JP3131605U - Double room bag - Google Patents

Double room bag Download PDF

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JP3131605U
JP3131605U JP2007001145U JP2007001145U JP3131605U JP 3131605 U JP3131605 U JP 3131605U JP 2007001145 U JP2007001145 U JP 2007001145U JP 2007001145 U JP2007001145 U JP 2007001145U JP 3131605 U JP3131605 U JP 3131605U
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chamber
storage chamber
drug storage
diluent
drug
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井上　冨士夫
立石　勇
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Otsuka Pharmaceutical Factory Inc
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Priority to CNA2007800514802A priority patent/CN101610747A/en
Priority to PCT/JP2007/075064 priority patent/WO2008102514A1/en
Priority to KR20097016899A priority patent/KR20090115146A/en
Priority to TW97105758A priority patent/TWI453009B/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3261—Flexible containers having several compartments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2024—Separating means having peelable seals

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Bag Frames (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)

Abstract

【課題】吸湿性を有する薬剤や酸化しやすい薬剤を収容して保存できる複室バッグを提供する。
【解決手段】薬剤収容室１の一端側に弱シール部２を介して希釈液室３が連設される一方、前記薬剤収容室１の他端側に弱シール部２を介して口部４を有する空室５が連設される複室バッグであって、薬剤収容室１、希釈液室３及び空室５は、透明なフィルム材からなり、かつ、薬剤収容室１の両面を、アルミ層を備えたガスバリアフィルム６で剥離可能に覆う。
【選択図】 図２The present invention provides a multi-chamber bag that can store and store a hygroscopic drug or a drug that easily oxidizes.
A diluent chamber is connected to one end side of a medicine storage chamber via a weak seal portion, while a mouth portion is connected to the other end side of the drug storage chamber via a weak seal portion. The drug storage chamber 1, the diluent chamber 3, and the empty chamber 5 are made of a transparent film material, and both surfaces of the drug storage chamber 1 are made of aluminum. A gas barrier film 6 having a layer is releasably covered.
[Selection] Figure 2

Description

本考案は、薬剤と希釈液とを分離した状態で収容し、使用時に混合するようにした複室バッグに関する。   The present invention relates to a multi-chamber bag in which a medicine and a diluent are stored in a separated state and mixed at the time of use.

従来この種の複室バッグは、例えば軟質の塩化ビニル製シートを融着手段によって融着して形成された薬剤収容室及び希釈液室と、薬剤収容室及び希釈液室の間に設けられた弱シール部とで構成されている。そして、使用時において、弱シール部を外部から圧迫して、薬剤収容室及び希釈液室を連通状態にし、薬剤と希釈液とを混合させている（例えば、特許文献１参照）。   Conventionally, this type of multi-chamber bag is provided between a medicine storage chamber and a dilution liquid chamber formed by fusing, for example, a soft vinyl chloride sheet by a fusing means, and between the medicine storage chamber and the dilution liquid chamber. It consists of a weak seal part. In use, the weak seal portion is pressed from the outside so that the medicine storage chamber and the diluent chamber are in communication with each other and the medicine and the diluent are mixed (see, for example, Patent Document 1).

特公昭６３−３６４８５１号公報Japanese Patent Publication No. 63-364851

しかしながら、従来の上記複室バッグは、保存に際して水分や酸素などによる経時変化を防止する手段がないため、吸湿性を有する薬剤や酸化しやすい薬剤を収容して保存するには不向きであるという問題がある。   However, the conventional multi-chamber bag is not suitable for storing and storing hygroscopic or oxidizable drugs because there is no means for preventing changes over time due to moisture or oxygen during storage. There is.

本願考案は、このような実情に鑑みてなされ、吸湿性を有する薬剤や酸化しやすい薬剤を収容して保存できる複室バッグを提供することを目的とする。   This invention is made in view of such a situation, and it aims at providing the multi-chamber bag which can accommodate and preserve | save the chemical | medical agent which has a hygroscopic property, and the chemical | medical agent which is easy to oxidize.

