JP2738648B2 - Feed additive for anticoccidiosis, feed, therapeutic agent, prevention method, treatment method - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a feed additive for anticoccidiosis , a feed containing the feed additive, an anticoccidiosis.
And a method for preventing and treating coccidiosis in animals.

[0002]

2. Description of the Related Art Coccidiosis in poultry such as chickens, turkeys, quails and snarling birds, livestock such as rabbits, cattle, sheep and pigs, and pets such as dogs and cats is caused by the infection of certain parasites It is a contagious disease that occurs and is common worldwide. Coccidiosis, for example, occurs in chickens with Eimer tenella (Eimer
ia tenella), Eimeria assulina (E.acervulin
a), Eimeria necatrix (E. necatrix), Eimeria brunetti (E. brunetti), Eimeria maxima (E. maxima), etc. E.adenoides), Eimeria Galopabonis
(E. gallopovonis) and the like. Animals infected with this exhibit symptoms such as diarrhea and bloody stool, and often die if treatment is delayed or if the symptoms are severe, and growth is inhibited even without death. For this reason, coccidiosis is one of the most vulnerable animal diseases and is a major disease that causes great economic loss especially to the broiler industry.

Hitherto, biological agents such as chemotherapeutic agents comprising antibiotics and synthetic antibacterial agents and vaccines have been mainly used in the prevention and treatment of the above-mentioned coccidiosis in animals. Conventionally, green tea component, catechin, is known to have antibacterial activity against C. perfringens, Staphylococcus aureus, etc.Green tea has antiviral action, antioxidant action, intestinal action, blood cholesterol. -It is known that the compound has an increase in the resistance to cartilage and has anti-caries and the like. In addition, the fair copy states that washing the affected area with cuts and abrasions in the field with cold tea will help stop bleeding.

[0004]

However, conventionally used antibiotics and chemotherapeutic agents cause side effects and protozoa causing coccidiosis acquire resistance to the drug, and the effect of the drug decreases. There was a problem to do. Conventionally, green tea has not been known to be effective against protozoa. Therefore, an object of the present invention is to provide a feed additive, a feed and an anti -coccidiovirus for safe anticoccidiosis with few problems of side effects.
An object of the present invention is to provide a method for preventing and treating coccidiosis.

[0005]

In order to solve the above problems,
The feed additive for anticoccidiosis according to claim 1 contains green tea and / or a green tea extract. The feed according to the second aspect contains the feed additive according to the first aspect. Further, according to claim 3
The anticoccidiosis agent is characterized by containing green tea and / or green tea extract. Coccidium according to claim 4
A method for preventing sickness is to inject green tea and / or green tea extract into animals.
It is characterized by giving. The red eye of claim 5.
The treatment method for sickness is to apply green tea and / or green tea extract to animals.
Administration.

[0006] The green tea means various Japanese teas such as gyokuro, matcha, sencha, and bancha. It also means a liquid obtained by extracting the green tea extract and green tea using water or hot water or an aqueous solution harmless to animals.

The amount of the feed additive according to claim 1 to be added to the feed varies depending on the form of the green tea in the feed additive, the type and age of the animal to which the feed is administered, the symptoms, the physical condition, and the like. Since it has almost no toxicity, it can be used safely by selecting an amount capable of providing an anticoccidiosis effect to the animal to which the animal is administered and the administration period at any time. Usually, 0.05 to 1.0% by weight of green tea powder based on the total weight of the feed is administered over several days to several tens of days.

[0008] The form of the feed additive can be any form such as powder, solid or liquid, using green tea and / or green tea extract as a raw material.

The above-mentioned animals include poultry such as chicken, quail, turkey, etc.
This means animals known to be infected with coccidiosis in domestic animals such as rabbits, cows, sheep, pigs, and pets such as dogs and cats, and in animals (excluding humans) infected with these coccidiosis. It can be used for the prevention and treatment of coccidiosis.

[0010] The dosage form of the anticoccidiosis agent includes:
It may be any of liquid, semi-solid (paste etc.) and solid. When solid, powder, granules, tablets,
It can be in the form of capsules, pills and the like. The anticoccidiosis agent may be green tea powder or green tea extract itself, or as long as it does not hinder the efficacy of anticoccidiosis, excipients, fillers ordinarily used in medicine,
Various components such as binders, disintegrants, sweeteners, seasonings, spices and the like can be included.

As a method for administering the above-mentioned anticoccidiosis agent, it may be administered orally or parenterally to the animal separately from the feed, but it is preferable to administer the coccidiosis agent in the feed or mixed with the drinking water. Desirable for ease of ingestion and ease of administration.

[0012]

[Action] The mechanism of action of green tea and / or green tea extract having an anticoccidiosis effect is not clear, but as described later, catechin in the green tea component alone can provide the same anticoccidiosis effect as green tea. It is considered that the anticoccidiosis effect is caused by the synergistic action of a plurality of components such as catechin, vitamin C, α-tocopherol and caffeine contained in green tea.

[0013]

[Examples] In this example, in addition to the problems of the present invention, compared with the case of using a conventional antibiotic or the like,
In some cases, there is provided a feed additive, a feed, and a method for preventing and treating coccidiosis capable of obtaining meat, eggs, and milk of livestock that can be safely consumed by humans. In the present example, the effect of green tea on coccidiosis caused by highly pathogenic Eimeria tenella in chicks whose immune function, in which coccidiosis is most problematic, is the main development, was examined by the following method. 11 days old chunky-10 male chicks
Seven wards were provided at the ratio of feathers / ward. In the first and seventh sections, a basal feed having the composition shown in Table 1 was freely fed with water. 2
In the groups 6 to 6, the basic feed with the composition shown in Table 1 was added to Table 2.
The foods mixed with each of the feed additives shown in Table 1 were freely fed with water. In this example, the average amount of feed consumed by one chick per day in one section was about 63 g.

