JP2784872B2 - Method for producing seamless capsule particles containing surfactant - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for producing seamless capsule particles containing a liquid containing a surfactant component as a content, and more particularly, to a method for use in the fields of pharmaceuticals, foods, luxury goods, bath products, and cleaning products. The present invention relates to a process for the preparation of possible surfactant-containing seamless capsule particles.

[0002]

2. Description of the Related Art Seamless capsule particles which contain an oily component such as vegetable oil as a content and do not contain a surfactant component have conventionally existed. However, since the seamless capsule particles are produced by utilizing the interfacial tension as disclosed in Japanese Patent Publication No. 36-3700, when the internal solution contains a surfactant component having a high HLB, the content liquid and the film And the interfacial tension with the substrate considerably decreases. Therefore, encapsulation was difficult.

JP-A-61-227519 and JP-A-1-238519 disclose capsule particles containing a nonionic surfactant having a relatively high HLB. Because it is manufactured, there is a seam in the film, not only is not desirable in appearance,
There is a problem that leakage of the contents from the seam is concerned, and a difference in the dissolution rate of the individual capsule particles occurs due to the unevenness of the average coating thickness. On the other hand, Shoko 5
JP-A-3-39193 and JP-A-55-99177 disclose seamless capsule particles having a multilayer structure using multiple nozzles and a method for producing the same. No mention was made of a method for producing capsule particles. In addition, Japanese Unexamined Patent Publication No.
JP-A-52639 discloses a seamless capsule in which a lower fatty acid ester of sucrose having surface activity is interposed between a content of a hydrophilic substance and a film. It does not disclose a capsule particle containing a component as a content.

Further, Japanese Patent Application Laid-Open No. 58-13508 discloses a seamless capsule containing a drug composition containing a drug insoluble in water and a polyglycerol fatty acid ester dispersed in a liquid oil. As for the method, JP-A-5-31352 discloses a method for producing a seamless capsule containing a hydrophilic substance as a content.
There is no disclosure of a method for producing capsule particles in which the liquid content of the obtained capsule is substantially emulsified and dispersed in water, or capsule particles in which a surfactant component is substantially uniformly dispersed or dissolved in an oil component.

[0005]

SUMMARY OF THE INVENTION As described above, seamless capsule particles containing a surfactant component and an oily component as a content liquid, and the emulsification and dispersibility of the content liquid,
Alternatively, a method for producing a surfactant component having excellent dispersibility and solubility in an oil component has not yet been known.
However, in particular, in the field of bath products, cleaning products, and the like, emulsification and dispersibility of the content liquid is required, and therefore, development of a method for producing such seamless capsule particles has been desired.

[0006] An object of the present invention is to solve the above-mentioned problems by providing a seamless film, containing a surfactant component and an oil component, and further emulsifying and dispersing the above-mentioned content liquid, or a surfactant component. It is an object of the present invention to provide a method for producing capsule particles having excellent dispersibility and solubility in oily components.

[0007]

That is, the gist of the present invention is as follows.
(1) In a method for producing seamless capsule particles using at least three or more multiple nozzles having a sequentially increasing diameter, a film-forming liquid is supplied from an outermost nozzle to an oil component from at least one of the other nozzles. An aqueous dispersion containing a surfactant and a surfactant component is continuously discharged to form multilayer droplets, and then the film forming liquid of the multilayer droplets is cured or gelled. In the method for producing a seamless capsule particle containing an activator, and (2) the method for producing a seamless capsule particle using a multi-nozzle having at least three or more nozzles having a sequentially increasing diameter, a liquid for forming a film is added from an outermost nozzle. An aqueous dispersion containing an oil component, a surfactant component, and a hydrophilic organic solvent is continuously discharged from at least one of the nozzles to form a multilayer droplet. A method for producing a surfactant-containing seamless capsule particle, characterized in that the liquid for forming a film of the multilayer droplet is cured or gelled after the formation, (3) at least three or more layers having a sequentially increasing diameter In the method for producing seamless capsule particles using multiple nozzles of the above, the film-forming liquid from the outermost nozzle, the liquid comprising the oil component and the surfactant component from at least one of the other nozzles, continuously And forming a multi-layer droplet by discharging the liquid to form a multi-layer droplet, and then curing or gelling the film-forming liquid of the multi-layer droplet. In the method for producing seamless capsule particles using multiple nozzles having at least three or more diameters having different diameters, the film-forming liquid is supplied from the outermost nozzle to a smaller amount of other nozzles. After a surfactant component is continuously discharged from at least one nozzle and an oil component is continuously discharged from at least one of the other nozzles to form a multilayer droplet, a liquid for forming a film of the multilayer droplet is formed. A method for producing a surfactant-containing seamless capsule particle, characterized by curing or gelling the following, (5) The surfactant-containing seamless capsule particle obtained in the above (1) to (4), Further, a method for producing a surfactant-containing seamless capsule particle, characterized in that the water content in the capsule particle is reduced to 25% by weight or less by removing water in the capsule particle, (6) The method according to the above (1) to (4). A method for producing surfactant-containing seamless capsule particles, characterized by further extracting and removing water in the capsule particles from the obtained surfactant-containing seamless capsule particles by using a hydrophilic organic solvent. And (7) the maximum linear velocity is 1.0 to 1.3 times the minimum linear velocity among the linear velocities of the liquid ejected from each of the multiple nozzles. ) To (4).

In the manufacturing method of the present invention, at least three or more multiple nozzles having a diameter which sequentially increases as described above are used, and the film forming liquid is continuously discharged from the outermost nozzle. The film-forming liquid is a solution in which the film-forming body is a molten liquid or a solution containing the film-forming body. The film-forming body is not particularly limited as long as it is a substance that is hardened or gelled by physical means such as cooling or chemical means such as a crosslinking reaction, and any of hydrophilic and lipophilic substances may be used. However, when used as a bath product (for example, a bath additive) or a cleaning product (for example, a body cleanser), a natural, semi-synthetic or synthetic hydrophilic polymer having high affinity for water is preferably used.