（１）本考案の複室バッグは、薬剤収容室の一端側に弱シール部を介して希釈液室が連設される一方、前記薬剤収容室の他端側に弱シール部を介して口部を有する空室が連設される複室バッグであって、
前記薬剤収容室及び希釈液室は、透明なフィルム材からなり、かつ、前記薬剤収容室の両面を、気体及び液体を実質的に透過させないアルミ層を備えたガスバリアフィルムで剥離可能に被覆してなることを特徴とする。 (1) In the multi-chamber bag of the present invention, a diluent chamber is connected to one end side of the drug storage chamber via a weak seal portion, and a mouth is connected to the other end side of the drug storage chamber via a weak seal portion. A multi-chamber bag in which vacancies having a portion are provided,
The drug storage chamber and the diluent chamber are made of a transparent film material, and both surfaces of the drug storage chamber are releasably covered with a gas barrier film having an aluminum layer that does not substantially transmit gas and liquid. It is characterized by becoming.

この構成においては、気体及び液体を実質的に透過させないアルミ層を備えたガスバリアフィルムによって薬剤収容室の両面を剥離可能に被覆することで、乾燥剤や脱酸素剤を使用することなく、薬剤が酸素や水分の影響を受けないように保護することができる。   In this configuration, the both sides of the medicine storage chamber are releasably covered with a gas barrier film having an aluminum layer that does not substantially allow gas and liquid to permeate, so that the medicine can be used without using a desiccant or an oxygen scavenger. It can be protected from being affected by oxygen and moisture.

さらに、薬剤収容室の両面からガスバリアフィルムを剥がした場合、薬剤収容室の両方から光が透過するようになり、外部から薬剤収容室の内部を透視することができ、収容された薬剤の状態及び弱シール部を破断して希釈液室から薬剤収容室に希釈液を導入して薬剤に混合したときに不溶性異物の有無等を明確に確認することができる。このようなガスバリアフィルムは、例えばアルミ箔又は樹脂層に対してアルミ蒸着されて形成されることが好ましい。また、製造工程においても異物の混入等を明確に検出することができる。   Further, when the gas barrier film is peeled off from both sides of the drug storage chamber, light can be transmitted from both of the drug storage chamber, the inside of the drug storage chamber can be seen through from the outside, and the state of the stored drug and When the weak seal portion is broken and the diluent is introduced from the diluent chamber into the medicine storage chamber and mixed with the medicine, the presence or absence of insoluble foreign matter can be clearly confirmed. Such a gas barrier film is preferably formed by aluminum deposition on an aluminum foil or a resin layer, for example. In addition, foreign matters can be clearly detected in the manufacturing process.

そして、その薬剤収容室と弱シール部を介して口部を有する空室を連設しているため、必ず薬剤が希釈液で希釈された状態で空室を介して投与されるため、誤った投与の発生を防ぐことができる。また、上記ガスバリアフィルムで覆われた薬剤収容室と弱シール部を介して口部を有する空室を連設しているため、口部及びその周辺においては、バリア性であることが要件とされず、その分材料費を低減することができる。   And since the vacant chamber having the mouth portion is connected through the drug storage chamber and the weak seal portion, the drug is always administered through the vacant chamber in the state diluted with the diluent, Occurrence of administration can be prevented. Further, since the medicine containing chamber covered with the gas barrier film and the vacant chamber having the mouth portion are connected through the weak seal portion, it is required that the mouth portion and the periphery thereof have a barrier property. Therefore, the material cost can be reduced accordingly.

本考案の複室バッグは、弱シール部を介して希釈液室が連設される薬剤収容室に弱シール部を介して口部を有する空室を連設すると共に、薬剤収容室の外側を、気体及び液体を実質的に透過させないアルミ層を備えたガスバリアフィルムで剥離可能に被覆するようにしたので、バリア性の向上が図られ、乾燥剤や脱酸素剤を使用することなく、薬剤が酸素や水分の影響を受けないようにすることができる。   The multi-chamber bag of the present invention has a vacant chamber having a mouth portion connected through a weak seal portion to a drug storage chamber in which a diluent solution chamber is connected through a weak seal portion, and an outer side of the drug storage chamber. Since the gas barrier film having an aluminum layer substantially impermeable to gas and liquid is releasably coated, the barrier property is improved, and the agent can be used without using a desiccant or oxygen scavenger. It is possible to avoid the influence of oxygen and moisture.

