JP2711703B2 - Soft capsule - Google Patents
Soft capsuleInfo
- Publication number
- JP2711703B2 JP2711703B2 JP64000897A JP89789A JP2711703B2 JP 2711703 B2 JP2711703 B2 JP 2711703B2 JP 64000897 A JP64000897 A JP 64000897A JP 89789 A JP89789 A JP 89789A JP 2711703 B2 JP2711703 B2 JP 2711703B2
- Authority
- JP
- Japan
- Prior art keywords
- soft capsule
- capsule
- soft
- cellulose
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Description
【発明の詳細な説明】 〔産業上の利用分野〕 本発明は新規な軟カプセル剤、更に詳細には、吸湿又
は加熱等によりカプセル同士が付着することのない軟カ
プセル剤に関する。Description: TECHNICAL FIELD The present invention relates to a novel soft capsule, and more particularly to a soft capsule in which capsules do not adhere to each other due to moisture absorption or heating.
軟カプセル剤は、一般に、ゼラチンにグリセリン、ソ
ルビトール等の可塑剤を配合して調製した皮膜中に有効
成分を充填して製造される。Soft capsules are generally produced by filling an active ingredient into a film prepared by blending gelatin with a plasticizer such as glycerin or sorbitol.
カプセル皮膜の硬度は、主として、配合されるグリセ
リンの量及び水分含量によって決まり、グリセリン及び
水分の含量が多い程カプセル皮膜は柔らかくなる。そし
て、使用者は、柔らかい軟カプセル剤を好む傾向にあ
る。The hardness of the capsule coating is mainly determined by the amount of glycerin and the water content, and the higher the content of glycerin and water, the softer the capsule coating. And users tend to prefer soft soft capsules.
このため、カプセル皮膜のグリセリンの量を多くする
ことが行われているが、軟カプセル剤は、硬いもので
も、高温又は多湿下に保存するとカプセル同士が付着す
ることを避けられなかったが、グリセリン量をふやすと
その付着傾向は益々増大し、甚しい場合には皮膜が溶解
してしまうという欠点があった。For this reason, the amount of glycerin in the capsule film has been increased, but even if the soft capsule is hard, it is inevitable that the capsules adhere to each other when stored under high temperature or high humidity. Increasing the amount increases the tendency to adhere, and in severe cases, has the disadvantage of dissolving the coating.
従来、これを解決する方法として、セラック、カルナ
ウバロウ等を表面にコーティングして吸湿を防止する方
法がとられているが、未だ充分に満足できるものではな
かった。Conventionally, as a method of solving this, a method of coating the surface with shellac, carnauba wax or the like to prevent moisture absorption has been taken, but it has not been sufficiently satisfactory.
斯かる実状において、本発明者は鋭意研究を行った結
果、カプセル皮膜中に水不溶性のセルロースまたはその
誘導体を配合すれば、上記問題点を解決できることを見
出し、本発明を完成した。Under such circumstances, the present inventors have conducted intensive studies and as a result, found that if the water-insoluble cellulose or its derivative is incorporated into the capsule film, the above problems can be solved, and the present invention has been completed.
すなわち、本発明は、水不溶性のセルロースまたはそ
の誘導体を含有する皮膜からなるカプセル剤を提供する
ものである。That is, the present invention provides a capsule comprising a film containing water-insoluble cellulose or a derivative thereof.
本発明で使用される水不溶性のセルロース又はその誘
導体としては結晶セルロース、エチルセルロース等が挙
げられる。これらのセルロース及びセルロース誘導体は
ゼラチン100重量部に対し３〜50重量部、特に５〜35重
量部を配合するのが好ましい。この配合量がこれより少
ないと本発明の目的が達成されず、またこれを超えて配
合すると成型性に問題がある。Examples of the water-insoluble cellulose or derivatives thereof used in the present invention include crystalline cellulose and ethyl cellulose. It is preferable that these celluloses and cellulose derivatives are blended in an amount of 3 to 50 parts by weight, particularly 5 to 35 parts by weight, based on 100 parts by weight of gelatin. If the amount is less than the above range, the object of the present invention cannot be achieved. If the amount exceeds the range, there is a problem in moldability.
本発明の軟カプセル剤は、皮膜に上記セルロース又は
セルロース誘導体を配合する以外は、自体公知の方法に
よって調製される。The soft capsule of the present invention is prepared by a method known per se except that the above-mentioned cellulose or cellulose derivative is added to the film.
本発明の軟カプセル剤は湿気及び加熱等によってカプ
セル同士が付着することがないので、夏期等の高温、多
湿時においても室温で安定に保存できる。Since the capsules of the present invention do not adhere to each other due to moisture, heating, and the like, they can be stably stored at room temperature even in high temperatures and high humidity such as in summer.
