JP3114058B2 - Manufacturing method of plastic pharmaceutical liquid container - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION This invention is a sterile condition is sterility even maintain after molding while being blown, upon not require a washing step prior to the drug solution filling, entering the sterilization chamber
The present invention relates to a method for producing a plastic drug solution container capable of sanitizing heat sterilization by heating .

[0002]

2. Description of the Related Art Heretofore, as a plastic container of this kind, a container described in Japanese Patent Application Laid-Open No. 63-245392 is known. The container has a cylindrical mouth formed by blow molding, and a burr for closing the surface is formed at an end of the mouth, and when filling the container with a drug solution as a medicine, the burr is formed. After resection and filling with a drug solution, a pull-top cap is welded to the open end of the mouth to seal the container. At the time of opening, the pull-top having the thin fragile portion is cut off to open.

[0003]

By the way, in the above-mentioned conventional plastic container, since the insertion hole of the blow nozzle is opened in the burr portion at the mouth of the container to be blow-molded, the container is completely completed. Since it is not kept in a sealed state, fine dust and the like may enter from the outside during storage and transportation, and there is a problem in the process that the inside of the container must be washed when filling with a chemical solution. Further, in the case where the pull-top cap is welded to the opening end of the mouth in this way, after opening the mouth and filling the liquid medicine, when welding the pull-top cap to the mouth, welding burrs are generated. The welding burrs fall into the chemical solution during storage and transport of the container, which not only causes a problem with the hygiene of the chemical solution, but also keeps the pull-top cap from being held externally during welding and cooling of the pull-top cap. Has to be kept compressed in the mouth.

As described above, this type of conventional container has problems in terms of hygiene until the contents are filled and after the contents are filled, but the present invention solves such problems. It is intended to be blow-molded in an aseptic condition and to maintain the aseptic condition even after molding, so that the medicinal solution can be filled as it is without washing the container, and when filling the medicinal solution, the container To
While rotating the container while holding the mouth down,
Insert a cutting blade between the mouth and the burr to drop the burr
To remove the burr and open the mouth.
Cutting chips fall into the container when the mouth is opened.
Can be prevented, and a rubber stopper can be inserted into the mouth after filling.
Weld the lower end of the wrapped stopper and seal the container to a high degree,
An object of the present invention is to provide a method for producing a plastic drug solution container capable of sanitizing heat sterilization by heating in a bacteria tank .

[0005]

According to the present invention, as a means for achieving the above object, the following method is used. That is, a method for producing a plastic drug solution container comprising forming a container having a cylindrical mouth portion by blow molding, filling the container with a drug solution, and sealing the cylindrical mouth portion with a stopper. By blowing a sterile pressure fluid from a blowing nozzle into a parison in a closed split mold, the end of the mouth has a burr portion having substantially the same diameter as the mouth, and a small diameter burr is provided in a part of the burr portion. a container having a blow hole blow molding, after blow molding, the container and sterile by sealing the blow hole by heating and melting the surrounding blow holes caused by blowing of the pressure fluid, then the mouth portion of the container Is down
While holding the container and rotating the container,
Inserting a cutting blade between them and dropping the burr to separate
The burr is removed and the mouth is opened, and the medicinal solution filling nozzle is inserted from the opened mouth to fill the container with the medicinal solution, and the lower end of the plug body containing the rubber stopper is welded to the filled mouth. the vessel was sealed to a high degree of Te, then sterilizing the highly sealed container
It is put in a tank and heat sterilized.

[0006]

According to the method of manufacturing a plastic drug solution container according to the present invention, the container is blow-molded by injecting aseptic pressure fluid from a blowing nozzle into a parison in a closed split mold, so that the end of the mouth is opened. A container having a burr portion having the same diameter as the mouth portion and a blow hole having a small diameter in a part of the burr portion is formed under aseptic conditions. And after blow molding,
Since the periphery of the blow hole generated by the injection of the pressure fluid is heated and melted to seal the blow hole, the container is completely sealed and maintains an aseptic condition.

When filling a container with a chemical solution, the container is
Hold the container down and rotate the container while holding the
Insert the cutting blade between the burr section and drop the burr section
Remove the burr by separating and open the mouth
It is not possible for cutting chips to fall into the container when the mouth is opened.
Can be prevented. After filling the solution with the filling nozzle, the mouth is sealed with a stopper and the container is heat-sterilized. The lower end of the stopper having a rubber stopper in the mouth after filling.
Is welded to the mouth to seal the container to a high degree.
Heat sterilization treatment of putting and heating can be sanitized .