そして、薬剤収容室の両面からガスバリアフィルムを剥がした場合は、外部から薬剤収容室の内部を透視することができ、収容された薬剤の状態及び薬剤に希釈液を混合したときに不溶性異物の有無等を明確に確認することができる。   When the gas barrier film is peeled off from both surfaces of the medicine storage chamber, the inside of the medicine storage chamber can be seen through from the outside, and the state of the medicine stored and the presence of insoluble foreign matter when the diluent is mixed with the medicine Etc. can be clearly confirmed.

また、必ず薬剤が希釈液で希釈された状態で空室を介して投与されるため、誤った投与の発生を防ぐことができる。また、口部及びその周辺においては、バリア性であることが要件とされず、その分材料費を低減することができる。   In addition, since the drug is always administered through the empty chamber in a state diluted with a diluent, it is possible to prevent erroneous administration. Moreover, it is not a requirement for the barrier property at the mouth portion and its periphery, and the material cost can be reduced accordingly.

以下に、本考案の最良の実施の形態に係る複室バッグについて図面を参照しつつ詳細に説明する。
図１は複室バッグの正面図、図２は図１の側断面図、図３はガスバリアフィルムを剥がした状態の正面図である。図１〜図３にて、符号１は、抗生剤等の各種薬剤を収納する薬剤収容室、２は弱シール部、３は希釈液室、４は口部、５は空室、６はアルミ層を備えたガスバリアフィルム、７は吊り孔である。この複室バッグは、薬剤収容室１の一端側に弱シール部２を介して希釈液室３が連設される一方、前記薬剤収容室１の他端側に弱シール部２を介して口部４を有する空室５が連設され、薬剤収容室１、希釈液室３及び空室５は、透明なフィルム材からなり、かつ、薬剤収容室１の外側の両面は、気体及び液体を実質的に透過させないアルミ層を備えたガスバリアフィルム６で剥離可能に覆われている。なお、図中６ａはガスバリアフィルム６のつまみである。 The multi-chamber bag according to the best mode of the present invention will be described in detail below with reference to the drawings.
1 is a front view of a multi-chamber bag, FIG. 2 is a side sectional view of FIG. 1, and FIG. 3 is a front view of a state where a gas barrier film is peeled off. 1 to 3, reference numeral 1 is a drug storage chamber for storing various drugs such as antibiotics, 2 is a weak seal portion, 3 is a diluent chamber, 4 is a mouth portion, 5 is an empty chamber, and 6 is aluminum. A gas barrier film provided with a layer, 7 is a suspension hole. The multi-chamber bag has a diluent chamber 3 connected to one end side of the medicine storage chamber 1 via a weak seal portion 2, and is connected to the other end side of the medicine storage chamber 1 via a weak seal portion 2. A vacant chamber 5 having a portion 4 is continuously provided, the drug containing chamber 1, the diluent chamber 3 and the vacant chamber 5 are made of a transparent film material, and both surfaces outside the drug containing chamber 1 are filled with gas and liquid. It is covered with a gas barrier film 6 having an aluminum layer that does not substantially permeate. In the figure, 6a is a knob of the gas barrier film 6.