Examples of such a hydrophilic polymer include glue, gelatin, collagen protein, casein,
Sodium alginate, carrageenan, furceleran, tamarind gum, pectin, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, agar, starch and other natural hydrophilic polymers; carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, phthalate acetate Semi-synthetic hydrophilic polymers such as cellulose acetate, propylene glycol alginate, oxidized starch, esterified starch, etherified starch, and cationic starch; and synthesis of sodium polyacrylate, polyethylene imine, polyvinyl alcohol, polyethylene oxide, polyvinyl pyrrolidone, etc. Examples include, but are not limited to, hydrophilic polymers. These hydrophilic polymers are used alone or in combination of two or more. When a solution containing a film-forming body is used as the film-forming liquid, a hydrophilic polymer is used as the film-forming body, and 0.1 to 80% by weight.
Is preferable, and more preferably a solution of 1 to 50% by weight. Although the solvent is not particularly limited, water is preferred.

At this time, one or more water-soluble polyhydric alcohols and derivatives thereof may be added together with the above-mentioned hydrophilic polymer. When a water-soluble polyhydric alcohol and its derivative are added, usually 5
To 100% by weight, preferably 10 to 80% by weight. Examples of the water-soluble polyhydric alcohol and its derivative to be added include glycerin, sorbitol, ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, ethylene oxide-propylene oxide copolymer, oligosaccharides, glycerides and the like. However, the present invention is not particularly limited to these. In the present invention, a lipophilic film-forming body can be used in the same manner, for example, polystyrene, polymethyl methacrylate, polybutadiene, styrene-butadiene rubber, vinyl acetate-ethylene copolymer, vinylidene chloride-acrylonitrile copolymer, A styrene-acrylate copolymer, ethyl cellulose, or the like can be used alone or as a mixture of two or more. When a solution containing a lipophilic film-forming body is used as the film-forming liquid, the solvent is not particularly limited as long as it is a good solvent for the film-forming body, and may be dichloromethane, chloroform, carbon tetrachloride, benzene, or the like. Is exemplified.

In the manufacturing method of the present invention, various liquids serving as the content liquid of the capsule particles are continuously discharged from the nozzles other than the outermost nozzle, and the liquid discharged from each nozzle is an oily component. Aqueous dispersion containing a surfactant component (first embodiment), aqueous dispersion containing an oil component, a surfactant component and a hydrophilic organic solvent (second embodiment), an oil component and a surfactant Liquid consisting of components (third
Embodiment), a liquid containing only an oil component (fourth embodiment), or a liquid containing only a surfactant component (fifth embodiment). The surfactant used herein is selected from one or more of an anionic surfactant, a cationic surfactant, a nonionic surfactant and an amphoteric surfactant. A surfactant having high solubility is suitably selected. When two or more surfactants are used, even if they have low solubility in oil, they only need to be mixed and have solubility as a whole. In the case where the inner solution comes into contact with the skin after the capsule particles are disintegrated, for example, one selected from one or more nonionic surfactants having less skin irritation is preferable.

The anionic surfactant is not particularly restricted but includes, for example, sodium lauryl sulfate,
Triethanolamine lauryl sulfate, ammonium lauryl sulfate, sodium dodecylbenzenesulfonate,
Sodium stearate, semi-hardened beef fatty acid sodium,
Semi-hardened beef fatty acid potassium, potassium oleate, castor oil potassium, sodium alkylnaphthalene sulfonate,
Sodium dialkyl sulfosuccinate, sodium alkyl diphenyl ether disulfonate, diethanolamine alkyl phosphate, potassium alkyl phosphate, sodium polyoxyethylene alkyl sulfate, triethanolamine polyoxyethylene alkyl ether sulfate, sodium polyoxyethylene alkyl phenyl ether sulfate, and the like. Can be

The cationic surfactant is not particularly restricted but includes, for example, lauryltrimethylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, distearyldimethylammonium chloride, alkylbenzenedimethylammonium chloride, stearylamine oleate. , Stearylamine acetate, stearylamine acid and the like.

The nonionic surfactant is not particularly restricted but includes, for example, glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, propylene fatty acid ester, glycerin fatty acid ester, Sugar fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene sorbite tetraoleate, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether,
Polyoxyethylene polyoxypropylene glycol,
Polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, and the like. Among these, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbitol fatty acid esters are preferable because of their low skin irritation.

The amphoteric surfactant is not particularly restricted but includes, for example, betaine alkyldimethylaminoacetate, alkyldimethylamine oxide, alkylcarboxymethylhydroxyethylimidazolium betaine, lecithin, laurylaminopropionic acid, alkyldiaminoethylglycine. And the like.

The HLB of the nonionic surfactant for seamless encapsulation is usually from 7 to 7 so that the oily component of the contents can be emulsified well when the capsule particles disintegrate in a water bath. 18, preferably 8 to 1
8, more preferably 9 to 18. When the HLB is less than 7, the emulsifying ability of the oily component is insufficient, and when the HLB is more than 18, encapsulation becomes difficult. When two or more nonionic surfactants are mixed, the HLB after mixing is 7 to 1
A nonionic surfactant having an HLB of less than 7 may be similarly mixed in order to adjust the HLB in the capsule particles. The HLB used for adjusting the HLB is 7
Less than the nonionic surfactant may be mixed with any of the liquids ejected from other multiple nozzles except the outermost nozzle.

Although the amount of the surfactant used is not particularly limited, it is usually 49: 1 to 1: 3, preferably 1 to 1, in terms of the weight ratio of the total oil component and the surfactant in the capsule particles.
9: 1 to 1.5: 1. When the amount of the surfactant used is less than 49: 1 in weight ratio to the total oil component, when the internal solution comes into contact with water, the oil component separates to cause a phenomenon such as oil floating and a stable emulsion is obtained. 1: 3
If it is larger, encapsulation becomes difficult.

In the present invention, the liquid ejected from each nozzle includes the first to fifth aspects as described above. Each of the aspects will be described below. First, a first aqueous dispersion containing an oil component and a surfactant component is used.
In the case of the embodiment, the aqueous dispersion comprises one or a mixture of two or more oily components, an anionic surfactant as described above,
One or more surfactants selected from cationic surfactants, nonionic surfactants, and amphoteric surfactants emulsify the oily component directly in water, or from water-in-oil emulsions to water It can be obtained by a known technique such as emulsification of an oily component in water through phase inversion to an oil dispersion type emulsion. As the emulsification method, various stirrers,
A known technique using a mixer or the like is used. The surfactant concentration in the aqueous dispersion is not particularly limited,
It is usually from 10 to 300% by weight, preferably from 50 to 250% by weight, based on the oil component in the aqueous dispersion. When the surfactant concentration is less than 10% by weight, the oily component of the contents is not emulsified when the capsules are disintegrated in a water bath, and the content is 300% by weight.
If it is larger, the viscosity of the aqueous dispersion increases, and the success rate of capsule particle generation at the time of capsule particle generation decreases, which is not preferable.

