JP2527933C - - Google Patents

Info

Publication number

JP2527933C

JP2527933C JP2527933C JP 2527933 C JP2527933 C JP 2527933C JP 2527933 C JP2527933 C JP 2527933C

Authority

JP

Japan

Prior art keywords

cavity

sample

coating

capillary

cell

Prior art date

1999-04-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

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• 210000001736 Capillaries Anatomy 0.000 claims description 60
• 239000011248 coating agent Substances 0.000 claims description 41
• 238000000576 coating method Methods 0.000 claims description 41
• 239000000463 material Substances 0.000 claims description 41
• 239000011521 glass Substances 0.000 claims description 20
• 239000007788 liquid Substances 0.000 claims description 17
• 238000006243 chemical reaction Methods 0.000 claims description 12
• 239000003153 chemical reaction reagent Substances 0.000 claims description 12
• 238000011068 load Methods 0.000 claims description 11
• 229920003023 plastic Polymers 0.000 claims description 11
• 239000004033 plastic Substances 0.000 claims description 11
• 108090001123 antibodies Proteins 0.000 claims description 9
• 102000004965 antibodies Human genes 0.000 claims description 9
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 8
• BQCADISMDOOEFD-UHFFFAOYSA-N silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 7
• 229910052709 silver Inorganic materials 0.000 claims description 7
• 239000004332 silver Substances 0.000 claims description 7
• 239000000427 antigen Substances 0.000 claims description 6
• 108091007172 antigens Proteins 0.000 claims description 6
• 102000038129 antigens Human genes 0.000 claims description 6
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 6
• 229910052737 gold Inorganic materials 0.000 claims description 6
• 239000010931 gold Substances 0.000 claims description 6
• 239000011230 binding agent Substances 0.000 claims description 5
• 229910052802 copper Inorganic materials 0.000 claims description 4
• RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
• 239000010949 copper Substances 0.000 claims description 4
• 230000001808 coupling Effects 0.000 claims description 4
• 238000010168 coupling process Methods 0.000 claims description 4
• 238000005859 coupling reaction Methods 0.000 claims description 4
• 229910052697 platinum Inorganic materials 0.000 claims description 4
• 239000007787 solid Substances 0.000 claims description 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
• 229910002804 graphite Inorganic materials 0.000 claims description 3
• 239000010439 graphite Substances 0.000 claims description 3
• BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 2
• 230000000717 retained Effects 0.000 claims description 2
• 210000004027 cells Anatomy 0.000 claims 2
• 229920002972 Acrylic fiber Polymers 0.000 claims 1
• 210000002421 Cell Wall Anatomy 0.000 claims 1
• 239000010410 layer Substances 0.000 description 31
• 239000002245 particle Substances 0.000 description 29
• 239000000523 sample Substances 0.000 description 27
• 229920000915 polyvinyl chloride Polymers 0.000 description 23
• 239000004800 polyvinyl chloride Substances 0.000 description 23
• 239000012528 membrane Substances 0.000 description 18
• 150000002500 ions Chemical class 0.000 description 17
• 239000011159 matrix material Substances 0.000 description 15
• 238000004519 manufacturing process Methods 0.000 description 12
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 12
• XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 12
• 108090000790 Enzymes Proteins 0.000 description 10
• 102000004190 Enzymes Human genes 0.000 description 10
• MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 10
• 102000004169 proteins and genes Human genes 0.000 description 10
• 108090000623 proteins and genes Proteins 0.000 description 10
• 239000000126 substance Substances 0.000 description 10
• 239000002555 ionophore Substances 0.000 description 9
• 230000000236 ionophoric Effects 0.000 description 9
• 229940088598 Enzyme Drugs 0.000 description 8
• 239000000758 substrate Substances 0.000 description 8
• XOLBLPGZBRYERU-UHFFFAOYSA-N Tin dioxide Chemical compound O=[Sn]=O XOLBLPGZBRYERU-UHFFFAOYSA-N 0.000 description 7
• 230000000875 corresponding Effects 0.000 description 7
• 239000000835 fiber Substances 0.000 description 7
• 239000000203 mixture Substances 0.000 description 7
• 239000004014 plasticizer Substances 0.000 description 7
• 239000004202 carbamide Substances 0.000 description 6
• 239000004973 liquid crystal related substance Substances 0.000 description 6
• 238000005259 measurement Methods 0.000 description 6
• 229920000647 polyepoxide Polymers 0.000 description 6
• 239000004593 Epoxy Substances 0.000 description 5
• 230000027455 binding Effects 0.000 description 5
• 239000011247 coating layer Substances 0.000 description 5
• 125000003700 epoxy group Chemical group 0.000 description 5
• 239000000377 silicon dioxide Substances 0.000 description 5
• 239000011780 sodium chloride Substances 0.000 description 5
• 239000002904 solvent Substances 0.000 description 5
• 229940037179 Potassium Ion Drugs 0.000 description 4
• HKZLPVFGJNLROG-UHFFFAOYSA-M Silver chloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 4
