JPH05238954A - Carrier suitable for chewing administration - Google Patents

Abstract

PURPOSE:To obtain a carrier, capable of being chewed and administered without causing an oily taste or touch and useful for a medicine, etc., sealed in a soft capsule. CONSTITUTION:The objective carrier, useful for a medicine or a food material and suitable for chewing administration is characterized in that it is composed of 50-99 pts.wt. uniformly mixed edible oil and 1-20 pts.wt. surfactant having 1-20HLB.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a carrier for medicines or foods, which can carry a drug or food material and is suitable for chewing.

[0002]

2. Description of the Related Art Conventionally, in the field of pharmaceuticals, soft capsules have been used as carriers for taking drugs. Soft capsules are mainly carriers for taking a predetermined amount of a drug, such as an oily drug, which is not suitable for a usual dosage form such as powders, tablets, hard capsules, etc., and which is difficult to quantitatively collect for each dose. However, since soft capsules are usually thick and tend to be large in size, they are difficult to swallow as they are and may not be easy to take depending on the patient. For this reason, the user may try to facilitate the administration by chewing soft capsules, but conventional soft capsules give a very greasy or bitter taste and feel when chewed, and thus they must be swallowed as they are. I didn't get it.

[0003]

In view of such a situation, the present invention provides a carrier for a drug or food material,
The object of the present invention is to provide a carrier that does not give an unpleasant taste or feel such as oiliness even when chewed, can be easily chewed and swallowed, and is particularly suitable for encapsulation in a soft capsule. To do. Another object of the present invention is to provide a solid carrier that does not require encapsulation in soft capsules.

[0004]

Means for Solving the Problems The present inventor has conducted various studies on the relationship between the physical properties of a carrier encapsulated in a soft capsule and the feel it gives to the oral cavity when chewed. As a result, a predetermined combination of edible oil and a predetermined surfactant is a material that does not give such a taste and feel even when chewed, and is suitable for carrying a drug or the like and encapsulating it in a soft capsule. It was found that a carrier that enables a wide range of dosage forms can be obtained, and further studies were conducted to complete the present invention.

That is, according to the present invention, first, 50 to 99 parts by weight of edible oil and 1 to 20 parts by weight of a surfactant having an HLB (hydrophilic / hydrophobic balance) of 1 to 20 are encapsulated in a soft capsule. It is a semi-fluid liquid carrier for a drug or food material suitable for chewing. The carrier may also contain up to 3 parts by weight of sweetener to further improve the taste and thereby maintain its capacity as a carrier.

Furthermore, the carrier of the present invention may contain up to 20 parts by weight of gelatin, whereby a carrier suitable for chewing, which is semi-fluid or solid at room temperature, depends on the amount of gelatin. Can be In the case of a semi-liquid, it can be enclosed in a soft capsule as in the case of not containing gelatin, and it can be used in the form of being injected into a tube. It can be taken as it is by chewing. However, it is not necessarily limited to these forms.

In addition, the carrier of the present invention can itself form a capsule by appropriately adjusting the amount of gelatin to give an appropriate hardness. By encapsulating the carrier having the desired hardness or fluidity of the present invention in this capsule, it is possible to provide a drug having a form similar to that of conventional soft capsules and hard capsules, which is also suitable for chewing. ..

In order to support the drug or food material on the carrier of the present invention, the drug or the like may be simply dissolved or dispersed and supported on the carrier of the present invention which has been melted by heating. A mixture suitable for chewing can be obtained. As described above, it can be enclosed in a soft capsule, a tube, or the like or molded into a desired shape to prepare a medicine or food.

Examples of the edible oil which can be used in the present invention include animal and vegetable oils, esters and the like. Among them, vegetable oil is preferable, and medium chain fatty acid triglyceride having 6 to 12 carbon atoms is particularly preferable.

