JP2025520225A - 多重特異性結合剤の製造および/または送達 - Google Patents

多重特異性結合剤の製造および/または送達 Download PDF

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JP2025520225A
JP2025520225A JP2024568439A JP2024568439A JP2025520225A JP 2025520225 A JP2025520225 A JP 2025520225A JP 2024568439 A JP2024568439 A JP 2024568439A JP 2024568439 A JP2024568439 A JP 2024568439A JP 2025520225 A JP2025520225 A JP 2025520225A
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cells
cell
btce
cancer
gene
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JP2025520225A5 (enExample
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ジェイ. ローリングス,デイヴィッド
ジー. ジェイムズ,リチャード
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シアトル チルドレンズ ホスピタル ディー/ビー/エイ シアトル チルドレンズ リサーチ インスティテュート
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • A61K35/14—Blood; Artificial blood
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/13—B-cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/33—Antibodies; T-cell engagers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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JP2024568439A 2022-05-18 2023-05-09 多重特異性結合剤の製造および/または送達 Pending JP2025520225A (ja)

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US202263343537P 2022-05-18 2022-05-18
US63/343,537 2022-05-18
US202363498202P 2023-04-25 2023-04-25
US63/498,202 2023-04-25
PCT/US2023/066760 WO2023225447A1 (en) 2022-05-18 2023-05-09 Production and/or delivery of multispecific binding agents

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JP2025520225A true JP2025520225A (ja) 2025-07-02
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US (1) US20250369020A1 (enExample)
EP (1) EP4526458A1 (enExample)
JP (1) JP2025520225A (enExample)
AU (1) AU2023273018A1 (enExample)
CA (1) CA3256784A1 (enExample)
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WO2026090418A1 (en) * 2024-10-24 2026-04-30 University Of Massachusetts Ultra-efficient rna switches and related expression systems

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EP3945800A1 (en) * 2019-04-03 2022-02-09 Regeneron Pharmaceuticals, Inc. Methods and compositions for insertion of antibody coding sequences into a safe harbor locus
WO2022099297A1 (en) * 2020-11-04 2022-05-12 Fate Therapeutics, Inc. Multiplexed engineered ipsc and immune effector cells targeting solid tumors

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AU2023273018A1 (en) 2024-11-14
EP4526458A1 (en) 2025-03-26
CA3256784A1 (en) 2023-11-23
US20250369020A1 (en) 2025-12-04

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