JP3054117B2 - Injection molding container for pharmaceutical liquid packaging - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a plastic one-piece injection molded container for disposable divided liquids, which can be administered in a predetermined amount and used for pharmaceuticals.

[0002]

2. Description of the Related Art Plastic containers for internal liquids such as divided liquids have been difficult to put into practical use due to the contamination of the containers with the necessity of sterilization. In particular, plastic ampules were used in Japan in the early 1970s. It was released, and in Germany, a sterilizer was installed in the chemical line of the blow-fill-seal system (BFS system: a system for simultaneous molding, filling and sealing of containers) developed by Fresenius and Brown in 1974. Large-capacity plastic containers for injections have been manufactured.

[0003] This BFS system (PHARM TECH JAPAN v
ol.13 No.8 P.29-40 1997) manufactures plastic containers by heating and melting thermoplastics, molding them into containers using molds, filling them immediately with a liquid content, and sealing them by welding. How to At present, this BFS system is used for cosmetics, drinks, contact lens cleaning agents, etc., and also in the pharmaceutical field, for infusions, eye drops, otolaryngological agents, diagnostic agents, packaging solutions, large and small volume injections. It is widely used for mass production. These containers manufactured by the BFS system are composed of a main body portion for containing the contents liquid and a head that is separated and discarded. However, since the blow molding method is used, it is difficult to partially adjust the thickness of the container. When the container is cut to take out the liquid content, there is always a structural space on the head that is connected to the hollow space of the main body, and as a result, the liquid enters the space of the head and remains. (For example, the actual opening 59
-196423). Therefore, the container using the BFS system has a drawback that the drug solution which has entered the space is not administered and is removed, and is not suitable as a drug for which a precise dose must be ensured. .

[0004] In the case of a suspension, in particular, solids aggregate in the space where the head is cut off, which is not suitable for administration of the suspension.

On the other hand, there has also been proposed a closed container having an integral structure in which a tube body made of a soft synthetic resin and a stopper are connected by a thin portion (for example, FIG. 3 of the present specification; Japanese Utility Model Laid-Open No. 3-534).
No. 54). However, this closed container has been developed for toothpaste and pasty foods, and has a tapered portion (5) formed integrally with the inner surface (2) of the nozzle tip and the stopper when resealing. ) Due to the line sealing structure with the surface, there is a problem that the sealing performance is poor and the plug is loosened due to the internal pressure. In addition, there is also a problem that the suspension in the drug solution enters the groove formed by the guide portion or the tapered portion and the container main body, and it is difficult to re-disperse the suspension during taking. Therefore, the container described in the publication is not suitable as a container for pharmaceuticals requiring a predetermined amount of administration, similarly to the container manufactured by the BFS system.

[0006]

DISCLOSURE OF THE INVENTION The present inventor has conducted intensive studies in order to provide a simple plastic integrally molded container for pharmaceuticals under the above-mentioned circumstances, and as a result, a portion cut off from a hollow body portion for accommodating a drug solution. No chemical solution remains in the
We succeeded in developing a disposable plastic integrated molded container for packaging liquids that can reliably take a prescribed amount of liquid medicine.

That is, the present invention relates to a plastic one-piece injection-molded container for a disposable liquid packaging material, comprising a hollow body portion for containing a chemical solution, an inner plug portion formed in contact with one end of the hollow body portion, and the hollow portion. A structure in which the body portion and the inner plug portion are connected by a detachable thin film, and there is no space for the chemical solution to enter the inner plug portion that is separated when taking the chemical solution, or even if it enters, it can be immediately dropped and taken out, and the chemical solution does not accumulate. The present invention provides a plastic one-piece injection molded container for a pharmaceutical packaging liquid agent, and if necessary, temporarily seals the inserted inner plug by inserting it into the opening of the hollow body part. An object of the present invention is to provide a plastic integrated injection molded container for a liquid medicine packaging liquid.

