JP2788198B2 - Multi-laser light scanning biopsy diagnosis and treatment device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for irradiating a living body with a laser beam, scanning the surface in a direction perpendicular to a direction parallel to the living body axis, and receiving a laser beam transmitted through the living body with a light receiving / detecting plate. The present invention relates to an apparatus for displaying an image of the state of the image to diagnose the state. Further, the present invention provides a method of scanning a surface in a direction perpendicular to a direction parallel to a living body while irradiating a laser beam toward a living body, and detecting a transmission position and a light amount of the laser beam transmitted through the living body, and detecting these. The present invention relates to a laser treatment apparatus that irradiates a laser beam having an appropriate intensity according to a symptom of a living body based on a value.

[0002]

2. Description of the Related Art Conventionally, biopsy images are mainly performed using X-rays. The image of the biopsy diagnosis by X-ray is displayed as a clear image close to the actual size at a lesion close to the film surface, but is displayed as an unclear image enlarged from the actual size as the lesion moves away from the film surface. It is.

[0003] In a malignant tumor or the like, the edge of the lesion is generally sharp at the boundary with normal tissue, has an irregular contour with irregular irregularities, and has a cell density inside the tumor that is lower than that of normal tissue. Since the density is high and the nucleus ratio of cells is large, the permeability is generally lower than that of normal tissue, and the inside of the tumor tends to have an uneven pattern image. In X-ray imaging, a lesion inside a living body is generally unclear in outline and inside due to X-ray scattering components inside and outside the living body, and the presence of the lesion is often unknown until the unevenness of density inside the tumor becomes significant.
In particular, in soft organs, the difference in X-ray transmittance between the tumor lesion and normal tissue was small, and it was not possible to capture the difference in shadow as an abnormal shadow of the tumor until the tumor became quite large and hard. .

[0004] Further, as a basic examination method, an X-ray using a contrast agent is used for performing image diagnosis of the digestive tract such as the stomach and intestine.
Fluoroscopy is well known. In this case, at present, fluoroscopic imaging is usually performed with one X-ray tube, and a plurality of X-ray tubes are used.
It has not been performed to perform fluoroscopic imaging of a living body from different directions almost simultaneously using a ray tube. Therefore, in order to obtain a fluoroscopic image of the in-vivo organ as viewed from two directions, front and side, it is necessary to change the body position and photograph it twice. Since the lesion itself is deformed, the front image and the side image photographed in this manner do not show the same organ and lesion as viewed from the front and side. Further, changing the body position is a time-consuming and difficult operation for the elderly and the disabled, and increases the total time required for imaging diagnosis.

Further, since X-rays are emitted in a conical shape from one small tube, the amount of exposure to each part of the film surface is not uniform, and analog images are easily obtained, but are suitable for digital image processing. Not. In addition, since X-rays are affected by scattered components from other parts of the body in addition to non-uniform irradiation, soft organs other than bones produce indistinct images of contrast. It was difficult to do. That is, it was almost impossible to perform a pseudo-color image analysis and diagnosis of a fine grayscale image using digitalized data, and to perform image processing of various differential images, integral images, difference images, and the like.

[0006]

On the other hand, when a colonoscope is inserted into a complicatedly bent large intestine or when a catheter is inserted into a deep part, it is necessary to check the insertion state by performing fluoroscopy. However, the subject, the doctor who performs the examination, and the caregiver cannot perform X-ray fluoroscopy continuously for safety because of the risk of exposure to X-rays. Is the current situation. Therefore, deep insertion of endoscopes and catheters poses technical difficulties and poses a problem for the subject.In addition, it is necessary to set up a protective wall for radiation protection or to have the surgeon wear protective equipment. Costs.

[0007] Further, after an iodine contrast agent is injected and perfused into a space of a luminal organ such as the gastrointestinal tract or a vascular organ and X-ray fluoroscopy is performed, the iodine contrast agent is diffused and absorbed into the body. Despite the benefits, patients with iodine sensitivity are often at risk of shock. In gastrointestinal X-ray fluoroscopy, barium, which is hardly biochemically absorbed and easily adsorbed on the gastrointestinal tract wall, is frequently used, but it is difficult to drink and excrete outside the body.
The risk of accidents such as bowel obstruction is not uncommon during severe constipation. That is, the material of the contrast agent that is difficult to transmit X-rays is very limited, and various problems remain. It was limited to X-ray transmission characteristics.

As a diagnostic method using light other than X-rays, a method of obtaining a fluoroscopic image by using a laser beam has been proposed. However, there is a problem of transparency in fluoroscopy of a trunk having a large thickness and including bone. Since laser beam irradiation has conventionally been performed by radiating the laser beam in a conical shape with a single laser light source dangling motion, it is common to the case of X-ray fluoroscopy. There are several issues.

An object of the present invention is to provide a fluoroscopy diagnostic apparatus which can solve the above-mentioned problems associated with fluoroscopy using an energy source other than X-rays. Another object of the present invention is to provide a doctor and a caregiver without exposure to radiant energy when performing an examination using an endoscope or a catheter, and to use a laser beam having good linearity to obtain a stereoscopic image of the inside of a living body. An object of the present invention is to provide a fluoroscopic diagnostic apparatus that can continuously observe for a long time.

