992A JP 3136310 B2 JP3136310 B2 JP 3136310B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- parts
- carrier
- fatty acid
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Formation And Processing Of Food Products (AREA)
- Medicinal Preparation (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、医薬品又は食品のため
の、薬物又は食品素材を担持することができ且つ咀嚼し
て服用するに適した担体に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a carrier for a drug or food, which can carry a drug or food material and is suitable for chewing and taking.
【０００２】[0002]
【従来の技術】従来、医薬品の分野において、薬物を服
用するための担体としてソフトカプセルが用いられてい
る。ソフトカプセルは主として、油状の薬物等のよう
な、散剤や錠剤、硬カプセル剤等の通常の剤形には適さ
ずしかも服用毎の定量採取の困難な薬物を所定量服用す
るための担体である。しかし、ソフトカプセルは通常肉
厚であるため寸法が大型になる傾向があり、そのままで
は嚥下しにくく、患者によっては服用が容易でない場合
がある。このため、服用者はソフトカプセルを噛み潰す
ことにより服用を容易化せんと試みる場合があるが、従
来のソフトカプセルは噛み潰すと非常に油っぽい又は苦
い味覚及び感触を与えるため、通常そのまま飲み込まざ
るを得なかった。2. Description of the Related Art Conventionally, in the field of pharmaceuticals, soft capsules have been used as carriers for taking drugs. Soft capsules are mainly carriers for taking a predetermined amount of a drug, such as an oily drug, which is not suitable for usual dosage forms such as powders, tablets, hard capsules and the like, and which is difficult to collect at every dose. However, since soft capsules are usually thick, they tend to be large in size, so that they are difficult to swallow as they are, and may not be easy to take for some patients. For this reason, the user may try to make it easier to chew by crushing the soft capsule, but conventional soft capsules give a very greasy or bitter taste and feel when crushed, so they are usually swallowed as it is. I didn't get it.
【０００３】[0003]
【発明が解決しようとする課題】本発明は、このような
状況に鑑み、薬物又は食品素材のための担体であって、
咀嚼しても油っぽさの等の不快な味覚や感触を与えるこ
とがなく、容易に咀嚼して嚥下することのできる、特に
ソフトカプセル内への封入に適した担体を提供すること
を目的とする。更に本発明は、ソフトカプセルへの封入
を要しない固形の担体の提供をも目的とする。SUMMARY OF THE INVENTION In view of such circumstances, the present invention relates to a carrier for a drug or food material,
An object of the present invention is to provide a carrier that can be easily chewed and swallowed without giving an unpleasant taste or feel such as oiliness even when chewed, and particularly suitable for encapsulation in a soft capsule. I do. Another object of the present invention is to provide a solid carrier that does not require encapsulation in a soft capsule.
【０００４】[0004]
【課題を解決するための手段】本発明者は、ソフトカプ
セルに封入される担体の有する物性と噛み潰したときに
それが口腔内に与える感触との関係について種々検討し
た。その結果、食用油と所定の界面活性剤との所定の組
合せによって、咀嚼してもかかる味覚・感触を与えるこ
とのない材質であって、医薬品等を担持してソフトカプ
セルに封入するに適し、一層広い製剤形態をも可能にす
る担体が得られることを見出し、更に検討を加えて本発
明を完成した。The present inventors have conducted various studies on the relationship between the physical properties of a carrier encapsulated in a soft capsule and the feel given to the oral cavity when chewed. As a result, by a predetermined combination of an edible oil and a predetermined surfactant, it is a material that does not give such a taste / feel even when chewed, and is suitable for carrying a drug or the like and enclosing it in a soft capsule. The present inventor has found that a carrier that enables a wide variety of formulation forms can be obtained, and further studies have made the present invention.
【０００５】すなわち本発明は、食用油として中鎖脂肪
酸トリグリセリド５０乃至９９重量部と、グリセリン脂
肪酸エステル及び／ショ糖脂肪酸エステルから選ばれた
界面活性剤５乃至１５重量部と、２０重量部までのゼラ
チンよりなることを特徴とする薬物又は食品素材のため
の咀嚼服用に適した担体に関する。担体は３重量部まで
の甘味料を含むことができる。[0005] That is, the present invention relates to an edible oil comprising 50 to 99 parts by weight of medium-chain fatty acid triglyceride, 5 to 15 parts by weight of a surfactant selected from glycerin fatty acid ester and / or sucrose fatty acid ester, and up to 20 parts by weight. The present invention relates to a carrier suitable for chewable medicine for a drug or a food material, which is made of gelatin. The carrier can contain up to 3 parts by weight of a sweetener.
