JP2766594B2 - Agent for relieving dry skin, atopic dermatosis, allergic dermatosis, skin mold - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a relieving agent for atopic dermatosis , xerosis, allergic dermatosis and dermatophyte.
You .

[0002]

2. Description of the Related Art The recent spread of aluminum sashes and air conditioners has
It is said that the house was closed and a low humidity environment was brought about. The use of electric blankets further promotes drying of the skin. In addition, an increase in the number of showers and baths results in excessive use of soap and shampoo, leading to a decrease in surface sebum, which is important for the skin. It is said that these factors contribute to an increase in dry skin diseases such as senile xeroderma and dry skin in children.

[0003] Dry skin of an adult is one of the skin diseases that are common in middle and old aged people, and has been increasing in recent years as the sebum secretion decreases and the living environment becomes lower in humidity with aging. The causes may be various things such as a decrease in secretion of sweat and sebum due to aging of the skin, a low humidity environment, excessive use of soap and the like, and friction of clothes made of synthetic fibers such as nylon. In addition, symptoms that should be called dandruff of the scalp and psoriasis that the scalp turns red,
Any symptoms such as clogging of the sebaceous glands in an oily person and the absence of sebum will promote hair loss. Wash your hands with soap or detergent too much, and you will have insufficient water and sebum, or oily people will have sebaceous glands clogging and no water or sebum will appear, causing itching, bulkiness, redness, etc. ing.

[0004] As symptoms, the shin, thighs, waist, flank, scalp, hands, etc. are bulky and powdery. Also, it becomes red and the skin surface becomes brown scab. As the condition progresses further, the stratum corneum proliferates,
It may be cracked. In many cases, itching and itching is impossible for some people. Itching and scratching may cause eczema. It is especially common in winter when the air is dry and the temperature drops.

[0005] As treatment, an ointment containing urea having hygroscopicity or an external preparation having a high moisturizing effect is used to maintain the water content. When itching is severe, an external preparation containing an antihistamine may be applied. In addition, when the symptoms are considerably advanced, it may be necessary to take an antihistamine drug and use an external preparation containing a weaker corticosteroid in combination.

[0006] Dry skin in children contains a great deal of what is called atopic skin. The skin of atopic skin is bulky and dry, most of which is itchy. Depending on how it is defined, it is distinguished from so-called atopic dermatitis. Generally, atopic dermatitis is referred to when atopic skin is accompanied by inflammatory symptoms such as redness, swelling and scratching.

[0007] Symptoms are that the skin of the limbs and trunk is dry and bulky, the powder becomes wispy, and the skin becomes thick and dull. Often accompanied by itching. These symptoms are exacerbated in winter and relieved or asymptomatic in summer.

As a treatment method, drying is prevented by a preparation containing urea having hygroscopicity or an ointment having high moisturizing property. When itching is severe, an external preparation containing an antihistamine may be applied, or an antihistamine may be taken internally. Care must be taken, such as cutting nails to avoid scratching, using mild soap and shampoo, avoiding nylon towels, and using cotton underwear for clothing. It is important that an ointment or lotion containing urea and vitamin E, which are natural moisturizing factors, smoothes dry skin and gives a moist feeling.

[0009] As allergic dermatosis, rhinitis due to cedar pollen and the like are well known. In addition, redness is caused by skin contact with various plants, sap, and pollen.
Itching or allergic dermatosis is characterized by individual differences among individuals.

[0010] On the other hand, symptomatic treatments such as suppression of histamine by an antihistamine ointment or oral medicine, and combination of an anti-itch ingredient to prevent scratching are mainly conducted. Although various studies have been made, there are difficulties such as different allergic sources for each person, and no fundamental treatment has been achieved. In addition, athlete's foot, caterpillars, green beans and the like, which are formed by the growth of mold on the skin, are known as dermatosis that is difficult to completely cure because mold enters the inside of the epidermis.

[0011]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a method for treating xeroderma especially in elderly people and children even when they are exposed to the same dry condition, and to provide allergic skin particularly to those with weak skin and those who are eating unevenly. It is an object of the present invention to solve the problem fundamentally by promoting the metabolism of the skin itself and promoting the secretion of sweat and sebum based on the fact that the skin is easily metabolized. Even when moisturized when applied like urea, it is easily dissolved in water, so it is not a symptomatic treatment that is easily washed away, but it actively stimulates the secretion of sweat and sebum from the body It is in. Another object of the present invention is to suppress mold on the surface of the human body and cure mold on the skin without using a strong chemical agent that may cause side effects on human skin.

[0012]

The present inventors previously disclosed in Japanese Patent Application Laid-Open No. Sho 63-215610 that when an extract of a specific seaweed was sprayed on a plant, the enhancement of the sugar content of the fruit was promoted, the luster was increased, and the vigor was increased. Was found to be extremely effective in improving the quality. Japanese Patent Application Laid-Open No. 4-275228 discloses a bactericidal action and an anti-inflammatory action against burns and tumors. This seaweed extract not only acts bactericidally and fungicidally, but also acts as a plant. It has the effect of increasing the metabolism of the mother and its mother body, thereby increasing the vigor of the plant body, assuming that the anti-inflammatory effect may also be synergistically improved, and atopic skin without bacterial infection Attempts have been made to achieve remarkable effects. In addition, the present invention was able to cure the fungus on the human body surface such as athlete's foot, caterpillar, and golden repellent in a short period of time, and reached the present invention.