It is still another object of the present invention to provide a fluoroscopic diagnostic apparatus which can obtain fluoroscopic images of a living body from a plurality of different directions without changing the position of the living body. Still another object of the present invention is to provide a fluoroscopic diagnostic apparatus which can display a lesion in a living body as a clear image with a high resolution while maintaining its actual size. Still another object of the present invention is to provide a safe fluoroscopic diagnostic apparatus capable of transmitting high-energy laser light without causing harmful effects on cells and tissue fluids of a living body.

Still another object of the present invention is to provide a light receiving / detecting device capable of irradiating a living body with a safe laser beam several times within a certain period of time at a diagnostic site of the living body and integrating the total amount of light per unit irradiation area. It is an object of the present invention to provide a fluoroscopic diagnostic apparatus which can obtain a clear image without giving a harmful effect to a living body.

Still another object of the present invention is to provide a fluoroscopic diagnostic apparatus capable of discriminating whether a living body has a malignant tumor, is inflamed, or is in a normal state. Still another object of the present invention is to provide a treatment apparatus capable of projecting a predetermined amount of laser beam onto a laser beam irradiation point according to a symptom of a living body to perform laser treatment of a tumor.

[0013]

According to the present invention, there is provided, according to the present invention, at least one laser light source for emitting a laser beam, wherein the laser beam is directed toward a living body and is perpendicular to a living body axis. A device for irradiating a laser beam directed to the living body in a direction parallel to a living body axis, a device for moving the laser beam directed to the living body in a direction perpendicular to the living body axis, and a living body. A laser having at least one set of a laser beam parallel scanning light receiving detection mechanism including a detection plate that receives a laser beam transmitted through the laser beam, and a device that rotatably supports the laser beam parallel scanning light receiving detection mechanism around a biological axis. An optical scanning biopsy diagnostic apparatus is provided.

The two sets of the laser beam parallel scanning light receiving detection mechanism are arranged at an angle of 90 ° around the axis of the living body, and the information detected by the two detection plates and viewed from two directions by the living body is processed by a computer. A stereoscopic image of a colonoscope, a catheter, and the like in the living body can be obtained. In addition, the lesions in the living body under a certain condition (such as using a contrast agent) can be calculated using fluoroscopic images obtained by changing these two sets of laser beam parallel scanning light receiving detecting mechanisms with respect to the living body in various directions. Can be displayed on a TV monitor.

[0015] Preferably, a plurality of laser beams emitted from the plurality of laser light sources and having an allowable light amount that is safe for the living body are focused on a dense laser beam group, and light energy having a large light amount is minutely dispersed in the living body. Irradiation as a modified laser beam can reduce harmful effects on cell tissues and tissue fluids of a living body.

Preferably, the photodetection plate is a photoelectron array board in which a large number of optoelectronic elements are integrated in a minute unit area on the surface of the living body and photoelectron units arranged on a plane are arranged in a lattice pattern. A microprocessor array board in which a number of microprocessors mounted on the back surface and connected to each optoelectronic unit are arranged in a grid, and a number of semiconductor memories attached to the back side of the microprocessor array board and connected to the respective microprocessors. And a semiconductor memory array board arranged in a lattice shape, and irradiates a living body diagnostic point several times with a laser parallel light densely focused on a plurality of small areas of a safe light amount to a living body within a certain time, The amount of light received by the two opto-electronic units is integrated to form a clear transparent image of the living body without giving a harmful effect to the living tissue. Rukoto can. The optoelectronic unit can obtain a high-resolution fluoroscopic image by setting the ON-OFF switch to be in the ON state only during the time when the unit is directly irradiated with the laser.

Furthermore, if a tumor-directed fluorescent agent is administered to a patient in advance for a certain period of time, the fluorescent substance accumulates in the tumor, so that fluorescence emission is observed in the tumor when laser scanning is performed. At this time, by sequentially replacing several fluorescent wavelength filters that transmit different fluorescent wavelengths within a certain wavelength band on the front surface of the optoelectronic array board, the fluorescence intensity and the transmitted fluorescent wavelength captured by each optoelectronic unit can be reduced. A characteristic curve is obtained, and by comparing this with a previously measured characteristic curve, a pseudo-color image is formed as to whether the fluoroscopic site has a malignant tumor, is inflamed, or is normal. Can be identified.

Further, according to the present invention, it is possible to detect which optoelectronic unit of the optoelectronic array panel is being irradiated with the laser beam, detect the amount of irradiation, and use the detected value to treat a preset symptom. Laser treatment can be performed by controlling the laser light source in comparison with an appropriate laser beam light amount.

Further, the treatment device can perform laser treatment according to the patient's condition in conjunction with the condition identification device. Other objects, configurations, functions and effects of the present invention will become apparent from the following description of preferred embodiments with reference to the drawings.