【０００６】更に、本発明の担体はゼラチンを２０重量
部まで含有してなることができ、そうすることによっ
て、ゼラチン量に依存して、常温で半流動体乃至固形の
咀嚼服用に適した担体とすることができる。半流動体の
場合にはゼラチンを含まない場合と同様にソフトカプセ
ルに封入することができるほか、チューブに注入した形
態で使用することができ、固形の場合には例えば直方
体、球形等の適宜の形状としてそのまま咀嚼服用するこ
とができる。但し、必ずしもこれらの形態に限定されな
い。[0006] Further, the carrier of the present invention can contain up to 20 parts by weight of gelatin, whereby, depending on the amount of gelatin, a carrier suitable for semi-liquid or solid chewable clothing at normal temperature. It can be. In the case of a semi-liquid, it can be encapsulated in a soft capsule similarly to the case without gelatin, and can be used in the form of being injected into a tube, and in the case of a solid, for example, an appropriate shape such as a rectangular parallelepiped or a sphere It can be taken as a chew as it is. However, it is not necessarily limited to these modes.
【０００７】加えて、本発明の担体は、ゼラチン量を適
宜調節して適当な硬さを与えることにより、それ自身カ
プセルを形成することもできる。このカプセルに本発明
の所望の硬さ又は流動性の担体を封入すれば、従来の軟
カプセル及び硬カプセルと類似の形態を有する医薬品で
あってしかも咀嚼服用に適したものを提供することもで
きる。[0007] In addition, the carrier of the present invention can form a capsule by itself by appropriately adjusting the amount of gelatin to give an appropriate hardness. By encapsulating the desired hardness or fluidity carrier of the present invention in the capsule, it is possible to provide a pharmaceutical product having a form similar to conventional soft capsules and hard capsules, which is suitable for mastication. .
【０００８】本発明の担体に薬物又は食品素材を担持さ
せるには、加熱融解した本発明の担体にこれら薬物等を
単に溶解又は分散させて担持させればよく、それにより
半流動性乃至固形の咀嚼服用に適した混合物を得ること
ができる。これを上述の通り、軟カプセル、チューブ等
に封入し又は所望の形状に成形して医薬品又は食品とす
ることができる。In order to carry a drug or a food material on the carrier of the present invention, the drug or the like may be simply dissolved or dispersed and carried on the carrier of the present invention which has been heated and melted. A mixture suitable for mastication can be obtained. As described above, this can be sealed in a soft capsule, a tube, or the like, or formed into a desired shape to obtain a drug or food.
【０００９】本発明において使用し得る食用油の例とし
ては、動植物油、エステル類等があり、このうち、植物
油が好ましく、特に炭素数６乃至１２の中鎖脂肪酸トリ
グリセリドが好ましい。Examples of the edible oil that can be used in the present invention include animal and vegetable oils and esters, among which vegetable oils are preferred, and medium chain fatty acid triglycerides having 6 to 12 carbon atoms are particularly preferred.
【００１０】本発明においてＨＬＢ１乃至２０の界面活
性剤が使用できるが、より好ましくはＨＬＢは３乃至８
である。適当な界面活性剤としては、グリセリン脂肪酸
エステル、ショ糖脂肪酸エステルがある。In the present invention, a surfactant having an HLB of 1 to 20 can be used, and more preferably, an HLB of 3 to 8 is used.
It is. Suitable surfactants include glycerin fatty acid esters and sucrose fatty acid esters.
【００１１】上記食用油と界面活性剤との使用比率は、
上記食用油７０乃至９９重量部に対し上記界面活性剤５
乃至１５重量部である。The use ratio of the above-mentioned edible oil and surfactant is as follows:
70 to 99 parts by weight of the edible oil and the surfactant 5
To 15 parts by weight.
【００１２】甘味料としては、食品や医薬品に通常使用
されている物である限り特に制限はない。[0012] The sweetener is not particularly limited as long as it is commonly used in foods and pharmaceuticals.
