JPH07255386A - Anticoccidiosis feed additive - Google Patents

Abstract

PURPOSE:To obtain an anticoccidiosis feed additive more excellent in safety than the conventional antibiotic. CONSTITUTION:Powdery green tea is blended in an amount of 0.1 to 0.4 wt.% based on the whole feed to prepare a feed and the prepared feed is given to a young bird of 11 day age for three day. Eimeria tenel'la is subsequently inoculated to the young bird and the feed containing powdery green tea is continuously given. A group to which the powdery green tea is given in 22 day age exhibits a more excellent relative rate of gain than a group to which an antibiotic is administrated and a lower lesion value than a group to which neither the antibiotic or the powdery green tea is given. That is to say, this feed additive containing green tea and/or an extract of green tea has an anticoccidiosis effect. Since green tea which is a food is used, the problem about manifestation of side effect is reduced in comparison with the case of an antibiotic. In addition, this additive is free from a fear about antibiotic remaining in an animal and excellent in safety also in the case human takes the animal to which green tea is administrated.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a feed additive for anticoccidiosis, a feed containing the feed additive and a method for preventing and treating coccidiosis in animals.

[0002]

BACKGROUND OF THE INVENTION Coccidiosis of poultry such as chickens, turkeys, quail and squirrel birds, domestic animals such as rabbits, cows, sheep and pigs, and pets such as dogs and cats is caused by the infection of certain parasitic protozoa. It is an infectious disease that occurs, and it occurs widely worldwide. Coccidiosis occurs in Eimer tenella (Eimer) in chickens, for example.
ia tenella), Eimeria assembler (E.acervulin
a), E. necatrix, E. brunetti, E. maxima, etc. E.adenoides), Eimeria gallopavonis
It is known to be caused by (E. gallopovonis). Animals infected with this exhibit symptoms such as diarrhea and bloody stool, and often die when treatment is delayed or severe, and the development is inhibited even if death does not occur. Therefore, coccidiosis is one of the most serious animal diseases, and is a major disease that causes a great economic loss to the broiler industry.

Conventionally, biopharmaceuticals such as chemotherapeutic agents consisting of antibiotics and synthetic antibacterial agents and vaccines have been mainly used in the prevention and treatment of coccidiosis in animals. Also, conventionally, catechin, which is a component of green tea, is known to have antibacterial activity against Clostridium perfringens, Staphylococcus aureus, etc., and green tea has antiviral action, antioxidant action, intestinal action, blood cholesterol. -It is known that it has an increase in curb and has an anti-caries effect. In addition, the Kishosho describes that washing the affected area of cuts and abrasions outdoors with cold tea is useful for hemostasis.

[0004]

[Problems to be Solved by the Invention] However, in the conventionally used antibiotics and chemotherapeutic agents, side effects occur, and the protozoa that cause coccidiosis acquire resistance to the drug, and the effect of the drug decreases. There was a problem to do. Further, it has not been known so far that green tea is effective against protozoa. Therefore, an object of the present invention is to provide a safe feed additive for anticoccidiosis, a feed and a method for preventing and treating coccidiosis, which have less side effects.

[0005]

[Means for Solving the Problems] In order to solve the above problems,
The feed additive for anticoccidiosis according to claim 1 is characterized by containing green tea and / or a green tea extract. The feed according to claim 2 is characterized by containing the feed additive according to claim 1. Further, the method for preventing and treating coccidiosis according to claim 3 comprises administering an anticoccidiosis agent containing green tea and / or a green tea extract or the feed according to claim 2 to an animal. Characterize.

The green tea means various Japanese teas such as gyokuro, matcha, sencha, and bancha. It also means a liquid obtained by extracting the green tea extract and green tea with water or hot water or an aqueous solution that is harmless to animals.