That is, the present invention is as follows. (1) red algae and Gekirinsai, Kirin of I及 beauty / or Igisu family dry skin diseases including an extract component seaweed belonging to, atopic skin disease, allergic skin diseases, skin fungus disease modifiers
There is .

[0014]

[0015] (2) red algae and Gekirinsai, and seaweed extracts belong to Eucheuma <br/> and / or Igisu family, the extract
1 to 10% by weight of vegetable oil and dispersion emulsion of both
Skin containing a mixture of organic acids with a pH of 2-5
Disease, atopic dermatosis, allergic dermatosis, mildew mold
Japanese medicine .

[0016] (3) extract the door Gekirinsai, Eucheuma, Keigisu, beams Igisu, after the heat treatment by 80~95 ℃ of hot water at least one of seaweed chosen from the group consisting of I Igisu is The filtrate according to the above (1) or (2), which is a filtrate.
Dry skin, atopic dermatosis, allergic dermatosis, skin
Fungicide relieving agent .

The present invention is a use invention in which a specific new use has been found for an extract of seaweed which is a main component of a plant / food additive disclosed in JP-A-63-215610. This onset Ming,
A relief agent for skin dryness, atopic dermatosis, allergic dermatosis, skin mold such as athlete's foot, beetles, and golden powder.
There is . The genus Kirinsai has been limited to Tokakirinsai and Kirinsai (scientific name: Eucheuma gel
atinae) is excluded because the amount of sulfate contained in the polysaccharide is small and it has a strong gelling power, does not become carrageenan and is inappropriate.

The seaweed extract of the present invention is obtained by thoroughly washing at least one species selected from the group consisting of the red algae Kirinsai, Tosekirinsai, Kirinsai, the genus Igaris, Hariishisu and Inineigis. , 80-95 [deg.] C. hot water, and the filtrate obtained by filtering seaweed solids from the boiled liquid is the original extract. A 1 to 10% by weight solution of this extract is used.

Since it is applied to the human skin, an extraction solution with water is optimal, but of course, it may be extracted with another organic solvent, preferably a hydrophilic organic solvent. Of course, a solvent that does not adversely affect the human body, such as ethyl alcohol, is preferred.

The method of using the present invention as a relieving agent for dry skin, atopic dermatosis, allergic dermatosis and dermatophytosis may be such that if the concentration becomes too high like other synthetic drugs, separate or side effects may occur. Since it does not occur, an undiluted extract solution may be used, but usually a solution diluted to about 1 to 10% by weight, or in the case of an ointment, freeze-dry the undiluted solution,
Powders may be added to the ointment base. Further, a moisturizing component such as urea, an immune-enhancing component such as vitamin E, an antihistamine agent for reducing itching, or the like may be added to a lotion containing the diluent, an extract or an ointment containing the powder thereof. Add scalp and fingers to soap and detergent,
At the same time as removing sweat, sebum and dirt on the surface, the extract of the present invention is coated to promote metabolism and secrete new sweat and sebum. Alternatively, the extract or a diluent thereof may be applied to absorbent cotton and applied to the scalp or fingers. The same means can be applied to athlete's foot, locusts, golden potatoes, etc.

The extract of the present invention contains agar as a carbohydrate,
Because it contains sulphate of galactan, which is a funicular substance, it forms a thin film when applied to the skin, which prevents the loss of water from the skin and promotes the penetration of active ingredients into the skin. It is thought that the metabolism will flourish. It has not yet been clarified what components promote skin metabolism.

Although the seaweed extract itself has a sterilizing ability, it is hardly perishable. However, it contains galactan sulfates such as agar and fuori as carbohydrates as main components, so that too many germs are contained. And if left for a long period of time, the result may be like an agar culture and may partially constitute the flora.

For the purpose of preventing such a problem, a small amount of a preservative such as methyl parahydroxybenzoate may be added to the ointment or lotion. However, when it is desired to avoid synthetic chemicals, acetic acid, edible vinegar, It is also preferable to add and mix organic acids such as citric acid, malic acid, tartaric acid and the like so as to have a pH of 2 to 5.

For the purpose of retaining skin fat, it is also preferable to add 1 to 10% by weight of vegetable oil to the extract, mix the two well, and disperse and emulsify. In addition, since the extract also has a surfactant activity, the emulsion is emulsified without adding any other surfactant. The vegetable oil may be selected from olive oil, rapeseed oil, soybean oil, castor oil, salad oil, corn oil and the like.

[0025]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, which should not be construed as limiting the present invention.

(Example 1) Parts by weight Olive oil 1.0 Edible vinegar 1.0 Polyoxyethylene (20E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 2.0 Ethanol 7.0 5.0% Urea aqueous solution 5.0 10% by weight dilution of Kirinsai extract 82.0 The above components were mixed to prepare a lotion. When this lotion was applied daily to the feet of elderly people suffering from senile xeroderma, the itch almost disappeared in about 10 days, and the symptoms remarkably improved.