【００１３】本発明の担体に担持されるべき薬物として
は、本発明の担体との混合によって不安定化等の不都合
を生じないものであり、且つ口中で咀嚼することに問題
のない内服用薬物であれば特に制限されない。また、食
品素材としては、加工食品に含まれうる種々の材料を担
持させることができる。The drug to be carried on the carrier of the present invention is a drug for internal use which does not cause inconvenience such as instability by mixing with the carrier of the present invention and which has no problem in chewing in the mouth. If it is, there is no particular limitation. Further, as the food material, various materials that can be contained in the processed food can be carried.
【００１４】[0014]
【実施例】以下、実施例に基づき本発明を更に詳細に説
明する。 〔実施例１〕 処方 中鎖脂肪酸トリグリセリド ８８重量部 グリセリン脂肪酸エステル（ＨＬＢ３） ８重量部 ショ糖脂肪酸エステル（ＨＬＢ１５） ２重量部 アスパルテーム １重量部 ハッカ油 １重量部 合 計 １００重量部 中鎖脂肪酸トリグリセリドにグリセリン脂肪酸エステル
を加え、６０〜７０℃の水浴上で加温し溶解する。これ
にショ糖脂肪酸エステル、アスパルテーム及びハッカ油
を加えて攪拌し、カプセル内容液を製する。この液を常
法に従い軟カプセル被膜に充填し軟カプセル剤を得る。The present invention will be described below in more detail with reference to examples. [Example 1] Formulation Medium-chain fatty acid triglyceride 88 parts by weight Glycerin fatty acid ester (HLB3) 8 parts by weight Sucrose fatty acid ester (HLB15) 2 parts by weight Aspartame 1 part by weight Mint oil 1 part by weight Total 100 parts by weight Medium-chain fatty acid triglyceride Glycerin fatty acid ester is added to the mixture, and the mixture is heated and dissolved on a water bath at 60 to 70 ° C. The sucrose fatty acid ester, aspartame and peppermint oil are added thereto and stirred to produce a capsule content liquid. This liquid is filled into a soft capsule film according to a conventional method to obtain a soft capsule.
【００１５】〔実施例２〕 処方 中鎖脂肪酸トリグリセリド ８８重量部 グリセリン脂肪酸エステル（ＨＬＢ６） １０重量部 アスパルテーム １重量部 ハッカ油 １重量部 合 計 １００重量部 中鎖脂肪酸トリグリセリドにグリセリン脂肪酸エステル
を加え、６０〜７０℃の水浴上で加温し溶解する。これ
にアスパルテーム及びハッカ油を加えて攪拌し、半流動
体の液を製する。この液を常法に従い軟カプセル被膜に
充填し、軟カプセル剤を得る。又は別に、この液をチュ
ーブに充填して製品とする。Example 2 Prescription 88 parts by weight of medium-chain fatty acid triglyceride 10 parts by weight of glycerin fatty acid ester (HLB6) 1 part by weight of aspartame 1 part by weight of mentha oil 100 parts by weight Heat and dissolve on a water bath at 60-70 ° C. Aspartame and peppermint oil are added thereto and stirred to produce a semi-liquid liquid. This liquid is filled into a soft capsule film according to a conventional method to obtain a soft capsule. Alternatively, this liquid is filled into a tube to obtain a product.
【００１６】〔実施例３〕 処方 中鎖脂肪酸トリグリセリド ７８重量部 グリセリン脂肪酸エステル １０重量部 アスパルテーム １重量部 ハッカ油 １重量部 ゼラチン １０重量部 合 計 １００重量部 中鎖脂肪酸トリグリセリドにグリセリン脂肪酸エステル
を加え、６０〜７０℃の水浴上で加温し溶解する。これ
にアスパルテーム、ハッカ油及び加温溶解したゼラチン
を加えて攪拌する。この液を型に流し込み、成型、乾燥
する。Example 3 Formulation 78 parts by weight of medium-chain fatty acid triglyceride 10 parts by weight of glycerin fatty acid ester 1 part by weight of aspartame 1 part by weight of mentha oil 10 parts by weight of gelatin 10 parts by weight in total 100 parts by weight of glycerin fatty acid ester was added to medium-chain fatty acid triglyceride Heat and dissolve on a water bath at 60-70 ° C. Aspartame, peppermint oil and gelatin dissolved by heating are added to this and stirred. This liquid is poured into a mold, molded and dried.