[0008]

Embodiments of the present invention will be described with reference to the drawings. FIG. 1 shows a blow molding mode of a chemical solution container, FIG. 2 shows a mode of cutting off a burr portion at an opening of a blow-molded chemical solution container, and FIG. 3 shows a mode of filling a chemical solution in a chemical solution container.
5 shows a container after filling with a chemical solution, and FIG. 5 shows a configuration of a mouth portion of the container after filling with a chemical solution.

In FIG. 1, reference numeral 1 denotes a container, and the container 1 is formed by blow molding of a thermoplastic resin. 2
Is a trunk, a cylindrical mouth 3 is integrally formed at one end of the trunk 2, and a hanging piece 4 is integrally formed at the other end. 5
Is a split mold for blow molding the container 1. The mouth portion 3 of the container 1 has a thread 6 formed on the outer peripheral surface thereof, and the opening end of the mouth portion 3 is formed by a burr portion 7 having substantially the same diameter as the mouth portion 3 formed by parison during blow molding. Sealed. Reference numeral 8 denotes a blow nozzle. Aseptic pressure gas is blown into the parison by the blow nozzle 8, and the container 1 is blow-molded in the closed split mold 5. When the blow nozzle 8 is pulled out after blowing, the burr portion A blow hole 7a, which is an insertion mark, is formed in a part of the sealing member 7. The blow hole 7a is melted by being brought into contact with a heated plate body, and is moved to close the sealing portion by moving the surrounding resin. And put the container 1 in a completely sterile and sealed state. A flange 9 is formed below the mouth 3. The heating means for melting and sealing the blow holes 7a can be indirect heating by blowing high-temperature air, in addition to the direct heating by the plate body. And then the mold for that part

[0010] Since the blow-molded container 1 is completely aseptically sealed as described above, the container 1 is kept hygienic even during storage or transportation.

When filling the container 1 with the chemical solution, as shown in FIG.
Open. That is, while holding the container 1 so that the mouth portion 3 faces down, the cutting blade 10 is inserted between the mouth portion 3 and the burr portion 7 while rotating the container 1, and the burr portion 7 is dropped. To separate. Therefore, cutting chips during the opening of the mouth portion 3 vessel 1
Do not fall inside. In addition, if the cutting blade 10 is heated, the burr portion 7 can be easily cut off.

Next, as shown in FIG. 3, a chemical liquid filling nozzle 11 is inserted into the container 1 through the opened mouth 3, and the chemical liquid is filled into the container 1 from the chemical liquid filling nozzle 11. After filling the container 1 with the chemical solution, the stopper 3 is screwed into the mouth 3 to seal the mouth 3, but when the stopper 12 is screwed, the flange 9 of the mouth 3 and the stopper 12 are screwed. A low melting point resin 13 is interposed between the lower portions of the plugs, and the plug body 12 is screwed in a tightened state. When the plug 12 is tightened, as shown in FIG. 5, the low melting point resin 13 is interposed between the flange 9 of the mouth 3 and the lower part of the plug 12 in a compressed state. 14 is a thread of the plug 12.

As described above, the container 1 filled with the chemical solution and sealed is placed in a sterilization tank (not shown) and heat-sterilized for a certain period of time.
3 is melted, and the mouth 3 and the lower end of the plug 12 are welded by the melted low melting point resin 13, so that the mouth 3 of the container 1
It is highly sealed by the plug 12 . The sterilization tank heats the container 1 to 115 ° C., and the low melting point resin 13 has a melting point of 120 ° C. or less, for example, ethylene vinyl acetate copolymer, high pressure method low density polyethylene, linear low density polyethylene. , Linear ultra-low density polyethylene, ionomer resin, low molecular weight polyester resin, and the like.

The plug 12 screwed to the mouth 3 is provided with a pull ring 15 as shown in FIGS. 4 and 5, and as shown in FIG. Can be resected. 17 is a score which is a thin fragile portion. Plug 1
A rubber stopper 18 is closely fitted in the inside 2.

According to the manufacturing method of this embodiment, the blow hole 7a formed in the burr portion 7 of the mouth portion 3 at the time of blow molding is sealed by heat welding, so that the blow molded container 1 is completely sealed. Sterility is maintained. Therefore, when storing and transporting the container 1 and filling the liquid medicine, the container 1 does not need to be washed, and the liquid medicine can be filled as it is.