The oily component used is not particularly limited, but may be selected from oils and fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils, and silicone oils. Species or mixtures of two or more are preferred.

Examples of fats and oils include soybean oil, nuka oil,
Jojoba oil, avocado oil, almond oil, olive oil, cocoa butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, tallow, lard, and other natural fats and oils, or cured products obtained by hydrogenating these natural fats and oils Examples include oil and synthetic triglycerides such as myristic glyceride and 2-ethylhexanoic acid glyceride. Examples of the waxes include carnauba wax, whale wax, beeswax, and lanolin. Examples of hydrocarbons include paraffin sulfate,
Vaseline, paraffin microcrystalline wax,
Ceresin, squalane, pristane and the like. Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid and the like. As higher alcohols,
Examples include lauryl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, 2-hexyldecanol and the like. Examples of the esters include cetyl octoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, and the like. As essential oils, for example, mint oil, jasmine oil, show brain oil, hinoki oil, spruce oil, ryu oil, turpentine oil, cinnamon oil, helgamot oil, tangerine oil, show oil, pine oil, lavender oil, bay oil, Clove oil, hiba oil, rose oil, eucalyptus oil, lemon oil, peppermint oil, rose oil, sage oil, menthol, cineole, eugenol, citral, citronellal, borneol, linalool, gellerol, camphor, thymol, spiranthol, pinene, limonene And terpel compounds. Examples of silicone oils include, but are not limited to, dimethylpolysiloxane and the like.

The concentration of the oily component in the aqueous dispersion is not particularly limited, but is usually from 2 to 150% by weight, preferably from 5 to 130% by weight, based on water. When the concentration of the oil component is more than 150% by weight, the viscosity of the aqueous dispersion increases, and the formability of the capsule particles at the time of forming the capsule particles is reduced. Thus, when the concentration is less than 2% by weight, a uniform aqueous dispersion cannot be obtained. Therefore, it is not preferable.

In the present invention, as a second embodiment, the viscosity of the aqueous dispersion can be reduced by adding a hydrophilic organic solvent to the aqueous dispersion of the first embodiment. When the surfactant concentration in the body is high, the formability of capsule particles during capsule formation is improved. The hydrophilic organic solvent used at this time is not particularly limited, for example, methanol, ethanol,
Monohydric alcohols such as 1-propanol and 2-propanol, dihydric alcohols such as ethylene glycol, 1,2-propanediol, 1,3-butanediol and 1,5-pentanediol, ketones such as acetone And these may be used alone or in combination of two or more. Here, the concentration of the hydrophilic organic solvent in the aqueous dispersion is not particularly limited.
２００200% by weight, preferably 0.1-100% by weight. When the content of the hydrophilic organic solvent is less than 0.01% by weight, the effect of lowering the viscosity of the aqueous dispersion by the addition of the hydrophilic organic solvent is small, and when the content is more than 200% by weight, the interfacial tension of the aqueous dispersion is too low, Since the aqueous dispersion is unlikely to be spherical, the success rate at the time of capsule formation is reduced, which is not preferable.

Next, in the case of the third embodiment in which a liquid composed of an oil component and a surfactant component is used, the same surfactant component and oil component as described above are used. In this case, the concentration of the oil component in the liquid composed of the oil component and the surfactant component is not particularly limited, but is 0.01 to 300% by weight, preferably 0.1% by weight, based on the surfactant component. ~ 200% by weight. If the oil component is less than 0.01% by weight, the effect of addition of a change in viscosity or the like is small, and if it is more than 300% by weight, when the internal solution comes into contact with water, the oil component separates to cause a phenomenon such as oil floating, It is not preferable because a stable emulsion is not obtained.

Further, in the fourth mode in which the oil component is used alone as the liquid to be discharged from each nozzle, and in the fifth mode in which the surfactant component is used alone, the types of the oil component and the surfactant component used are as follows. Each is the same as in the above case.

In the production method of the present invention, as the liquid flowing from a nozzle other than the nozzle for flowing the liquid containing the surfactant component, an oil component and an aqueous component are appropriately selected within a range that does not hinder the encapsulation. . That is, as components contained in the layers adjacent to each other, components that do not substantially mix (dissolve) with each other, such as oil components and aqueous components, or mix (dissolve)
A component that is difficult to perform is appropriately selected. In this case, the same oily component as described above is used, and as the aqueous component, water, an aqueous acetone solution, an aqueous lower alcohol solution, or the like is used.

For example, in the case of producing seamless capsule particles containing a surfactant using a triple nozzle, various examples of combinations of liquids discharged from each nozzle are given as follows (the outermost nozzle / intermediate nozzle, respectively). / Indicates the liquid discharged from the innermost nozzle.) Hydrophilic film former / oil component / aqueous dispersion containing surfactant / oil component Hydrophilic film former / oil component / aqueous dispersion containing surfactant / oil component / organic solvent Hydrophilic film former / oil component / Surfactant / oil component Hydrophilic film former / oil component / surfactant Lipophilic film former / aqueous component / surfactant / oil component Lipophilic film former / surfactant / oil component Lipophilic film former / Aqueous dispersion containing surfactant / oil component / oil-based component Lipophilic film-forming product / Aqueous dispersion containing surfactant / oil component / organic solvent / oil component

Next, the method for producing the surfactant-containing seamless capsule particles according to the present invention using the above-mentioned raw materials will be described in more detail with reference to FIG. FIG. 1 is a cross-sectional view schematically showing one example of a nozzle portion of a manufacturing apparatus used in the manufacturing method of the present invention. In this figure, a triple nozzle having the same discharge port end face is illustrated. However, in the present invention, the shape and the like are particularly limited as long as the multiple nozzle has at least three or more nozzles having a sequentially increasing diameter. However, the end surfaces of the nozzles may not be aligned in this manner.

