JP3043081B2 - Particle size measuring device in fluidized bed granulator - Google Patents
Particle size measuring device in fluidized bed granulatorInfo
- Publication number
- JP3043081B2 JP3043081B2 JP3027448A JP2744891A JP3043081B2 JP 3043081 B2 JP3043081 B2 JP 3043081B2 JP 3027448 A JP3027448 A JP 3027448A JP 2744891 A JP2744891 A JP 2744891A JP 3043081 B2 JP3043081 B2 JP 3043081B2
- Authority
- JP
- Japan
- Prior art keywords
- particle size
- adhesive film
- granular material
- granulation
- fluidized bed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 title claims description 66
- 239000008187 granular material Substances 0.000 claims description 46
- 238000005469 granulation Methods 0.000 claims description 46
- 230000003179 granulation Effects 0.000 claims description 45
- 239000002313 adhesive film Substances 0.000 claims description 40
- 239000000853 adhesive Substances 0.000 claims description 14
- 230000001070 adhesive effect Effects 0.000 claims description 14
- 238000002347 injection Methods 0.000 claims description 14
- 239000007924 injection Substances 0.000 claims description 14
- 238000003384 imaging method Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 description 29
- 238000000034 method Methods 0.000 description 9
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000010191 image analysis Methods 0.000 description 3
- 239000013618 particulate matter Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009477 fluid bed granulation Methods 0.000 description 1
- 239000011361 granulated particle Substances 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
Landscapes
- Glanulating (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、粉粒体を製造する流動
層造粒機に設けられ、その造粒機で製造される粉粒体の
粒度を連続的に実測する粒度測定装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a particle size measuring apparatus which is provided in a fluidized bed granulator for producing granules and continuously measures the particle size of the granules produced by the granulator.
【０００２】[0002]
【従来の技術】粉粒体を製造する方法の一つとして流動
層造粒法がある。この造粒法は、造粒容器内で流動状態
とされた粉粒体に液状物質を散布して、その粒度を徐々
に増大させる方法であり、医薬品製剤を始めとする各種
分野で採用されている。しかし、このような流動造粒法
では、製品粒度のばらつきが大きいという問題がある。
そのため、製品粒度を目標値に可能な限り揃える粒度制
御法が、例えば、特公昭58-26966号公報、特公昭58-558
07号公報等各種提案されている。2. Description of the Related Art Fluid bed granulation is one of the methods for producing powders. This granulation method is a method in which a liquid substance is sprayed on a granular material in a fluidized state in a granulation container to gradually increase the particle size, and is employed in various fields including pharmaceutical preparations. I have. However, in such a fluidized-granulation method, there is a problem that variation in product particle size is large.
For this reason, a particle size control method for aligning the product particle size to a target value as much as possible is disclosed in, for example, Japanese Patent Publication No. 58-26966 and Japanese Patent Publication No. 58-558.
Various proposals such as Japanese Patent Publication No. 07 have been made.
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、このよ
うな粒度制御法でも、流動造粒法では、製品粒度のばら
つきは、ある程度までしか制御できない。その理由の一
つとして、造粒中に造粒容器内の粉粒体の粒度を実測す
ることができず、実際に製造されている粉粒体の粒度を
認識できないと考えられる。すなわち、造粒中に造粒容
器内で成長する粉粒体を迅速にかつ連続的に採取されな
いと、造粒度、粒度分布といった造粒状態が判明せず、
理論的に優れた画像解析等の粒度および分布測定法ある
いは粒度制御法であっても、粉粒体を正確な粒度に制御
できず、十分な効果をあげることができない。However, even with such a particle size control method, the variation in the particle size of the product can be controlled only to a certain extent by the fluidized granulation method. As one of the reasons, it is considered that the particle size of the granules in the granulation container cannot be actually measured during granulation, and the granules of the granules actually manufactured cannot be recognized. That is, unless the granules growing in the granulation container are collected quickly and continuously during granulation, the granulation state such as the granulation size and the particle size distribution cannot be determined,
Even a method of measuring particle size and distribution, such as image analysis, which is theoretically excellent, or a method of controlling particle size cannot control the granular material to an accurate particle size, and cannot provide a sufficient effect.
