JP2025517657A - シンシチン-1融合タンパク質及び標的細胞へのカーゴ送達のためのその使用 - Google Patents
シンシチン-1融合タンパク質及び標的細胞へのカーゴ送達のためのその使用 Download PDFInfo
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- JP2025517657A JP2025517657A JP2024566207A JP2024566207A JP2025517657A JP 2025517657 A JP2025517657 A JP 2025517657A JP 2024566207 A JP2024566207 A JP 2024566207A JP 2024566207 A JP2024566207 A JP 2024566207A JP 2025517657 A JP2025517657 A JP 2025517657A
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
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- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16042—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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- C12N2740/00011—Details
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- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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- Proteomics, Peptides & Aminoacids (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
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- Diabetes (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22305688 | 2022-05-10 | ||
| EP22305688.8 | 2022-05-10 | ||
| PCT/EP2023/062497 WO2023217904A1 (en) | 2022-05-10 | 2023-05-10 | Syncitin-1 fusion proteins and uses thereof for cargo delivery into target cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025517657A true JP2025517657A (ja) | 2025-06-10 |
| JP2025517657A5 JP2025517657A5 (https=) | 2026-03-06 |
Family
ID=81984672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024566207A Pending JP2025517657A (ja) | 2022-05-10 | 2023-05-10 | シンシチン-1融合タンパク質及び標的細胞へのカーゴ送達のためのその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20250223326A1 (https=) |
| EP (1) | EP4522630A1 (https=) |
| JP (1) | JP2025517657A (https=) |
| WO (1) | WO2023217904A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025257403A1 (en) * | 2024-06-14 | 2025-12-18 | Dotbio Pte. Ltd. | Virus-like particles |
| CN118557718A (zh) * | 2024-08-01 | 2024-08-30 | 中国人民解放军军事科学院军事医学研究院 | 一种以peg10蛋白为载体的纳米颗粒及其制备方法和应用 |
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| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4960716A (en) | 1984-05-01 | 1990-10-02 | Ciba Corning Diagnostics Corp. | Monoclonal antibodies specific for 330 KD breast tumor antigen and assay using said monoclonal antibodies |
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
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| CA2044421C (en) | 1990-11-27 | 2005-06-21 | Thomas Hyatt Duffy | Squamous cell carcinoma-like immunoreactive antigen from human female urine |
| AU657102B2 (en) | 1991-04-12 | 1995-03-02 | Bio-Rad Laboratories, Inc. | CA 195-like immunoreactive antigen from human amniotic fluid |
| DK1621554T4 (da) | 1992-08-21 | 2012-12-17 | Univ Bruxelles | Immunoglobuliner blottet for lette kæder |
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| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3235828A1 (en) | 2016-04-21 | 2017-10-25 | Genethon | Stable pseudotyped lentiviral particles and uses thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| EP3284819A1 (en) | 2016-08-16 | 2018-02-21 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Method for the generation of t cell hybridoma for cloning and analysis of receptors using engineered measles virus fusogenic glycoproteins |
| CA3078096A1 (en) * | 2017-10-20 | 2018-10-19 | Genethon | Use of syncytin for targeting drug and gene delivery to regenerating muscle tissue |
| IL273923B2 (en) * | 2017-10-20 | 2024-08-01 | Genethon | Using syncytin for drug targeting and gene delivery to lung tissue |
| JP7693552B2 (ja) | 2019-02-13 | 2025-06-17 | ビーム セラピューティクス インク. | アデノシンデアミナーゼ塩基エディターおよびそれを用いて標的配列中の核酸塩基を改変する方法 |
| US20220184225A1 (en) * | 2019-04-23 | 2022-06-16 | Case Western Reserve University | Fusogenic particles and related methods for delivering therapeutic agents to cells |
| AU2020344547A1 (en) | 2019-09-09 | 2022-03-24 | Beam Therapeutics Inc. | Novel nucleobase editors and methods of using same |
-
2023
- 2023-05-10 US US18/853,878 patent/US20250223326A1/en active Pending
- 2023-05-10 WO PCT/EP2023/062497 patent/WO2023217904A1/en not_active Ceased
- 2023-05-10 EP EP23726074.0A patent/EP4522630A1/en active Pending
- 2023-05-10 JP JP2024566207A patent/JP2025517657A/ja active Pending
Also Published As
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|---|---|
| WO2023217904A1 (en) | 2023-11-16 |
| US20250223326A1 (en) | 2025-07-10 |
| EP4522630A1 (en) | 2025-03-19 |
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