In the manufacturing method of the present invention, for example,
Using a double nozzle, the film-forming liquid is supplied from the outermost nozzle inlet 4, an oil component is supplied from the intermediate nozzle inlet 5, and a liquid containing a surfactant component is supplied from the innermost nozzle inlet 6, Each liquid is continuously discharged from the outermost nozzle 3, the intermediate nozzle 2, and the innermost nozzle 1 in a gas phase or a liquid phase, respectively, to generate a multilayer droplet. In this case, the liquid phase is not particularly limited as long as it does not substantially mix or dissolve with the film-forming body. However, a hardening agent or a gelling agent as described below is preferably used in production. Next, the film-forming liquid of the multilayer droplets is cured or gelled by physical or chemical means to produce surfactant-containing seamless capsule particles. Here, physical methods include, for example, a method in which a film-forming liquid is brought into contact with a cooled hardener to cool the film-forming liquid, and curing is performed, and chemical methods include a gel formed by a chemical reaction between the film-forming liquid and the hardening agent. For example, a method of hardening or gelling the film-forming liquid is not limited thereto.

The curing agent is not particularly limited as long as it is a liquid capable of hardening or gelling the film-forming liquid by physical or chemical means. A substance having substantially no solubility in the film-forming body obtained by the above method is appropriately used. For example, for a hydrophilic film-forming body, one or a mixture of two or more kinds selected from oils and fats, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils, and silicone oils. Oils are used, and water, methanol, ethanol, 1-propanol, 2-propanol, and mixtures thereof are used for the lipophilic film-forming body. The cooling temperature is not particularly limited as long as the film-forming liquid is cured.

When the film forming liquid is chemically gelled, for example, sodium alginate is a solution containing calcium chloride and calcium phosphate, and polyvinyl alcohol is an aqueous solution containing borax, formalin and hydrochloric acid.
As gelatin, an aqueous solution containing calcium chloride and zirconium nitrate is appropriately selected, and gelation occurs due to a reaction such as crosslinking between the film forming liquid and these hardeners.

In the manufacturing method of the present invention, as described above, each liquid is discharged from the multiple nozzles to form a multilayer droplet. At this time, the total liquid flow rate, the viscosity of the liquid, the interfacial tension of the liquid, and the vibration described later The particle size of the capsule particles can be controlled by the number or the like. Furthermore, if the particle size of the capsule particles is determined, the average coating thickness can be controlled by the flow ratio of the flow rate of the outermost nozzle to the total flow rate of the other nozzles. The average film thickness t at this time can be obtained, for example, from the following equation.

[0032]

(Equation 1)

T: average coating thickness [cm] D: capsule particle average particle diameter [cm] D ₁ : capsule particle average inner layer diameter [cm] V ₁ : capsule particle inner layer volume [cm ³ ] = W ₁ / ρ ₁ =
Q ₁ / IV ₂ : Capsule particle coating volume [cm ³ ] = W ₂ / ρ ₂ =
Q ₂ / I W ₁ : Capsule particle inner layer weight [g] W ₂ : Capsule particle coating weight [g] Q ₁ : Total flow rate of inner layer liquid from nozzle [cm ³ / min] Q ₂ : For film formation from nozzle Total flow of liquid [cm ³ /
min] ρ ₁ : Average density of inner layer liquid [g / cm ³ ] ρ ₂ : Density of film forming liquid [g / cm ³ ] I: Number of capsule particles generated [pcs / min]

In the present invention, the coating ratio, which is the weight ratio of the coating to the weight of the capsule particles, is usually 5 to 60% by weight, preferably 5 to 60% by weight, from the viewpoint of the storage stability of the capsule particles and the disintegration of the capsule particles in water such as in a bathtub. It is 10 to 50% by weight, more preferably 13 to 40% by weight. If the coating rate is less than 5% by weight, the capsule particles are easily disintegrated during storage, and if it exceeds 60% by weight, the disintegration and complete solubility of the capsule particles in water such as in a bathtub become poor.

The average particle size of the capsule particles of the present invention is not particularly limited, but is usually preferably from 0.2 mm to 2 cm, and from the viewpoint of productivity, preferably from 3 mm to 2 cm.
cm. The reason is that, for example, when the capsule particles are manufactured using a multiple nozzle described later, the larger the average particle diameter is, the higher the productivity per multiple nozzle is.
However, the average particle size is shown by weight average. The average coating thickness of the capsule particles is not particularly limited, but is usually in the range of 0.01 mm to 5 mm, preferably 0.03 mm to 1 mm. When it is larger than 5 mm, when dissolving the capsule and releasing the contents, a long dissolution time is required, which is not preferable.
In the following, it is not preferable because the film forming body is easily disintegrated when the capsule particles are formed, and the success rate of the capsule formation is remarkably reduced. The average film thickness referred to here is a value measured by a known measuring technique, for example, a micrometer or the like.

In the present invention, as described above, the multi-droplets are formed by continuously discharging the respective liquids from the respective nozzles of the multi-nozzle. At this time, vibration is applied to the multi-layer liquid column discharged from the multi-nozzle. Thereby, the particle diameter of the capsule particles, the film thickness, and the like can be made more uniform. At this time, a known vibration imparting means is used, but the method of imparting the vibration is not particularly limited, either, the nozzle is vibrated, or the liquid flowing into the nozzle is given a pulsating flow, or the liquid is ejected from the nozzle. A method of giving vibration to the external phase of the multilayer liquid column is exemplified. The frequency given to the multi-layer liquid column is appropriately selected from the liquid column linear velocity and the liquid viscosity used, and the particle size of the capsule particles can be controlled by the relationship between these, the frequency, the discharge flow rate from the nozzle, and the like. is there. The frequency to be applied is not particularly limited, but is preferably 1 to 30 in terms of productivity of the capsule particles and uniformity of the particle diameter of the capsule particles.
00 Hz, preferably 1 to 2000 Hz, particularly preferably 1 to 1000 Hz. If it is less than 1 Hz, the vibration is not sufficient, and if it exceeds 3000 Hz, the particle size of the capsule particles becomes non-uniform. In the present invention, a method for obtaining a droplet without applying vibration is also selected.