【０００４】本発明は上記従来の問題を解決するもので
あり、その目的は、造粒中に造粒容器内の粉粒体の粒度
を直接測定することができる流動層造粒機における粒度
測定装置を提供することにある。The present invention has been made to solve the above-mentioned conventional problems, and an object of the present invention is to provide a fluidized bed granulator capable of directly measuring the particle size of a granular material in a granulating container during granulation. It is to provide a device.
【０００５】[0005]
【課題を解決するための手段】本発明の流動層造粒機に
おける粒度測定装置は、流動層造粒機における造粒容器
の内部にある一方の端部が該造粒容器の外部に位置され
た他方の端部に連通する粉粒体取出管と、該粉粒体取出
管内を造粒容器内の粉粒体が通過するように、造粒容器
の内部から該粉粒体取出管内へ高圧ガスを噴射するガス
噴射ノズルと、該粉粒体取出管を通過した粉粒体が粘着
面に付着するように、該粘着面を粉粒体取出管の造粒容
器の外部に位置する端面開口に対向された粘着フィルム
と、該粘着フィルムの粘着面に捕捉された粉粒体を撮像
してその粒度を計測する粒度計測手段と、を具備してな
り、そのことにより上記目的が達成される。According to the present invention, there is provided a particle size measuring apparatus for a fluidized bed granulator, wherein one end of the inside of the granulating vessel in the fluidized bed granulator is located outside the granulating vessel. And a high pressure granule from the inside of the granulation container to the inside of the granule container so that the granules in the granulation container pass through the inside of the granule container. A gas injection nozzle for injecting gas, and an end face opening located at the outside of the granulation container of the powder-particle taking-out tube such that the granules passing through the powder-take-out tube adhere to the adhesive surface. And a particle size measuring means for measuring the particle size by imaging the granular material captured on the adhesive surface of the adhesive film, thereby achieving the above object. .
【０００６】[0006]
【作用】本発明の流動層造粒機における粒度測定装置
は、流動層造粒機における造粒容器内の粉粒体が、ガス
噴出ノズルまたは粉粒体のころがりにより粉粒体取出管
を通過される。粉粒体取出管を通過した粉粒体は、粘着
フィルムの粘着面に付着され、該粘着フィルムに付着し
た粉粒体が、粒度計測手段により、光学的に撮像され
て、その粒度が計測される。粘着フィルムを取出管端面
から外すことにより、造粒容器内部の陰圧または外部か
らの圧空で清掃され粘着フィルムに付着されなかった粉
粒体は造粒容器内部に戻すことができ、粉粒体が入れ替
わることにより迅速に測定が可能になる。According to the particle size measuring device in the fluidized bed granulator of the present invention, the powder in the granulation container in the fluidized bed granulator passes through the powder discharge pipe by the gas ejection nozzle or the rolling of the powder. Is done. The granular material that has passed through the granular material take-out tube is attached to the adhesive surface of the adhesive film, and the granular material attached to the adhesive film is optically imaged by the particle size measuring means, and the particle size is measured. You. By removing the adhesive film from the end face of the take-out tube, the powder particles that have been cleaned by negative pressure inside the granulation container or compressed air from the outside and have not adhered to the adhesive film can be returned to the inside of the granulation container. As a result, the measurement can be quickly performed.
【０００７】[0007]
【実施例】以下に本発明を実施例について説明する。The present invention will be described below with reference to examples.
