JP2799568B2 - Antioxidant composition - Google Patents
Antioxidant compositionInfo
- Publication number
- JP2799568B2 JP2799568B2 JP63084668A JP8466888A JP2799568B2 JP 2799568 B2 JP2799568 B2 JP 2799568B2 JP 63084668 A JP63084668 A JP 63084668A JP 8466888 A JP8466888 A JP 8466888A JP 2799568 B2 JP2799568 B2 JP 2799568B2
- Authority
- JP
- Japan
- Prior art keywords
- antioxidant
- glutathione
- vitamin
- present
- products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は酸化防止剤組成物に関し、更に詳しくは皮膚
外用製品に好適で、抗酸化性の向上を目的としたビタミ
ンＥとグルタチオンとをそれぞれ特定量含有する酸化防
止剤組成物に関する。Description: FIELD OF THE INVENTION The present invention relates to an antioxidant composition, and more particularly to vitamin E and glutathione, which are suitable for an external skin product and improve antioxidant properties, respectively. It relates to an antioxidant composition containing a specific amount.
［従来の技術］ 一般に不飽和系油脂や界面活性剤は紫外線または空気
中の酸素等によって酸化を受け易く、その結果変色や変
臭を生じることが知られており、従ってそれら成分を含
む製品には酸敗を防ぐために通常酸化防止剤を配合する
ことが多い。[Prior art] Generally, unsaturated fats and oils and surfactants are susceptible to oxidation by ultraviolet rays or oxygen in the air, and are known to cause discoloration and odor. In many cases, antioxidants are usually added to prevent rancidity.
また近年、過酸化物は皮膚に対して有害となり、化粧
品のような皮膚外用製品に過酸化物が含まれているとそ
の使用で皮膚のかぶれやかゆみ、さらに黒皮症や肝斑等
の疾病を引き起こすおそれがあることも報じられてい
る。そこで製品中の酸化による過酸化物の生成を防止す
る上で酸化防止剤の果たす役割は重要となり、積極的に
配合検討がなされると同時に油脂や界面活性剤等の構成
成分面での選択も必要とされてきた。In recent years, peroxides have become harmful to the skin. If peroxides are contained in external skin products such as cosmetics, their use will cause skin rashes, itchiness, and other diseases such as melasma and melasma. It has also been reported that it may cause Therefore, the role of antioxidants in preventing the formation of peroxides due to oxidation in products is important, and the formulation is actively studied, and at the same time, the selection of components such as fats and oils and surfactants is also required. It has been needed.
従来、かくした酸化防止剤としては、ビタミンＥ、2,
4−ジ−tert−ブチル−ｐ−クレゾール、tert−ブチル
ヒドロキシアニソール、没食子酸エステル等が代表的な
ものとして挙げられ、使用されてきた。Conventionally, such antioxidants include vitamin E, 2,
4-Di-tert-butyl-p-cresol, tert-butylhydroxyanisole, gallic acid ester and the like have been cited as typical examples and have been used.
［発明が解決しようとする課題］ しかしながら、前記した従来公知の酸化防止剤は、酸
化防止を期待して使用されているが所期の目的達成にと
ってほとんど効果が得られず、また多量に用いるにして
も配合面での制約から充分な効果が得難い、或いは皮膚
安全性面で好ましくないといったものがあって必ずしも
満足し得るところでなかった。[Problems to be Solved by the Invention] However, the above-mentioned conventionally known antioxidants have been used in anticipation of antioxidation, but have little effect on achieving the intended purpose, and have been used in large amounts. However, it was difficult to obtain a sufficient effect due to restrictions on the composition, or it was unfavorable in terms of skin safety.