薬剤収容室１、希釈液室３及び空室５を形成するフィルム材は、例えば、内面側から順にポリエチレン（ＰＥ）とポリプロピレン（ＰＰ）の混合樹脂層（厚さ２０μｍ）１１、ポリエチレン（ＰＥ）層（厚さ６０μｍ）１２、シクロオレフィンコポリマー（ＣＯＣ）層又はシクロオレフィンポリマー（ＣＯＰ）層（厚さ２０μｍ）１３、ポリエチレン（ＰＥ）層（厚さ５０μｍ）１２が積層され、２枚のフィルム材の周縁部同士が溶着され、かつ、その薬剤収容室１と希釈液室３の間、及び、薬剤収容室１と空室５の間には、それぞれ弱シールが施されて弱シール部２が形成されている。   The film material forming the drug storage chamber 1, the diluent chamber 3, and the empty chamber 5 is, for example, a mixed resin layer (thickness 20 μm) 11 of polyethylene (PE) and polypropylene (PP) in order from the inner surface side, polyethylene (PE) A layer (thickness 60 μm) 12, a cycloolefin copolymer (COC) layer or a cycloolefin polymer (COP) layer (thickness 20 μm) 13, a polyethylene (PE) layer (thickness 50 μm) 12 are laminated, and two film materials Are bonded to each other, and a weak seal is provided between the drug storage chamber 1 and the diluent chamber 3 and between the drug storage chamber 1 and the empty chamber 5, respectively. Is formed.

一方、薬剤収容室１の外側の両面を覆う上記ガスバリアフィルム６は、例えば、内面側から順にポリエチレン（ＰＥ）とポリプロピレン（ＰＰ）の混合樹脂層／接着剤層／アルミ箔／接着剤層／ポリエチレンテレフタレート（ＰＥＴ）が積層されてもよく、又は、内面側から順にポリエチレン（ＰＥ）とポリプロピレン（ＰＰ）の混合樹脂層／接着剤層／アルミ箔／接着剤層／ナイロン／ポリエチレンテレフタレート（ＰＥＴ）が積層されてもよく、或いは、内面側から順にポリエチレン（ＰＥ）とポリプロピレン（ＰＰ）の混合樹脂層／接着剤層／アルミ箔／接着剤層／ナイロン／２軸延伸ポリプロピレン（ＯＰＰ）が積層されてもよい。   On the other hand, the gas barrier film 6 covering both the outer surfaces of the medicine storage chamber 1 is, for example, a mixed resin layer / adhesive layer / aluminum foil / adhesive layer / polyethylene of polyethylene (PE) and polypropylene (PP) in order from the inner surface side. Terephthalate (PET) may be laminated, or a mixed resin layer of polyethylene (PE) and polypropylene (PP) / adhesive layer / aluminum foil / adhesive layer / nylon / polyethylene terephthalate (PET) in order from the inner surface side. Alternatively, a mixed resin layer of polyethylene (PE) and polypropylene (PP) / adhesive layer / aluminum foil / adhesive layer / nylon / biaxially oriented polypropylene (OPP) may be laminated in order from the inner surface side. Also good.

このようなガスバリアフィルム６で薬剤収容室１の外側を覆うことによって、乾燥剤や脱酸素剤を使用することなく、薬剤が酸素や水分の影響を受けないようにすることができる。   By covering the outside of the medicine storage chamber 1 with such a gas barrier film 6, it is possible to prevent the medicine from being affected by oxygen and moisture without using a desiccant or an oxygen scavenger.

そして、図３に示すように、つまみ６ａを把持して薬剤収容室１の外側の両面側からガスバリアフィルム６を剥がすことによって、外部から薬剤収容室１の内部を透視することができ、収容された薬剤の状態及び弱シール部２を破断して希釈液室３から薬剤収容室１に希釈液を導入して薬剤に混合したときに不溶性異物の有無等を明確に確認することができる。また、製造工程においても異物の混入等を明確に検出することができる。   Then, as shown in FIG. 3, by grasping the knob 6a and peeling off the gas barrier film 6 from both sides of the outside of the medicine storage chamber 1, the inside of the medicine storage chamber 1 can be seen through from the outside. It is possible to clearly check the state of the drug and the presence or absence of insoluble foreign matter when the weak seal portion 2 is broken and the diluent is introduced from the diluent chamber 3 into the drug storage chamber 1 and mixed with the drug. In addition, foreign matters can be clearly detected in the manufacturing process.