In the present invention, among the linear velocities of the liquid ejected from each of the multiple nozzles, the maximum linear velocity is preferably 1.0 to 1.3 times the minimum linear velocity.
More preferably 1.0 to 1.1 times, and still more preferably 1.
It is 0 to 1.05 times. As described above, when the ratio of the linear velocities is 1.0 to 1.3 times, concentric capsule particles are easily generated, and a film having a uniform film thickness can be obtained. Further, in order to produce capsule particles containing a large amount of the content liquid, the diameter of each nozzle is appropriately selected so that the ratio of the linear velocities of the liquids discharged from the respective nozzles is within the above range. Can be produced stably. Furthermore, when manufacturing capsule particles with small interfacial tension, capsule particles are easily generated. On the other hand, when the multilayer liquid column is vibrated to generate capsule particles, the success rate of encapsulation becomes higher.

In the present invention, when the physical properties such as fluidity and non-caking properties of the capsule particles are deteriorated due to the interaction between the water in the capsule particles and the film-forming body, the seamless capsule particles containing a surfactant may be used. Can be dried to remove water in the particles. At this time, it is possible to adjust the water concentration in the particles as needed by a known drying method such as a hot air drying method, a vacuum drying method, and a freeze drying method,
Further, after removing water in the particles by extraction, the particles can be dried. The water concentration in the present invention is usually 25% by weight.
Or less, preferably 20% by weight or less, more preferably 1% by weight or less.
5% by weight or less. If it exceeds 25% by weight, the adhesiveness of the particle surface is so high that it is not preferable when used as dry particles.

In the present invention, the water content in the capsule particles is further extracted and removed from the obtained capsule particles using a hydrophilic organic solvent, so that the inside of the capsule particles can be reduced in a shorter time than the other methods described above. It is possible to remove moisture, and it is easy to obtain capsule particles having a beautiful film surface without wrinkles or depressions. When water is removed by this method, the hydrophilic organic solvent used is not particularly limited, but may be a monohydric alcohol such as methanol, ethanol, 1-propanol, or 2-propanol, or a ketone such as acetone. These may be selected and used alone or in combination of two or more. In addition, water may be added to the hydrophilic organic solvent used in order to prevent wrinkles from forming during drying. The amount of water added is usually within 2.5 parts by weight, preferably within 1.0 part by weight, particularly preferably within 0.5 part by weight, per 1 part by weight of the hydrophilic organic solvent. Water 2.
If the amount is more than 5 parts by weight, the capsule particles are easily deformed. In the above method, the surface of the coating film is more beautiful and the removal of water from the capsule particles can be accelerated while keeping the capsule particles free from wrinkles and dents, as compared with a known method such as drying. In the present invention, the surface of the coating is more beautiful, wrinkles, and the capsule particles have no dents.In order to speed up the removal of moisture in the capsule particles, as the moisture in the capsule particles is removed, the hydrophilic organic solvent A method for sequentially reducing the water concentration is also appropriately selected. Further, a hydrophobic organic solvent may be appropriately added to the hydrophilic organic solvent in order to control the drying speed, and water and a hydrophobic organic solvent may be added to the hydrophilic organic solvent.

The temperature for extracting water is usually 1 to 40 ° C., preferably 5 to 30 ° C., particularly preferably 10 to 20 ° C.
If the temperature is less than 1 ° C., the efficiency of removing water from the capsule particles is poor, and 4
If the temperature exceeds 0 ° C., the capsule particles are likely to be deformed. The amount of the hydrophilic organic solvent to be used is generally 0.5 to 50 parts by weight, preferably 0.7 to 30 parts by weight, particularly preferably 1 to 10 parts by weight, per 1 part by weight of the non-water-removed capsule particles. If the amount is less than 0.5 part by weight, adhesion between the capsule particles tends to occur. If the amount is more than 50 parts by weight, industrially efficient extraction cannot be performed. For the extraction operation, a known solid-liquid extraction operation is used. As the extraction method, a known method such as batch extraction, batch multistage extraction, or continuous countercurrent extraction is appropriately selected.

The thus obtained surfactant-containing seamless capsule particles are excellent in emulsifiability.
For example, when the content liquid of the capsule particles is poured into water at 40 ° C. and stirred to emulsify and disperse the oily component of the inner layer, it is observed that the emulsified phase hardly separates and is substantially not separated from water. Is done. That is, the oily component of the inner layer is immediately emulsified and dispersed in the water bath, and the surface of the turbid emulsified water does not float and the oil phase is not separated and remains in an emulsified state. In the capsule particles of the present invention, the surfactant component contained in the inner layer is substantially uniformly dispersed or dissolved in the oil component. Therefore, for example, when the content liquid of the capsule particles is taken out and transferred to a container and allowed to stand in an atmosphere of 25 ° C. and 60% humidity, a state where the oil component and the surfactant component are not separated is observed. The surfactant-containing seamless capsule particles obtained by the present invention can be used in the fields of medicines, foods, luxury goods, bath products, and cleaning products by appropriately blending useful components and additives according to various uses. is there.

[0042]

The present invention will be described in more detail with reference to the following Examples and Comparative Examples, but the present invention is not limited to these Examples and the like.

Example 1 A triple nozzle having a sequentially increasing diameter [the inner diameter of the innermost nozzle is 0.9 mm, the outer diameter is 1.2 mm; the inner diameter of the intermediate nozzle is 2 m
m, outer diameter 2.5 mm; inner diameter of the outermost nozzle 3.5 mm], 6% by weight of glycerin tri (caprylate capric acid) [manufactured by Coconado MT Kao Corporation] and polyoxyethylene (average Number of moles added 20) Sorbitan trioleate 12.6% by weight [HLB: 11], sorbitan sesquioleate 1.4% by weight [HLB: 3.7]
[Average HLB: 10.3], and 80% by weight of water was added thereto to obtain an aqueous dispersion at a flow rate of 3.7 [g / min] from the innermost nozzle and tri (from the intermediate nozzle). Glycerin (caprylic capric acid) at a flow rate of 4.4 [g / m
In], an aqueous solution of 30% by weight of gelatin, 4% by weight of glycerin and 66% by weight of water maintained at 70 ° C. was simultaneously discharged from the outermost nozzle at a flow rate of 5.8 [g / min] into the gas phase to form a multilayer. Droplets are formed and dropped on liquid paraffin cooled to 2 ° C., so that the weight ratio between the surfactant and the oil component in the particles is 1: 9, and the innermost layer contains the oil component and the surfactant component. Surfactant-containing seamless capsule particles, which were aqueous dispersions, in which the intermediate layer was composed of an oily component and the outermost layer had a film-forming body, were obtained. When the particle size D of the capsule particles was measured with a vernier caliper, the average particle size was 5.1 mm.
And the coefficient of variation of the particle size distribution was 6.3%. The average film thickness t was measured with a micrometer.
5 mm. The coating ratio was 41.7% by weight.