その上現状として、製品の酸化防止ばりでなく、皮膚
表面でも常に皮表脂質から過酸化脂質が生成され、過酸
化脂質の蛋白変性作用や老化との係り合い等も示されて
おり、従って製品由来であれ、皮表脂質由来であれ、過
酸化物を可能な限り排除することが望ましく、酸化防止
効果を一層高め、過酸化物による皮膚障害を予防するこ
とが大切な問題となってきている。In addition, as the current situation, not only the antioxidant burrs of the product, but also lipid peroxide is always generated from the skin surface lipid on the skin surface, and the relationship between lipid peroxide's protein denaturing action and aging has been shown. It is desirable to eliminate peroxide as much as possible, regardless of its origin, or from skin surface lipids. It is becoming an important issue to further enhance the antioxidant effect and prevent skin damage due to peroxide. .
［課題を解決するための手段］ 本発明者等は、前記した事情に鑑み、従来に増して抗
酸化性をより一層向上させるべく鋭意検討を重ねた結
果、特定量のビタミンＥとグルタチオンとを併用するこ
とにより、過酸化物の生成を有効に抑制でき、顕著な酸
化防止効果が得られることを見い出し、この知見をもっ
て本発明を完成させたのである。[Means for Solving the Problems] In view of the circumstances described above, the present inventors have made intensive studies to further improve the antioxidant properties more than before, and as a result, have determined that specific amounts of vitamin E and glutathione It has been found that by using them together, the generation of peroxide can be effectively suppressed and a remarkable antioxidant effect can be obtained, and the present invention has been completed based on this finding.
すなわち本発明は、ビタミンE0.0001〜5.0重量％とグ
ルタチオン0.0001〜3.0重量％とを含有してなる酸化防
止剤組成物に関するものである。That is, the present invention relates to an antioxidant composition containing 0.0001 to 5.0% by weight of vitamin E and 0.0001 to 3.0% by weight of glutathione.
以下本発明の構成について説明する。 Hereinafter, the configuration of the present invention will be described.
本発明で使用されるビタミンＥとしては、天然ビタミ
ンＥ、α−トコフェロール、β−トコフェロール、γ−
トコフェロール、δ−トコフェロール等であり、これら
の一種または二種以上を適宜選択して用いることができ
る。As the vitamin E used in the present invention, natural vitamin E, α-tocopherol, β-tocopherol, γ-
Tocopherol, δ-tocopherol, and the like, and one or more of these can be appropriately selected and used.
またグルタチオンは、公知の物質であって、γ−Ｌ−
グルタミル−Ｌ−システイニルグリシンで下記の構造式
（１）で示されるものである。本発明で使用されるグル
タチオンは、酵母などの微生物や動物・植物から抽出・
精製して使用しても良く、また、市販されているのもの
をそのまま用いても良い。Glutathione is a known substance, and γ-L-
Glutamyl-L-cysteinyl glycine represented by the following structural formula (1). Glutathione used in the present invention is extracted and extracted from microorganisms such as yeast and animals and plants.
It may be used after purification, or commercially available one may be used as it is.
本発明におけるビタミンＥとグルタチオンの酸化防止
剤組成物としての使用量は、最終製品の全量あたり、ビ
タミンＥの場合、0.0001〜5.0重量％、グルタチオンの
場合、0.0001〜3.0重量％の範囲であり、この範囲であ
れば酸化防止効果を期待する効果的な添加量として好ま
しく、充分量である。そしてこれらは目的に応じて最適
組成比を随時設定し、配合することで用いられる。 The amount of vitamin E and glutathione used as an antioxidant composition in the present invention is in the range of 0.0001 to 5.0% by weight for vitamin E and 0.0001 to 3.0% by weight for glutathione, based on the total amount of the final product, Within this range, it is preferable and sufficient as an effective addition amount for expecting an antioxidant effect. These are used by setting the optimum composition ratio at any time according to the purpose and blending them.
本発明の酸化防止剤組成物は、酸化を受け易いオリー
ブ油、ホホバ油、アーモンド油、スクワレン等の不飽和
系油脂、モノオレイン酸グリセリン、セスキオレイン酸
ソルビタン、トリオレイン酸ポリオキシエチレンソルビ
タン等の不飽和系界面活性剤またこれらを含む製品に対
して使用することにより、抗酸化性面での安定性を図る
ことができる。The antioxidant composition of the present invention can be easily oxidized to unsaturated oils such as olive oil, jojoba oil, almond oil, and squalene, glycerin monooleate, sorbitan sesquioleate, and polyoxyethylene sorbitan trioleate. By using it for a saturated surfactant or a product containing these, it is possible to achieve stability in antioxidant properties.