[0020]

FIG. 1 is a side view showing an outline of a laser beam parallel scanning light receiving detection mechanism of a laser beam scanning living body fluoroscopy diagnostic apparatus of the present invention, and FIG. 2 is a schematic diagram showing a cross section of the mechanism. As shown in FIG. 1, a laser beam parallel scanning light receiving detection mechanism according to the present invention comprises a laser beam parallel irradiation scanning device 3 arranged above a living body 2 lying on a bed 1 and a light receiving detection plate 4 arranged below. It is composed of The laser beam parallel irradiation scanning device 3 irradiates a laser beam emitted from a laser light source toward the living body 2 as described later, and applies the laser beam in a longitudinal direction parallel to a central axis of the living body (hereinafter referred to as a living body axis). And a lateral direction perpendicular to the axis of the living body, and parallel scanning is performed on the entire surface of a predetermined diagnostic portion of the living body. The parallel scanning laser beam transmitted through the living body is received by the light receiving detection plate.

As shown in FIG. 2, a laser parallel scanning light receiving and detecting mechanism comprising a set of a laser beam parallel irradiation scanning device 3 and a light receiving and detecting plate 4 is supported rotatably about the living body 2. The laser beam parallel irradiation / scanning device 3 is rotated to an arbitrary angle position while lying on the bed 1 in a stationary state without changing the body position, and fluoroscopic data of the living body viewed from any direction can be obtained. Further, as shown in FIG. 2, when another set of laser beam parallel scanning and light receiving detection mechanisms including a laser beam parallel irradiation scanning device 3 'and a light receiving and detecting plate 4' are provided at appropriate angular intervals, simultaneously, from two different directions. Obtained perspective data is obtained. The data obtained by these light receiving detection plates 4 and 4 'are directly converted into electric signals by the monitor televisions 5 and 5'.
And displayed as a perspective image in each direction. Also, as shown in FIG. 3, two sets of laser beam parallel scanning light receiving detection mechanisms are provided at 90 ° angular intervals, and the laser parallel irradiation scanning device 3 is placed above the living body 2, and the laser beam parallel irradiation scanning device 3 ′ is placed in the living body. 2 and a laser beam parallel plane scan is performed, fluoroscopic data of the living body 2 viewed from above and from the side are obtained on the light receiving detection plates 4 and 4 ', respectively. A colonic endoscope, a catheter, and the like can be stereoscopically displayed on a monitor television, so that deep insertion observation of these can be facilitated. Also, two sets of laser parallel light scanning and light receiving detection mechanisms are set in various directions with respect to the living body 2 to obtain fluoroscopic images in the respective directions. 3D) can be displayed on the television monitor 7 by computer graphics. Note that two or more sets of laser beam parallel scanning light receiving detection mechanisms may be provided as necessary.

If the irradiation of the illumination for observing the inside of the living organ with the endoscope and the irradiation of the laser beam are performed simultaneously, it is difficult to obtain a clear image because they interfere with each other. It is necessary to perform time sharing. Similarly, when a plurality of laser beam parallel scanning light receiving detection mechanisms are used, it is necessary to perform time sharing so that the laser beams emitted from the respective laser beam parallel irradiation scanning devices do not collide in the living body. Such time sharing can be performed by ON-OFF control of the light source so that a plurality of laser beams emitted from a plurality of light sources are alternately shifted and irradiated intermittently, but other appropriate It is also possible to perform time sharing using an optical device.

FIG. 4 shows an example of this. Reference numeral 8 denotes a disk rotating around a shaft 9. The disk 8 is provided with a plurality of through holes 10 on the same circumference. Is a mirror surface. A laser beam 11 emitted from a single laser light source is applied to one point on the circumference provided with the through-hole 10, and one of the through-holes 10 of the rotating disc 8 is irradiated with the beam 11.
When the beam 11 comes down, the beam 11 passes through the through-hole 10 and becomes a downward laser beam 11 ′. When the beam 11 comes to a portion between the two through-holes 10, the beam 11 is reflected and becomes an upward laser beam 11 ″. Become. Thus, the single laser beam 11 becomes two time-shared laser beams 11 ′ and 11 ″ that progress intermittently. These laser beams 11 'and 11''are used so as to be irradiated from two laser beam parallel irradiation scanning devices 3 and 3', respectively.

FIG. 5 shows an embodiment of a laser beam parallel irradiation scanning device. This embodiment uses a plurality of laser light sources 12.
Are arranged in a plurality of rows (three rows in the figure), and in each row, a plurality of (five in the figure) laser light sources 12 are arranged at intervals in one plane as shown in FIG. Laser light source 1
Laser beam 13 emitted from 2 at different projection angles
Is projected on the prism 14. Upper surface 15 of prism 14
Is formed at a different angle for each part hit by each laser beam so that the projected laser beam 13 is refracted at a different angle and becomes a parallel beam 16 in the vertical direction. The parallel laser beam 16 is projected on the axis 17 of the upper rotating mirror 19 and is converted as a parallel laser beam 18 into the upper parabolic curved mirror 20.
Reflected toward. Similarly, laser beams emitted from a plurality of laser light sources 12 in other rows are converted into parallel beams 16 ′ and 16 ″ through the respective prisms 14, projected on the axis of the upper rotating mirror 19, and from there parallel lasers The beams are reflected toward the upper parabolic mirror 20 as beams 18 'and 18''.