After filling with the chemical, the stopper 3 is inserted into the mouth 3.
Is screwed, and a low melting point resin 13 is interposed between the mouth 3 and the plug 12.
During the heat sterilization process, the low melting point resin 13 is melted and the plug 12 is fixed to the mouth portion 3. In this manner, after filling the liquid medicine, the mouth 3 is sealed with the stopper 12 into which the mouth 3 is screwed, and the lower end of the stopper 12 is welded to the mouth 3 so as to have a high degree.
Since it is sealed , there is no danger of welding burrs falling into the container 1, and heat sterilization is performed in which the container 1 is placed in a sterilization tank and heated.
Even so, the drug solution in the container 1 is kept hygienic.

Further, the flange 9 of the mouth 3 and the plug 12
The low melting point resin 13 is interposed in a compressed state between the lower portions, so that the time until the low melting point resin 13 is melted and welded can be shortened.

In the illustrated embodiment, the container 1 has a bottle shape. However, the container 1 may have a bag shape in addition to the bottle shape.

[0019]

Industrial Applicability According to the present invention, a plastic drug solution can be filled as it is without cleaning the container by blow molding under aseptic conditions and maintaining the aseptic condition even after molding. The effect that a container can be manufactured is acquired.

According to the present invention, the following effects can be further obtained in addition to the above effects. That is, according to the present invention, since the blow holes are sealed after blow molding,
Compared to the case where the container is sealed in the blow mold during the blow molding, the container molded from the blow mold can be taken out without waiting for complete cooling, and it is excellent in mass productivity. The mold can also have a simple structure.

In addition, since the burr portion has a burr portion having substantially the same diameter as the mouth portion and a small-diameter blow hole is provided in a part of the burr portion, heating and melting for sealing the blow hole can be performed in a short time. The effect of heat or the like at that time is not exerted on the final product, and the diameter of the nozzle for filling the chemical is not restricted by the size of the small-diameter blow hole.

In addition, the drug solution container obtained by the present invention has the entire container, including the stopper, subjected to heat sterilization.
In addition, since the stopper body contains a rubber stopper, hygiene is maintained from the time of storage to the time of use.

Further, according to the present invention, the filling of the chemical solution is performed.
Hold the container with the mouth facing down before turning the container.
While turning, insert a cutting blade between the mouth and the burr,
Removal of burrs by dropping and separating burrs
To open the mouth, cutting chips when opening the mouth
Can be prevented from dropping into the container.
Weld the lower end of a stopper body with a rubber stopper in the mouth to the container
Heat sterilized by heating in a sterilization tank
Makes the process hygienic.

[Brief description of the drawings]

FIG. 1 is a partially broken front view showing a blow molding mode of a container according to a method for manufacturing a plastic drug solution container according to an embodiment of the present invention.

FIG. 2 is a front view showing a mode of cutting off a burr portion of a blow-molded container.

FIG. 3 is a partially cutaway front view showing an aspect of filling a container with a chemical solution.

FIG. 4 is a front view of a container showing an embodiment after filling with a drug solution.

FIG. 5 is an enlarged cross-sectional view showing a mouth portion of the container in FIG. 4 and a peripheral portion thereof.

[Explanation of symbols]

 REFERENCE SIGNS LIST 1 container 2 body 3 mouth 5 split mold 6 screw 7 burr 7 a blow hole 8 blow nozzle 9 flange 10 cutting blade 11 chemical filling nozzle 12 plug 13 low melting point resin 14 screw 15 pull ring 16 top plate 17 Thin-walled fragile part 18 Rubber stopper

Claims (1)

(57) [Claims] 1. A method for producing a plastic drug solution container comprising forming a container having a cylindrical mouth by blow molding, filling the container with a chemical solution, and sealing the cylindrical mouth with a stopper. By blowing a sterile pressure fluid from a blowing nozzle into a parison in a closed split mold, a burr portion having substantially the same diameter as the mouth is provided at an end of the mouth and a part of the burr portion. Blow molding a container having a small diameter blow hole, and after blow molding, heat and melt the periphery of the blow hole generated by the blowing of the pressure fluid to seal the blow hole to make the container aseptic, and then the container The mouth down
Between the mouth and burr while holding the
Inserting a cutting blade into the
Thus opened the mouth to remove the burrs, a chemical solution filled in a container by inserting the drug solution filling nozzle from the opened mouth, a lower end of the plug body containing therein a rubber stopper is welded to the mouth after filling the vessel was sealed to a high degree of Te, then sterile tank highly sealed container
A method for producing a plastic drug solution container, wherein the container is subjected to heat sterilization treatment.