そして本発明の酸化防止剤組成物としての使用は、化
粧品等の皮膚外用製品に好適である。化粧品としては例
えば、ローション、乳液、クリーム、ペースト状の皮膚
化粧料をはじめ、洗顔料、パック料、メーキャップ化粧
料、頭髪・頭皮用製品、口唇用製品、爪用製品等での利
用に適するものであり、これら製品に抗酸化安定性を付
与できるので極めて有用である。The use as the antioxidant composition of the present invention is suitable for skin external products such as cosmetics. Suitable for use in cosmetics, for example, lotions, emulsions, creams, paste-like skin cosmetics, facial cleansers, packs, makeup cosmetics, hair and scalp products, lip products, nail products, etc. These products are extremely useful because they can impart antioxidant stability to these products.
［実施例］ 次に、本発明について、実施例を挙げてさらに説明す
る。これらは本発明を何ら限定するものでない。[Examples] Next, the present invention will be further described with reference to examples. They do not limit the invention in any way.
実施例［１］ 本発明の効果を確認するために表１に示す試料、〜
の５種を用い、自動酸化に対する安定性試験を行っ
た。試験方法は、基準油脂分析試験法（日本油化学協
会）のAOM試験に準じ、油浴の温度は97.8℃に、空気流
量は2.3ml/secに設定し、5.5時間後に各試料のPOVを測
定することにより行った。結果は表１に示す。尚、表中
のデータは試験を３回実施した測定結果の平均値で表わ
した。Example [1] Samples shown in Table 1 to confirm the effects of the present invention,
The stability test against autoxidation was conducted using the five types of. The test method is based on the AOM test of the Standard Oils and Fats Analysis Test Method (Japan Oil Chemicals Association). The oil bath temperature is set to 97.8 ° C, the air flow rate is set to 2.3 ml / sec, and the POV of each sample is measured after 5.5 hours. It was done by doing. The results are shown in Table 1. In addition, the data in the table was represented by the average value of the measurement results obtained by performing the test three times.
表１の結果に認められるように、d1−α−トコフェロ
ールとグルタチオンを併用した場合（試料〜）は、
それぞれを単独で用いた場合（試料〜）と比較し、
POVが低く、オレイン酸メチルに対して過酸化物の生成
が有効に抑制され、酸化防止効果が顕著に発揮されるこ
とが明らかになり、酸化防止剤として極めて有用である
ことが判る。 As can be seen from the results in Table 1, when d1-α-tocopherol and glutathione were used in combination (sample to),
Compared to the case of using each alone (sample ~),
It is clear that the POV is low, the generation of peroxide is effectively suppressed with respect to methyl oleate, and the antioxidant effect is remarkably exhibited, indicating that it is extremely useful as an antioxidant.
実施例［２］クリーム （処方） （重量％） （１）オリーブ油 5.0 （２）アーモンド油 10.0 （３）ステアリルアルコール 3.0 （４）モノオレイン酸グリセリン 1.5 （５）セスキオレイン酸ソルビタン 0.5 （６）モノオレイン酸ポリオキシエ 1.0 チレンソルビタン（20 E.O.） （７）グリセリン 7.0 （８）α−トコフェロール 0.1 （９）グルタチオン 0.05 （10）グアイアズレン 0.002 （11）香料 0.2 （12）パラオキシ安息香酸メチル 0.1 （13）精製水 残量 （製法） 成分（１）〜（５）を混合し、加熱溶解する。これを別
に混合、加熱溶解した成分（６）〜（13）に徐々に添加
して乳化を行ない、冷却してクリームを得た。Example [2] Cream (Formulation) (% by weight) (1) Olive oil 5.0 (2) Almond oil 10.0 (3) Stearyl alcohol 3.0 (4) Glycerin monooleate 1.5 (5) Sorbitan sesquioleate 0.5 (6) Mono Polyoxye oleate 1.0 Tylenesorbitan (20 EO) (7) Glycerin 7.0 (8) α-Tocopherol 0.1 (9) Glutathione 0.05 (10) Guaiazulene 0.002 (11) Fragrance 0.2 (12) Methyl paraoxybenzoate 0.1 (13) Purified water Remaining amount (production method) Components (1) to (5) are mixed and dissolved by heating. This was separately added and gradually added to the components (6) to (13) which were heated and dissolved to emulsify, and then cooled to obtain a cream.