[0014]

[Table 1]

[0015]

[Table 2]

In Table 1, numerical units are parts by weight. Table 2
Medium, the ratio of each feed additive is ppm
Or it is shown by weight%. Green tea in sections 5 and 6 was prepared by blending high-grade green tea in the form of green tea powder. The 14-day-old chicks fed each of the above feeds were weighed, and all chicks in the 1st to 6th ward were Eimeria tenella oocyst 6
Oral inoculation was performed at 000 birds / wing. In the seventh section, no oocysts were inoculated, and this was used as a standard for the relative weight gain described below. The body weight of the chicks was measured at the age of 22 days, and the relative weight gain was calculated according to the following formula, using the body weight at the age of 14 days as the starting weight. Weight gain = weight gain / body weight at start x 100 Relative weight gain = gain rate of drug group or non-infected group / weight gain rate of non-infected non-medicated group (section 7) x 100 Each chick was necropsied and the cecal lesion index was determined and totaled as lesion value. The number of oocysts (hereinafter abbreviated as OPG) of the contents of the cecum was counted. The determination index of the lesion index is as follows. Lesion index 0: no lesion lesion index 1: very small number of petechial bleeding spots on the cecal wall but no thickening of the wall. Lesion index 2: The content contains a small amount of blood, and many bleeding foci are observed. The cecal wall is somewhat thickened. Lesion index 3: Includes a large amount of blood or cecal core (coagulated or gray-white cheese) in the cecum, thickening of the cecal wall,
And cecum deformity and atrophy are evident. Lesion index 4: The cecum is significantly atrophied, and the lesion reaches the rectum. The cecal wall is extremely thick and contains a cecal core within the cecum.
Or, in the case of death due to chicken coccidiosis Table 3 shows the results of the above relative gain, lesion value, OPG and survival rate.

[0017]

[Table 3] In Table 3, the numerical unit of OPG is the number of oscists per gram of content.

As shown in Table 3, the 6th section to which the diet supplemented with 0.4% by weight of green tea was administered had the highest relative weight gain among the 1st to 6th sections to which the protozoa was administered. Next, in the five sections to which the diet containing 0.1% by weight of green tea was administered, the relative gain was higher, and in the section to which these green teas were administered, the diet containing salinomycin, which is a conventionally used antibiotic, was added. The relative gain was higher than the value of the relative gain in the two groups administered. At necropsy, it was confirmed that the group to which green tea was administered recovered better after the lesion from the state of the intestinal mucosa than the group to which antibiotics were administered.

In addition, all results of OPG, lesion value, and relative weight gain in the 3rd section or the 4th section, respectively, to which the feed supplemented with 0.1% by weight or 0.05% by weight of catechin, which is a component of green tea, was administered were obtained. This anticoccidiosis effect observed in green tea is not attributable only to catechin, one of the components contained in green tea, as it is worse than the results in sections 5 and 6 in which the diet supplemented with green tea was administered. It is understood that there is no.

In Table 3, the lesion values in the 5th and 6th sections where the green tea was administered were smaller than those in the 1st section where the protozoa was administered and the drug, green tea and catechin were not administered. The small number indicates that green tea has a preventive effect as well as a therapeutic effect on coccidiosis.
As shown in this example, green tea is easily available,
Excellent anticoccidial effects were obtained by administering safe, inexpensive foods that were easy to handle, to chicks with weak immunity. Therefore, when humans eat meat and eggs obtained from chicks to which green tea has been administered, compared to the case where conventional antibiotics or chemotherapeutic agents are administered, antibiotics or chemotherapeutic agents are applied to meat or eggs. There is no fear of remaining, and its safety is high. Since green tea, which is a food, is administered, the dosage and administration period are not strictly limited as in the case of conventional drugs. Another advantage is that there are no problems such as side effects of conventional antibiotics and chemotherapeutic agents, and reduction in effects due to acquisition of drug resistance. In addition, since the occurrence of coccidiosis in the field is greatly affected by the complication of clostridial disease, the catechin contained in green tea has an antibacterial effect on clostridial disease.Also, when treating coccidiosis using green tea. Is advantageous. Green tea is also superior to conventional vaccines because it has not only a preventive but also therapeutic effect on coccidiosis.

In this example, green tea powder was added to the feed, but an aqueous extract or hot water extract of green tea could be added to the feed or administered separately from the feed, or the green tea powder could be added to the feed. Similar effects were obtained when administered separately.

[0022]

Effects of the Invention The feed additive of claim 1 or claim 2 anticoccidial according to feed or claim 3 according to
According to the agent or the method for preventing coccidiosis in an animal according to claim 4 and the treatment method according to claim 5, it is possible to prevent and treat coccidiosis in an animal using green tea as a food. There is an advantage that the problem of the occurrence of side effects is very small.

Claims (5)

(57) [Claims] 1. A feed additive for anticoccidiosis, comprising green tea and / or green tea extract. 2. A feed comprising the feed additive according to claim 1. 3. An anticoccidiosis agent comprising green tea and / or a green tea extract. 4. Administering green tea and / or green tea extract to animals
To prevent coccidiosis in animals
Law. 5. Administering green tea and / or green tea extract to animals
For treating coccidiosis in animals
Law.