その薬剤収容室１と弱シール部２を介して口部４を有する空室５を連設しているため、必ず薬剤が希釈液で希釈された状態で空室５を介して投与されるため、誤った投与の発生を防ぐことができる。また、上記ガスバリアフィルム６で覆われた薬剤収容室１と弱シール部２を介して口部４を有する空室５を連設しているため、口部４及びその周辺においては、バリア性であることが要件とされず、その分材料費を低減することができる。   Since the medicine chamber 1 and the vacant chamber 5 having the mouth portion 4 are connected through the weak seal portion 2, the medicine is always administered through the vacant chamber 5 in a state diluted with a diluent. Can prevent the occurrence of incorrect administration. Further, since the medicine containing chamber 1 covered with the gas barrier film 6 and the vacant chamber 5 having the mouth portion 4 are connected through the weak seal portion 2, the mouth portion 4 and its surroundings have barrier properties. There is no requirement, and the material cost can be reduced accordingly.

なお、本考案は、前記実施の形態に限定されることなく、考案の要旨を逸脱しない限りにおいて、適宜、必要に応じて、設計変更や改良等を行うのは自由であり、また、各実施の形態間での流用・転用も自由である。   It should be noted that the present invention is not limited to the above-described embodiment, and it is free to make design changes and improvements as necessary, as long as it does not depart from the gist of the invention. The diversion and conversion between these forms is also free.

本考案の実施の形態に係る複室バッグの正面図である。It is a front view of the multi-chamber bag which concerns on embodiment of this invention. 図１の側断面図である。It is a sectional side view of FIG. ガスバリアフィルムを剥がした状態の正面図である。It is a front view of the state which peeled off the gas barrier film.

符号の説明Explanation of symbols

１…薬剤収容室、２…弱シール部、３…希釈液室、４…口部、５…空室、６…ガスバリアフィルム   DESCRIPTION OF SYMBOLS 1 ... Drug storage chamber, 2 ... Weak seal part, 3 ... Diluent chamber, 4 ... Mouth part, 5 ... Empty room, 6 ... Gas barrier film

Claims (3)

薬剤収容室の一端側に弱シール部を介して希釈液室が連設される一方、前記薬剤収容室の他端側に弱シール部を介して口部を有する空室が連設される複室バッグであって、
前記薬剤収容室及び希釈液室は、透明なフィルム材からなり、かつ、前記薬剤収容室の両面を、気体及び液体を実質的に透過させないアルミ層を備えたガスバリアフィルムで剥離可能に被覆してなることを特徴とする複室バッグ。 A dilution chamber is connected to one end side of the drug storage chamber via a weak seal portion, while a vacant chamber having a mouth portion is connected to the other end side of the drug storage chamber via a weak seal portion. A room bag,
The drug storage chamber and the diluent chamber are made of a transparent film material, and both surfaces of the drug storage chamber are releasably covered with a gas barrier film having an aluminum layer that does not substantially transmit gas and liquid. A multi-chamber bag characterized by 前記アルミ層は、アルミ箔であることを特徴とする請求項１に記載の複室バッグ。   The multi-chamber bag according to claim 1, wherein the aluminum layer is an aluminum foil. 前記アルミ層は、樹脂層に対してアルミ蒸着されて形成されてなることを特徴とする請求項１に記載の複室バッグ。   The multi-chamber bag according to claim 1, wherein the aluminum layer is formed by depositing aluminum on a resin layer.
JP2007001145U 2007-02-23 2007-02-23 Double room bag Expired - Lifetime JP3131605U (en)

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JP2007001145U JP3131605U (en) 2007-02-23 2007-02-23 Double room bag
CNA2007800514802A CN101610747A (en) 2007-02-23 2007-12-27 Multi-chamber-bag
PCT/JP2007/075064 WO2008102514A1 (en) 2007-02-23 2007-12-27 Multi-chamber bag
KR20097016899A KR20090115146A (en) 2007-02-23 2007-12-27 Multi-chamber bag
TW97105758A TWI453009B (en) 2007-02-23 2008-02-19 Multi-chamber bag

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