JP2539197B2 - Centrifuge container assembly - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to a centrifuge container assembly for a continuous centrifuge, and more particularly, to a continuous centrifuge suitable for washing blood of patients with hematological disorders. The present invention relates to a centrifuge container assembly for a device.

[Prior Art and its Problems] Patients with hematological disorders such as jaundice have dirty plasma, and in the treatment of such jaundice, blood is continuously taken from the patient, and the taken blood is continuously taken. It has been practiced to separate the contaminated plasma by centrifuging and dispose of it, and then add the plasma preparation to blood other than plasma and return it to the patient's body.

A continuous blood centrifuge is used for such separation and washing of blood. In such a centrifuge, a patient and a centrifuge container are separated into a stationary system and a rotating system. Nevertheless, it is an absolute requirement that the entire system of blood entry / exit tubes (hereinafter referred to as blood tubes) that connect these sections be a completely closed system.
This is because if the system is imperfect, bacteria and the like will be mixed into the blood and pose a risk to the patient. It is also required that the blood tube has a long breaking life. This is because if the life is short, the blood tube will be damaged during blood washing, bacteria and the like will be mixed into the blood, and a large amount of blood will flow out from the patient's body, thus putting the patient at risk. Furthermore, during such blood cleansing treatment, the patient is given a certain amount of pain, and therefore, it is necessary to complete the blood cleansing in a short time. Therefore, high separation efficiency is required. Here, as a continuous centrifugal separator capable of realizing a completely closed system, for example, there is one shown in JP-A-51-120470. This structure and mechanism are briefly shown in FIGS. 7 and 8.

In FIG. 7, reference numeral 71 indicates a rotator for centrifugation, in which a centrifuge container 72, an injection nozzle 73 for injecting blood into the centrifuge container, and a centrifuge container 72 are centrifuged. It has a discharge nozzle group 74 for discharging the liquid.
The injection nozzle 73 and the discharge nozzle group 74 extend below the rotating body 71 and the tube twist prevention rotary table 75.
Is rotatably held at one end by a holder 76 or the like, and is rotatably held by a holder 78 at one end of an arm 77 extending above the end of the tube twist prevention rotary table 75. It is connected to the outside through a protective tube 79 fixed to an upper fixing member 80 located on the center axis of rotation. In this state, when the tube twisting prevention table 75 is rotated in the same direction as the rotating body 71 and at a rotation speed of 1/2, the protection tube 79 and the injection / discharge nozzles 73 and 74 will be completely rotated even if the rotating body rotates. As a result, no twist occurs. However, in the holder 76 and the holder 78, and in the curved portion of the tube, the tube is temporarily twisted, causing torsional vibration, and unnecessary force acts on the tube to destroy the tube. There was an occasion.

Further, FIG. 8 shows a cross-sectional top view of the rotating body 71 shown in FIG. Here, the centrifugation container 72 is symmetrically arranged on the rotating body 71, and the injection nozzle 73 and the discharge nozzle group 74 are arranged.
And were extended in the same direction. Therefore, the blood injected from the injection nozzle 73 may be directly discharged from the discharge nozzle 74 and may not be sufficiently separated, and sufficient separation efficiency may not be obtained.

Therefore, realization of safe and high separation efficiency of continuous centrifugation of blood, etc. could not be expected.

[Problems to be Solved by the Present Invention] The present invention can eliminate or eliminate the above-mentioned problems, that is, the incompleteness of blood separation, the lengthening of the separation time, and the occurrence of torsional vibration that causes tube breakage. A centrifuge container assembly for a continuous centrifuge is provided.

[Means for Solving Problems] In order to solve the above-mentioned problems, in the present invention, in order to integrally hold a tube group extending from a centrifuge container, tube protectors are provided at a plurality of positions of the tube system. Along with partial integration, the centrifuge container is made into a box shape, and both ends are connected by communication pipes to improve the separation efficiency, and the blood injection nozzle opening and blood inside the centrifuge container The opening of the component discharge nozzle is located on the opposite side of the rotary shaft so that the separated blood is not discharged.

Further, when integrally holding the tube group connected to the nozzle group, if the tube group portion is on a substantially straight line, the rigidity of the tube group can be further increased by integrating the entire straight line portion. .

[Examples] Examples according to the present invention will be described below with reference to Figs.