実施例［13］パウダーファンデーション （処方） （重量％） （１）酸化チタン 10.0 （２）カオリン 25.0 （３）タルク 40.0 （４）ベンガラ 0.8 （５）黄酸化鉄 2.5 （６）黒酸化鉄 0.1 （７）マイカ 残量 （８）オリーブ油 7.0 （９）セスキオレイン酸ソルビタン 1.0 （10）グリセリン 3.0 （11）天然ビタミンＥ 0.05 （12）グルタチオン 0.1 （13）β−カロチン 0.001 （14）香料 0.1 （15）パラオキシ安息香酸メチル 0.05 （製法） 成分（１）〜（７）を混合し、粉砕して均質にする。こ
れに予め混合、加熱溶解した成分（８）〜（15）を加
え、均一に混合した後、粉砕し、次いでプレス成型して
パウダーファンデーションを得た。Example [13] Powder foundation (prescription) (% by weight) (1) Titanium oxide 10.0 (2) Kaolin 25.0 (3) Talc 40.0 (4) Bengala 0.8 (5) Yellow iron oxide 2.5 (6) Black iron oxide 0.1 ( 7) Mica balance (8) Olive oil 7.0 (9) Sorbitan sesquioleate 1.0 (10) Glycerin 3.0 (11) Natural vitamin E 0.05 (12) Glutathione 0.1 (13) β-carotene 0.001 (14) Fragrance 0.1 (15) Methyl parahydroxybenzoate 0.05 (Production method) Mix components (1) to (7) and homogenize by mixing. The components (8) to (15) previously mixed and dissolved by heating were added thereto, mixed uniformly, crushed, and then press-molded to obtain a powder foundation.
実施例［４］ピールオフ型パック （処方） （重量％） （１）酢酸ビニル樹脂エマルション 15.0 （２）ポリビニルアルコール 10.0 （３）オリーブ油 3.0 （４）天然ビタミンＥ 0.1 （５）セスキオレイン酸ソルビタン 0.5 （６）グルタチオン 1.0 （７）コンドロイチン硫酸ナトリウム 0.2 （８）酸化チタン 8.0 （９）カオリン 7.0 （10）エチルアルコール 5.0 （11）香料 0.1 （12）精製水 残量 （製法） 成分（２）〜（５）、（10）を混合後、成分（12）を加
え、加熱溶解する。次いでこれに成分（６）〜（９）、
（11）を加えて混合し、冷却した後、成分（１）を添
加、混合してピールオフ型パックを得た。Example [4] Peel-off type pack (Formulation) (% by weight) (1) Vinyl acetate resin emulsion 15.0 (2) Polyvinyl alcohol 10.0 (3) Olive oil 3.0 (4) Natural vitamin E 0.1 (5) Sorbitan sesquioleate 0.5 ( 6) Glutathione 1.0 (7) Sodium chondroitin sulfate 0.2 (8) Titanium oxide 8.0 (9) Kaolin 7.0 (10) Ethyl alcohol 5.0 (11) Fragrance 0.1 (12) Purified water Remaining (Production method) Ingredients (2) to (5) After mixing (10) and (10), add component (12) and heat to dissolve. Then, components (6) to (9)
After adding and mixing (11) and cooling, the component (1) was added and mixed to obtain a peel-off type pack.