• 108010046334 Urease Proteins 0.000 description 4
• 239000000853 adhesive Substances 0.000 description 4
• 230000001070 adhesive Effects 0.000 description 4
• 238000004166 bioassay Methods 0.000 description 4
• UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
• 239000002131 composite material Substances 0.000 description 4
• 239000004020 conductor Substances 0.000 description 4
• -1 crystal Substances 0.000 description 4
• 239000003822 epoxy resin Substances 0.000 description 4
• 238000005530 etching Methods 0.000 description 4
• 239000010408 film Substances 0.000 description 4
• 238000000034 method Methods 0.000 description 4
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
• 239000011591 potassium Substances 0.000 description 4
• 229910052700 potassium Inorganic materials 0.000 description 4
• NPYPAHLBTDXSSS-UHFFFAOYSA-N potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 4
• 229910001414 potassium ion Inorganic materials 0.000 description 4
• 229920005989 resin Polymers 0.000 description 4
• 239000011347 resin Substances 0.000 description 4
• 150000003839 salts Chemical class 0.000 description 4
• 238000007650 screen-printing Methods 0.000 description 4
• 239000000243 solution Substances 0.000 description 4
• 239000005720 sucrose Substances 0.000 description 4
• CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
• CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 description 3
• 239000000919 ceramic Substances 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
• 238000009792 diffusion process Methods 0.000 description 3
• 239000003365 glass fiber Substances 0.000 description 3
• 229920000642 polymer Polymers 0.000 description 3
• 230000001235 sensitizing Effects 0.000 description 3
• 231100000202 sensitizing Toxicity 0.000 description 3
• 238000007873 sieving Methods 0.000 description 3
• 150000004763 sulfides Chemical class 0.000 description 3
• 229910001887 tin oxide Inorganic materials 0.000 description 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
• 108010093096 Immobilized Enzymes Proteins 0.000 description 2
• 210000000088 Lip Anatomy 0.000 description 2
• 239000004793 Polystyrene Substances 0.000 description 2
• XUARKZBEFFVFRG-UHFFFAOYSA-N Silver sulfide Chemical compound [S-2].[Ag+].[Ag+] XUARKZBEFFVFRG-UHFFFAOYSA-N 0.000 description 2
• 108010067973 Valinomycin Proteins 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 238000007605 air drying Methods 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 239000000337 buffer salt Substances 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 238000000502 dialysis Methods 0.000 description 2
• 230000000694 effects Effects 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 239000008103 glucose Substances 0.000 description 2
• 230000000670 limiting Effects 0.000 description 2
• 230000001264 neutralization Effects 0.000 description 2
• 239000003973 paint Substances 0.000 description 2
• 239000002985 plastic film Substances 0.000 description 2
• 229920002223 polystyrene Polymers 0.000 description 2
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
• 238000007639 printing Methods 0.000 description 2
• 238000000159 protein binding assay Methods 0.000 description 2
• 239000010453 quartz Substances 0.000 description 2
• 229910052904 quartz Inorganic materials 0.000 description 2
• 239000012488 sample solution Substances 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 238000004528 spin coating Methods 0.000 description 2
• 238000010998 test method Methods 0.000 description 2
• WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
• FCFNRCROJUBPLU-DNDCDFAISA-N valinomycin Chemical compound CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC(=O)[C@H](C(C)C)NC(=O)[C@H](C)OC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C(C)C)OC1=O FCFNRCROJUBPLU-DNDCDFAISA-N 0.000 description 2
• 238000005406 washing Methods 0.000 description 2
• VNHGETRQQSYUGZ-UHFFFAOYSA-N 1-nitro-2-phenoxybenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1OC1=CC=CC=C1 VNHGETRQQSYUGZ-UHFFFAOYSA-N 0.000 description 1
• 108010062580 Concanavalin A Proteins 0.000 description 1
• BWFPGXWASODCHM-UHFFFAOYSA-N Copper monosulfide Chemical compound [Cu]=S BWFPGXWASODCHM-UHFFFAOYSA-N 0.000 description 1
• 229940109239 Creatinine Drugs 0.000 description 1
• VIZORQUEIQEFRT-UHFFFAOYSA-N Diethyl adipate Chemical compound CCOC(=O)CCCCC(=O)OCC VIZORQUEIQEFRT-UHFFFAOYSA-N 0.000 description 1
• VJHINFRRDQUWOJ-UHFFFAOYSA-N Dioctyl sebacate Chemical compound CCCCC(CC)COC(=O)CCCCCCCCC(=O)OCC(CC)CCCC VJHINFRRDQUWOJ-UHFFFAOYSA-N 0.000 description 1
• 108010015776 EC 1.1.3.4 Proteins 0.000 description 1
• 210000000887 Face Anatomy 0.000 description 1
• KTWOOEGAPBSYNW-UHFFFAOYSA-N Ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
• 229940116332 GLUCOSE OXIDASE Drugs 0.000 description 1
• 239000004366 Glucose oxidase Substances 0.000 description 1
• 108010058683 Immobilized Proteins Proteins 0.000 description 1
• 241000406668 Loxodonta cyclotis Species 0.000 description 1
• MSFPLIAKTHOCQP-UHFFFAOYSA-M Silver iodide Chemical compound I[Ag] MSFPLIAKTHOCQP-UHFFFAOYSA-M 0.000 description 1
• SWZDQOUHBYYPJD-UHFFFAOYSA-N Tridodecylamine Chemical compound CCCCCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC SWZDQOUHBYYPJD-UHFFFAOYSA-N 0.000 description 1