FIG. 1 shows the overall construction of a continuous centrifugation container assembly according to the present invention. This continuous centrifugation container assembly includes a centrifugation container 1 and nozzle groups 5 for injecting blood into the centrifugation container and discharging separated blood components from the centrifugation container 1.
8 and a metal tube 3 rotatably held by a holder 76 provided on the tube twist prevention table 75 shown in FIG.
A spring 2 that positively removes the twist of the tube group between the centrifuge container 1 and the metal tube 3, a tube protector 9 that integrally holds the tube group, and a tube group 15
To 18 and a tube fixing bush 11 integrated at the inlet of the tube group into the covering tube. The injection tube 15 is the injection nozzle 5, and the discharge tubes 16, 17, and 18 are the discharge nozzles, respectively.
It is connected to 6,7,8. Here, each component will be described below.

(A) Centrifuge vessel 1 FIG. 3 shows a top view of the centrifuge vessel 1 according to the present invention, and FIG. 4 shows a cross-sectional view of the centrifuge vessel on the ZZ plane. Here, the centrifuge container 1 is the third
Further, as shown in FIG. 4, it is a substantially rectangular parallelepiped, and the blood injection nozzle 5 and the blood component discharge nozzles 6 and 7 extend to the opposite side via the center of rotation, respectively. These nozzles 5-8
Extends toward the outside of the centrifuge vessel 1 through a shaft 4 provided at the center of rotation. Further, a semicircular communication pipe 14 is connected to the both ends of the centrifugation container 1 so as to communicate with each other. These centrifuge vessel 1 and communication pipe 14 are made of transparent acrylic pipe of appropriate thickness (for example, the outer peripheral arc of centrifuge vessel 1 is φ35 × φ43, and communication pipe 14 is φ5 × φ10). It is convenient to make it. Here, the distance from the center of rotation of the openings of the blood injection nozzle 5 and the blood component discharge nozzles 6 to 8 varies depending on the specific gravity of the blood to be injected and the content of the component to be centrifuged, so that the distance can be freely changed. It is preferable that In this embodiment, for example, the distance from the center of rotation of the opening end of the blood injection nozzle 5 is 40 mm, the distance from the red blood cell component discharge nozzle (the specific gravity of red blood cells is the largest compared to other components) is 60 mm, the platelets, The distance of the white blood cell component nozzle
A 30 mm plasma component nozzle (the specific gravity of the plasma component is the smallest compared to other components) was extended upward along the central axis of rotation, and the distance was set to 0 mm. The height of each nozzle 5-8 from the bottom of the centrifuge container also depends on the specific gravity of the blood and components to be centrifuged, but in this embodiment, the heights of the blood injection nozzle and the erythrocyte component discharge nozzle 6 are connected by a communication pipe. 14
The height of the nozzle 8 for the platelet / white blood cell component is set below the center height of the communication pipe 14,
The plasma component nozzle 7 is directed upward from the center of rotation. This height relationship is shown in FIGS. 6 and 5 showing the XX section and the YY section of FIG.

Here, the blood injection nozzle 5 and the blood component discharge nozzle 6 to
The reason why the open end of 7 is directed in the opposite direction is to prevent the centrifugal separation from being performed only on one side of the centrifuge container (with the rotation center axis as a boundary), and to perform the whole centrifugal container. To allow more separation in a single centrifugation operation, and
It is also prevented that the injected blood is directly discharged from the blood component discharging nozzle without being separated.

Next, the operation of the communication pipe 14 will be described. Blood
When injected into the centrifuge container from the injection nozzle 5 and the centrifuge container 1 is rotated at a high speed [about 3000 rpm (600-1200G)], plasma components having a low specific gravity gather in the central part of the container, and red blood cell components having a high specific gravity. Collect by centrifugation at the periphery of the container. Then, the erythrocyte component moves to the opposite side of the centrifuge container through the communication pipes 14 provided at both ends (periphery) of the container, and is discharged to the outside of the centrifuge container through the erythrocyte component discharge nozzle 6. is there. Here, since the centrifugal separation container 1 has a substantially rectangular shape, the centrifugal separation performance is improved, and the both ends of the centrifugal separation container 1 are connected by the communication pipe 14, so that the blood injection nozzle 5 and Even if the blood component discharge nozzles 6 and 7 are arranged on the opposite sides of the central axis of rotation, only one blood component discharge nozzle 6 and 7 are provided respectively, and the necessary blood component is discharged from the centrifuge container. It is possible.