【０００８】本発明の粒度測定装置は、図１に示すよう
に、流動層造粒機の造粒容器10内で流動している粉粒体
の粒度を測定するために用いられる。造粒容器10は、上
部が大径となった倒立円錐状をしており、その側壁11
に、粒度測定装置を装着するための開口部11aが設けら
れている。流動層造粒機は、造粒容器10内を上昇するガ
ス流により該容器10内の粉粒体を流動状態とし、容器10
内の上部から下方へ向けて噴射される液状物質と接触さ
せることにより、徐々に粉粒体の粒度を増大させる。As shown in FIG. 1, the particle size measuring apparatus of the present invention is used for measuring the particle size of a powder flowing in a granulation vessel 10 of a fluidized bed granulator. The granulation vessel 10 has an inverted conical shape with a large diameter at the top,
Is provided with an opening 11a for mounting the particle size measuring device. The fluidized-bed granulator brings the powder and granules in the granulation vessel 10 into a fluidized state by a gas flow rising in the
The particle size of the granular material is gradually increased by being brought into contact with the liquid substance which is sprayed downward from the upper portion of the inside.
【０００９】造粒容器10内の粉粒体の粒度測定に使用さ
れる本発明の粒度測定装置は、造粒容器10の開口部11a
に一方の端部が造粒容器10内に連通する粉粒体取出管30
が嵌合されている。The particle size measuring apparatus of the present invention used for measuring the particle size of the granular material in the granulation container 10 includes an opening 11 a of the granulation container 10.
The powdery and granular material take-out pipe 30 whose one end communicates with the inside of the granulation vessel 10
Are fitted.
【００１０】該粉粒体取出管30の他方の端部は、粘着フ
ィルム50とこれを支持するフィルム支持手段65により取
出管30内の気密性を保持している。粉粒体取出管30の内
周面は、造粒容器10側の端部が小径、粘着フィルム50に
接触する外部の端部が大径になった円錐状の粉粒体流出
路31を形成している。The other end of the powder take-out tube 30 is kept airtight within the take-out tube 30 by an adhesive film 50 and a film supporting means 65 for supporting the same. The inner peripheral surface of the powder discharge tube 30 forms a conical powder discharge passage 31 having a small diameter at the end on the side of the granulation container 10 and a large diameter at the outer end in contact with the adhesive film 50. doing.
【００１１】該粉粒体取出管30の造粒容器10側の端部に
は、ガス噴射ノズル40が取付けられている。該ガス噴射
ノズル40は、先端部を除いて粉粒体取出管30の端部壁面
に埋め込まれている。ガス噴射ノズル40の先端部は、粉
粒体取出管30の端面から造粒容器10内に突出し、その先
端部が粉粒体取出管30内の粉粒体流出路31に対向するよ
うに湾曲している。ガス噴射ノズル40には、ガス供給手
段がカップラー41およびホース42を介して連結されてい
る。ガス供給手段は、ガス噴射ノズル40の前方に流動す
る最大粒度の粉粒体が粉粒体取出管30を通り抜けて粘着
フィルム50に接触する圧力の高圧ガスを、ガス噴射ノズ
ル40から瞬間的、かつ周期的に噴射させるようになって
いる。A gas injection nozzle 40 is attached to the end of the powdery and granular material take-out tube 30 on the side of the granulation container 10. The gas injection nozzle 40 is embedded in the end wall surface of the granular material take-out tube 30 except for the tip. The tip of the gas injection nozzle 40 protrudes into the granulation container 10 from the end face of the powder / particle discharge tube 30 and curves so that the tip faces the powder / particle discharge passage 31 in the powder / particle discharge tube 30. doing. Gas supply means is connected to the gas injection nozzle 40 via a coupler 41 and a hose 42. The gas supply means provides a high-pressure gas at a pressure at which the powder having the maximum particle size flowing in front of the gas injection nozzle 40 passes through the powder removal tube 30 and contacts the adhesive film 50, instantaneously from the gas injection nozzle 40, And it is made to inject periodically.