FIG. 6B shows an embodiment of a prism device for producing a large number of parallel laser beams. The device shown in FIG. 6B has ten laser light sources 12 per row, and these laser light sources 12 are divided into four at the center and three at the left and right. The prism device is composed of three prisms 1 in the upper stage.
4 ′ and one lower prism 14 ″, and the laser beams 13 emitted from the four central laser light sources 12, respectively, pass through the upper central prism 14 ′ to form four parallel parallel laser beams. The laser beams 13 emitted from the three laser light sources 12 on the left and right sides are converted into three parallel laser beams extending in three inclined directions through the left and right upper prisms 14 '. Lower prism 14 ''
The surface where the four parallel laser beams are projected at the center of the upper surface is a horizontal surface, and the projected portions of the three parallel laser beams on the left and right are inclined surfaces, thus passing through the lower prism 14 ''. Ten parallel parallel laser beams are obtained. These ten parallel laser beams are supplied to the upper rotating mirror 1 as in the case of FIG.
9 is projected perpendicularly onto the axis 17 of FIG. Although exaggerated in these drawings, it should be understood that the parallel laser beams projected on the upper rotating mirror 19 are extremely small and equally spaced as long as mutual interference and diffraction do not occur. . Note that the number of laser light sources is not limited to the above example, and the number of rows may be increased or decreased as needed, or the number in each row may be increased or decreased. Some components of the laser beam projected on the prism are reflected at the front of the prism 14, 14 'or 14'', and the reflected components are erased by the optical trap.

One of the total laser beams projected onto the upper rotary mirror 19, preferably the laser beam at the center of the bundle of all laser beams, is periodically interrupted for a minimum time by inputting a pulse signal. As will be described later, the laser beam bundle detects the position coordinates of the living body part being scanned. By doing so, 3
All the laser beam groups in the row are projected as dense parallel light onto a living body as described later, and are translated to perform surface scanning.

As shown in FIG. 5, the axis of the upper rotary mirror 19 is located at the focal point of an upper parabolic curved mirror 20 whose inner surface is a paraboloid and extends in a semi-cylindrical shape in a direction perpendicular to the biological axis. The three rows of parallel laser beams 18, 18 ', 18 "reflected by the upper rotating mirror 19 hit the upper parabolic mirror 20, where they are reflected and directed downwards, 21, 21'. , 2
1 ''. The beam groups 21, 21 ′, and 21 ″ are irradiated on the rotation axis of the lower rotary mirror 22 while moving in the direction parallel to the biological axis with the rotation of the upper rotary mirror 19.

The lower rotating mirror 22 is located at the focal point of a lower parabolic curved mirror 23 whose inner surface is also a paraboloid and extends in a quarter cylindrical shape in a direction parallel to the biological axis. The laser beam group reflected by the rotating mirror 22 is further reflected toward the living body 2 by the lower parabolic curved mirror 23, and irradiated while scanning the living body 2 in a direction perpendicular to the living body axis with the rotation of the lower rotating mirror 22. I do. Therefore, by rotating the upper rotary mirror 19 and the lower rotary mirror 22, it is possible to perform parallel scanning with a parallel laser beam group (hereinafter, referred to as a “focused parallel laser beam group”) over the entire required portion of the living body at a small area. it can. By irradiating a plurality of laser beams as a group and concentratingly irradiating a minute area of a living body, it is possible to perform fluoroscopic detection of a living body part having a large thickness and a hardly penetrating living body such as bone. In addition, since intense light energy is dispersed and radiated in a certain minute area without being concentratedly radiated to one point, it is possible to avoid damage to cell tissues.

The rotating mirrors 19 and 22 can reflect the laser beam toward the parabolic mirrors 20 and 23 only in a certain small rotation angle range. By utilizing this property, when two sets of laser beam parallel scanning light receiving detection mechanisms are used, the irradiation timing of the two laser beams can be shared. In this case, the rotation phases of the two upper rotating mirrors 19 are shifted, and when one upper rotating mirror reflects the laser beam to the upper parabolic curved mirror 20 paired with it, the other upper rotating mirror is paired with it. The time-sharing can be performed by preventing the laser beam from being reflected toward the upper parabolic curved mirror.

