JP2547684B2 - Biological signal measuring device - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention In order to facilitate observation of a plurality of other biological signal waveforms based on, for example, an electrocardiogram waveform, the present invention is synchronized with a specific waveform position of the reference waveform and is displayed on the time axis. The present invention relates to a biological signal measuring device capable of displaying a marker line.

[0002]

2. Description of the Related Art In a polygraph, which is a multi-drawing recorder, a plurality of biological signals such as an electrocardiogram, a pulse wave, a phonocardiogram, and a blood pressure waveform measured by a cardiac catheter test are simultaneously displayed on a monitor screen for observation or a printer. Thus, a plurality of biological signals can be recorded at the same time. By the way, when the biological signal to be observed is a circulatory biological signal, a plurality of biological signals are generated in synchronization with the cardiac cycle. Therefore, the waveforms of the biomedical signals displayed simultaneously on the monitor screen and the plurality of biomedical signals recorded on the recording paper are examined according to the phase of the cardiac cycle. In this case, other biological signals are compared with each other based on the biological signal whose heart cycle is easy to understand. For example, in the case of a phonocardiogram, which is an acoustic waveform generated by mechanical activity of the heart, only the phonocardiogram includes the I sound generated when the atrioventricular valve is closed and the II sound generated when the meniscus is closed. It is difficult to distinguish between the I sound and the II sound by referring to an electrocardiogram or the like. Further, in the case of a blood pressure waveform measured by a cardiac catheter test, the waveform and the amplitude greatly change depending on the insertion position of the catheter, so it is difficult to identify from which part of the heart the waveform is obtained only by the blood pressure waveform. Therefore, the blood pressure waveform is examined with reference to the electrocardiogram. The electrocardiogram and pulse wave are easy to use as reference waveforms for other biological signals because the cardiac cycle is easy to understand. The electrocardiogram is a biological signal generated at the beginning of the cardiac cycle, and the start position of the P wave, the QRS wave, the end point of the T wave, and the like represent the delimiters of the cardiac cycle. The pulse wave is the biological signal of the circulatory system that is most easily obtained, which facilitates the recognition of the cardiac cycle, and the start position of the waveform and DN (dicro).
(tic notch) etc. represent the delimitation of the cardiac cycle.

By the way, when observing a plurality of biological signals with reference to the cardiac cycle, conventionally, the sweep of the biological signal waveform displayed on the monitor screen is temporarily stopped, and the cursor is moved to a specific waveform position of the electrocardiogram, for example, by a technique. Then, other biological signals were observed using the electrocardiogram as a reference.
When considering multiple biological signals on recording paper, the scales on the recording paper were used to compare waveforms with each other, or a line was drawn at a time corresponding to a specific waveform position such as an electrocardiogram to compare other biological signals. .

[0004]

As described above, the conventional C
When simultaneously observing a plurality of biological signals displayed on a monitor screen such as RT, the waveforms are swept even when trying to compare other waveforms with reference to the electrocardiogram, etc. Since it is difficult to observe the waveform, the sweeping of the waveform is stopped and the cursor is moved to an arbitrary position by a technique as needed. Also, when observing biosignals on recording paper, the generation of biosignals is not constant in time, but fluctuates.Therefore, on the scale of the recording paper attached at fixed time intervals, the waveform observed according to the phase of the cardiac cycle is observed. However, it was necessary to draw a line on the time axis that matched the reference point of the cardiac cycle using a ruler. Such work has a problem that it takes time and labor, and it takes a lot of time to carry out this work for all heartbeats, which is practically difficult work.

The present invention has been proposed in order to solve the problems of the prior arts described above, so that a plurality of other biological signals can be easily compared and observed with reference to, for example, an electrocardiogram. Therefore, it is an object of the present invention to provide a biological signal measuring device capable of displaying a marker line on a time axis in synchronization with a specific waveform position of a reference waveform.

[0006]

In order to achieve this object, a biological signal measuring apparatus according to the present invention is an apparatus for displaying a plurality of biological signal waveforms on a single screen or recording paper with their time axes aligned. a synchronization signal generating means for generating a synchronizing signal synchronized with the cardiac cycle detected from the biological signal, of identity
The plurality of raw signals are generated in the direction orthogonal to the time axis when the
Generates a marker line that is displayed across the body signal waveform
And a marker line generating means for causing the marker line to be generated .

[0007]

According to the configuration of the present invention, one screen or
Marker lines are displayed on the recording paper together with multiple biological signal waveforms.
Shown.