【００１２】粉粒体取出管30の外部端部には、図２に示
すように、粘着フィルム50を支持するフィルム支持手段
60が設けられている。粘着フィルム50は、透面な樹脂テ
ープの片面に、同じく透面な粘着剤が塗布されて巻回さ
れ、コイル51とされている。該粘着フィルム50を巻取る
モーターリール62は、粘着フィルム50の送給手段を兼ね
ており、粉粒体取出管30の側方に配設されたコイル51を
支持するコイル支持部61と、該コイル支持部61に支持さ
れたコイル51から粘着フィルム50を所定長さずつ間欠的
に引き出して粒度取出管30端面に沿って移動させた後に
巻き取る。該モーターリール62が送給時に粘着フィルム
50を巻取るとき、コイル51から引き出された粘着フィル
ム50は、粘着面を粉粒体取出管30の開口端面に対向され
て該端面に沿って通過するように、一対のガイドローラ
63および63にて支持されている。そして、粘着フィルム
50は粉粒体取出管30の開口端面に対向して停止され、該
粘着フィルム50は、上下一対のシリンダー64およびガイ
ドローラ63（図１参照）にて駆動されるフィルム支持手
段である押板65にて粉粒体取出管30の開口端面に押し付
けられる。これにより、ガス噴射ノズルの圧空で、粉粒
体取出管30を通過した粉粒体が粘着面に付着される。As shown in FIG. 2, a film supporting means for supporting an adhesive film 50 is provided at the outer end of the powdery material take-out tube 30.
There are 60 provided. The adhesive film 50 is wound on a transparent resin tape on one side of which the same transparent adhesive is applied and wound. A motor reel 62 that winds the adhesive film 50 also serves as a feeding unit for the adhesive film 50, and a coil supporting portion 61 that supports a coil 51 disposed on a side of the powder material take-out tube 30, The adhesive film 50 is intermittently drawn out by a predetermined length from the coil 51 supported by the coil support portion 61, moved along the end face of the particle size extracting tube 30, and then wound up. When the motor reel 62 is supplied with the adhesive film
When winding up the adhesive film 50, the adhesive film 50 pulled out from the coil 51 has a pair of guide rollers so that the adhesive surface is opposed to the open end surface of the granular material take-out tube 30 and passes along the end surface.
Supported at 63 and 63. And adhesive film
The pressure-sensitive adhesive film 50 is stopped by opposing the open end surface of the powdery material take-out tube 30. At 65, the powder is pressed against the opening end face of the powder take-out tube 30. As a result, the granular material that has passed through the granular material discharge pipe 30 is adhered to the adhesive surface by the compressed air of the gas injection nozzle.
【００１３】該粉粒体が粘着面に付着したフィルム50に
対向して、粒度計測手段70が配設されている。該粒度計
測手段70は、粉粒体取出管30の開口端面の粘着フィルム
50に対向して配設されたテレビカメラ71を有している。
該テレビカメラ71は、対向する粘着フィルム50に焦点を
合わせており、その光軸は、粉粒体取出管30の中心軸に
対して、粘着フィルム50の１送りピッチ分だけモーター
リール52の側に偏位している。テレビカメラ71の前方に
は、粘着フィルム50を照明するリング状の螢光ランプ72
が設けられている。該粒度計測手段70は、テレビカメラ
71が撮像した粘着フィルム50の画像を画像解析装置へ出
力し、粘着フィルム50の粘着面に付着した全ての粉粒体
のそれぞれの粒度を計測するようになっている。A particle size measuring means 70 is provided so as to face the film 50 on which the powdery particles adhere to the adhesive surface. The particle size measuring means 70 is a pressure-sensitive adhesive film on the opening end face of the granular material take-out tube 30.
It has a television camera 71 arranged opposite to 50.
The television camera 71 focuses on the opposing adhesive film 50, and its optical axis is on the side of the motor reel 52 by one feed pitch of the adhesive film 50 with respect to the center axis of the powder take-out tube 30. Is deviated to In front of the television camera 71, a ring-shaped fluorescent lamp 72 for illuminating the adhesive film 50 is provided.
Is provided. The particle size measuring means 70 is a television camera
The image of the adhesive film 50 picked up by 71 is output to an image analysis device, and the particle size of all the powder particles attached to the adhesive surface of the adhesive film 50 is measured.