In the present invention, a surfactant having an HLB of 1 to 20 can be used, and more preferably, the HLB is 3 to 8. Suitable surfactants include polyhydric alcohols, polyethylene glycol, animal and plant components,
Among these, sugar ester, glycerin acyl ester, sorbitan acyl ester, and polyoxyethylene sorbitan acyl ester are preferable, and glycerin fatty acid ester and sucrose fatty acid ester are particularly preferable.

The use ratio of the above-mentioned edible oil and surfactant is
1 to 50 parts by weight of the edible oil to 1 part of the surfactant
The amount of the surfactant is 1 to 15 parts by weight, more preferably 50 to 99 parts by weight of the edible oil.
Parts by weight, and particularly preferably the edible oils 70 to 9
The amount of the surfactant is 5 to 15 parts by weight based on 9 parts by weight.

The sweetener is not particularly limited as long as it is a commonly used sweetener in foods and pharmaceuticals.

The drug to be loaded on the carrier of the present invention does not cause instability such as destabilization by mixing with the carrier of the present invention, and is a drug for oral administration which has no problem in chewing in the mouth. If there is no particular limitation. Further, as the food material, various materials that can be included in the processed food can be supported.

[0014]

The present invention will be described in more detail based on the following examples. [Example 1] Prescription Medium-chain fatty acid triglyceride 88 parts by weight Glycerine fatty acid ester (HLB3) 8 parts by weight Sucrose fatty acid ester (HLB15) 2 parts by weight Aspartame 1 part by weight Mint oil 1 part by weight Total 100 parts by weight Medium-chain fatty acid triglyceride Glycerin fatty acid ester is added to and heated in a water bath at 60 to 70 ° C. to dissolve. Sucrose fatty acid ester, aspartame and peppermint oil are added to this and stirred to prepare a capsule content liquid. This solution is filled into a soft capsule film according to a conventional method to obtain a soft capsule agent.

Example 2 Formulation Medium chain fatty acid triglyceride 88 parts by weight Glycerine fatty acid ester (HLB6) 10 parts by weight Aspartame 1 part by weight Mint oil 1 part by weight Total 100 parts by weight Glycerin fatty acid ester was added to medium chain fatty acid triglyceride, Dissolve by heating on a water bath at 60 to 70 ° C. Aspartame and peppermint oil are added to this and stirred to prepare a semi-fluid liquid. This solution is filled into a soft capsule film according to a conventional method to obtain a soft capsule. Alternatively, a tube is filled with this liquid to obtain a product.

Example 3 Formulation Medium chain fatty acid triglyceride 78 parts by weight Glycerine fatty acid ester 10 parts by weight Aspartame 1 part by weight Mint oil 1 part by weight Gelatin 10 parts by weight Total 100 parts by weight Glycerin fatty acid ester is added to medium chain fatty acid triglyceride , Warm on a water bath at 60-70 ° C to dissolve. Aspartame, peppermint oil, and warmed and dissolved gelatin are added to this and stirred. This liquid is poured into a mold, molded and dried.

[Evaluation of Chewing Ability of Preparations of Each Example] When the preparations of Examples 1 to 3 were chewed in the mouth, a refreshing feeling and sweetness were felt, but the oily taste and feel peculiar to the base were It was not felt, and it was confirmed that the preparation was suitable for chewing.

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Claims (6)

[Claims] 1. A chewable dose for a drug or food material, which comprises 50 to 99 parts by weight of a uniformly mixed edible oil and 1 to 20 parts by weight of a surfactant having an HLB of 1 to 20. Suitable carrier. 2. A uniform mixture of edible oil 50 to 99 parts by weight, 1 to 20 parts by weight of HLB 1 to 20 parts by weight and up to 3 parts by weight of a sweetener. A chewable carrier suitable for drugs or food materials. 3. The carrier according to claim 1, which further comprises gelatin. 4. A solid material according to claim 3, wherein the solid material is a solid material.
The carrier according to. 5. The carrier according to any one of claims 1 to 4, wherein the drug or food material is dissolved or dispersed and carried. 6. The carrier according to claim 1, wherein the carrier is encapsulated in a soft capsule.