Moreover, the marker line is synchronized with the cardiac cycle.
The plurality of biological signal waveforms in the direction orthogonal to the time axis.
It is displayed to cross.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Specific embodiments of the biological signal measuring apparatus according to the present invention will be described in detail below with reference to the drawings. FIG. 1 is a block diagram showing an embodiment of this biological signal measuring device. In this embodiment, biological signals of the circulatory system are observed as a plurality of biological signals, and an electrocardiogram is used as a reference waveform representing a cardiac cycle. In this figure, an electrocardiogram signal is derived from the electrodes attached to the living body of the subject,
This electrocardiographic signal is sent from the input terminal IN1 to the electrocardiographic amplifier 1
After being taken up by and amplified by an analog-to-digital converter (hereinafter referred to as an A / D converter) 2, it is converted into a digital signal. The electrocardiogram signal converted into a digital signal is then stored in the waveform memory 3. Further, for example, the aortic blood pressure signal and the right ventricular blood pressure signal extracted by the cardiac catheter test are input from the input terminals IN2 and IN3 to the blood pressure signal amplifiers 4 and 7, respectively, and are amplified by A
After being converted to digital signals by the / D converters 5 and 8,
It is stored in the waveform memories 6 and 9. The pulse wave signal obtained from the transducer attached to the subject is input to the pulse wave amplifier 10 from the input terminal IN4, and the amplifier 1
After being amplified by 0, it is converted into a digital signal by the A / D converter 11 and stored in the waveform memory 12. Further, a phonocardiogram signal is taken out from the microphone attached to the subject, and the phonocardiogram signal is input from the input terminal IN5 to the phonocardiogram amplifier 13 and amplified, and then the A / D
Waveform memory 1 converted into a digital signal by converter 14
5 is stored. The diagram central electrocardiogram amplifier 1, blood pressure signal amplifiers 4, 7, pulse wave amplifier 10, and electrocardiogram amplifier 13 constitute input means 41, and are for simultaneously fetching and amplifying a plurality of biological signal waveforms. . The waveform memories 3, 6, 9, 12, and 15 constitute a memory means 42 and store a plurality of biological signal waveforms.

The electrocardiogram signal stored in the waveform memory 3 is
The waveform recognition unit 16 reads out the waveform recognition unit 1.
Taken in 6. In the waveform recognition unit 16, as shown in the electrocardiogram W1 in FIG. 2, the P wave corresponding to the atrial excitation time,
The QRS wave corresponding to the ventricular excitement time and the T wave corresponding to the ventricular excitement extinction time are recognized. Next, the procedure of the waveform recognition processing in the waveform recognition unit 16 will be described with reference to the flowchart of FIG. First, the electrocardiogram W1 which is the original waveform is transferred from the waveform memory 3 to the waveform recognition memory 17 (step S1). Subsequently, the electrocardiogram W1 read from the waveform recognition memory 17 is taken into the QRS wave recognition unit 18 and the QRS wave is detected (step S2). This QRS wave can be detected by a known technique. After the QRS wave is detected, the data of the memory address on the waveform recognition memory 17 corresponding to the detection point of the QRS wave is stored in the memory 19 (step S3). Then, based on the data of the detected QRS wave detection points, Q
The T-wave recognition unit 2 detects the end point of the T-wave located after the RS wave.
0, and the data of the memory address at the detection point of the T wave end point is stored in the memory 19 (steps S4 to S4).
5). Then, based on the data of the detection point of the QRS wave,
The P wave located in front of the QRS wave is detected by the P wave recognition unit 21, and the data of the memory address of the P wave detection point is stored in the memory 19 (steps S6 to S7). Until the end of the waveform recognition memory 17 is reached, steps S2 to S7
The process up to is repeated. When it is determined in step S8 that the waveform has reached the end of the waveform recognition memory 17, the electrocardiogram W1 of the original waveform is read again from the waveform memory 3 and transferred to the waveform recognition memory 17, and the same processing is repeated thereafter. Be done.

On the other hand, the marker line synchronization position setting means 22
Then, when drawing the marker line synchronized with the electrocardiogram W1 on the time axis, it is possible to set which waveform point position of the electrocardiogram W1 the marker line is displayed. In this marker line synchronization position setting means 22, P
Wave, QRS wave, or T wave can be selected as the marker line display position, and the marker line display position is an arbitrary position deviated from the selected waveform point position by the correction value in the front-back direction on the time axis. Can be set. For example, Q
Settings such as RS wave ± correction value are possible. When the display position of this marker line is set in step S9 shown in FIG. 4, a setting signal is output from the marker line synchronization position setting means 22 and the marker line display position calculation unit 23 is output.
Sent to In the display position calculating unit 23, when the setting condition is the setting for displaying the marker line in synchronization with the P wave, the memory address of the detection point of the P wave is read from the memory 19, and when the correction value is involved, the memory is read. The address in 19 is converted into the address of the waveform display memory 26 in consideration of this correction value (steps S10 to S11, S16).
If the setting condition is to display a marker line at the QRS wave position, the data at the memory address at the QRS wave detection point is read from the memory 19, and this memory address is associated with the waveform display memory 26. Converted to street address data. When the correction value is included, it is converted into the address of the waveform display memory 26 to which the correction value is added (steps S12 to S13, S16). If the setting condition is the T wave, the data of the memory address of the T wave detection point is read from the memory 19, and if there is a correction value, it is converted to the address of the waveform display memory 26 to which the correction value is added. (Steps S14 to S16). If the address of the waveform recognition memory 17 and the address of the waveform display memory 26 have a one-to-one correspondence, the display memory address can be calculated by converting only the correction value.