The amount of the feed additive according to claim 1 added to the feed varies depending on the form of green tea in the feed additive, the type and age of the animal to which the feed is administered, the symptoms, the physical condition, etc. Since it has almost no toxicity, it can be safely used by optionally selecting the amount and the administration period that can exert the anticoccidiosis effect on the animal to which it is administered. Usually, 0.05 to 1.0% by weight, calculated as green tea powder based on the total weight of the feed, is usually administered over several days to several tens of days.

The form of the feed additive may be any form such as powder, solid or liquid using green tea and / or green tea extract as a raw material.

The above-mentioned animals are poultry such as chickens, turtles and turkeys,
It means animals known to be infected with coccidiosis in domestic animals such as rabbits, cows, sheep, pigs, and pets such as dogs and cats, and the animals (excluding humans) infected with these coccidiosis It can be used for the prevention and treatment of coccidiosis.

The dosage form of the anticoccidiosis agent is as follows:
It may be liquid, semi-solid (paste, etc.) or solid. In the case of solid form, powder, granules, tablets,
It can be in the form of capsules, pills or the like. The anticoccidiosis agent may be green tea powder or the green tea extract itself, or as long as it does not interfere with the efficacy of anticoccidiosis, the excipients, fillers, etc. usually used in medicines,
Various ingredients such as binders, disintegrants, sweeteners, seasonings, spices and the like can be included.

As a method of administering the anticoccidiosis agent, it may be orally or parenterally administered to an animal separately from the feed, but it is preferable to administer the coccidiosis agent in the feed or mixed with drinking water. It is desirable because of ease of intake and ease of administration.

[0012]

[Action] The mechanism of action of green tea and / or green tea extract having anticoccidiosis effect is not clear, but as described later, catechin alone in the green tea component can provide the same anticoccidiosis effect as green tea. Therefore, it is considered that the anticoccidiosis action occurs due to the synergistic action of a plurality of components such as catechin, vitamin C, α-tocopherol, and caffeine contained in green tea.

[0013]

EXAMPLE In addition to the problem of the present invention, the problem in this example is that, compared with the case of using a conventional antibiotic,
(EN) A feed additive capable of obtaining meat, eggs, and milk of livestock that can be more safely eaten by humans, a feed, and a method for preventing and treating coccidiosis. In this example, the effect of green tea on coccidiosis caused by Eimeria tenella, which is highly pathogenic in chicks whose cognitive function is the most important, is the development of the immune function, was examined by the following method. 11-day-old Chunky-10 male chicks
Seven wards were established at a rate of feathers / ward. In the 1st and 7th plots, the basic feed having the composition shown in Table 1 was freely fed together with water. Two
Tables 2 to 6 for the basic feed having the composition shown in Table 1.
The feed mixed with each of the feed additives shown in 1 was freely fed with water. In this Example, the average feed intake of one chick per day per day was about 63 g.

[0014]

[Table 1]

[0015]

[Table 2]

In Table 1, numerical units are parts by weight. Table 2
In the above, the mixing ratio of each feed additive is ppm to the basic feed
Alternatively, it is shown in% by weight. The green teas in the 5th and 6th districts were blended with high-grade green tea in the form of green tea powder. The 14-day-old chicks fed each of the above feeds were weighed, and all the chicks in the 1st to 6th wards had Eimeria tenella oocysts 6
Oral inoculation was performed at 000 cells / wing. The 7th ward was not inoculated with ocysts, and was used as the standard for the relative weight gain described below. The body weight of the chicks was measured at 22 days of age, and the relative weight gain was calculated according to the following formula using the weight at 14 days of age as the starting weight. Weight gain rate = Weight gain ÷ Start weight x 100 Relative weight gain = Weight gain rate of medicated group or infected non-medication group / Non-infected non-medication group (7 wards) x 100 Also, each group at 22 days old Each chick was necropsied to examine the lesion index of the cecum and summed to obtain the lesion value. In addition, the number of oocysts (hereinafter abbreviated as OPG) of the cecal contents was counted. The judgment index of this lesion index is as follows. Lesion index 0: No lesion found Lesion index 1: Very few petechial hemorrhagic spots scattered on the cecal wall, but no wall thickening. Lesion index 2: A small amount of blood is mixed in the contents, and numerous bleeding lesions are seen. The cecal wall is somewhat thickened. Lesion index 3: A large amount of blood or cecal core (coagulated or grayish cheese) is contained in the cecum, and thickening of the cecal wall,
Deformation and atrophy of the cecum are obvious. Lesion index 4: The cecum is significantly atrophied and the lesion reaches the rectum. The cecal wall is extremely thick and contains the cecal core within the cecum.
Or, in the case of deceased due to chicken coccidiosis, the results of the relative weight gain, lesion value, OPG and survival rate are shown in Table 3.