FIG. 7 shows an embodiment in which the laser beam can be reflected toward the upper parabolic curved mirror 20 irrespective of the phase of the upper rotary mirror 19. In this embodiment, three rotating mirrors 19, 19 ′, 1 are attached to the rotating shaft of the upper rotating mirror 19.
9 '' is reciprocated right and left as shown by a double-headed arrow A while rotating the rotating shaft while attaching the phase while shifting the phase by, for example, 60 °. When the rotating mirror 19 'deviates from the angle range for reflecting the laser beam toward the upper parabolic curved mirror 20, the next rotating mirror 19''catches the laser beam and directs the laser beam toward the upper parabolic curved mirror 20. When the beam is reflected and the rotating mirror 19 '' cannot perform the predetermined reflecting action, the rotating mirror 19 '''' is brought to the position for receiving the laser beam, and the rotating mirror 19 '''' performs the reflecting action. When finished, the rotation axis is returned so that the rotation mirror 19 'operates again. Thus, the laser beam can be constantly reflected toward the upper parabolic curved mirror 20 during the rotation of the upper rotary mirror 19. The number of rotating mirrors and the fixed angle interval can be appropriately selected as needed. By adopting the same configuration for the lower rotating mirror 22, the laser beam can be constantly reflected toward the lower parabolic curved mirror 23 during rotation.

FIG. 8 shows an upper rotating mirror 19 and an upper parabolic mirror 20 for moving the laser beam in parallel to the biological axis.
6 shows another embodiment which performs the same longitudinal scanning action of the living body as the mechanism of FIG. The laser beam is emitted from a laser light source 24 in a direction parallel to the living body axis, and directed downward by a reflecting mirror 25 inclined at 45 ° to the laser beam. The reflecting mirror 25 has a double-headed arrow B while maintaining a 45 ° inclination.
As shown in (1), the laser beam moves parallel to the living body axis, and the laser beam directed downward is moved in the longitudinal direction of the living body. Furthermore,
As a mechanism for moving and scanning the laser beam directed downward in the lateral direction of the living body, a mechanism including a lower rotating mirror 22 and a lower parabolic curved mirror 23 as shown in FIG. 5 may be used,
Other suitable mechanisms can be used.

FIG. 9 shows an embodiment of the light receiving / detecting plate 4 used in combination with the laser beam group parallel scanning irradiation apparatus of FIG. This light receiving detection plate is arranged in order from the top
, A microprocessor array board 27 and a semiconductor memory array board 28 in a three-layer structure. The opto-electronic arrangement board 26 is formed by arranging a large number of opto-electronic units 26 'having a small area in a grid pattern.
Is constituted by an integrated planar array of a large number of microelectronic elements, and has an area capable of receiving the whole of a bundle of dense laser beams normally emitted from the lower parabolic curved mirror 23 in FIG. However, the area for receiving a bundle of laser beams by a plurality of optoelectronic units may be used. The microprocessor array board 27 has a plurality of one microprocessors 27 'connected to one optoelectronic unit arranged in a lattice pattern, and performs necessary arithmetic processing according to the total amount of laser light received by the optoelectronic units. I do. The semiconductor memory array board 28 is formed by arranging a large number of semiconductor memories 28 ', each of which is paired with one microprocessor 27', in a lattice pattern. It holds data processed by the processor 27 'and instructions required by the microprocessor 27'.

When a laser beam is directly applied to the light receiving and detecting plate under the condition that there is no living body above the light receiving and detecting plate 4, the all-optical electronic unit needs to receive a uniform amount of laser light. On the other hand, the position of the optoelectronic unit to be irradiated with the laser beam is determined by the rotational positions of the upper rotary mirror 19 and the lower rotary mirror 22 to which the marker laser beam is applied as described above. Accordingly, the rotational positions of the two rotating mirrors 19 and 22 are input to the laser light source as electric signals, and the microprocessor 27 'performs a correction calculation so that the amount of light received by the optoelectronic unit 26' irradiated with the laser beam becomes a reference value. Do. This change in light amount is mainly due to fluctuations in the power supply of the laser light source and fluctuations due to differences in the total attenuation of the laser beam by the optical circuit system such as the prism, rotating mirror and parabolic curved mirror from the laser light source to the optoelectronic unit. Things. The correction value calculated by the microprocessor is fed back to the laser light source to control the energy of the laser beam emitted toward a predetermined optoelectronic unit.

When performing a fluoroscopic diagnosis of a living body, all the electronic units are scanned at least once while the microprocessor switch is turned ON only while the laser group scans each optoelectronic unit. Further, all the optoelectronic units are scanned a plurality of times while the patient stops breathing and stays still, the total amount of light received by each optoelectronic unit is integrated by the microprocessor and the semiconductor memory, and this is sent to the monitor television 29 as an electric signal. It appears at the position of the cathode ray tube with respect to each electronic unit, and the whole portion of the living body that has been perspectively scanned is displayed on the cathode ray tube as a grayscale image, or the grayscale difference is displayed as a pseudo-color image for each gradation.

When a laser fluorescence image is obtained in order to diagnose the presence or absence of a tumor or to make a qualitative diagnosis of a tumor, excitation according to the fluorescent dye used on the light receiving and detecting plate 4 as shown in FIG. By inserting the light cut filter 30, a biological fluoroscopic image can be displayed on the monitor television 29 (FIG. 9).