The output signal from the marker line display position calculating section 23 is sent to the marker signal generating section 24, and a marker signal necessary for displaying the marker line as a thin line or a broken bright line is produced. The marker signal generated by the marker signal generator 24 is sent to the waveform synthesizer 25. Here, the waveform recognition unit 16, the memory 19, the marker line display position calculation unit 23, and the marker signal generation unit 24 constitute the marker line generation unit 43, and the marker line is set at the position set by the marker line synchronization position setting unit 22. Is for generating. The waveform synthesizer 25 receives the electrocardiogram signal, the two blood pressure signals, the pulse wave signal, and the phonocardiogram signal read from each of the waveform memories 3, 6, 9, 12, and 15, and the biological signals and the markers. The signal and the waveform are synthesized (step S17). The composite signal of the biomedical signal and the marker signal output from the waveform synthesizing unit 25 is stored in the waveform display memory 26, and then sequentially read from the display memory 26 to display signal processing unit 27.
And is converted into a display signal that can be displayed on the monitor 28.

Thus, as shown in FIG. 5, a plurality of biological signals such as an electrocardiogram W1, an aortic blood pressure waveform W2, a right ventricular blood pressure waveform W3, a pulse wave W4, and a heart sound diagram W5 are simultaneously displayed on the monitor screen 28A as continuous waveforms. At the same time, for example, the marker line ML synchronized with the position on the time axis of the QRS wave of the electrocardiogram W1 can be simultaneously displayed (step S18). By displaying the marker line ML, a plurality of biological signals can be displayed, for example, on the electrocardiogram W.
It becomes possible to observe in synchronization with the cardiac cycle of 1 QRS wave. In addition, by correcting the display position of the marker line ML by inputting the correction value, it is possible to perform a more detailed examination between biological signal waveforms. Further, the signal output from the waveform display memory 26 is sent to the printer circuit unit 29 constituting the recording unit and subjected to signal processing, so that the printer 30 records the same as the display waveform on the monitor screen 28A. For example, a marker line ML synchronized with the QRS wave of the electrocardiogram W1 can be superimposed and drawn on a plurality of biological signal waveforms on the recording paper. Here, the waveform synthesizer 2
5, the waveform display memory 26, the display signal processing unit 27 and the monitor 28 constitute a display device 44, which displays a plurality of biological signal waveforms that are simultaneously taken in, and a marker line generated by the marker line generating means 43. Is displayed so as to be orthogonal to the time axis of the plurality of biological signal waveforms.

Next, a biological signal measuring apparatus according to another embodiment shown in FIG. 6 will be described. In the figure, the same symbols as in FIG. 1 indicate the same configurations. In this embodiment, the waveform recognizing section 16, the marker line display position calculating section 23 and the marker signal generating section 24 which constitute a part of the marker line generating means 43 of FIG.
U31). This CPU3
1 includes waveform memories 3, 6, which constitute the memory means 42.
9, 12, 15 and a random access memory 32 (hereinafter referred to as RAM 32) having storage areas corresponding to the memory 17 for waveform recognition and the memory 19 for forming a part of the marker line generating means 43 are connected. , C
A read only memory 33 (hereinafter referred to as ROM 33) in which a program corresponding to the processing procedure of the PU 31 is stored is connected. The CPU 31 takes in the electrocardiogram signal, the two blood pressure signals, the pulse wave signal, and the phonocardiogram signal which are digital signals output from the A / D converters 2, 5, 8, 11, and 14, and are stored in the RAM 32. It Then, the CPU 31, for example, reads a reference electrocardiogram signal from the RAM 32, and performs a series of processes similar to the process flow of FIG. 3 based on the program in the ROM 33, whereby the P wave, the QRS wave, and the T wave. Each waveform point position of the wave is recognized, and the data of each detected waveform point position is stored in the RAM 32. When the position where the marker line is desired to be displayed is set by the marker line synchronization position setting means 22, the setting signal indicates the CPU 3
1, the data of the waveform point position corresponding to the set position is read from the RAM 32 based on the processing procedure shown in FIG. 4, and is converted into the address of the waveform display memory 26 together with the correction value at the time of setting. When the output position of the marker line is determined, the composite signal obtained by superimposing the marker line on the plurality of biological signal waveforms read from the RAM 32 is the CPU.
It is created by 31, and is output to the waveform display memory 26. The combined signal sequentially read from the waveform display memory 26 is sent to the display signal processing unit 27 and converted into a signal that can be displayed on the monitor 28. Thereby, as shown in FIG. 5, the marker line ML synchronized with the specific waveform point position of the electrocardiogram W1 can be superimposed and displayed on the plurality of biological signal waveforms displayed on the monitor screen 28A. Also, a marker line synchronized with the electrocardiogram W1 can be drawn on a plurality of biological signal waveforms recorded by the printer 30.