Example 2 Parts by weight A Squalane 20.0 Olive oil 2.0 Mink oil 1.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 2.0 Sorbitan monostearate 2.0 B 5% by weight dilution of the extract of the above-mentioned silicate 47.9 polyoxyethylene (20E.O.) sorbitan monostearate 2.0 polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 Glycerin 5.0 5.0% aqueous urea solution 5.0 Methyl parahydroxybenzoate 0.1 A and B are each weighed, heated to 80 ° C., and A is gradually added to B while stirring, and then slowly stirred. 20
Cooled to ° C. This produced an atopic skin cream. The above-mentioned cream was applied daily from the waist to the feet to children suffering from atopic skin. As a result, in 5 days, she became less bulky and itchy, and she relieved before she could sleep well.

(Example 3) Parts by weight A Squalane 20.0 Olive oil 2.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 2.0 Sorbitan monostearate 2.0 Vitamin E 1.0B 10% by weight dilution of the extract of Kirinsai and Hariishis 47.9 Polyoxyethylene (20E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) cured castor Oil 1.0 Glycerin 4.0 Antihistamine 1.0 1.0 Aqueous urea solution 5.0% Methyl parahydroxybenzoate 0.1 A and B are each weighed, heated to 75 ° C., and A is stirred into B After slowly adding, slowly stirring 15
Cooled to ° C. This produced an atopic skin cream. For a child suffering from atopic skin, the above-mentioned cream was taken daily and applied to the dry part mainly on the part of the skin and the softened skin. In one week, the amount of skin taken and skin was reduced, and itching was relieved, and almost completely resolved in half a month.

(Example 4) 10 parts by weight of a 10% by weight dilution of the ginseng-mixed extract of the present invention 93.0 Olive oil 5.0 Acetic acid 2.0 A liquid obtained by dispersing and emulsifying this was used as a lotion. .
When this lotion was applied daily from the waist to the feet of a senile xeroderma, the symptoms were almost alleviated in about 2 weeks. (Example 5) A 1% by weight aqueous solution of the dispersion emulsion of the present invention described in Example 4 was used as a rinse after scalp dry dandruff by a person with dry dandruff, and without subsequent washing with water. After having been air-dried, dandruff almost alleviated in about 2 weeks. (Example 6) A person whose reddish and eczema-like scalp was applied to the eczema part of the head every day with absorbent cotton dipped with a 5% by weight aqueous solution of the dispersion emulsion described in Example 4, In one month, the redness almost disappeared and the itch disappeared. (Example 7) With a soap containing 2% by weight of a seaweed extract solution component of the present invention, a person with dry itch on his hands was washed his hands. After about 3 weeks, almost no itch was felt. (Example 8) A housewife whose hands were roughened by kitchen detergent was used with a detergent containing 1% by weight of the seaweed extract solution component of the present invention. I no longer feel. (Example 9) A person suffering from athlete's foot was patted daily with a cotton wool immersed in a 3% by weight aqueous solution of the dispersion containing the seaweed extract of the present invention, and was almost alleviated in about 3 months after application. .

[0030]

EFFECTS OF THE INVENTION The present invention provides dry skin and atopic skin.
Dermatitis, allergic dermatosis, mildew mold relievers , especially in the elderly and children, dry skin, atopic skin,
It has a remarkable effect on dermatosis such as allergic dermatosis and dermatophytosis, improves taking and sore skin, and relieves itching. It not only works for moisturizing but also kills mold on the skin,
It promotes metabolism inside the skin, stimulates the secretion of water and sebum, and leads to fundamental healing. It is effective when added to soaps and detergents.

────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification symbol FI C11D 3/382 C11D 3/382 (56) References JP-A-1-221306 (JP, A) JP-A-4-275228 (JP) , A) Tokuyo Sho 60-500290 (JP, A) Tokuyohei 5-504583 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 35/80 ADA A61K 35/80 ABF A61K 35/80 ADZ

Claims (3)

(57) [Claims] 1. A red algae and Gekirinsai, skin dry, including an extract component seaweed belonging to Kirin of I及 beauty / or Igisu family
Dryness, atopic dermatosis, allergic dermatosis, skin mold
Moderator . 2. A red algae and Gekirinsai, and seaweed extracts belong to Kirin of I及 beauty / or Igisu family, for this extract, P vegetable oil 1 to 10% by weight and both dispersion emulsion
Xeroderma containing a mixture with an organic acid wherein H is 2 to 5 ,
Relieves atopic dermatosis, allergic dermatosis, moldy mildew
Agent . 3. The method according to claim 1, wherein the extract is a spinach, giraffe,
Keigisu, beam Igisu, according to claim 1 or claim 2 wherein is a filtrate after the heat treatment by 80 to 95 ° C. hot water at least one seaweed selected from the group consisting of I Igisu
Dry skin, atopic dermatosis, allergic dermatosis, skin
Fungicide relieving agent .