【００１４】このような構成の本発明の粒度測定装置
は、造粒容器10内を流動する粉粒体の粒度を次のように
して測定する。The particle size measuring apparatus of the present invention having such a configuration measures the particle size of the powder flowing in the granulation container 10 as follows.
【００１５】流動層造粒機で造粒が行われているとき
は、その造粒容器10内で種々の粒度の粉粒体が流動して
流動層を形成している。造粒容器10の内部圧力は、大気
圧よりも若干低い負圧とされている。粒度測定装置で
は、フィルム支持手段60のコイル支持部61に粘着テープ
50のコイル51がセットされ、該コイル51から引き出され
た粘着フィルム60の先端部がモーターリール62に巻取ら
れている。When granulation is performed by a fluidized bed granulator, powders of various particle sizes flow in the granulation container 10 to form a fluidized bed. The internal pressure of the granulation container 10 is a negative pressure slightly lower than the atmospheric pressure. In the particle size measuring device, the adhesive tape is attached to the coil supporting portion 61 of the film supporting means 60.
Fifty coils 51 are set, and the tip of the adhesive film 60 pulled out from the coil 51 is wound around a motor reel 62.
【００１６】このような状態で、フィルム支持手段60の
押板65で粉粒体取出管30の端面開口に粘着フィルム50の
粘着面を押し付けるべく、シリンダー54および54を動作
させる。粉粒体取出管30の開口端面に粘着フィルム50の
粘着面が押し付けられると、該ガス噴射ノズル40から例
えば圧縮空気が所定の短時間だけ噴射される。ガス噴射
ノズル40からの圧縮空気の圧力は、該ガス噴射ノズル40
の先端部に浮遊する最大粒度の粉粒体が粘着フィルム50
に到達するように設定されている。これにより、ガス噴
射ノズル40の前方に浮遊する全ての粉粒体が粉粒体取出
管30内の粉粒体流出路31を通って粘着フィルム50に衝突
し、その粘着面に付着する。In such a state, the cylinders 54 and 54 are operated so that the pressure plate 65 of the film supporting means 60 presses the adhesive surface of the adhesive film 50 against the end face opening of the powder take-out tube 30. When the pressure-sensitive adhesive surface of the pressure-sensitive adhesive film 50 is pressed against the open end surface of the powdery material take-out tube 30, for example, compressed air is injected from the gas injection nozzle 40 for a predetermined short time. The pressure of the compressed air from the gas injection nozzle 40 is
Of the largest particle size floating on the tip of the adhesive film 50
Is set to reach. As a result, all the particulate matter floating in front of the gas injection nozzle 40 collides with the adhesive film 50 through the particulate matter outflow passage 31 in the particulate matter take-out pipe 30, and adheres to the adhesive surface.
【００１７】ガス噴出が終了すると、モーターリール52
が駆動されてコイル51から１ピッチ分の粘着フィルム50
が引き出される。該粘着フィルム50を巻取るとき、同時
に上下一対のシリンダー64および64が駆動され、押板64
を押し広げて粘着フィルム50を巻取る張力で一対のガイ
ドローラ63および63が粉粒体取出管30の開口端面と反対
方向に押し広げられる。これにより、造粒容器10内の陰
圧で空気が吸い込まれ、粘着フィルム50にて捕捉されず
流出路31に対して粉粒体は造粒容器10内に戻されて粉粒
体取出管内はクリーニングされる。同時に、粘着フィル
ム50の粉粒体付着部分が、モーターリール52側へ移動し
て、粒度計測手段70におけるテレビカメラ71の視野内に
入る。このとき、粉粒体取出管30の開口端面には、新た
に粘着フィルム50の粉粒体未付着部分が対向される。When the gas ejection is completed, the motor reel 52
Is driven and the adhesive film 50 for one pitch from the coil 51
Is pulled out. When winding the adhesive film 50, the pair of upper and lower cylinders 64 and 64 are simultaneously driven, and the pressing plate 64
The pair of guide rollers 63 and 63 are pushed and spread in the direction opposite to the opening end face of the granular material take-out tube 30 by the tension that pushes and spreads the adhesive film 50. Thereby, air is sucked in by the negative pressure in the granulation container 10, and the granules are not caught by the adhesive film 50 but are returned to the granulation container 10 with respect to the outflow passage 31, and the inside of the granule take-out pipe is Will be cleaned. At the same time, the portion of the adhesive film 50 to which the granular material adheres moves toward the motor reel 52 and enters the field of view of the television camera 71 in the particle size measuring means 70. At this time, a portion of the adhesive film 50 to which no powder is attached is newly opposed to the opening end face of the powder extraction tube 30.
