JP2025511940A5 - - Google Patents

Info

Publication number
JP2025511940A5
JP2025511940A5 JP2024559584A JP2024559584A JP2025511940A5 JP 2025511940 A5 JP2025511940 A5 JP 2025511940A5 JP 2024559584 A JP2024559584 A JP 2024559584A JP 2024559584 A JP2024559584 A JP 2024559584A JP 2025511940 A5 JP2025511940 A5 JP 2025511940A5
Authority
JP
Japan
Prior art keywords
cancer
seq
antibody
antagonist
gremlin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024559584A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025511940A (ja
Filing date
Publication date
Priority claimed from GBGB2205200.5A external-priority patent/GB202205200D0/en
Application filed filed Critical
Publication of JP2025511940A publication Critical patent/JP2025511940A/ja
Publication of JP2025511940A5 publication Critical patent/JP2025511940A5/ja
Pending legal-status Critical Current

Links

JP2024559584A 2022-04-08 2023-04-06 グレムリン-1アンタゴニストとシチジン類似体又はデオキシシチジン類似体の組み合わせ Pending JP2025511940A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2205200.5A GB202205200D0 (en) 2022-04-08 2022-04-08 Combination with chemotherapy
GB2205200.5 2022-04-08
PCT/EP2023/059271 WO2023194584A1 (en) 2022-04-08 2023-04-06 Combination of a gremlin-1 antagonist with a cytidine analogue or deoxycytidine analogue

Publications (2)

Publication Number Publication Date
JP2025511940A JP2025511940A (ja) 2025-04-16
JP2025511940A5 true JP2025511940A5 (https=) 2026-04-14

Family

ID=81653327

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024559584A Pending JP2025511940A (ja) 2022-04-08 2023-04-06 グレムリン-1アンタゴニストとシチジン類似体又はデオキシシチジン類似体の組み合わせ

Country Status (11)

Country Link
US (1) US20250243267A1 (https=)
EP (1) EP4504778A1 (https=)
JP (1) JP2025511940A (https=)
KR (1) KR20250004732A (https=)
CN (1) CN119343372A (https=)
AU (1) AU2023251209A1 (https=)
CA (1) CA3255381A1 (https=)
GB (1) GB202205200D0 (https=)
IL (1) IL315762A (https=)
MX (1) MX2024012464A (https=)
WO (1) WO2023194584A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117965736A (zh) * 2024-02-05 2024-05-03 南京医科大学康达学院 Grem1作为预测非小细胞肺癌转移或不良预后的生物标志物及其应用
CN117801109B (zh) * 2024-03-01 2024-05-03 再少年(北京)生物科技有限公司 iPS诱导定向分化成内皮祖细胞的方法及应用
WO2026027660A1 (en) 2024-08-02 2026-02-05 UCB Biopharma SRL Formulations of anti-gremlin-1 antibodies

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
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AU7247191A (en) 1990-01-11 1991-08-05 Molecular Affinities Corporation Production of antibodies using gene libraries
US5780225A (en) 1990-01-12 1998-07-14 Stratagene Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
GB9113120D0 (en) 1991-06-18 1991-08-07 Kodak Ltd Photographic processing apparatus
PT1024191E (pt) 1991-12-02 2008-12-22 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
WO1995015982A2 (en) 1993-12-08 1995-06-15 Genzyme Corporation Process for generating specific antibodies
DE69534347T2 (de) 1994-01-31 2006-05-24 Trustees Of Boston University, Boston Bibliotheken aus Polyklonalen Antikörpern
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JP2978435B2 (ja) 1996-01-24 1999-11-15 チッソ株式会社 アクリロキシプロピルシランの製造方法
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ES2551439T5 (es) 2003-07-01 2018-11-08 Ucb Biopharma Sprl Fragmentos Fab de anticuerpos modificados
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US8383349B2 (en) * 2007-03-16 2013-02-26 The Board Of Trustees Of The Leland Stanford Junior University Bone morphogenetic protein antagonist and uses thereof
EP2535349A1 (en) 2007-09-26 2012-12-19 UCB Pharma S.A. Dual specificity antibody fusions
EP2826790B1 (en) * 2012-03-15 2019-02-13 SNU R&DB Foundation Anti-gremlin-1 antibody
EA201591762A1 (ru) 2013-03-14 2015-12-30 Ридженерон Фармасьютикалз, Инк. Человеческие антитела к grem1
WO2017158396A1 (en) * 2016-03-16 2017-09-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Cytidine deaminase inhibitors for the treatment of pancreatic cancer
GB201621635D0 (en) 2016-12-19 2017-02-01 Ucb Biopharma Sprl Crystal structure
MX2020013808A (es) 2018-06-18 2021-05-27 UCB Biopharma SRL Antagonista de gremlina-1 para la prevencion y el tratamiento del cancer.
WO2022152290A1 (en) * 2021-01-18 2022-07-21 Suzhou Transcenta Therapeutics Co., Ltd. Novel anti-gremlin1 antibodies

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