【００１７】〔各実施例の製剤の咀嚼適正の評価〕 実施例１および２は参考例であるが、各実施例の製剤を
口中で咀嚼したところ、清涼感と甘味が感じられたが、
油っぽさは感じられなかった。[Evaluation of Mastication Suitability of Preparations of Each Example] Examples 1 and 2 are reference examples. When the preparations of each example were chewed in the mouth, a refreshing feeling and a sweet taste were felt.
I couldn't feel greasy.
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 平３−200728（ＪＰ，Ａ) 特開 昭63−130535（ＪＰ，Ａ) 特開 昭61−275214（ＪＰ，Ａ) 特開 平３−56423（ＪＰ，Ａ) 特開 昭62−249920（ＪＰ，Ａ) 特開 昭62−93232（ＪＰ，Ａ) 特開 昭61−36217（ＪＰ，Ａ) 特開 昭62−89617（ＪＰ，Ａ) 特開 平２−212417（ＪＰ，Ａ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61K 47/14,47/42,9/48 A23P 1/04 ──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-3-200728 (JP, A) JP-A-63-130535 (JP, A) JP-A-61-275214 (JP, A) JP-A-3-2007 56423 (JP, A) JP-A-62-249920 (JP, A) JP-A-62-93232 (JP, A) JP-A-61-36217 (JP, A) JP-A-62-89617 (JP, A) JP-A-2-212417 (JP, A) (58) Fields investigated (Int. Cl. 7 , DB name) A61K 47/14, 47/42, 9/48 A23P 1/04
Claims (5)
ド５０乃至９９重量部と、グリセリン脂肪酸エステル及
び／又はショ糖脂肪酸エステルから選ばれた界面活性剤
５乃至１５重量部と、２０重量部までのゼラチンよりな
ることを特徴とする薬物又は食品素材のための咀嚼服用
に適した担体。1 to 50 parts by weight of a uniformly mixed medium-chain fatty acid triglyceride, 5 to 15 parts by weight of a surfactant selected from glycerin fatty acid esters and / or sucrose fatty acid esters, and up to 20 parts by weight. A carrier suitable for chewable medication for a drug or food material, which comprises gelatin.
請求項１に記載の担体。2. The carrier according to claim 1, further comprising up to 3 parts by weight of a sweetener.
は２に記載の担体。3. The carrier according to claim 1, wherein the carrier is a solid.
している請求項１乃至３のいずれかに記載の担体。4. The carrier according to claim 1, wherein the carrier carries the drug or food material dissolved or dispersed therein.
乃至４のいずれかに記載の担体。5. The method according to claim 1, wherein the capsule is encapsulated in a soft capsule.
5. The carrier according to any one of items 1 to 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP04075149A JP3136310B2 (en) | 1992-02-26 | 1992-02-26 | Carriers suitable for chewing clothing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP04075149A JP3136310B2 (en) | 1992-02-26 | 1992-02-26 | Carriers suitable for chewing clothing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05238954A JPH05238954A (en) | 1993-09-17 |
| JP3136310B2 true JP3136310B2 (en) | 2001-02-19 |
Family
ID=13567858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP04075149A Expired - Fee Related JP3136310B2 (en) | 1992-02-26 | 1992-02-26 | Carriers suitable for chewing clothing |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3136310B2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7763276B1 (en) | 1999-02-26 | 2010-07-27 | Shionogi & Co., Ltd. | Chewable soft capsules having improved administration properties and process for producing the same |
| AU2003231126A1 (en) * | 2002-04-25 | 2003-11-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
| FR2850275B1 (en) * | 2003-01-24 | 2005-04-08 | Scherer Technologies Inc R P | SOFT MACHINE CAPSULES CONTAINING AN ACTIVE ACTIVE SUBSTANCE WITH MASK TASTE |
| JP4808392B2 (en) * | 2003-09-04 | 2011-11-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pharmacological composition concealing bitterness |
| JP4889262B2 (en) * | 2005-08-19 | 2012-03-07 | 理研ビタミン株式会社 | Fat-soluble drug composition |
| GB0601498D0 (en) | 2006-01-25 | 2006-03-08 | Probio Nutraceuticals As | Product |
| GB0818473D0 (en) | 2008-10-08 | 2008-11-12 | Probio Nutraceuticals As | Composition |
| JP6445239B2 (en) * | 2014-02-20 | 2018-12-26 | アリメント工業株式会社 | Soft capsule filling composition and soft capsule filled with the soft capsule filling composition |
-
1992
- 1992-02-26 JP JP04075149A patent/JP3136310B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05238954A (en) | 1993-09-17 |
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