次に実施例を挙げて説明する。 Next, an example will be described.
実施例1. （ｉ）ゼラチン10kg、グリセリン15kg、結晶セルロース
4kg及び精製水7kgを80℃で３時間加熱攪拌してゼラチン
のゾル溶液とし、真空脱気したのち、50℃の恒温槽に貯
留して、軟カプセル皮膜剤とした。Example 1. (i) Gelatin 10 kg, glycerin 15 kg, crystalline cellulose
4 kg and 7 kg of purified water were heated and stirred at 80 ° C. for 3 hours to form a gelatin sol solution, degassed under vacuum, and stored in a thermostat at 50 ° C. to obtain a soft capsule coating agent.
（ii）酢酸トコフェロール1kg及びゴマ油0.5kgを攪拌し
て均一な混合液とし、この液を内容液として、ライナー
社製ロータリー充填機を用いて常法により、上記の軟カ
プセル皮膜で被包成型し、通常の乾燥工程を経て、内容
量150mgの球形の軟カプセル剤を製造した。(Ii) 1 kg of tocopherol acetate and 0.5 kg of sesame oil are stirred to form a uniform mixed solution, and this solution is used as a content liquid and encapsulated with the above soft capsule film by a conventional method using a rotary filling machine manufactured by Liner. Through a usual drying process, a spherical soft capsule having an inner volume of 150 mg was produced.
比較例１ 実施例１（ｉ）において、結晶セルロースを配合しな
い以外は同様にして軟カプセル皮膜剤を調製し、これを
用いて実施例１（ii）と同様にして軟カプセル剤を製造
した。Comparative Example 1 A soft capsule coating agent was prepared in the same manner as in Example 1 (i) except that no crystalline cellulose was blended, and a soft capsule agent was produced using this in the same manner as in Example 1 (ii).
試験例１ 実施例１、及び比較例１で得た軟カプセル剤を、ガラ
スビン中に密栓し、40℃で１ヶ月放置したときの結果を
第１表に、また35℃、75％RHで１ヶ月放置したときの結
果を第２表に示す。Test Example 1 The results obtained when the soft capsules obtained in Example 1 and Comparative Example 1 were sealed in a glass bottle and left at 40 ° C. for 1 month are shown in Table 1, and the results are shown in Table 1 at 35 ° C. and 75% RH. Table 2 shows the results when left for months.
試験例２ 実施例１、及び比較例１で得た軟カプセル剤をガラス
ビン中に密栓し、40℃で１ヶ月及び３ヶ月放置した後、
日本薬局方、一般試験法のカプセル剤の項によって崩壊
時間を測定した。その結果を第３表に示す。 Test Example 2 The soft capsules obtained in Example 1 and Comparative Example 1 were sealed in a glass bottle and left at 40 ° C. for 1 month and 3 months.
The disintegration time was measured by the capsule section of the General Test Method, Japanese Pharmacopoeia. Table 3 shows the results.
Claims (1)
含有する皮膜からなる軟カプセル剤。1. A soft capsule comprising a film containing water-insoluble cellulose or a derivative thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP64000897A JP2711703B2 (en) | 1989-01-06 | 1989-01-06 | Soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP64000897A JP2711703B2 (en) | 1989-01-06 | 1989-01-06 | Soft capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02180815A JPH02180815A (en) | 1990-07-13 |
| JP2711703B2 true JP2711703B2 (en) | 1998-02-10 |
Family
ID=11486473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP64000897A Expired - Lifetime JP2711703B2 (en) | 1989-01-06 | 1989-01-06 | Soft capsule |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2711703B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450471C (en) * | 2006-08-25 | 2009-01-14 | 石药集团欧意药业有限公司 | Soft capsule of atovastatine salts and prepn. method therefor |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5742769A (en) * | 1996-05-06 | 1998-04-21 | Banyan Systems, Inc. | Directory with options for access to and display of email addresses |
| CN104068401A (en) * | 2014-06-27 | 2014-10-01 | 安徽先知缘食品有限公司 | Preparation method for natural vitamin E soft capsules |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61115019A (en) * | 1984-11-09 | 1986-06-02 | Nippi Zerachin Kogyo Kk | Gelatin capsule coating film |
-
1989
- 1989-01-06 JP JP64000897A patent/JP2711703B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100450471C (en) * | 2006-08-25 | 2009-01-14 | 石药集团欧意药业有限公司 | Soft capsule of atovastatine salts and prepn. method therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH02180815A (en) | 1990-07-13 |
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