JP3032287B2 - 診断薬または治療薬の抗体ターゲティング - Google Patents
診断薬または治療薬の抗体ターゲティングInfo
- Publication number
- JP3032287B2 JP3032287B2 JP02508109A JP50810990A JP3032287B2 JP 3032287 B2 JP3032287 B2 JP 3032287B2 JP 02508109 A JP02508109 A JP 02508109A JP 50810990 A JP50810990 A JP 50810990A JP 3032287 B2 JP3032287 B2 JP 3032287B2
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- enzyme
- drug
- conjugate
- substrate
- antibody
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
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Landscapes
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- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Arrangement Of Elements, Cooling, Sealing, Or The Like Of Lighting Devices (AREA)
- Non-Portable Lighting Devices Or Systems Thereof (AREA)
- Led Device Packages (AREA)
- Fastening Of Light Sources Or Lamp Holders (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1989/005441 WO1991008770A1 (en) | 1989-12-11 | 1989-12-11 | Method for antibody targeting of diagnostic or therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05501543A JPH05501543A (ja) | 1993-03-25 |
| JP3032287B2 true JP3032287B2 (ja) | 2000-04-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP02508109A Expired - Fee Related JP3032287B2 (ja) | 1989-12-11 | 1989-12-11 | 診断薬または治療薬の抗体ターゲティング |
Country Status (7)
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| US9828429B2 (en) | 2007-09-26 | 2017-11-28 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
| US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| US11214623B2 (en) | 2014-09-26 | 2022-01-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody capable of neutralizing substance having activity alternative to function of coagulation factor VIII (FVIII) |
| US11649262B2 (en) | 2015-12-28 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
| US12359001B2 (en) | 2015-04-01 | 2025-07-15 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773435A (en) * | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
| US6610299B1 (en) | 1989-10-19 | 2003-08-26 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
| DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
| US7241595B2 (en) | 1989-10-20 | 2007-07-10 | Sanofi-Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
| US5578289A (en) * | 1992-03-04 | 1996-11-26 | Akzo N.V. | In vivo binding pair pretargeting |
| US5965106A (en) * | 1992-03-04 | 1999-10-12 | Perimmune Holdings, Inc. | In vivo binding pair pretargeting |
| DE4233152A1 (de) | 1992-10-02 | 1994-04-07 | Behringwerke Ag | Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung |
| US7011812B1 (en) | 1996-05-03 | 2006-03-14 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
| JPH1160499A (ja) * | 1997-08-22 | 1999-03-02 | Hiroshi Maeda | 抗腫瘍剤 |
| US6919076B1 (en) | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
| US6361774B1 (en) * | 1999-09-17 | 2002-03-26 | Immunomedics, Inc. | Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug |
| US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| ES2327898T3 (es) | 2000-03-01 | 2009-11-05 | EISAI R&D MANAGEMENT CO., LTD. | Comprimido de desintegracion rapida que contiene poli(alcohol vinilico). |
| AU2001272017A1 (en) | 2000-06-20 | 2002-01-02 | Immunomedics Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
| WO2005035753A1 (ja) | 2003-10-10 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | 機能蛋白質を代替する二重特異性抗体 |
| WO2007114319A1 (ja) | 2006-03-31 | 2007-10-11 | Chugai Seiyaku Kabushiki Kaisha | 抗体の血中動態を制御する方法 |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9518087B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| RU2620071C2 (ru) | 2010-11-17 | 2017-05-22 | Чугаи Сеияку Кабушики Каиша | Мультиспецифическая связывающая антиген молекула, которая обладает альтернативной функцией к функции фактора свертывания крови viii |
| GB201106742D0 (en) * | 2011-04-20 | 2011-06-01 | Spheritech Ltd | Cross-linked poly-e-lysine |