Hereinafter, the present invention will be described in detail. The novel plastic integrated injection molding container for a divided liquid agent according to the present invention has been developed as a product for a pharmaceutical requiring a predetermined amount of administration, and is listed in the following 1) to 3). This is a characteristic technical means in terms of structure and use.

[0009] 1) The hollow body portion for storing the chemical solution and the inner plug portion are connected by a detachable thin film,
The surface of the inner plug portion that comes into contact with the chemical has a flat surface, and has a structure in which the chemical does not accumulate structurally. In addition, for those items that need to be temporarily stored after opening, the inside plug portion is inserted to prevent foreign matter from entering and leakage of the chemical solution. 2) The hollow body part and inner plug part are formed into a size and shape that can be separated by hand, and the part to be separated is a thin film made of plastic thinner than other parts, keeping airtightness and easily separating. The structure is 3) The sealing performance between the hollow body portion and the inner plug portion is such that a groove or a projection is provided on the fitting surface where the hollow body portion and the inner plug portion slidably contact each other. By being contained, the airtightness is enhanced, and the sealing performance can be further ensured.

[0010] The plastic injection molded container for a pharmaceutical packaging liquid according to the present invention having the above-mentioned features is used as a container for common cold medicine or an antacid, and is not used for medical pharmaceuticals. It is suitable as a container for a drug solution such as ambroxol hydrochloride, which is a protein, and as a container for a suspension such as aluminum hydroxide gel / magnesium hydroxide in combination. In particular, the container for a drug-packaging liquid according to the present invention is a very effective container for a suspension because no drug remains on the head that is cut off for opening the container when used (during taking).

Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 shows an embodiment of a plastic integrated injection-molded container for a drug-packaging liquid according to the present invention,
The hollow body portion 2 for storing the chemical solution, the inner plug 3 for preventing the outflow of the chemical solution, the detachable thin film 4 for engaging the hollow body portion 2 with the inner plug 3, and the hollow body portion 2 after the filling with the chemical solution.
Container body 1 made of plastic, comprising a welded sealing part 5
It is shown.

Although the thin film 4 is a thin film that can be cut with a small force, it is designed to be capable of sufficiently withstanding a load due to transportation or a load due to loading in a final form as a packaging liquid after a chemical solution is stored.

The inner surface of the inner plug 3 is formed as a flat surface 16 so as not to allow a chemical solution to enter therein, and the slightly smaller outer diameter of the neck 6 which is in contact with the hollow body portion 2 of the inner plug 3 has the outer diameter of the hollow body portion. 2, the thin film 4 engaging the neck 6 of the inner plug 3 and the neck 7 of the hollow body part 2 is cut off, and a part of the liquid medicine is taken out. In the case of storage, the neck 6 of the inner plug 3 is slidably pressed into the neck 7 of the hollow body portion 2 so as to be sealed.

FIG. 2 shows an example of a container in which an annular groove 9 is provided on the inner wall of the neck 7 of the hollow body portion 2 and an annular projection 8 is provided on the outer wall of the neck 6 of the inner plug 3. During integral molding, the hollow body and the inner plug are connected by a thin film as in FIG. The thin film is cut off and a predetermined amount of the drug solution is administered. When temporarily storing the remaining part of the chemical solution as necessary, the neck 6 of the inner plug 3 is inserted into the neck 7 of the hollow body portion 2 and the groove 9 and the projection 8 are engaged to enhance the sealing performance. It plays a role. In addition, in the embodiment of the integrated injection-molded container for a drug-packaging liquid according to the present invention, a handle having an appropriate shape can be provided outside the inner plug in order to easily separate or remove the inner plug.