(B) Barrel 3 and spring 2 A nozzle 5 for injecting blood into the centrifugal container 1 as described above.
As shown in FIG. 7, the nozzles 6 to 8 for discharging blood components extend downward from the center of rotation of the centrifuge container, and are rotatably held by a holder 76 provided on the twist prevention table 75. Here, when the centrifuge container rotates, in the structure shown in FIG. 7, in the entire pipe system (ABCD), the pipe is not twisted, but partially, for example, AB
Twist occurs temporarily between BC, between BC, and between CD. Therefore, it is necessary to remove the twist that partially occurs so that the twist does not affect the tube. In particular, between A and B, because the tube is curved, and the number of rotations of the centrifuge container and the twist prevention table (a part of the tube is held on it) are different,
The twist that occurs temporarily is large. Tube 3 is tube 15
The fixing method is to fix the tubes 15 to 18 so that they are equidistant from the rotation center O and equiangular, as shown in FIG. 2, for example. Is preferred. Here, a spring 2 is provided so as to surround these tubes 15 to 18, one end of which is fixed to the barrel 3 and the other end thereof is fixed to the centrifuge container 1. Further, since the barrel 3 is made rotatable with the holder 76, it is more preferable that the holder be a bearing and the barrel 3 be shaped and structured to be fixed to the inner ring of the bearing. And this spring 2 is the centrifuge container 1
However, when it is not rotating, keep it in the normal state. Here, when the centrifuge vessel 1 rotates, the tubes 15 to 18 are twisted between AB, and this twist also acts on the spring 2 provided between the barrel 3 and the centrifuge vessel 1. However, when the spring 2 is twisted, the reaction between the springs 2 (which works so as to return to the twist) positively removes the twist between the ABs, so that the tube between the ABs does not exert a twisting force. Here, the metal tube and the spring are provided only between AB, but between BC,
Further, it may be provided between CDs.

(C) Tube protector 9, covered tube 12, tube fixing bush 11, and covered tube protector 13 Between the BCDs, a large centrifugal force acts on the tubes 15 to 18, so that a large amount of twisting is removed between the BCDs. It is not preferable to provide a mechanism, for example, a metal bar and a spring provided between AB. Therefore, in the embodiment according to the present invention, the tube protector 9 is provided between BCs to increase the torsional strength of the tube, and
Between the CDs, a covering tube 12 and a tube fixing bush 11 are provided in order to integrate the tubes 15 to 18 and further increase the torsional strength thereof.

Here, the tube protector 9 is, as shown in FIG.
Basically, good results were obtained with any number between 2 but 1 to 20. The tubes 15 to 18 pass through the tube protector 9 and are fixed in the arrangement (similar to the fixing to the tube) as shown in FIG. 2, for example.

Furthermore, it is more preferable that the tube protector 9 and the tubes 15 to 18 be fixed in a state where they are installed between BCs, that is, in a state where a centrifuge container, a pipe and the like are placed in the centrifuge.

Next, between CDs, the tubes 15-18 are almost straight, so the tubes 15-18 are integrated so that they are covered tubes.
Put tubes 15-18 in 12 and
Is fixed to the tubes 15 to 18 by the covered tube protector 13. Here, the covering tube 12 and the covering tube protector 13
May be vinyl chloride, silicone resin, or the like. Further, it is preferable to provide a tube fixing bush 11 for integrally fixing the tubes 15 to 18 at the inlet portion where the tubes 15 to 18 enter the covering tube 12. Here, the fixing bush 11 may be made of the same material as the covering tube protector 13. Thus, between BCD tubes 15-18
Since they are integrated, the rigidity is increased and the strength against twisting is improved, so that the pipe breakage at this portion can be prevented.

Thus, in the entire pipe system, breakage due to twisting of the pipe can be prevented by positively removing the twist between AB and by increasing the strength of the pipe between BCD.

[Effects of the Invention] The effects of the present invention are various as described above, but are summarized as follows.

As a whole of the present invention, a continuous type centrifuge having a high separation efficiency, a safe liquid injection tube to a centrifuge and a tube discharging a separated liquid component, which does not generate unnecessary twisting force, and which has a long life and is safe. There is an effect that a centrifuge container assembly for a separation device can be realized.