Further, in order to obtain a laser fluorescence spectral image, as shown in FIG. 11, a fluorescence wavelength filter 31 that transmits only fluorescence components of various specific wavelength bands is inserted further above the laser excitation light cut filter 30. I do. If a tumor-directed fluorescent agent is administered to a patient in advance for a certain period of time, the fluorescent substance accumulates in the tumor, so that fluorescence emission is observed in the tumor when laser scanning is performed. In this state, several fluorescence wavelength filters 31 that transmit different fluorescence wavelengths are prepared and placed, and these are sequentially replaced, and the intensity of the fluorescence transmitted through the cut filter 30 is measured by the optoelectronic unit 26 ′ to transmit the fluorescence. A characteristic curve showing the relationship between the wavelength and the intensity of the fluorescence is obtained, and by comparing this with the characteristic curve measured in advance, the perspective is malignant, inflamed, or normal. Can be identified by the spectral pattern. By plotting these identified perspectives in different colors on a monitor television, a pseudo-color spectral image can be displayed on a CRT.

The upper and lower parabolic curved mirrors 20 and 23 of the laser beam group parallel scanning irradiation apparatus shown in FIG. 5 are used when a polarization grating board (FIG. 12) is set or various fluorescent wavelength cut filters are inserted. If it is necessary to compensate for the decrement of the total amount of light transmitted through the living body, by reducing the density of the focused parallel laser beam group that irradiates the living body by making the size smaller than the standard size, the unit area of the living body to be surface-scanned In addition, it is possible to compensate by increasing the amount of light per unit time. In this case, as shown in FIG. 12, a polarizing grating board composed of a number of window frames 32 having vertical walls aligned with the four sides of each optoelectronic unit 26 'is mounted on the upper surface of the optoelectronic array board 26 of FIG. Then, only the linear components of the laser beam group irradiated from the laser beam parallel scanning irradiation device 3 and transmitted through the living body are received by the optoelectronic unit 26 ', and the light components reflected and scattered in the living body are removed. Thus, a high-resolution laser transmission image can be obtained by the straight laser beam group transmitted through the narrow part of the living body.

FIG. 13 is a schematic diagram showing a state in which a laser treatment is performed on a lesion of a living body using the laser parallel light irradiation scanning device of FIG. 5 and the light receiving and detecting plate of FIG. Prisms 14, 14 ', 1 emitted from laser light source 12
4 '', the laser beam 21 radiated to the living body through the upper rotating mirror 19, the upper parabolic curved mirror 20, the lower rotating mirror 22, and the lower parabolic curved mirror 23 passes through the living body 2 and reaches the light receiving / detecting plate 4 It is projected onto one of the optoelectronic units 26 'of the upper optoelectronic array board 26. The two-dimensional coordinates (Xn, Xn) of the optoelectronic unit on which the laser beam is projected are determined by the rotational angle positions of the upper rotary mirror 19 and the lower rotary mirror 22, as described above. Is converted into an electric signal as information representing the X and Y coordinates of the optoelectronic unit that has received the laser beam, and is input to the control device 35 of the laser light source 12 through lines 33 and 34.

The amount of the laser beam received by the same optoelectronic unit 26 'is also input to the control device 31 through the line 36 so that the amount of light received by all optoelectronic units is constant when the living body is not lying down. In addition, a correction is made in consideration of the fluctuation of the total attenuation transmittance of the optical path passing through the prisms 14, 14 ', 14'', the upper rotating mirror 19, the upper parabolic curved mirror 20, the lower rotating mirror 22, and the lower parabolic curved mirror 23. To control the laser power. FIG. 13 shows one line 36.
Although only one is shown, wiring is performed between each of the all optoelectronic units 26 'and the line 36 so that the respective amounts of light detected by all the optoelectronic units are sent to the controller 35 through the line 36.

In order to control the laser to generate a predetermined output, a sensor 37 is provided immediately below the exit of the laser light source, and the detected laser output is fed back to the laser light source controller 35 through a line 38. Further, if the direction and position of the laser beam emitted from the laser beam source deviate from the predetermined direction and position due to the wavelength of the laser beam and the like, the direction and position of the laser beam are detected, and the laser beam source is detected in accordance with the detected value. A control device is provided to emit a laser beam in a predetermined direction and position. The treatment apparatus has been described as using a single laser beam as an example, but actually uses a focused parallel laser beam group as described with reference to FIGS. 5 and 9. It can be easily understood that similar output control can be performed with such a group of focused parallel laser beams. Each optoelectronic unit 2
6 'is turned on only when the laser beam group is scanning, and the other optoelectronic units are turned off. This O
The N-OFF control can be easily performed by interlocking with the X, Y coordinate detecting device of the optoelectronic unit. In this way, it is possible to prevent the miscellaneous signals from being input to the control device 35 from the optoelectronic unit other than during scanning.

The laser light source control unit 35 has a therapeutic graphic program 39 indicating the relationship between the coordinates (Xn, Yn) of the optoelectronic unit and the laser output I (Xn, Yn) to be irradiated thereon, as shown in FIG. It has been entered in advance. When the group of focused parallel laser beams is scanned once or several times in parallel over a predetermined portion of the living body while the living body is lying down, the weakened laser beam group transmitted through the living body is generated by each optoelectronic unit 26 '. The total amount of light is calculated by the semiconductor memory 28 'and the microprocessor 27', and all the calculated values are sent to the laser light source controller 35 through the line 40.