［発明の効果］ 以上詳述した如く、本発明は特定量のビタミンＥとグ
ルタチオンとを含有することにより、これら成分の酸化
防止効果が発揮された酸化防止剤組成物を提供するもの
である。[Effects of the Invention] As described in detail above, the present invention provides an antioxidant composition in which specific amounts of vitamin E and glutathione are contained, thereby exhibiting an antioxidant effect of these components.
すなわち本発明により、従来に増して顕著な酸化防止
効果を有するものであって、不飽和系油脂や界面活性剤
の酸化を防止し、化粧品等の製品の劣化防止が可能であ
ると共に、過酸化物の生成を効果的に抑制できることか
ら化粧品等に添加し、適用した際に過酸化物の皮膚に対
する悪影響の防止が期待でき、さらには製品に配合して
利用することにおいて安定性、安全性がよく、極めて有
用な酸化防止剤組成物が得られたのである。That is, the present invention has a remarkable antioxidant effect more than before, prevents oxidation of unsaturated fats and oils and surfactants, and can prevent deterioration of cosmetics and other products, as well as peroxidation. It can be expected to prevent the adverse effect of peroxide on the skin when added to cosmetics, etc. when applied to cosmetics, etc., because it can effectively suppress the formation of products, and furthermore, the stability and safety when blended into products and used Well, a very useful antioxidant composition was obtained.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) C09K 15/28 C09K 15/34 A61K 7/00──────────────────────────────────────────────────続 き Continued on front page (58) Field surveyed (Int.Cl. 6 , DB name) C09K 15/28 C09K 15/34 A61K 7/00
Claims (1)
ン0.0001〜3.0重量％とを含有してなることを特徴とす
る酸化防止剤組成物。1. An antioxidant composition comprising 0.0001 to 5.0% by weight of vitamin E and 0.0001 to 3.0% by weight of glutathione.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63084668A JP2799568B2 (en) | 1988-04-06 | 1988-04-06 | Antioxidant composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63084668A JP2799568B2 (en) | 1988-04-06 | 1988-04-06 | Antioxidant composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01256586A JPH01256586A (en) | 1989-10-13 |
| JP2799568B2 true JP2799568B2 (en) | 1998-09-17 |
Family
ID=13837091
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63084668A Expired - Fee Related JP2799568B2 (en) | 1988-04-06 | 1988-04-06 | Antioxidant composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2799568B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130129206A (en) * | 2010-11-18 | 2013-11-27 | 베르살리스 에스.피.에이. | Stabilized composition comprising homopolymers or copolymers of ethylene and natural antioxidants |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3091270B2 (en) * | 1990-09-28 | 2000-09-25 | 協和醗酵工業株式会社 | Whitening cosmetics |
| FR2704754B1 (en) * | 1993-05-07 | 1995-06-30 | Oreal | USE OF AN ALKYL ESTER OF GLUTATHION IN A COSMETIC OR DERMATOLOGICAL COMPOSITION FOR TOPICAL TREATMENT OF CUTANEOUS AGING. |
| CA2346700A1 (en) | 1998-10-09 | 2000-04-20 | Ajinomoto Co., Inc. | Cysteine derivatives |
| IN2000KO00299A (en) * | 1999-05-28 | 2005-11-18 | Johnson & Johnson Consumer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4935417A (en) * | 1972-08-08 | 1974-04-02 |
-
1988
- 1988-04-06 JP JP63084668A patent/JP2799568B2/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 蟇目浩吉 外６名編「ハンドブック−化粧品・製剤原料−改訂版」日光ケミカルズ株式会社 昭和５２年２月１日発行 Ｐ．４５３〜４５４ |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130129206A (en) * | 2010-11-18 | 2013-11-27 | 베르살리스 에스.피.에이. | Stabilized composition comprising homopolymers or copolymers of ethylene and natural antioxidants |
| KR101863980B1 (en) | 2010-11-18 | 2018-06-01 | 베르살리스 에스.피.에이. | Stabilized composition comprising homopolymers or copolymers of ethylene and natural antioxidants |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01256586A (en) | 1989-10-13 |
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