JP2025512445A - Ｓｃａｐ活性を調節するための組成物及び方法 - Google Patents

Ｓｃａｐ活性を調節するための組成物及び方法 Download PDF

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JP2025512445A
JP2025512445A JP2024560613A JP2024560613A JP2025512445A JP 2025512445 A JP2025512445 A JP 2025512445A JP 2024560613 A JP2024560613 A JP 2024560613A JP 2024560613 A JP2024560613 A JP 2024560613A JP 2025512445 A JP2025512445 A JP 2025512445A
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seq
nucleotides
antisense strand
nos
sense strand
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JP2025512445A5 (https=
Inventor
ボブ デール ブラウン
ヘンリク ティー ドゥデク
ソンムン チョン
ニコル アレクシス スピーゲルマン
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Dicerna Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024560613A 2022-04-15 2023-04-14 Ｓｃａｐ活性を調節するための組成物及び方法 Pending JP2025512445A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263363091P 2022-04-15 2022-04-15
US63/363,091 2022-04-15
PCT/US2023/018657 WO2023201043A1 (en) 2022-04-15 2023-04-14 Compositions and methods for modulating scap activity

Publications (2)

Publication Number Publication Date
JP2025512445A true JP2025512445A (ja) 2025-04-17
JP2025512445A5 JP2025512445A5 (https=) 2026-04-21

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Country Link
US (1) US20230374522A1 (https=)
EP (1) EP4508218A1 (https=)
JP (1) JP2025512445A (https=)
KR (1) KR20250005108A (https=)
CN (1) CN119013402A (https=)
AR (1) AR129073A1 (https=)
AU (1) AU2023254798A1 (https=)
CA (1) CA3245064A1 (https=)
IL (1) IL315878A (https=)
MX (1) MX2024012729A (https=)
TW (1) TW202345873A (https=)
WO (1) WO2023201043A1 (https=)

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US5889136A (en) 1995-06-09 1999-03-30 The Regents Of The University Of Colorado Orthoester protecting groups in RNA synthesis
US5998203A (en) 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
US6111086A (en) 1998-02-27 2000-08-29 Scaringe; Stephen A. Orthoester protecting groups
ES2336887T5 (es) 2000-03-30 2019-03-06 Whitehead Inst Biomedical Res Mediadores de interferencia por ARN específicos de secuencias de ARN
CA2429814C (en) 2000-12-01 2014-02-18 Thomas Tuschl Rna interference mediating small rna molecules
US20050159378A1 (en) 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
WO2003040395A2 (en) 2001-11-07 2003-05-15 Applera Corporation Universal nucleotides for nucleic acid analysis
US20070265220A1 (en) 2004-03-15 2007-11-15 City Of Hope Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
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US8691971B2 (en) 2008-09-23 2014-04-08 Scott G. Petersen Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
US20100249214A1 (en) 2009-02-11 2010-09-30 Dicerna Pharmaceuticals Multiplex dicer substrate rna interference molecules having joining sequences
KR101728655B1 (ko) 2008-12-18 2017-04-19 다이서나 파마수이티컬, 인크. 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
WO2011005860A2 (en) 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
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Publication number Publication date
MX2024012729A (es) 2024-11-08
CA3245064A1 (en) 2023-10-19
IL315878A (en) 2024-11-01
KR20250005108A (ko) 2025-01-09
WO2023201043A1 (en) 2023-10-19
AR129073A1 (es) 2024-07-10
TW202345873A (zh) 2023-12-01
AU2023254798A1 (en) 2024-09-19
EP4508218A1 (en) 2025-02-19
US20230374522A1 (en) 2023-11-23
CN119013402A (zh) 2024-11-22

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