【００１８】テレビカメラ71の視野内に粘着フィルム50
の粉粒体が付着した部分が誘導されると、その粉粒体付
着部分がテレビカメラ71にて撮像され、そのデータが画
像解析装置へ出力される。そして、該画像解析装置によ
り、粘着フィルム50に付着する全ての粉粒体の粒度が計
測される。これにより、造粒容器10内で造粒中に流動す
る粉粒体の造粒度および粒度分布が直接測定される。The adhesive film 50 is located within the field of view of the television camera 71.
When the portion to which the granular material is attached is guided, the portion where the granular material is attached is imaged by the television camera 71, and the data is output to the image analysis device. Then, the image analyzer measures the particle sizes of all the powders adhered to the adhesive film 50. Thereby, the granulated particle size and the particle size distribution of the powder flowing during granulation in the granulation container 10 are directly measured.
【００１９】このような圧空噴射、粘着フィルムへの粉
粒体の付着、撮像、およびクリーニングの動作が繰り返
されることにより、造粒容器10内を流動する粉粒体の造
粒度や粒度分布の経時変化が、造粒中にリアルタイムで
正確に検出することができる。従って、正確なタイミン
グで液条物質の散布の停止または流動条件の設定等の造
粒操作が行え、また、乾燥状態における粒度変化等に対
して粒度制御を高精度で実施できる。The operations of the compressed air jet, the adhesion of the granular material to the adhesive film, the imaging, and the cleaning operation are repeated, so that the granularity and the particle size distribution of the granular material flowing in the granulating container 10 are controlled. Changes over time can be accurately detected in real time during granulation. Therefore, granulation operations such as stopping spraying of the liquid material or setting flow conditions can be performed at an accurate timing, and the particle size can be controlled with high precision against a change in particle size in a dry state.
【００２０】なお、本発明の粒度測定装置は、流動層造
粒機以外の造粒機、例えば、粉流体乾燥装置、調粒装
置、粉砕装置、転動造粒装置等において、粉粒体の粒度
の測定に利用することもできる。The particle size measuring apparatus of the present invention can be used in a granulating machine other than a fluidized bed granulator, for example, a powder fluid drying device, a granulating device, a crushing device, a tumbling granulating device and the like. It can also be used for measuring particle size.
【００２１】[0021]
【発明の効果】本発明の流動層造粒機における粒度測定
装置は、このように、ガス噴射で造粒容器内の粉粒体を
造粒容器外へ排出し、その粉粒体を粘着フィルムに付着
させた状態で、その粉粒体を撮像することにより、各粉
粒体の粒度が直接かつ正確に実測することができる。ま
た、粒度測定に要する時間が短く、造粒中に粒度測定を
繰り返し行うこともできる。従って、造粒容器内の状態
がリアルタイムで正確に検出され、正確なタイミングで
造粒操作が行えるので、高精度な粒度制御が可能にな
る。As described above, the particle size measuring apparatus in the fluidized bed granulator according to the present invention discharges the granules in the granulation container to the outside of the granulation container by gas injection, and converts the granules into an adhesive film. By imaging the particles in a state in which the particles are adhered, the particle size of each particle can be directly and accurately measured. Further, the time required for particle size measurement is short, and the particle size measurement can be repeatedly performed during granulation. Therefore, the state in the granulation container is accurately detected in real time, and the granulation operation can be performed at an accurate timing, so that highly accurate particle size control can be performed.