Specifically, the centrifugal separation container itself has a box shape to improve the separation efficiency, and the centrifugal separation container has the opening end of the liquid injection nozzle with respect to the opening end of the liquid component discharge nozzle. Since it is provided on the opposite side with respect to the rotation axis of, the unseparated liquid is prevented from being discharged from the liquid component discharge nozzle, and further, by connecting both ends of the box-type centrifugal separation container with communication pipes, as described above. Even if the opening end of the liquid injection nozzle and the opening end of the liquid component nozzle are located on opposite sides, the processing can be performed without increasing the number of liquid component nozzles.

Further, a metal tube for fixing the liquid injection tube and the liquid component discharge tube is provided in the middle of the tube system, and a spring is provided between the metal tube and the centrifuge container so as to surround the tube system, By fixing both ends of this spring to a metal tube and a centrifuge container respectively, the twist generated in the tube part surrounded by the spring is positively removed by using the reaction force (returning force) of the spring, which is unnecessary for the tube. It is possible to extend the life of the tube by preventing the application of excessive force.

Furthermore, by twisting a plurality of tubes extending from the centrifuge container, the torsional strength of the entire tube system can be increased and the tubes can be prevented from being broken. There are two types of springs, one is a partial fixing method and the other is a whole fixing method.However, if the tube has a curved portion, a partial fixing method is desirable, and the tube is almost straight. In some cases, a method of fixing the whole body can obtain higher torsional rigidity. Further, the torsional rigidity can be further improved by combining these and fixing them as a whole, and then fixing them further partially.

It is obvious that those skilled in the art can make various modifications and improvements based on the above description.

[Brief description of drawings]

FIG. 1 is an overall configuration diagram of a centrifuge container assembly for a continuous centrifuge according to the present invention; FIG. 2 is an enlarged view of a WW cross section of FIG. 1; and FIG. 3 is an embodiment according to the present invention. Fig. 4 is a top view of the centrifuge container; Fig. 4 is a ZZ sectional view of Fig. 3, Figs. 5 and 6 are XX and YY sectional views of Fig. 4, respectively. Fig. 7 is a conventional centrifuge container assembly. FIG. 8 is a top view of a conventional centrifuge container, and FIG.

Claims (6)

(57) [Claims] 1. A centrifuge container (1), a nozzle (5) for injecting blood into the centrifuge container, and a group of nozzles (6, 7,) for discharging the blood component separated in the centrifuge container. 8)
And, the liquid injecting nozzle (5) and the drainage nozzle group (6, 7,
8) and an injecting tube (15) and a draining tube group (16, 17,
18) and a centrifugal container assembly for a continuous blood component centrifuging device having: The tube (1
5,16,17,18) A cylinder member (3) that allows rotation about the longitudinal direction of the bundle, and each of the cylinder member (3) and the centrifuge container (1). Spring means (2) surrounding the tube (15,16,17,18)
And at least one tube protector (9) for integrally holding and fixing the tubes (15,16,17,18) after inversion, and covering the tubes (15,16,17,18) Holds together and each tube (15,16,17,18) in the external stationary system
A centrifuge container assembly, comprising: a coating tube (12) connecting the two. 2. The assembly according to claim 1, wherein the centrifuge container has a substantially rectangular shape, and both ends thereof are provided with communication pipes for continuation with each other. And the liquid injection nozzle (5) and the liquid discharge nozzle group (6,
7, 8) are provided on opposite sides of the centrifuge container with respect to the center of rotation of the centrifuge container. 3. The assembly according to claim 2, wherein at least one of the drainage nozzle groups extends in the rotation axis direction, and the centrifuge container is a single tank. A centrifuge container assembly characterized in that 4. The assembly according to claim 1, wherein the tube (1) is provided at an intermediate portion of the coating tube (12).
An assembly including at least one cover tube protector (13) for tightening the member (2) and fixing the liquid injection tube and the drain tube group communicating therewith to the cover tube. 5. The assembly according to claim 1, further comprising a tube fixing bush (11) for integrally fixing the liquid injection tube and the drainage tube group at an inlet portion of the coating tube (12). Assembly. 6. The assembly according to claim 1, wherein the barrel member (3) and the tube protector (9) are equidistant from the center of rotation of the injection tube and the drainage tube group, An assembly that is arranged and fixed so that it is equiangular.