Example 2 The surfactant-containing seamless capsule particles prepared in Example 1 were cooled (4 ° C.) for 12 hours in liquid paraffin in a refrigerator, and then dried at 21 ° C. and 60% humidity for 12 hours. A surfactant-containing seamless capsule having a weight ratio of surfactant to oily component in the particles of 1: 9, an inner layer substantially consisting of an oily component and a surfactant component, and having a film-forming body on the outside thereof. Particles were obtained. When the particle diameter D of the capsule particles was measured with a vernier caliper, the average particle diameter was 4.2 m.
m, and the coefficient of variation of the particle size distribution was 6.6%.
The average film thickness t was measured with a micrometer,
0.29 mm. The water content in the capsule particles was 3.5% by weight. The coating ratio was 25.3% by weight.

Example 3 Using an apparatus having a triple nozzle (same nozzle as in Example 1) having a sequentially increasing diameter, 20% by weight of tri (caprylic capric acid) glycerin and polyoxyethylene (average addition mole) were used. Number 20) sorbitan trioleate 72
A mixture of 8% by weight [HLB: 3.7] and 8% by weight sorbitan sesquioleate [HLB: 3.7] [average HLB: 1]
0.3] from the innermost nozzle at a flow rate of 0.2 [g / min]
And from the middle nozzle, tri (caprylic capric acid)
Glycerin was supplied at a flow rate of 0.6 [g / min] from the outermost nozzle with 30% by weight of gelatin, 4% by weight of glycerin, and 66% of water.
Weight% of an aqueous solution maintained at 70 ° C. at a flow rate of 1.1 g / mi.
n], the droplets are simultaneously discharged into the gas phase to form multilayer droplets, and the droplets are dropped on liquid paraffin cooled to 2 ° C., so that the weight ratio of the surfactant to the oil component in the particles is 1:
In 4, the innermost layer is composed of an oil component and a surfactant component,
Surfactant-containing seamless capsule particles having an intermediate layer composed of an oily component and having a film-forming body in the outermost layer were obtained. When the particle size D of the capsule particles was measured with a vernier caliper, the average particle size was 4.8 mm, and the variation coefficient of the particle size distribution was 7.2%. The average coating thickness t was 0.9 mm when measured with a micrometer. The coating rate is 5
It was 7.9% by weight.

Example 4 Polyoxyethylene (average number of moles added: 20) sorbitan trioleate 90 was prepared using an apparatus having a triple nozzle (the same nozzle as in Example 1) having a sequentially increasing diameter.
[HLB: 11], 10% by weight of sorbitan sesquioleate [HLB: 3.7] [Average HLB:
10.3] to 40 ° C and a flow rate of 0.3 from the innermost nozzle.
[G / min], and tri (caprylic capric acid) glycerin was flowed from the intermediate nozzle at a flow rate of 1.2 [g / min].
30% by weight of gelatin and glycerin 4 from the outermost nozzle
An aqueous solution of 70% by weight and 66% by weight of water is discharged simultaneously into the gas phase at a flow rate of 1.8 [g / min] at a flow rate of 1.8 [g / min] to form multilayer droplets, which are dropped onto liquid paraffin cooled to 2 ° C. By doing so, the surfactant in the particles has a weight ratio of the oil component to the oil component of 1: 4, the innermost layer is composed of the surfactant component, the intermediate layer is the oil component, and the outermost layer has the film-forming body. Agent-containing seamless capsule particles were obtained. When the particle diameter D of the capsule particles was measured with a vernier caliper, the average particle diameter was 4.6 mm, and the variation coefficient of the particle diameter distribution was 8.
It was 0%. The average coating thickness t was 0.9 mm when measured with a micrometer. The coating rate was 54.
It was 6% by weight.

Comparative Example 1 Double nozzle [inner diameter of innermost nozzle 0.6 mm, outer diameter 1.0
mm; inner diameter of the outermost nozzle 1.5 mm] from the innermost nozzle, tri (caprylic capric acid) glycerin 90% by weight,
Polyoxyethylene (average number of moles added: 20) sorbitan trioleate 9% by weight [HLB: 11], sorbitan sesquioleate 1% by weight [HLB: 3.7] and [average HLB: 10.3] flow rate 7.8 [ g / min], 30% by weight of gelatin, 4% by weight of glycerin from the outermost nozzle,
An aqueous solution of 66% by weight of water maintained at 70 ° C. was supplied at a flow rate of 5 g / m 2.
in] and simultaneously discharged into the gas phase to produce multilayer droplets, which were dropped onto liquid paraffin cooled to 2 ° C.
The surfactant component in the content liquid diffused into the coating liquid, and the interfacial tension between the coating liquid and the content liquid and the interfacial tension between the coating liquid and the cooling liquid were reduced, and the capsule did not form a capsule.