【図１】本発明の流動層造粒機における粒度測定装置の
一例を示す縦断側面図である。FIG. 1 is a vertical sectional side view showing an example of a particle size measuring device in a fluidized bed granulator of the present invention.
【図２】その内部構造を示す平面図である。FIG. 2 is a plan view showing the internal structure.
10 造粒容器 30 粉粒体取出管 40 ガス噴射ノズル 50 粘着フィルム 60 フィルム支持手段 70 粒度計測手段 10 Granulation container 30 Powder removal tube 40 Gas injection nozzle 50 Adhesive film 60 Film support means 70 Particle size measurement means
───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 昭56−31436（ＪＰ，Ａ) 実開 昭62−189648（ＪＰ，Ｕ) (58)調査した分野(Int.Cl.7，ＤＢ名) B01J 2/00 - 2/30 G01N 15/02 ──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-56-31436 (JP, A) JP-A-62-189648 (JP, U) (58) Fields investigated (Int. Cl. 7 , DB name) B01J 2/00-2/30 G01N 15/02
Claims (1)
ある一方の端部が該造粒容器の外部に位置された他方の
端部に連通する粉粒体取出管と、該粉粒体取出管内を造
粒容器内の粉粒体が通過するように、造粒容器の内部か
ら該粉粒体取出管内へ高圧ガスを噴射するガス噴射ノズ
ルと、該粉粒体取出管を通過した粉粒体が粘着面に付着
するように、該粘着面を粉粒体取出管の造粒容器の外部
に位置する端面開口に対向された粘着フィルムと、該粘
着フィルムの粘着面に捕捉された粉粒体を撮像してその
粒度を計測する粒度計測手段と、を具備する流動層造粒
機における粒度測定装置。1. A granule taking-out pipe in which one end inside a granulation container of a fluidized bed granulator communicates with the other end located outside the granulation container, and A gas injection nozzle for injecting high-pressure gas from the inside of the granulation container into the granular material take-out tube and the granular material take-out tube so that the granular material in the granulate container passes through the body take-out tube. The adhesive film was adhered to the adhesive surface of the adhesive film opposed to the end face opening located outside the granulation container of the granular material take-out tube so that the granular material adhered to the adhesive surface, and the adhesive surface was captured by the adhesive surface of the adhesive film. A particle size measuring device for a fluidized bed granulator, comprising: a particle size measuring means for imaging a granular material and measuring the particle size.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3027448A JP3043081B2 (en) | 1991-02-21 | 1991-02-21 | Particle size measuring device in fluidized bed granulator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3027448A JP3043081B2 (en) | 1991-02-21 | 1991-02-21 | Particle size measuring device in fluidized bed granulator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04265142A JPH04265142A (en) | 1992-09-21 |
| JP3043081B2 true JP3043081B2 (en) | 2000-05-22 |
Family
ID=12221403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3027448A Expired - Lifetime JP3043081B2 (en) | 1991-02-21 | 1991-02-21 | Particle size measuring device in fluidized bed granulator |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3043081B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3355536B2 (en) * | 1993-10-26 | 2002-12-09 | 不二パウダル株式会社 | Imaging equipment for granulation and coating |
| WO1997015816A1 (en) * | 1995-10-25 | 1997-05-01 | Freund Industrial Co., Ltd. | Particle measuring device for granule processing apparatus and particle measuring method |
| JP3605627B2 (en) * | 1996-06-21 | 2004-12-22 | エーザイ株式会社 | Granule particle size measuring device |
| US7112449B1 (en) * | 2000-04-05 | 2006-09-26 | Nanogram Corporation | Combinatorial chemical synthesis |
| GB2422898B (en) * | 2005-02-07 | 2009-10-28 | Univ Sheffield | Sampling device |
-
1991
- 1991-02-21 JP JP3027448A patent/JP3043081B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04265142A (en) | 1992-09-21 |
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