| WO2015046467A1 (ja) | 2013-09-27 | 2015-04-02 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
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| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| EP3395835B1 (en) | 2015-12-25 | 2021-02-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
| MX2019002510A (es) | 2016-09-06 | 2019-06-24 | Chugai Pharmaceutical Co Ltd | Metodos para usar un anticuerpo biespecifico que reconoce el factor de coagulacion ix y/o el factor de coagulacion ix activado y el factor de coagulacion x y/o factor de coagulacion x activado. |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| US10759870B2 (en) | 2017-09-29 | 2020-09-01 | Chugai Seiyaku Kabushiki Kaisha | Multispecific antigen-binding molecules having blood coagulation factor VIII (FVIII) cofactor function-substituting activity and pharmaceutical formulations containing such a molecule as an active ingredient |
| WO2019217628A1 (en) | 2018-05-09 | 2019-11-14 | The University Of Chicago | Compositions and methods concerning immune tolerance |
| JP2021530507A (ja) | 2018-07-18 | 2021-11-11 | マンザニータ ファーマシューティカルズ，インク． | 神経細胞に抗がん剤を送達するためのコンジュゲート、その使用方法及び製造方法 |
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| WO1989010140A1 (en) | 1988-04-22 | 1989-11-02 | Cancer Research Campaign Technology Limited | Further improvements relating to drug delivery systems |
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| FR2523445A1 (fr) * | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| CA1282069C (en) * | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
| US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
| KR0185967B1 (ko) * | 1989-01-23 | 1999-05-01 | 에프. 쥐. 엠. 헤르만스; 에이. 쥐. 제이. 베르미렌 | 치료용 약물의 부위 특이적 생체내 활성작용 |
| AU633867B2 (en) * | 1989-02-02 | 1993-02-11 | Eli Lilly And Company | Delivery of cytotoxic agents |
| DE3935016A1 (de) * | 1989-10-20 | 1991-04-25 | Behringwerke Ag | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten |
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1989
- 1989-12-11 AT AT90908737T patent/ATE177321T1/de not_active IP Right Cessation
- 1989-12-11 KR KR1019910700828A patent/KR100236375B1/ko not_active Expired - Fee Related
- 1989-12-11 JP JP02508109A patent/JP3032287B2/ja not_active Expired - Fee Related
- 1989-12-11 EP EP90908737A patent/EP0505357B1/en not_active Expired - Lifetime
- 1989-12-11 AU AU56736/90A patent/AU649952B2/en not_active Ceased
- 1989-12-11 WO PCT/US1989/005441 patent/WO1991008770A1/en active IP Right Grant
- 1989-12-11 DE DE68928946T patent/DE68928946T2/de not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989010140A1 (en) | 1988-04-22 | 1989-11-02 | Cancer Research Campaign Technology Limited | Further improvements relating to drug delivery systems |
Non-Patent Citations (2)
| Title |
|---|
| Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ，Ｖｏｌ．３４（１９７４）ｐ．２１５９−２１６４ |
| Ｔｈｅ Ｌａｎｃｅｔ，Ｖｏｌ．１，Ｎｏ．８４８１（１９８６）ｐ．６０３−６０５ |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| US9828429B2 (en) | 2007-09-26 | 2017-11-28 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
| US11214623B2 (en) | 2014-09-26 | 2022-01-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody capable of neutralizing substance having activity alternative to function of coagulation factor VIII (FVIII) |
| US12359001B2 (en) | 2015-04-01 | 2025-07-15 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| US11649262B2 (en) | 2015-12-28 | 2023-05-16 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991008770A1 (en) | 1991-06-27 |
| DE68928946T2 (de) | 1999-10-21 |
| KR100236375B1 (ko) | 1999-12-15 |
| JPH05501543A (ja) | 1993-03-25 |
| AU5673690A (en) | 1991-07-18 |
| ATE177321T1 (de) | 1999-03-15 |
| EP0505357A1 (en) | 1992-09-30 |
| EP0505357B1 (en) | 1999-03-10 |
| AU649952B2 (en) | 1994-06-09 |
| DE68928946D1 (de) | 1999-04-15 |
| EP0505357A4 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1994-03-16 |
| KR920702819A (ko) | 1992-10-28 |
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