As described above, the plastic integrally molded container for pharmaceutical packaging liquid according to the present invention illustrated in each figure is simultaneously (continuously) performed in a molding machine equipped with a container injection molding, filling with a chemical solution and a sealing structure. It also has technical significance in being commercialized. First, a mold having a predetermined container shape is set in a molding machine, and a thermoplastic plastic material melted by heating is supplied into the mold to be integrally molded into an unsealed container shape. After cooling the unsealed container to a required temperature, a predetermined amount of the heat-sterilized or filter-sterilized drug solution is filled from the filling port, and the final filling port is sealed 5 by welding or the like to seal the product. It is said. The usage mode of the product filled with the chemical is as follows.

The thin film 4 connecting the hollow body portion 2 containing the medicinal solution and the inner plug 3 of the plastic integrated container 1 for a drug-packing liquid is cut off by screwing or tearing. After cutting off the hollow body part 2, the opening of the hollow body part 2 is turned downward. If necessary, the hollow body part is pressed to take out the drug solution from the hollow body part 2 and take it. When taking a part of the medicinal solution, the remaining medicinal solution is resealed by inserting the inner plug 3 separated from the thin film 4 into the opening of the inner plug body portion 2 after taking the drug, and temporarily after opening the container. Prevents foreign matter from entering into the liquid separating container during storage and leakage of the drug solution from the container.

[0017]

As described in detail above, the plastic integrated injection-molded container for a liquid medicine packaging liquid according to the present invention opens the inner plug for preventing leakage of the liquid medicine from the hollow body portion for storing the liquid medicine with one touch. Can be taken out and taken, and in the case of a medicine requiring a fixed amount of administration, a predetermined amount of the medicine can be reliably administered because the medicine is not accumulated in the inner stopper.

When the remaining chemical solution is temporarily stored by appropriately increasing or decreasing, etc., the separated inner plug is inserted into the opening of the hollow body portion to reseal, and foreign matter is mixed into the packaging solution container. And leakage of the drug solution from the container can be prevented. In addition, there is an advantage that the container can be manufactured in one piece at low cost by injection molding using a combination of concave and convex molds using a thermoplastic plastic such as polyethylene or polypropylene.

Further, in the case of a container in which a hollow body portion and a cap, which are conventionally used in the pharmaceutical field, are made separately, it is necessary to sterilize the chemical solution and the container in separate steps. The use of the integral injection-molded container of the present invention allows the steps of container molding, filling with a chemical solution, and sealing to be performed simultaneously, so that not only the filling operation is simplified, but also the effect of reducing the cost of the product is extremely low. Is big.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view of one embodiment of a plastic integrated injection-molded container for a packaging liquid according to the present invention.

FIG. 2 is a partial cross-sectional view of an example of a type in which an annular groove is provided inside a hollow body portion and an annular protrusion is provided on an outer periphery of an inner plug in the integrally molded container according to the present invention.

FIG. 3 is a partial sectional view of a conventional sealed container.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Integrally molded plastic container for liquid packaging 2 Hollow body part 3 Inner plug 4 Thin film 5 Welding seal 6 Neck of inner plug 7 Neck of hollow body part 8 Protrusion 9 Groove 16 Surface in contact with chemical solution

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int. Cl. ⁷ , DB name) A61J 1/06 B65D 1/00-1/48 B65D 17/00-17/52

Claims (2)

(57) [Claims] 1. A disposable plastic sealed container for a liquid dispenser, which is slidably fitted to a hollow body portion for containing a chemical solution and one end of the hollow body portion opposite to a sealing portion. The hollow body portion and the inner plug are connected by a detachable thin film, and the surface of the inner plug that comes into contact with the chemical solution is flat and has a structure that does not allow a chemical solution to enter. Integrated injection-molded plastic container for a liquid medicine packaging liquid capable of administering a predetermined amount of a liquid medicine. 2. A plurality of projections or grooves are provided annularly on the outer peripheral surface of the inner plug, and a plurality of annular grooves or projections corresponding to the inner plug are provided on the inner wall of the opening of the hollow body. 2. The plastic integral injection molded container for a drug-packaging liquid according to claim 1, wherein the sealability is enhanced by engagement of the protrusion with the projection.