• 229910052946 acanthite Inorganic materials 0.000 description 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
• 125000003172 aldehyde group Chemical group 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 239000012491 analyte Substances 0.000 description 1
• 238000004873 anchoring Methods 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 239000012298 atmosphere Substances 0.000 description 1
• SWXQKHHHCFXQJF-UHFFFAOYSA-N azane;hydrogen peroxide Chemical compound [NH4+].[O-]O SWXQKHHHCFXQJF-UHFFFAOYSA-N 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
• 230000024881 catalytic activity Effects 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 230000005591 charge neutralization Effects 0.000 description 1
• 239000007795 chemical reaction product Substances 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 239000000460 chlorine Substances 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• GTKRFUAGOKINCA-UHFFFAOYSA-M chlorosilver;silver Chemical compound [Ag].[Ag]Cl GTKRFUAGOKINCA-UHFFFAOYSA-M 0.000 description 1
• 238000004140 cleaning Methods 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 230000003750 conditioning Effects 0.000 description 1
• 229920001940 conductive polymer Polymers 0.000 description 1
• DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• HAKMAMKAFTZXOZ-UHFFFAOYSA-N dioctoxyphosphorylbenzene Chemical compound CCCCCCCCOP(=O)(OCCCCCCCC)C1=CC=CC=C1 HAKMAMKAFTZXOZ-UHFFFAOYSA-N 0.000 description 1
• 238000003618 dip coating Methods 0.000 description 1
• 239000007772 electrode material Substances 0.000 description 1
• 230000002255 enzymatic Effects 0.000 description 1
• 238000006911 enzymatic reaction Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 238000005755 formation reaction Methods 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 238000007429 general method Methods 0.000 description 1
• 235000019420 glucose oxidase Nutrition 0.000 description 1
• 239000003292 glue Substances 0.000 description 1
• 150000004820 halides Chemical class 0.000 description 1
• GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
• 238000003384 imaging method Methods 0.000 description 1
• 239000003547 immunosorbent Substances 0.000 description 1
• 238000011065 in-situ storage Methods 0.000 description 1
• 230000000415 inactivating Effects 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 238000010348 incorporation Methods 0.000 description 1
• 229910001410 inorganic ion Inorganic materials 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 230000000873 masking Effects 0.000 description 1
• 238000000691 measurement method Methods 0.000 description 1
• QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
• 229910052753 mercury Inorganic materials 0.000 description 1
• 238000001465 metallisation Methods 0.000 description 1
• CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
• 230000004048 modification Effects 0.000 description 1
• 238000006011 modification reaction Methods 0.000 description 1
• 239000002365 multiple layer Substances 0.000 description 1
• 238000006386 neutralization reaction Methods 0.000 description 1
• 230000003287 optical Effects 0.000 description 1
• 229920000620 organic polymer Polymers 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
• 229910052760 oxygen Inorganic materials 0.000 description 1
• 239000006174 pH buffer Substances 0.000 description 1
• 238000010422 painting Methods 0.000 description 1
• 239000002861 polymer material Substances 0.000 description 1
• 229920005597 polymer membrane Polymers 0.000 description 1
• 229920002635 polyurethane Polymers 0.000 description 1
• 239000004814 polyurethane Substances 0.000 description 1
• 239000011118 polyvinyl acetate Substances 0.000 description 1
• 229920002689 polyvinyl acetate Polymers 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 235000011962 puddings Nutrition 0.000 description 1
• 238000010791 quenching Methods 0.000 description 1
• 230000000171 quenching Effects 0.000 description 1
• 230000035484 reaction time Effects 0.000 description 1
• 230000002829 reduced Effects 0.000 description 1
• 239000004065 semiconductor Substances 0.000 description 1
• BLRPTPMANUNPDV-UHFFFAOYSA-N silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
• 229910000077 silane Inorganic materials 0.000 description 1
• 229940045105 silver iodide Drugs 0.000 description 1
• 229940056910 silver sulfide Drugs 0.000 description 1
• 239000002689 soil Substances 0.000 description 1
• 238000007711 solidification Methods 0.000 description 1
• 238000000935 solvent evaporation Methods 0.000 description 1
• 238000000527 sonication Methods 0.000 description 1
• 238000003892 spreading Methods 0.000 description 1
• 238000004381 surface treatment Methods 0.000 description 1
• 239000010409 thin film Substances 0.000 description 1
• WVPGXJOLGGFBCR-UHFFFAOYSA-N trioctyl phosphate Chemical compound CCCCCCCCOP(=O)(OCCCCCCCC)OCCCCCCCC WVPGXJOLGGFBCR-UHFFFAOYSA-N 0.000 description 1
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
• 238000003466 welding Methods 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N β-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1