Example 5 Tri (caprylic capric acid) glycerin [Coconard MT Kao Co., Ltd.] was prepared by using an apparatus having a triple nozzle (same nozzle as in Example 1) having a diameter increasing gradually.
6% by weight and polyoxyethylene (average number of moles added: 20)
12.6% by weight of sorbitan trioleate [HLB: 1
1], 1.4% by weight of sorbitan sesquioleate [HL
B: 3.7], [average HLB: 10.3], 70% by weight of water was added thereto and stirred to obtain an aqueous dispersion, and 10% by weight of ethanol was added to the mixture to contain a hydrophilic organic solvent. The flow rate of the aqueous dispersion from the innermost nozzle is 3.7 [g / min].
And from the middle nozzle, tri (caprylic capric acid)
Glycerin was supplied at a flow rate of 4.4 [g / min] from the outermost nozzle with 30% by weight of gelatin, 4% by weight of glycerin, and 66% of water.
The aqueous solution maintained at 70 ° C. at a flow rate of 5.8 g / mi
n], the droplets are simultaneously discharged into the gas phase to form multilayer droplets, and the droplets are dropped on liquid paraffin cooled to 2 ° C., so that the weight ratio of the surfactant to the oil component in the particles is 1:
9. The surfactant-containing seamless capsule in which the innermost layer is an aqueous dispersion containing an oily component, a surfactant component and a hydrophilic organic solvent, the intermediate layer is an oily component, and the outermost layer has a film-forming body. Particles were obtained. When the particle size D of the capsule particles was measured with a vernier caliper, the average particle size was 5.2 mm.
And the coefficient of variation of the particle size distribution was 6.1%. The average film thickness t was measured with a micrometer.
5 mm. The coating ratio was 41.7% by weight.

Example 6 Tri (caprylic capric acid) glycerin [manufactured by Coconado MT Kao Co., Ltd.] was used by using an apparatus having a triple nozzle (the same nozzle as in Example 1) having a diameter increasing gradually.
6% by weight and polyoxyethylene (average number of moles added: 20)
12.6% by weight of sorbitan trioleate [HLB: 1
1], 1.4% by weight of sorbitan sesquioleate [HL
B: 3.7] (average HLB: 10.3), 70% by weight of water was added thereto, and the mixture was stirred to obtain an aqueous dispersion. The dispersion is flowed from the innermost nozzle at a flow rate of 7.4 g / min.
And from the middle nozzle, tri (caprylic capric acid)
Glycerin was supplied at a flow rate of 8.8 [g / min] from the outermost nozzle with 30% by weight of gelatin, 4% by weight of glycerin, and 66% of water.
Weight% aqueous solution maintained at 70 ° C. at a flow rate of 11.6 g / m 2
In], the nozzle is ejected into the gas phase while applying a vibration of 10 Hz to form a multi-layer droplet, and the droplet is dropped on liquid paraffin cooled to 2 ° C., whereby the amount of the surfactant and the weight of the oil component in the particle are reduced. A surfactant-containing seamless capsule particle having a ratio of 1: 9, wherein the innermost layer is an aqueous dispersion containing an oily component and a surfactant component, the middle layer is an oily component, and the outermost layer has a film-forming body. I got When the particle size D of the capsule particles was measured with a caliper, the average particle size was
The particle size distribution was 4.5 mm, and the coefficient of variation of the particle size distribution was 4.8%. The average coating thickness t was 0.3 mm when measured with a micrometer. The coating ratio was 41.7% by weight.

Example 7 Tri (caprylic capric acid) glycerin [manufactured by Coconado MT Kao Co., Ltd.] was used by using an apparatus having a triple nozzle (same nozzle as in Example 1) having a diameter increasing gradually.
6% by weight and polyoxyethylene (average number of moles added: 20)
12.6% by weight of sorbitan trioleate [HLB: 1
1], 1.4% by weight of sorbitan sesquioleate [HL
B: 3.7] (average HLB: 10.3), and an aqueous dispersion in which 80% by weight of water was added was supplied at a flow rate of 3.7 [g / min] from the innermost nozzle and from the intermediate nozzle. Tri (caprylic capric acid) glycerin was supplied at a flow rate of 4.4 g.
/ Min] at a flow rate of 5.8 [g / min] with an aqueous solution of 0.8% by weight of sodium alginate from the outermost nozzle.
Simultaneously, the mixture is discharged into the gas phase and dropped into an aqueous solution containing 3% by weight of calcium chloride. The ratio of the surfactant in the particles to the weight of the oil component is 1: 9, and the innermost layer is formed of the oil component and the surfactant component. , A surfactant-containing seamless capsule particle having an oily component in the intermediate layer and a film-forming body in the outermost layer. When the particle size D of the capsule particles was measured with a vernier caliper, the average particle size was 5.1 mm, and the variation coefficient of the particle size distribution was 6.4%. The average film thickness t was 1.5 m when measured with a micrometer.
m. The coating ratio was 41.7% by weight.

Example 8 Using an apparatus having a triple nozzle (the same nozzle as in Example 1) having a diameter increasing gradually, tri (caprylic capric acid) glycerin was supplied at a flow rate of 4.4 g from the innermost nozzle.
/ Min], and tri (caprylic capric acid) glycerin (Coconard MT Kao Corporation) from the intermediate nozzle.
6% by weight and polyoxyethylene (average number of moles added: 20)
12.6% by weight of sorbitan trioleate [HLB: 1
1], 1.4% by weight of sorbitan sesquioleate [HL
B: 3.7] (average HLB: 10.3), and an aqueous dispersion obtained by adding 80% by weight of water thereto was supplied at a flow rate of 3.7 [g].
/ Min], 12% by weight of polystyrene from the outermost nozzle
At a flow rate of 5.8 g / min.
Simultaneously, the mixture is discharged into the gas phase and dropped into water. The weight ratio of the surfactant in the particles to the oil component is 1: 9, the innermost layer is the oil component, and the middle layer is the oil component and the surfactant component. Thus, surfactant-containing seamless capsule particles having an outermost layer having a film-forming product were obtained. Next, the temperature of the aqueous dispersion containing the capsule particles was raised to 50 ° C.
The dichloromethane in the film was removed under a reduced pressure of Torr for 2 hours, and the particle diameter D was measured with a caliper. The average particle diameter was 4 mm, and the variation coefficient of the particle diameter distribution was 7.8%. The average coating thickness t was 0.2 mm when measured with a micrometer. The coating rate is 7.9% by weight.
Met.