The detected coordinates of the optoelectronic unit and the total amount of light are formed on a cathode ray tube and, at the same time, are compared with the therapeutic graphic program 35 'input to the laser light source control device 31, to follow this program. As described above, the laser output is weighted and controlled by the amount required for the treatment. This laser treatment method can be applied to laser processing of a product by comparing the detected coordinate information and light amount information with a preset laser processing reference command.

The laser treatment apparatus shown in FIG. 13 can display a laser fluorescence spectral pattern by inserting various fluorescent wavelength filters 31 on the photoelectric array board 26 as shown in FIG. By connecting to the device, laser diagnosis and treatment can be performed simultaneously. In addition, a laser fluorescence spectral image analysis treatment can be performed by sequentially changing the laser wavelength using a dye laser (variable wavelength laser) to obtain a plurality of spectral wavelength images.

[0044]

According to the present invention, not only barium and iodine but also a complex of a binding substance of a dye and various intermediate metabolites which are absorbed by perfusing an organ in a living body and metabolized in the organ are absorbed. For example, using a green-yellow vegetable and carbohydrate-binding substance that is easily absorbed from the digestive tract as a contrast agent, the state of absorption and digestion from the gastrointestinal mucosa and the state of moving to various organs through blood vessels and lymphatic vessels. Observation, diagnosis of enlarged perfusion distribution of swollen sites due to malignant tumors and their metastasis to lymph nodes, diagnosis by fluoroscopy spectroscopy, and study of metabolic state of solid organs such as liver and kidney .

Further, by rotating the two sets of laser beam parallel scanning light receiving detection mechanisms at a maximum angle apart from each other in a range in which they do not oppose each other and sequentially changing the directions, biopsy images from various directions can be obtained. Since the same number of images can be obtained in about one half of the time required to obtain a biological fluoroscopic image from various directions by a set of detection mechanisms, it is easy to obtain a high-quality computer graphics stereoscopic image.

[Brief description of the drawings]

FIG. 1 is a side view showing the outline of the principle of a laser beam parallel scanning light receiving detection mechanism according to the present invention.

FIG. 2 is a cross-sectional view showing an outline when two sets of laser beam parallel scanning light receiving detection mechanisms of FIG. 1 are used.

FIG. 3 is a schematic diagram of an apparatus for graphically displaying a stereoscopic perspective image using the apparatus of FIG. 2;

FIG. 4 illustrates one embodiment of an apparatus for creating two time-shared beams from a single laser beam to send two time-shared laser beams to each of two sets of laser beam parallel scanning light receiving detection mechanisms. The perspective view which shows an example.

FIG. 5 is a schematic diagram showing an embodiment of an apparatus for irradiating a plurality of laser beams emitted from a plurality of laser light sources as a bundle of parallel laser beams while scanning in parallel in a longitudinal direction and a lateral direction of a living body.

FIG. 6 (a) is an optical prism which projects each of laser beams emitted from a plurality of laser light sources in a row as a plurality of parallel laser beam groups along a rotation axis of a rotating mirror in the embodiment of FIG. FIG. 2B is a schematic diagram showing an optical system obtained by modifying the prism device of FIG. 1A so as to project a larger number of parallel laser beams along the rotation axis of the rotating mirror.

FIG. 7 is a perspective view showing another embodiment of the rotary mirror used in the apparatus of FIG.

FIG. 8 is a schematic diagram showing another embodiment of a device for horizontally moving a laser beam emitted from a laser light source in a horizontal direction in a longitudinal direction of a living body.

FIG. 9 is a perspective view showing an outline of a preferred embodiment of a laser beam receiving / detecting plate used in combination with the laser parallel scanning irradiation apparatus of FIG. 5;

FIG. 10 is a schematic diagram showing a state in which a laser excitation light cut filter is inserted on the laser beam receiving / detecting plate of FIG. 9 in order to display a biological fluoroscopic image on a monitor television.

FIG. 11 is a view showing a state of a see-through portion of a living body.
FIG. 11 is a schematic diagram showing a state in which a fluorescence wavelength filter is further inserted on the laser excitation light cut filter of FIG. 10 in order to obtain a laser fluorescence spectroscopic image.

FIG. 12 is a partial perspective view showing a state in which a deflecting grating board is mounted on an optoelectronic array board so that only a linear component of a laser beam is projected onto each electronic unit of the laser beam receiving / detecting plate of FIG.

FIG. 13 is a schematic diagram of an apparatus for performing laser treatment using the apparatus of FIG.

14 shows an example of a treatment graphic program used in the laser treatment apparatus of FIG.