[0017]

[Table 3] In Table 3, the numerical unit of OPG is the number of oocysts per 1 g of the content.

As shown in Table 3, the 6 groups to which the feed containing 0.4% by weight of green tea was administered had the highest relative weight gain in the 1 to 6 groups to which the protozoa were administered. Next, the relative weight gain was high in the 5 groups to which the feed containing 0.1% by weight of green tea was administered, and in the groups to which these green teas were administered, the diet containing salinomycin, which is a conventional antibiotic, was added. The value was higher than the value of the relative weight gain in the 2 treated zones. At autopsy, it was confirmed that the group treated with green tea had better recovery from the condition of the intestinal mucosa after the lesion than the group treated with antibiotics.

All the results of OPG, lesion value and relative weight gain in 3 or 4 groups treated with the feed containing 0.1% or 0.05% by weight of catechin which is a component of green tea are shown. The anticoccidiosis effect observed in green tea is not due solely to catechin, which is one of the components contained in green tea, because it is worse than the results in the 5th and 6th groups administered with the green tea-added feed. It is understood that there is no.

Further, in Table 3, the lesion values of the 5th and 6th groups to which green tea was administered were smaller than the lesion value of the 1st group to which the protozoa were administered and the drug, green tea or catechin was not administered, and the rate of onset of disease was From the small amount, it can be seen that green tea has not only a therapeutic effect on coccidiosis but also a preventive effect.
As shown in this example, green tea is easily available,
An excellent anticoccidial effect was obtained by administering a food that was easy to handle, safe, and inexpensive to chicks with weak immunocompetence. Therefore, compared to the conventional administration of antibiotics and chemotherapeutic agents, when humans eat meat and eggs obtained from chickens to which green tea has been administered, antibiotics and chemotherapeutic agents are added to the meat and eggs. There is no worry of remaining and its safety is high. Since green tea, which is a food, is administered, there is no strict limitation on the dose and the administration period, unlike the conventional drugs. There is also an advantage that there are no problems such as the occurrence of side effects of conventional antibiotics and chemotherapeutic agents and the diminished effect due to the acquisition of resistance to the agents. In addition, since the occurrence of coccidiosis in the field increases the damage due to complications with clostridia, catechin contained in green tea also has an antibacterial effect on clostridia, and therefore, when coccidiosis is treated using green tea. Is advantageous. In addition, green tea is superior to conventional vaccines because it has not only the preventive effect against coccidiosis but also the therapeutic effect.

Although green tea powder was added to the feed in this example, the water extract or the hot water extract of green tea was added to the feed, or the green tea powder was administered separately from the feed, or the green tea powder was different from the feed. Similar effects were obtained when administered separately.

[0022]

According to the feed additive according to claim 1 or the feed according to claim 2 or the method for preventing and treating coccidiosis of an animal according to claim 3, an animal using green tea as a food is used. Since coccidiosis can be prevented and treated, there is an advantage that the problem of side effects on animals is very small.

Claims (3)

[Claims] 1. A feed additive for anticoccidiosis comprising green tea and / or a green tea extract. 2. A feed containing the feed additive according to claim 1. 3. A method for preventing coccidiosis of an animal, which comprises administering an anticoccidiosis agent containing green tea and / or a green tea extract or the feed according to claim 2 to the animal, and Method of treatment.