JP2025513289A - ファルネソイドｘ受容体アゴニストの使用 - Google Patents

ファルネソイドｘ受容体アゴニストの使用 Download PDF

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Publication number
JP2025513289A
JP2025513289A JP2024561602A JP2024561602A JP2025513289A JP 2025513289 A JP2025513289 A JP 2025513289A JP 2024561602 A JP2024561602 A JP 2024561602A JP 2024561602 A JP2024561602 A JP 2024561602A JP 2025513289 A JP2025513289 A JP 2025513289A
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JP
Japan
Prior art keywords
patient
compound
pharma
score
amino acid
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Pending
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JP2024561602A
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English (en)
Japanese (ja)
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JP2025513289A5 (cg-RX-API-DMAC10.html
Inventor
トーマス カポッツァ，
Original Assignee
インターセプト ファーマシューティカルズ， インコーポレイテッド
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Application filed by インターセプト ファーマシューティカルズ， インコーポレイテッド filed Critical インターセプト ファーマシューティカルズ， インコーポレイテッド
Publication of JP2025513289A publication Critical patent/JP2025513289A/ja
Publication of JP2025513289A5 publication Critical patent/JP2025513289A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2024561602A 2022-04-21 2023-04-21 ファルネソイドｘ受容体アゴニストの使用 Pending JP2025513289A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263333287P 2022-04-21 2022-04-21
US63/333,287 2022-04-21
US202263381752P 2022-10-31 2022-10-31
US63/381,752 2022-10-31
PCT/US2023/019448 WO2023205447A2 (en) 2022-04-21 2023-04-21 Uses of farnesoid x receptor agonists

Publications (2)

Publication Number Publication Date
JP2025513289A true JP2025513289A (ja) 2025-04-24
JP2025513289A5 JP2025513289A5 (cg-RX-API-DMAC10.html) 2026-04-28

Family

ID=88420596

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024561602A Pending JP2025513289A (ja) 2022-04-21 2023-04-21 ファルネソイドｘ受容体アゴニストの使用

Country Status (10)

Country Link
US (1) US20250288600A1 (cg-RX-API-DMAC10.html)
EP (1) EP4511012A4 (cg-RX-API-DMAC10.html)
JP (1) JP2025513289A (cg-RX-API-DMAC10.html)
KR (1) KR20250006156A (cg-RX-API-DMAC10.html)
CN (1) CN119136794A (cg-RX-API-DMAC10.html)
AU (1) AU2023257308A1 (cg-RX-API-DMAC10.html)
CA (1) CA3249500A1 (cg-RX-API-DMAC10.html)
IL (1) IL315941A (cg-RX-API-DMAC10.html)
MX (1) MX2024012966A (cg-RX-API-DMAC10.html)
WO (1) WO2023205447A2 (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024097247A1 (en) * 2022-10-31 2024-05-10 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists
US12677339B2 (en) * 2022-11-14 2026-07-07 Intel Corporation Sensing by proxy (SBP) termination frame with termination control field

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015314830B2 (en) * 2014-09-12 2021-01-07 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
PE20180690A1 (es) * 2015-04-27 2018-04-23 Intercept Pharmaceuticals Inc Composiciones de acido obeticolico y metodos de uso
EA038632B1 (ru) * 2016-03-11 2021-09-27 Интерсепт Фармасьютикалз, Инк. 7,11-дигидрокси-6-этил-5-холан-24-овая кислота и фармацевтические композиции на ее основе для лечения или предупреждения заболевания или состояния, опосредованных фарнезоидным х-рецептором (fxr)
IL271343B2 (en) * 2017-06-23 2023-12-01 Intercept Pharmaceuticals Inc Methods and intermediates for the preparation of bile acid derivatives

Also Published As

Publication number Publication date
CN119136794A (zh) 2024-12-13
IL315941A (en) 2024-11-01
AU2023257308A1 (en) 2024-10-10
EP4511012A2 (en) 2025-02-26
WO2023205447A3 (en) 2024-04-04
MX2024012966A (es) 2024-11-08
KR20250006156A (ko) 2025-01-10
WO2023205447A2 (en) 2023-10-26
EP4511012A4 (en) 2026-06-24
CA3249500A1 (en) 2023-10-26
US20250288600A1 (en) 2025-09-18

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