Example 9 A triple nozzle having a sequentially increasing diameter [the inner diameter of the innermost nozzle is 2 mm, the outer diameter is 2.2 mm; the inner diameter of the intermediate nozzle is 2.5 m
m, outer diameter 2.7 mm; inner diameter of outermost nozzle 3.5 mm], 6.6% by weight of tri (caprylate capric acid) glycerin [Coconad MT Kao Corporation]
And polyoxyethylene (average number of moles added: 20) sorbitan trioleate 10.5% by weight [HLB: 11], sorbitan sesquioleate 1.2% by weight [HLB: 3.
7] (average HLB: 10.3), and water 8
The aqueous dispersion charged with 1.7% by weight was flowed from the innermost nozzle at a flow rate of 1.4 g / min and a linear velocity of 0.45 m / mi.
n] and tri (caprylate capric acid) glycerin from the intermediate nozzle at a flow rate of 0.55 [g / min] and a linear velocity of 0.53 [m / min], and gelatin 3 from the outermost nozzle.
70% of 0% by weight, 4% by weight of glycerin and 66% by weight of water
, And cooled to 45 ° C. with an aqueous solution at a flow rate of 2.193.
[G / min] · A linear velocity of 0.52 [m / min] is discharged simultaneously into the liquid phase of liquid paraffin cooled to 2 ° C. to form multilayer droplets, the amount of surfactant in the particles and the oil component Is about 1: 4, the innermost layer is an aqueous dispersion composed of an oil component and a surfactant component, the intermediate layer is composed of an oil component, and the outermost layer is a surfactant-containing seam having a film-forming body. No capsule particles were obtained. Under the above conditions, the maximum linear velocity of the liquid ejected from each nozzle was 1.18 times the minimum linear velocity. When the particle size D of the capsule particles was measured with a vernier caliper, the average particle size was 7.5.
mm, and the coefficient of variation of the particle size distribution was 6.0%. The average coating thickness t was uniform at 1.2 mm when measured with a micrometer. The coating ratio was 47% by weight.

Example 10 The surfactant-containing seamless capsule particles (water content in the capsule particles was 48.7% by weight) produced in Example 1 were
Immediately after the liquid-liquid paraffin and solid-liquid separation of the cooling liquid, the mixture is put into a 70% aqueous ethanol solution (15 ° C.) twice as much as the liquid, and after 3 hours, replaced with the same amount of an 80% aqueous ethanol solution (15 ° C.). A 90% aqueous ethanol solution (15 ° C.) and a 99.5% aqueous ethanol solution (15
° C) to remove water from the capsule. Thereafter, the same amount of hexane at 20 ° C. was replaced to remove the cooling liquid adhering to the capsule particles.
After drying at 5 ° C. for 30 minutes, the weight ratio of the surfactant and the oil component in the capsule particles is about 1: 9, the inner layer is composed of the oil component and the surfactant component, and the outermost layer has the surface-forming substance having the film-forming body. Agent-containing seamless capsule particles were obtained. When the particle size D of the capsule particles was measured with a vernier caliper, the average particle size was 4.2 mm, and the variation coefficient of the particle size distribution was 5.
9%. The average coating thickness t was measured with a micrometer and was uniform at 0.29 mm. The water content in the capsule particles was 3.0% by weight. Further, the coating ratio was 25.3% by weight.

[0054]

According to the present invention, unlike the conventional method, it is possible to provide a method for producing capsule particles having a seamless film and containing a surfactant component and an oil component. The capsule particles are also preferable in appearance, have a sharp particle size distribution, have a uniform film thickness, and have excellent solubility.
In addition, since it contains a surfactant component and an oily component, it can be effectively used in the fields of bath products, cleaning products, and the like. Particularly when used as a bath agent, an oily component effective on the skin is emulsified and dispersed by a surfactant. It is useful because it can.

[Brief description of the drawings]

FIG. 1 is a sectional view schematically showing an example of a nozzle portion of a manufacturing apparatus used in a manufacturing method of the present invention.

[Explanation of symbols]

 1 innermost nozzle 2 intermediate nozzle 3 outermost nozzle 4 outermost nozzle entrance 5 intermediate nozzle entrance 6 innermost nozzle entrance

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-5-191784 (JP, A) JP-A-61-151119 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) B01J 13/02-13/22 A01J 3/07 A61K 7/00-7/56

Claims (7)

(57) [Claims] 1. At least 3 having a progressively increasing diameter
In the method for producing seamless capsule particles using multiple nozzles more than heavy, the film forming liquid from the outermost nozzle,
An aqueous dispersion containing an oil component and a surfactant component is continuously discharged from at least one of the other nozzles to form multilayer droplets, and then a film-forming liquid of the multilayer droplets is formed. A method for producing surfactant-containing seamless capsule particles, characterized by curing or gelling. 2. At least 3 having progressively increasing diameter
In the method for producing seamless capsule particles using multiple nozzles more than heavy, the film forming liquid from the outermost nozzle,
An aqueous dispersion containing an oily component, a surfactant component, and a hydrophilic organic solvent from at least one of the other nozzles is continuously discharged to form multilayer droplets.
A process for producing a surfactant-containing seamless capsule particle, comprising curing or gelling the film-forming liquid of the multilayer droplet. 3. At least 3 having a progressively increasing diameter
In the method for producing seamless capsule particles using multiple nozzles more than heavy, the film forming liquid from the outermost nozzle,
A liquid comprising an oil component and a surfactant component is continuously discharged from at least one of the other nozzles to form multilayer droplets, and then the film-forming liquid of the multilayer droplet is cured or A method for producing a surfactant-containing seamless capsule particle, characterized by gelling. 4. At least 3 with progressively increasing diameter
In the method for producing seamless capsule particles using multiple nozzles more than heavy, the film forming liquid from the outermost nozzle,
After the surfactant component is continuously discharged from at least one of the other nozzles and the oily component is continuously discharged from at least one of the other nozzles to form a multilayer droplet, the multilayer droplet is formed. A method for producing surfactant-containing seamless capsule particles, comprising curing or gelling a film-forming liquid. 5. The surfactant-free seamless capsule particles obtained in claim 1, wherein the water content in the capsule particles is further removed to reduce the water content in the particles to 25% by weight or less. A method for producing seamless capsule particles containing a surfactant. 6. The seamless capsule particles containing surfactants obtained in claims 1 to 4, wherein water in the capsule particles is further extracted and removed using a hydrophilic organic solvent. 5. The production method according to 5. 7. Among the linear velocities of the liquid ejected from each of the multiple nozzles, the maximum linear velocity is the minimum linear velocity of 1.
5. The method according to claim 1, wherein the ratio is 0 to 1.3 times.