Although the electrocardiogram W1 is used as the reference waveform of the cardiac cycle in the above two embodiments, the pulse wave W4 is used.
The marker line ML may be displayed with the reference waveform as. When the pulse wave W4 is used, it is possible to create a differential waveform or a secondary differential waveform and use the time point at which the waveform rises or crosses the zero level as a time reference. When the pulse wave W4 is used as a reference, the time difference with the QRS wave of the electrocardiogram W1 and the time difference with the electrocardiogram W5 can be confirmed, and examination is performed between other biological signal waveforms using the pulse wave W4 as a reference of the cardiac cycle. be able to.

As described above, according to the present invention, one
Bio-signal waves displayed on the screen or on the recording paper
It is important to associate the shapes with the cardiac cycle for mutual comparative observation.
It can be done with reference to Kalrain, so that observation
Is extremely easy. With this, conventionally, when it is attempted to compare a plurality of biological signal waveforms of the circulatory system with, for example, an electrocardiogram, the sweep of the waveform displayed on the monitor screen is temporarily stopped and the cursor is moved to the reference electrocardiogram. No need for complicated work such as moving,
There is no need for the troublesome work of drawing a guideline synchronized with the cardiac cycle on a recording paper using a ruler. Also conventionally, when the waveform on the monitor screen is swept, Kokoroshu
Although it was impossible to examine the waveform synchronized with the period , in the present invention, since the marker line is automatically displayed on the continuous waveform on the monitor screen, while detecting a plurality of biological signals from the subject, There is an advantage that other biological signal waveforms associated with the cardiac cycle can be examined. Thus, according to the present invention,
In this case, the biological signal waveform can be efficiently examined in clinical, examination, and research, and detailed waveform analysis can be performed, which is highly effective in contributing to medical care.

[Brief description of drawings]

FIG. 1 is a block diagram showing an embodiment of a biological signal measuring device according to the present invention.

FIG. 2 is a waveform chart showing a general electrocardiogram waveform.

FIG. 3 is a flowchart showing a processing procedure for recognizing the position of each waveform point on the electrocardiogram.

FIG. 4 is a flowchart showing a processing procedure for converting the position of a waveform detection point into an address of a waveform display memory and outputting a marker line.

FIG. 5 is a display waveform diagram showing a plurality of biological signal waveforms displayed on a monitor screen and marker lines generated in synchronization with, for example, an electrocardiogram.

FIG. 6 is a block diagram showing a biological signal measuring device of another embodiment.

[Explanation of symbols]

 1 Electrocardiogram Amplifier 4,7 Blood Pressure Signal Amplifier 10 Pulse Wave Amplifier 13 Heart Sound Diagram Amplifier 2,5,8,11,14 A / D Converter 3,6,9,12,15 Waveform Memory 16 Waveform Recognition Part 17 Waveform recognition memory 18 QRS wave recognition part 19 Memory 20 T wave recognition part 21 P wave recognition part 22 Marker line synchronization position setting means 23 Marker line display position calculation part 24 Marker signal generation part 25 Waveform synthesis part 26 For waveform display Memory 27 Display signal processing unit 28 Monitor 28A Monitor screen 29 Printer circuit unit 30 Printer 31 CPU 32 RAM 33 ROM 41 Input means 42 Memory means 43 Marker line generating means 44 Display device

Claims (1)

(57) [Claims] 1. A device for displaying a plurality of biological signal waveforms on a single screen or recording paper with their time axes aligned, and a synchronizing signal generating means for generating a synchronizing signal synchronized with a cardiac cycle detected from the biological signals. , Time axis at the time of generation of the synchronizing signal
So as to cross the plurality of biological signal waveforms in a direction orthogonal to
Marker line generation to generate the marker line to be displayed on
Biological signal measuring apparatus characterized by comprising a means.