[Explanation of symbols]

 Reference Signs List 1 bed 2 living body 3 laser beam parallel irradiation scanning device 4 light receiving and detecting plate 5 monitor television 6 computer 12 laser light source 13 laser beam 14 prism 14 'prism 14' 'prism 19 upper rotating mirror 20 upper parabolic curved mirror 22 lower rotating mirror 23 Lower parabolic curved mirror 26 Opto-electronic array board 27 Microprocessor array board 28 Semiconductor memory array board 29 Monitor television 30 Laser excitation light cut filter 31 Fluorescence wavelength filter 32 Window frame 35 Laser light source control device 37 Laser output sensor 39 Treatment graphic program

Claims (10)

(57) [Claims] At least one laser beam is emitted.
A plurality of light sources, an apparatus for irradiating the laser beam toward a living body in a direction perpendicular to a living body axis, and an apparatus for continuously moving the laser beam directed to the living body in a direction parallel to the living body axis, a device for the laser beam allowed to move in a direction perpendicular to continuously biological axis directed to the living body, a detection plate for receiving the laser beam transmitted through the living body, at least one pair of laser over beam parallel scanning light detecting mechanism consisting of And a device for supporting the laser beam parallel scanning mechanism rotatably about a living body axis. 2. The diagnostic apparatus according to claim 1, wherein the two sets of the laser beam parallel scanning light receiving detection mechanisms are arranged at 90 ° intervals about a biological axis. 3. Based on the laser beams detected by the respective detection plates of the two sets of laser beam parallel scanning detection mechanisms,
The diagnostic apparatus according to claim 2, wherein fluoroscopic images in various directions in a living body are stereoscopically displayed. 4. An apparatus for moving a laser beam in a direction parallel to a living body axis, wherein the inner surface is formed as a parabolic surface, and covers a living body. A parabolic curved mirror, and a first parabolic mirror which is supported at the focal point of the first parabolic curved mirror, is rotatably supported about an axis extending in a direction perpendicular to the living body axis, and receives a laser beam from a laser beam irradiation device. An apparatus for moving the laser beam in a direction perpendicular to a living body axis, the apparatus comprising a first rotating mirror for reflecting the light on a curved mirror, wherein the first parabolic curved mirror covers the living body below the first parabolic curved mirror; A second quarter parabolic curved mirror having an inner surface formed as a paraboloid and extending in a direction perpendicular to the second direction, and a direction parallel to the biological axis positioned at the focal point of the second parabolic curved mirror The first support is rotatably supported about an axis extending
The diagnostic apparatus according to claim 1, further comprising a second rotating mirror that receives the laser beam reflected by the parabolic curved mirror and reflects the laser beam to the second parabolic curved mirror. 5. A plurality of laser light sources for emitting a plurality of laser beams, means for converging the plurality of laser beams into one bundle, and directing the converged laser beam toward a living body in a direction perpendicular to a living body axis. 2. The diagnostic device according to claim 1, further comprising a device that irradiates the light in parallel directions. 6. A plurality of laser beam sources arranged in a plurality of rows, and at least one prism having an upper surface for receiving a plurality of laser beams emitted from the plurality of laser beam sources in each row. 6. The diagnostic device according to claim 5, wherein the prism has an upper surface formed to refract the plurality of laser beams into a plurality of vertical parallel laser beams. 7. The photodetection plate comprises: a photoelectronic array board in which a large number of optoelectronic units in which a plurality of optoelectronic elements are integrated on a surface of a living body in a very small area are arranged in a grid; A microprocessor array board in which a number of microprocessors attached and connected to each of the optoelectronic units are arranged in a grid, and a number of semiconductor memories mounted on the back of the microprocessor array board and connected to each of the microprocessors in a grid. The diagnostic apparatus according to claim 5, comprising a semiconductor memory array board arranged in a shape. 8. A laser excitation light cut filter is inserted above the front optoelectronic array board, and a biological fluoroscopic image is displayed on a monitor television based on data obtained by the light receiving and detecting plate. A diagnostic device according to claim 7. 9. A different specific wavelength filter is sequentially replaced and inserted above the optoelectronic array board to obtain a characteristic curve showing a relationship between the wavelength and the intensity of transmitted fluorescence, thereby identifying symptoms of a living body and displaying the same on a monitor television. 9. The diagnostic apparatus according to claim 7, wherein a pseudo-color spectral pattern image is displayed. 10. A plurality of light sources for emitting a plurality of laser beams, and an apparatus for irradiating a plurality of laser beams emitted from the plurality of light sources to a living body as a group of dense parallel laser beams. At least two sets of: a device for scanning a plane parallel to a living body axis with a laser beam group directed toward the living body and a direction perpendicular to the living body axis; and a detection plate for receiving the laser beam group transmitted through the living body. A device for supporting the laser beam parallel scanning light receiving detection mechanism rotatably about a living body axis at a predetermined angular interval, wherein the light receiving detection plate has a large number of optoelectronic units arranged in a lattice pattern on its light receiving surface. Device for detecting the position of an optoelectronic unit on which a group of laser beams transmitted through a living body is projected, and a laser beam received by the optoelectronic unit. A device for detecting the amount of light of a beam group, and a laser light source for inputting the detected position of the optoelectronic unit and the amount of received light, and emitting a laser beam group having predetermined energy corresponding to the position of the optoelectronic unit. And a device for controlling the laser treatment.